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WO2014033865A1 - Dispositif d'administration de médicament - Google Patents

Dispositif d'administration de médicament Download PDF

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Publication number
WO2014033865A1
WO2014033865A1 PCT/JP2012/071914 JP2012071914W WO2014033865A1 WO 2014033865 A1 WO2014033865 A1 WO 2014033865A1 JP 2012071914 W JP2012071914 W JP 2012071914W WO 2014033865 A1 WO2014033865 A1 WO 2014033865A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
syringe
administration device
exterior member
drug administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/071914
Other languages
English (en)
Japanese (ja)
Inventor
小川　淳一
陽一郎 岩瀬
立川　浩一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to PCT/JP2012/071914 priority Critical patent/WO2014033865A1/fr
Publication of WO2014033865A1 publication Critical patent/WO2014033865A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the present invention relates to a drug administration device for administering a drug to the body, various medical devices, infusion containers, and the like.
  • a prefilled syringe (medicine administration device) in which a syringe is preliminarily filled with a chemical solution has been widely used.
  • a prefilled syringe it is not necessary to suck the drug solution from the vial into the syringe at the time of drug solution administration, and the time required for administration can be shortened.
  • a prefilled syringe includes an outer cylinder and a plunger.
  • the plunger When administering a medicine into the body using a prefilled syringe, the plunger is operated, and the medicine filled in the liquid chamber of the outer cylinder is discharged into the body through an injection needle connected to the cylinder tip of the outer cylinder.
  • a small prefilled syringe with a small liquid chamber is used when a small amount of medicine is administered.
  • a drug is administered by puncturing the injection needle perpendicularly to the upper layer of the skin, a large injection pressure is required, and in order to prevent the drug from leaking, it is necessary to strongly press the prefilled syringe against the skin.
  • the conventional small prefilled syringe does not have a structure suitable for continuing to press against the skin with a strong force and is difficult to use.
  • Patent Document 1 discloses a drug administration device with improved operability.
  • the drug administration device described in Patent Document 1 includes a cylinder having a liquid chamber for storing a drug, a pusher part that moves inside the cylinder, a gripping part, and a connecting part.
  • the pusher portion includes a rod-shaped plunger and a gasket.
  • the grip portion is provided along the outer periphery of the cylindrical body, and the connecting portion is formed between the cylindrical body and the end portion of the grip portion.
  • the grip portion since the grip portion is provided along the outer periphery of the cylindrical body, the grip portion can be easily gripped, and a force can be strongly applied to the pusher portion.
  • the present invention has been made in consideration of such a situation, and an object of the present invention is to provide a drug administration device that can be miniaturized while the drug is stored in a liquid chamber.
  • a drug administration device of the present invention includes a syringe, a plunger, an exterior member, and a slide member.
  • the syringe has a cylindrical side peripheral portion that forms a liquid chamber in which a medicine is stored, and a discharge portion that is formed at one end of the side peripheral portion.
  • the plunger includes a gasket that is movably disposed inside a side peripheral portion of the syringe, a plunger main body that is coupled to the gasket, and a first engagement portion.
  • An exterior member is formed in the cylinder shape which covers the outer periphery of the side periphery part in a syringe, and the syringe is being fixed coaxially.
  • the slide member is disposed coaxially with the exterior member and is connected in the axial direction, and has a second engagement portion that engages with the first engagement portion of the plunger. And a slide member will be in the accommodation state and the protrusion state which moved to the axial direction of the syringe from the accommodation state.
  • the second engagement portion is positioned closer to the discharge portion than the first engagement portion of the plunger.
  • the second engagement portion is engaged with the first engagement portion of the plunger.
  • the slide member When storing the drug administration device of the present invention, the slide member is set in the housed state. Thereby, the length along the axial direction of the syringe at the portion where the slide member and the exterior member overlap is shortened, and the medicine administration device storing the medicine in the liquid chamber can be miniaturized.
  • the slide member when using a medicine administration device, the slide member is in a protruding state. Thereby, while the length along the axial direction of the syringe in the part which a slide member and an exterior member overlap becomes long, a slide member engages with a plunger. As a result, the medicine stored in the liquid chamber can be discharged from the discharge portion by operating the plunger via the slide member.
  • the drug administration device of the present invention it is possible to reduce the size while the drug is stored in the liquid chamber.
  • FIG. 1 is a perspective view showing a drug administration device according to a first embodiment of the present invention. It is an exploded perspective view of the administration device main part in the medicine administration device concerning a 1st embodiment of the present invention. It is sectional drawing when the slide member of the administration instrument main body in the chemical
  • FIG. 1 is a perspective view of a drug administration device according to a first embodiment of the present invention.
  • FIG. 2 is an exploded perspective view of the administration device body of the drug administration device according to the first embodiment of the present invention.
  • FIG. 3 is a cross-sectional view of the drug administration device according to the first embodiment of the present invention.
  • FIG. 4 is an explanatory view of an exterior member in the drug administration device according to the first embodiment of the present invention.
  • the drug administration device 1 includes an administration device body 2 and a cap 3 that is detachably attached to the administration device body 2.
  • the administration device body 2 includes a syringe 11, a plunger 12, an adapter member 13, an exterior member 14, and a slide member 15.
  • the syringe 11 is a prefilled syringe that is pre-filled with a medicine P (see FIG. 3).
  • the syringe 11 has a side peripheral portion 21 formed in a substantially cylindrical shape and a discharge portion 22 formed at one end of the side peripheral portion 21.
  • a liquid chamber 23 for storing the medicine P is formed inside the side peripheral portion 21.
  • the diameter of the side peripheral portion 21 is appropriately set according to the use and the volume of the medicine accommodated in the liquid chamber 23.
  • the outer diameter D1 of the side peripheral portion 21 is preferably set to 6.8 to 8.2 mm.
  • the outer diameter D1 of the side peripheral portion 21 is preferably set to 8.1 to 9.4 mm.
  • the axial length L1 of the side peripheral portion 21 is preferably about 47 to 60 mm, for example.
  • Examples of the chemical solution P include various vaccines for preventing various infectious diseases such as influenza, but are not limited to vaccines.
  • drugs P other than vaccines include glucose injection solutions such as glucose, electrolyte correction injection solutions such as sodium chloride and potassium lactate, vitamin agents, antibiotic injection solutions, contrast agents, steroid agents, and proteolytic enzymes. Inhibitors, fat emulsions, anticancer agents, anesthetics, heparin calcium, antibody drugs and the like.
  • a flange 24 is provided at the other end of the side peripheral portion 21.
  • the flange 24 protrudes radially outward from the outer peripheral surface at the other end portion of the side peripheral portion 21, and the outer peripheral contour is formed in a substantially elliptical shape.
  • the contour of the outer periphery of the flange 24 is formed by two arc sides 24a facing each other and two linear sides 24b continuing from the two arc sides 24a and facing each other.
  • the radius of curvature of the two arc sides 24a is preferably about 6.5 to 9.5 mm.
  • Two connecting claws 46 described later of the adapter member 13 are engaged with the two straight sides 24b.
  • the discharge part 22 is continuous with one end of the side peripheral part 21 and is formed in a substantially cylindrical shape coaxial with the side peripheral part 21.
  • the discharge part 22 is formed in a tapered shape whose diameter continuously decreases toward the tip that is opposite to the side peripheral part 21.
  • the cylindrical hole of the discharge part 22 communicates with the cylindrical hole of the side peripheral part 21.
  • the luer lock part 26 is joined to the discharge part 22.
  • the luer lock portion 26 includes a cylindrical portion 27 formed in a substantially cylindrical shape coaxial with the discharge portion 22, and a fitting portion 28 provided at an end portion of the cylindrical portion 27 on the side peripheral portion 21 side. .
  • the outer diameter of the cylindrical portion 27 is set larger than the outer diameter of the side peripheral portion 21, and a gap of a predetermined distance is formed between the inner peripheral surface of the cylindrical portion 27 and the outer peripheral surface of the discharge portion 22. (See FIG. 3).
  • An internal thread portion 27 a is formed on the inner peripheral surface of the cylindrical portion 27.
  • the fitting portion 28 includes a plurality of protrusions 28 a that protrude radially inward from the inner peripheral surface of the cylindrical portion 27.
  • the plurality of protrusions forming the fitting portion 28 are arranged at an appropriate interval in the circumferential direction of the cylindrical portion 27.
  • the fitting portion 28 is fitted to a base portion (an end portion on the side peripheral portion 21 side) of the discharge portion 22.
  • Examples of the material of the syringe 11 include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate. And various resins such as polyester such as butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Among them, it is preferable to use a resin such as polypropylene, cyclic polyolefin, polyester, or poly- (4-methylpentene-1) in terms of easy molding. In addition, it is preferable that the material of the syringe 11 is substantially transparent in order to ensure internal visibility.
  • the plunger 12 includes a gasket 31 that is movably disposed inside the side peripheral portion 21 of the syringe 11, and a plunger main body 32 that is connected to the gasket 31.
  • the gasket 31 is formed in a substantially cylindrical shape.
  • the gasket 31 moves while being in liquid tight contact with the inner peripheral surface of the side peripheral portion 21 of the syringe 11.
  • the gasket 31 partitions the space in the side peripheral portion 21 into two.
  • the space on the discharge portion 22 side of the gasket 31 in the side peripheral portion 21 and the space in the discharge portion 22 become a liquid chamber 23 filled with the medicine P.
  • a plunger main body 34 (to be described later) of the plunger main body 32 is disposed in the space on the other end side of the gasket 31 in the side peripheral portion 21.
  • One end portion of the gasket 31 is formed in a tapered shape whose diameter continuously decreases toward the tip. This taper shape corresponds to the shape of the inner surface at one end of the side peripheral portion 21. Therefore, when the gasket 31 is moved to the one end portion side of the side peripheral portion 21, one end portion of the gasket 31 comes into contact with the inner surface of the one end portion of the side peripheral portion 21 so that no gap is generated.
  • a fitting hole 31 a is provided on the other end surface of the gasket 31.
  • a female screw portion or a concavo-convex portion for screwing a connection projection 37 described later of the plunger main body 34 is formed on the inner surface of the gasket 31 that forms the fitting hole 31a.
  • the material of the gasket 31 is not particularly limited, but is preferably made of an elastic material in order to improve the liquid tightness with the side peripheral portion 21.
  • the elastic material include various rubber materials such as natural rubber, isobutylene rubber, and silicone rubber, various thermoplastic elastomers such as olefin and styrene, and mixtures thereof.
  • the plunger main body 32 includes a plunger main body 34 that is connected to the gasket 31, a side piece portion 35 that is disposed between the adapter member 13 and the exterior member 14, and a connecting portion that connects the plunger main body 34 and the side piece portion 35. 36.
  • a plunger main body 34 that is connected to the gasket 31, a side piece portion 35 that is disposed between the adapter member 13 and the exterior member 14, and a connecting portion that connects the plunger main body 34 and the side piece portion 35. 36.
  • various resins mentioned as the material of the syringe 11 can be applied.
  • the plunger body 34 is formed in a substantially cylindrical shape.
  • a connection projection 37 is provided at one end of the plunger body 34.
  • the connection protrusion 37 is formed in a substantially cylindrical shape coaxial with the plunger main body 34, and is connected to the gasket 31.
  • On the outer peripheral surface of the connection protrusion 37 a male screw portion or a concavo-convex portion that is screwed into the female screw portion of the gasket 31 is formed.
  • the connection method of the connection protrusion 37 and the gasket 31 is not limited to screwing,
  • other connection methods such as the connection by the press injection of a connection protrusion, and the connection using an adhesive agent, are employ
  • the side piece 35 is formed in a cylindrical shape covering the outer peripheral surface of the plunger main body 34.
  • a cross section of the side piece portion 35 in a direction orthogonal to the axial direction is formed in a substantially oval shape.
  • a gap for arranging the side peripheral portion 21 of the syringe 11 and the adapter member 13 is formed.
  • the plunger body 34 protrudes from one end of the side piece 35.
  • an engagement portion 38 showing a specific example of the first engagement portion is provided.
  • the engaging portion 38 is formed in a flange shape protruding outward in the radial direction from the outer peripheral surface of the other end portion of the side piece portion 35.
  • the contour of the inner periphery of the engaging portion 38 is formed in an elliptical shape that is slightly larger than the flange 24 of the syringe 11.
  • An engaging claw 62 (to be described later) of the slide member 15 is engaged with the engaging portion 38.
  • two locked protrusions 39 showing a specific example of the second locking portion are provided on the inner surface of the side piece portion 35 (see FIG. 4).
  • the two locked protrusions 39 face each other in the minor axis direction of the side piece 35.
  • These two locked protrusions 39 are formed in a substantially rectangular parallelepiped shape, and have an inclined surface 39 a that is inclined so as to become lower toward one end of the side piece 35.
  • the two locked protrusions 39 abut on a locking surface 44 described later of the adapter member 13.
  • the connecting portion 36 connects the other end portion of the plunger main body 34 and the other end portion of the side piece portion 35.
  • the connecting portion 36 is formed in a plate shape that is continuous with the outer peripheral surface of the plunger main body 34 and the inner peripheral surface of the side piece portion 35.
  • the connecting portion 36 has two through holes 36 a for avoiding interference with two connecting claws 46 described later of the adapter member 13.
  • the adapter member 13 is formed in a substantially cylindrical shape that covers the outer peripheral surface of the side peripheral portion 21 in the syringe 11.
  • the adapter member 13 is formed such that the diameter of the tip end portion is larger than the diameter of the other end portion, and a taper portion is formed between the tip end portion and the other end portion.
  • the adapter member 13 is provided with four holding pieces 41A, 41B, 41C, and 41D that can be flexibly deformed by providing four notches extending in the axial direction from one end in the axial direction to a midway portion.
  • the holding piece 41A and the holding piece 41C face each other in the radial direction of the adapter member 13, and the holding piece 41B and the holding piece 41D face each other in the radial direction of the adapter member 13.
  • a connecting claw 42 is formed at the tip of each holding piece 41A to 41D.
  • the connection claw 42 has an outer engagement portion 42 a that engages with one end portion of the exterior member 14 and an inner engagement portion 42 b that engages with one end portion of the side peripheral portion 21 of the syringe 11.
  • the outer engaging portion 42 a is a portion of the connecting claw 42 that bulges outward in the radial direction of the adapter member 13, and the inner engaging portion 42 b is a surface facing the inner side of the connecting claw 42.
  • the holding pieces 41A to 41D are bent and deformed, the inner engagement portion 42b of the coupling claw 42 is engaged with one end portion of the side peripheral portion 21 of the syringe 11, and the distal end portion of the holding pieces 41A to 41D is the syringe 11 The side periphery 21 is held.
  • a fitting projection 43 is provided at the intermediate portion of each holding piece 41A to 41D.
  • the fitting protrusion 43 protrudes outward in the radial direction of the adapter member 13, and a plane orthogonal to the axial direction of the adapter member 13 is formed in a substantially arc shape.
  • the fitting protrusion 43 is fitted into a fitting recess 55 (see FIG. 4) described later of the exterior member 14.
  • the adapter member 13 is fixed to the exterior member 14 while holding the side peripheral portion 21 of the syringe 11. Thereby, the syringe 11 is fixed to the exterior member 14 via the adapter member 13.
  • the adapter member 13 is fixed to the exterior member 14 by fitting the fitting protrusion 43 of the adapter member 13 into the fitting recess 55 (see FIG. 4) of the exterior member 14.
  • the adapter member 13 may be fixed to the exterior member 14 by, for example, fixing the contact portion between the outer engagement portion 42a of the connection claw 42 of the adapter member 13 and one end portion of the exterior member 14 with an adhesive. Good.
  • the adapter member 13 is provided with four notches 44 extending substantially in the axial direction by providing four notches extending in the axial direction from one axial end to the middle.
  • the two locking surfaces 44 show a specific example of the first locking portion, between the base of the holding piece 41A and the base of the holding piece 41B, and the base of the holding piece 41C and the base of the holding piece 41D. It is arranged between.
  • Two connecting claws 46 are provided at the other end of the adapter member 13 in the axial direction.
  • the two connection claws 46 are opposed to each other in the radial direction of the adapter member 13 and protrude in the axial direction of the adapter member 13. These two connection claws 46 engage with the two straight sides 24b of the flange 24 of the syringe 11, respectively.
  • the material of the adapter member 13 various resins mentioned as the material of the syringe 11 can be applied.
  • the material of the adapter member 13 is substantially transparent in order to ensure internal visibility.
  • the exterior member 14 is formed in a substantially cylindrical shape that covers the outer periphery of the side peripheral portion 21 of the syringe 11.
  • One end of the exterior member 14 in the axial direction is formed in a tapered shape whose diameter continuously decreases toward the tip. Therefore, the diameter of the opening 51 at one end in the axial direction of the exterior member 14 is smaller than the diameter of the opening 52 at the other end.
  • One end portion of the side peripheral portion 21 and the discharge portion 22 in the syringe 11 protrude from the opening 51 of the exterior member 14.
  • Two guide grooves 53 extending in the axial direction are formed in the exterior member 14.
  • the two guide grooves 53 are grooves that penetrate the exterior member 14 and face each other in the radial direction of the exterior member 14.
  • Two engagement protrusions 61 (described later) of the slide member 15 are engaged with the two guide grooves 53.
  • a flange 54 is provided at the other end of the exterior member 14. The flange 54 projects outward in the radial direction from the outer peripheral surface at the other end of the exterior member 14, and the outer contour is formed in a substantially circular shape.
  • the fitting recess 55 is formed as an arc-shaped recess and has a bottom surface 55a that is substantially orthogonal to the axial direction of the exterior member 14 and three side surfaces 55b, 55c, and 55d that are continuous to the bottom surface 55a.
  • the fitting protrusion 43 of the adapter member 13 is fitted into the fitting recess 55 of the exterior member 14. Thereby, the adapter member 13 is fixed to the exterior member 14.
  • the material of the exterior member 14 various resins mentioned as the material of the syringe 11 can be applied.
  • the material of the exterior member 14 is substantially transparent in order to ensure internal visibility.
  • the outer diameter D2 of the other end portion in the axial direction of the exterior member 14 is preferably set to a size that allows the exterior member 14 to be easily gripped, and is preferably set to 17 to 30 mm, for example.
  • the slide member 15 is formed in a substantially cylindrical shape with a bottom that is open at one end.
  • the slide member 15 is connected to the exterior member 14 in a nested manner, and is disposed between the inner peripheral surface of the exterior member 14 and the outer peripheral surface of the side piece portion 35 of the plunger 12.
  • Two engaging projections 61 are provided at one end of the slide member 15 in the axial direction.
  • the two engaging protrusions 61 protrude outward in the radial direction from the outer peripheral surface at one end of the slide member 15 and are formed in a substantially rectangular parallelepiped shape.
  • the two engaging protrusions 61 are arranged at positions different from each other by 180 degrees on the outer peripheral surface of the slide member 15.
  • the two engaging protrusions 61 are respectively engaged with the two guide grooves 53 of the exterior member 14. Accordingly, the length in the width direction of the engaging protrusion 61 is set slightly smaller than the length in the width direction of the guide groove 53.
  • the height of the engaging protrusion 61 is set to a height that does not protrude from the outer peripheral surface of the exterior member 14 when the engaging protrusion 61 engages with the guide groove 53.
  • two engagement claws 62 showing a specific example of the second engagement portion are provided on the inner peripheral surface of the slide member 15.
  • the two engaging claws 62 project radially inward from the axial intermediate portion of the slide member 15 and face each other in the radial direction of the slide member 15.
  • These two engaging claws 62 are formed in a substantially rectangular parallelepiped shape, and have an inclined surface 62 a that is inclined so as to become lower toward the other end of the slide member 15.
  • the two engaging claws 62 are engaged with the engaging portion 38 of the plunger 12.
  • the slide member 15 can be set to a storage state in which the other end portion in the axial direction is left and stored in the exterior member 14 and a protruding state in which the slide member 15 is pulled out from the exterior member 14.
  • the two engagement claws 62 are located closer to the discharge portion 22 of the syringe 11 than the engagement portion 38 of the plunger 12.
  • the slide member 15 moves from the housed state to the side opposite to the discharge portion 22 in the axial direction of the syringe 11, the slide member 15 is pulled out from the exterior member 14 and enters a protruding state.
  • the two engaging claws 62 get over the engaging portion 38 of the plunger 12 and are engaged with the engaging portion 38.
  • the material of the slide member 15 various resins mentioned as the material of the syringe 11 can be applied.
  • the material of the slide member 15 is substantially transparent in order to ensure internal visibility.
  • the cap 3 is formed in a bottomed substantially cylindrical shape having a discharge portion insertion hole 73, and has a large-diameter portion 71 that forms one end portion in the axial direction and the other end portion in the axial direction. And a small-diameter portion 72 that forms the shape.
  • the large diameter portion 71 has a larger diameter than the small diameter portion 72.
  • a plurality of grooves 71 a extending along the axial direction of the cap 3 are formed on the outer peripheral surface of the large diameter portion 71.
  • the groove 71a is provided to increase the frictional resistance generated between the cap 3 and fingers when the user removes the cap 3 from the syringe 11.
  • a male screw portion 72a that is screwed into a female screw portion 27a formed in the luer lock portion 26 of the syringe 11 is formed.
  • the discharge part insertion hole 73 extends along the axial direction of the cap 3. One end of the discharge portion insertion hole 73 is opened in the end face of the small diameter portion 72, and the other end is located in the middle portion of the large diameter portion 71. A packing 76 made of a substantially cylindrical elastic member (for example, rubber) is fitted to the other end side of the discharge portion insertion hole 73.
  • a packing convex portion 77 protruding in the axial direction of the cap 3 is formed at a substantially central portion of the packing 76.
  • the packing convex part 77 seals the discharge port of the discharge part 22. Thereby, it can prevent that the chemical
  • the discharge part 22 of the syringe 11 is inserted into the discharge part insertion hole 73 of the cap 3.
  • the small diameter portion 72 of the cap 3 is inserted into the cylindrical portion 27 of the luer lock portion 26.
  • the cap 3 is rotated in the attaching direction.
  • the male screw portion 72 a of the small diameter portion 72 is screwed into the female screw portion 27 a of the luer lock portion 26, and the packing convex portion 77 seals the discharge port of the discharge portion 22.
  • wearing of the cap 3 to the administration instrument main body 2 is completed.
  • the length L2 from the tip of the cap 3 to the flange 24 of the syringe 11 is preferably about 79 to 92 mm, for example.
  • the syringe 11 is fixed to the exterior member 14 via the adapter member 13. That is, the discharge part 22 of the syringe 11 is penetrated through the opening 51 of the exterior member 14. Then, the fitting protrusion 43 of the adapter member 13 is fitted into the fitting recess 55 of the exterior member 14, and the outer engagement portion 42 a of the connection claw 42 is engaged with one end of the exterior member 14.
  • one end of the exterior member 14 presses the holding pieces 41A to 41D of the adapter member 13 inward in the radial direction of the syringe 11.
  • the holding pieces 41A to 41D are bent and deformed, the inner engagement portion 42b of the coupling claw 42 is engaged with one end portion of the side peripheral portion 21 of the syringe 11, and the distal end portion of the holding pieces 41A to 41D is the syringe 11.
  • the side periphery 21 is held.
  • the fitting protrusion 43 of the adapter member 13 is fitted into the fitting recess of the exterior member 14, the rotation around the axis of the adapter member 13 holding the syringe 11 is restricted. Further, since the fitting protrusion 43 is fitted in the fitting recess of the exterior member 14 and the outer engagement portion 42a of the coupling claw 42 is engaged with one end portion of the exterior member 14, the syringe 11 is held. The adapter member 13 is restricted from moving in the axial direction.
  • the luer lock part 26 is joined to the discharge part 22 of the syringe 11. That is, the fitting portion 28 of the luer lock portion 26 is fitted and fixed to the discharge portion 22. Then, the male screw portion 72 a of the cap 3 is screwed into the female screw portion 27 a of the luer lock portion 26, and the cap 3 is attached to the luer lock portion 26. Thereby, the discharge port of the discharge part 22 in the syringe 11 is sealed by the packing 76.
  • the medicine P is filled into the side peripheral portion 21 of the syringe 11.
  • the plunger 31 connected to the gasket 31 of the plunger 12 and the gasket 31 is inserted into the side peripheral portion 21 from the other end of the side peripheral portion 21 of the syringe 11.
  • the gasket 31 and the plunger main body 34 are inserted into the side peripheral portion 21 by, for example, a vacuum plugging method.
  • the two locked protrusions 39 of the plunger 12 come into contact with the two locking surfaces 44 of the adapter member 13.
  • the locked protrusion 39 is formed with an inclined surface 39a. Therefore, the locked protrusion 39 easily gets over the other end of the adapter member 13, is disposed in a notch that forms the locking surface 44 of the adapter member 13, and contacts the locking surface 44.
  • the adapter member 13 restricts and locks the movement of the plunger 12 in the direction away from the discharge portion 22.
  • the slide member 15 is nested and connected to the exterior member 14 while being deformed. Thereby, the two engaging protrusions 61 of the slide member 15 are engaged with the two guide grooves 53 of the exterior member 14. Further, the engaging claw 62 of the slide member 15 is disposed closer to the discharge portion 22 than the engaging portion 38 of the plunger 12. Thereby, the medicine administration device 1 is assembled.
  • FIG. 5 is a cross-sectional view when the slide member 15 of the drug administration device 1 is in a protruding state.
  • FIG. 6 is a cross-sectional view showing a state where the medicine P is discharged from the discharge portion 22 of the administration device body 2.
  • the slide member 15 of the administration device body 2 When storing the drug administration device 1, the slide member 15 of the administration device body 2 is placed in the housed state (see FIG. 3). Thereby, since the slide member 15 is accommodated in the exterior member 14, the length in the axial direction of the drug administration device 1 in which the drug P is stored in the liquid chamber 23 can be shortened to be downsized.
  • the drug administration device 1 can be stored upright with the cap 3 facing upward. Therefore, the space required for storing the drug administration device 1 can be reduced.
  • the cap 3 when storing the medicine administration device 1, the cap 3 is attached to the luer lock portion 26 of the administration device body 2. Therefore, the slide member 15 cannot be operated to move the plunger 12 in a direction approaching the discharge unit 22.
  • the slide member 15 When the drug P is discharged from the discharge portion 22 of the syringe 11 using the drug administration device 1, first, the slide member 15 is pulled out from the exterior member 14 (see FIG. 5). Thereby, the slide member 15 will be in a protrusion state. At this time, the length L3 from the front end of the exterior member 14 to the bottom surface of the slide member 15 is preferably about 55 to 120 mm.
  • the two engaging claws 62 of the slide member 15 When the slide member 15 is in the protruding state, the two engaging claws 62 of the slide member 15 get over the two engaging portions 38 of the plunger 12 and are engaged with the engaging portions 38, respectively. At this time, since the engaging claw 62 has the inclined surface 62a, it is possible to easily get over the engaging portion 38 of the plunger 12. Further, the locked projection 39 of the plunger 12 is in contact with the locking surface 44. Thereby, the plunger 12 does not move in the direction away from the discharge part 22 together with the slide member 15.
  • the cap 3 is removed from the luer lock portion 26. Thereby, the medicine administration device 1 (administration device body 2) is in a state where the medicine P can be discharged from the discharge portion 22.
  • a needle holding member is attached to the discharge part 22 of the administration device body 2.
  • the needle holding member includes a needle tube and a needle hub that holds the needle tube.
  • the needle hub may be directly attached to the discharge part 22 or may be screwed to the luer lock part 26.
  • the needle holding member is attached to the discharge portion 22, the needle hole of the needle tube and the inside of the discharge portion 22 are in fluid-tight communication.
  • the needle tube is punctured into the living body.
  • the slide member 15 is pushed into the exterior member 14. That is, the slide member 15 is moved in a direction approaching the discharge unit 22 (see FIG. 6). Accordingly, the plunger 12 is pressed by the slide member 15 and moves in a direction approaching the discharge unit 22 together with the slide member 15. As a result, the gasket 31 moves in the side peripheral portion 21 of the syringe 11 and the medicine P in the liquid chamber 23 (see FIG. 5) is administered to the living body through the discharge portion 22 and the needle tube.
  • the drug administration device 1 is not limited to the one used by attaching the needle holding member.
  • the drug administration device 1 may be used by connecting the discharge portion 22 to a connector (a female luer) provided on a medical tube.
  • FIG. 7 is a perspective view of a drug administration device according to the second embodiment of the present invention.
  • FIG. 8 is a cross-sectional view of a drug administration device according to the second embodiment of the present invention.
  • the drug administration device 91 which is the second embodiment of the drug administration device of the present invention has the same configuration as the drug administration device 1 of the first embodiment described above.
  • the drug administration device 91 is different from the drug administration device 1 of the first embodiment in that a cover member 93 is provided. Therefore, here, the cover member 93 will be described, the same reference numerals are assigned to portions common to the drug administration device 1, and duplicate description will be omitted.
  • the drug administration device 91 includes an administration device main body 92 and a cap 3.
  • the administration device main body 92 is obtained by adding a cover member 93 to the administration device main body 2 according to the first embodiment.
  • the cover member 93 is formed in a substantially cylindrical shape that covers the other end side of the exterior member 14.
  • the inner diameter of the cover member 93 is set substantially equal to the outer diameter of the exterior member 14.
  • a recess for avoiding interference with the flange 54 of the exterior member 14 is formed on the inner peripheral surface of the cover member 93.
  • the cover member 93 is fixed to the outer peripheral surface of the exterior member 14 using, for example, an adhesive. That is, the adhesive is interposed between the inner peripheral surface of the cover member 93 and the outer peripheral surface of the exterior member 14.
  • a method of fixing the cover member 93 according to the present invention to the exterior member 14 for example, a method of press-fitting the exterior member 14 into the cover member 93 or a method using a screw may be used.
  • the cover member 93 covers the substantially central portion from the other end of the two guide grooves 53 in the exterior member 14. Therefore, the cover member 93 covers a region from the substantially central portion to the other end of the guide groove 53 of the exterior member 14.
  • One end of the cover member 93 in the axial direction is formed in a tapered shape such that the diameter continuously decreases toward the tip. Thereby, the level
  • a flange 94 is provided at the other axial end of the cover member 93.
  • the flange 94 protrudes radially outward from the outer peripheral surface at the other end of the cover member 93, and the outer peripheral contour is formed in a substantially hexagonal shape.
  • the drug administration device 91 can obtain the same effect as the drug administration device 1 of the first embodiment described above. That is, when the slide member 15 of the administration device main body 92 is placed in the housed state, the slide member 15 is housed inside the exterior member 14, and thus the axial length of the medicine administration device 91 containing the medicine P in the liquid chamber 23. Can be shortened to reduce the size.
  • the adapter 11 is used to fix the syringe 11 to the exterior member 14.
  • the exterior member according to the present invention may have a structure in which a syringe is directly fixed. Such a structure can be realized, for example, by integrally forming the adapter member 13 and the exterior member 14.
  • the luer lock portion 26 is provided in the discharge portion 22 of the syringe 11.
  • the syringe according to the present invention may not have a luer lock part.
  • the cap may be formed of an elastic material such as rubber and attached to the discharge portion of the syringe.
  • the slide member 15 is formed in a bottomed cylindrical shape with one opening closed.
  • the slide member according to the present invention is not limited to a bottomed cylindrical shape, and may be any shape that is connected to the exterior member so as to be movable in the axial direction of the syringe.
  • the slide member 15 is connected to the exterior member 14 in a nested manner.
  • the medicine administration device of the present invention may be configured such that the exterior member is housed in the slide member in a nested manner. In that case, a groove that avoids interference with the locking claw of the slide member may be formed in the exterior member.
  • the guide groove 53 of the exterior member 14 guides the slide member 15 in the axial direction of the syringe 11.
  • any guide groove according to the present invention may be used as long as it guides at least in the axial direction of the syringe.
  • the guide groove is guided in the axial direction of the syringe while rotating the slide member around the axial center line of the syringe. It is good.
  • the guide groove 15 penetrating the side peripheral portion of the exterior member 14 is provided.
  • the guide groove according to the present invention may be a recess formed on the inner peripheral surface of the exterior member 14.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
PCT/JP2012/071914 2012-08-29 2012-08-29 Dispositif d'administration de médicament Ceased WO2014033865A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/071914 WO2014033865A1 (fr) 2012-08-29 2012-08-29 Dispositif d'administration de médicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/071914 WO2014033865A1 (fr) 2012-08-29 2012-08-29 Dispositif d'administration de médicament

Publications (1)

Publication Number Publication Date
WO2014033865A1 true WO2014033865A1 (fr) 2014-03-06

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Application Number Title Priority Date Filing Date
PCT/JP2012/071914 Ceased WO2014033865A1 (fr) 2012-08-29 2012-08-29 Dispositif d'administration de médicament

Country Status (1)

Country Link
WO (1) WO2014033865A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07185000A (ja) * 1991-07-24 1995-07-25 Medico Dev Investment Co 注射器
JP2008541907A (ja) * 2005-05-31 2008-11-27 ノボ・ノルデイスク・エー／エス 視覚的な内容量終了表示を有する注入デバイス

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07185000A (ja) * 1991-07-24 1995-07-25 Medico Dev Investment Co 注射器
JP2008541907A (ja) * 2005-05-31 2008-11-27 ノボ・ノルデイスク・エー／エス 視覚的な内容量終了表示を有する注入デバイス

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