[go: up one dir, main page]

WO2014141296A3 - Process for the preparation of tapentadol via novel intermediate - Google Patents

Process for the preparation of tapentadol via novel intermediate Download PDF

Info

Publication number
WO2014141296A3
WO2014141296A3 PCT/IN2014/000151 IN2014000151W WO2014141296A3 WO 2014141296 A3 WO2014141296 A3 WO 2014141296A3 IN 2014000151 W IN2014000151 W IN 2014000151W WO 2014141296 A3 WO2014141296 A3 WO 2014141296A3
Authority
WO
WIPO (PCT)
Prior art keywords
tapentadol
preparation
formula
via novel
alkaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2014/000151
Other languages
French (fr)
Other versions
WO2014141296A2 (en
Inventor
Rajesh Vinodrai Naik
Gurdeep Singh Sarin
Perminder Singh Johar
Manjit Singh BANGA
Homendra Singh CHONGTHAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Original Assignee
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND-SWIFT LABORATORIES Ltd, Ind Swift Laboratories Ltd filed Critical IND-SWIFT LABORATORIES Ltd
Publication of WO2014141296A2 publication Critical patent/WO2014141296A2/en
Publication of WO2014141296A3 publication Critical patent/WO2014141296A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a commercially viable and improved process for preparation of tapentadol of formula I and its pharmaceutically acceptable salts, Formula I via novel intermediates tertiary hydroxy protected sulfonyl compound of formula III. Formula III wherein R 1 is selected from hydrogen, straight chain or branched alky I, aryl, aralkyl, alkaryl which can be substituted or unsubstituted; and R 2 represents CH 3 -CO-, CF 3 -CO-, CH 2 CICO-, CHCI 2 -CO-, CCI 3 -CO-, CH 3 O-CO-CO-, CH 3 O-CO-, CH 3 CH 2 O-CO-, CH 3 CH 2 O-CO-CO, phenyl-CO-, or meta-CH 3 COO-phenyl- CO- or -S02R'; wherein R' can be selected from hydrogen, straight chain or branched alkyl, aryl, aralkyl, alkaryl, heteroalkyl, heteroaryl and like which can be substituted or unsubstituted.
PCT/IN2014/000151 2013-03-09 2014-03-07 Process for the preparation of tapentadol via novel intermediate Ceased WO2014141296A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN685DE2013 2013-03-09
IN685/DEL/2013 2013-03-09

Publications (2)

Publication Number Publication Date
WO2014141296A2 WO2014141296A2 (en) 2014-09-18
WO2014141296A3 true WO2014141296A3 (en) 2014-12-24

Family

ID=51538246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000151 Ceased WO2014141296A2 (en) 2013-03-09 2014-03-07 Process for the preparation of tapentadol via novel intermediate

Country Status (1)

Country Link
WO (1) WO2014141296A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008012046A1 (en) * 2006-07-24 2008-01-31 Grünenthal GmbH Preparation of 3-[(1r,2r)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol
WO2011128784A2 (en) * 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
WO2012038974A1 (en) * 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008012046A1 (en) * 2006-07-24 2008-01-31 Grünenthal GmbH Preparation of 3-[(1r,2r)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol
WO2011128784A2 (en) * 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
WO2012038974A1 (en) * 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative

Also Published As

Publication number Publication date
WO2014141296A2 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
MA35452B1 (en) 3-pyrimidin-4-yl-oxazolidin-2-ones as mutant idh inhibitors
MD20180040A2 (en) Inhibitors of hepatitis C virus
JO3387B1 (en) Derivatives of betulin
MY164776A (en) Heterocyclic compound
IN2012DN02751A (en)
WO2014041559A3 (en) Process for preparation of dabigatran etexilate and intermediates thereof
MX2013011257A (en) Process for preparation of dronedarone by n-butylation.
WO2013098836A8 (en) A bis-quinophthalone pigment and a process for preparing the same
WO2009154754A3 (en) Synthesis of deuterated morpholine derivatives
WO2012117357A3 (en) Process for preparation of ketolide intermediates
MX2017017022A (en) Method for the synthesis of rapamycin derivatives.
MX352607B (en) Process for preparing benzoxaboroles.
IN2014DN00144A (en)
MY160882A (en) Biocidal composition and method
CY1117087T1 (en) PROCEDURE FOR STANDARD PREPARATION (5-FLUOR-2-Methyl-3-quinolin-2-ylmethyl-indol-1-yl) - ACIC ACID
WO2018091964A8 (en) Process for preparing methoxy methyl pyridine dicarboxylate
IN2015DN02424A (en)
IN2014MN00971A (en)
EA201071424A1 (en) SOLIDEAPEYE SOLI 2-AMIN-3-КАРБЕКСИАМИНОО-6- (4-ФТОРБЕНЗИЛАМИНО) ПИРИДИНА
UA111950C2 (en) HETEROCYCLIC COMPOUNDS FOR TREATMENT OR PREVENTION OF DISORDERS CAUSED BY REDUCED NERROTRANSMISSION OF SEROTONIN, NOREPINEPHIN OR DOPIN
WO2012140490A3 (en) Processes for preparing pitavastatin calcium
WO2010148063A3 (en) Cyclohexene 1,4-carboxylates
FR2973377B1 (en) 2,9-DIPYRIDYL-1,10-PHENANTHROLINE DERIVATIVES AS LIGANDS OF ACTINIDES, PROCESS FOR THEIR SYNTHESIS AND USES THEREOF
PH12014502845B1 (en) Novel cholecystokinin receptor ligands
TN2014000329A1 (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive

Legal Events

Date Code Title Description
122 Ep: pct application non-entry in european phase

Ref document number: 14762797

Country of ref document: EP

Kind code of ref document: A2