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WO2014016584A3 - Diagnostic for determining skeletal health - Google Patents

Diagnostic for determining skeletal health Download PDF

Info

Publication number
WO2014016584A3
WO2014016584A3 PCT/GB2013/051964 GB2013051964W WO2014016584A3 WO 2014016584 A3 WO2014016584 A3 WO 2014016584A3 GB 2013051964 W GB2013051964 W GB 2013051964W WO 2014016584 A3 WO2014016584 A3 WO 2014016584A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic
skeletal health
determining
determining skeletal
health
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2013/051964
Other languages
French (fr)
Other versions
WO2014016584A2 (en
Inventor
Richard Stephen SAVAGE
Usman Ahmed
Paul J. THORNALLEY
Naila Rabbani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Warwick filed Critical University of Warwick
Publication of WO2014016584A2 publication Critical patent/WO2014016584A2/en
Publication of WO2014016584A3 publication Critical patent/WO2014016584A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

The invention concerns the use of Citrullinated proteins (CP) in a diagnostic method for determining skeletal health before or during a treatment regimen and particularly for determining whether an individual, human or animal, has a skeletal disorder such as, but not limited to osteoarthritis and/or is responding to treatment for said condition.
PCT/GB2013/051964 2012-07-23 2013-07-23 Diagnostic for determining skeletal health Ceased WO2014016584A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1213012.6 2012-07-23
GB201213012A GB201213012D0 (en) 2012-07-23 2012-07-23 Diagnostic for determining skelektal health
GB1222554.6 2012-12-14
GB201222554A GB201222554D0 (en) 2012-07-23 2012-12-14 Diagnostic for determining skeletal health

Publications (2)

Publication Number Publication Date
WO2014016584A2 WO2014016584A2 (en) 2014-01-30
WO2014016584A3 true WO2014016584A3 (en) 2014-05-30

Family

ID=46881778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2013/051964 Ceased WO2014016584A2 (en) 2012-07-23 2013-07-23 Diagnostic for determining skeletal health

Country Status (2)

Country Link
GB (2) GB201213012D0 (en)
WO (1) WO2014016584A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10309974B2 (en) 2010-11-12 2019-06-04 Cedars-Sinai Medical Center Citrullinated proteins: a post-translated modification of myocardial proteins as marker of physiological and pathological disease
WO2016205828A2 (en) 2015-06-18 2016-12-22 Cedars-Sinai Medical Center Role of citrullination in diagnosing diseases
EP3502696A1 (en) * 2017-12-21 2019-06-26 Universität zu Köln Detection of autoantibodies for diagnosis of degenerative diseases of the skeletal system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAZUISHI KUBOTA ET AL: "Determination of sites citrullinated by peptidylarginine deiminase using18O stable isotope labeling and mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 19, no. 5, 1 January 2005 (2005-01-01), pages 683 - 688, XP055087559, ISSN: 0951-4198, DOI: 10.1002/rcm.1842 *
ORDONEZ ADRIANA ET AL: "Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE; US, vol. 104, no. 6, 1 December 2010 (2010-12-01), pages 1143 - 1149, XP009162325, ISSN: 0340-6245, DOI: 10.1160/TH10-05-0297 *
X. CHANG: "Citrullination of fibronectin in rheumatoid arthritis synovial tissue", RHEUMATOLOGY, vol. 44, no. 11, 21 June 2005 (2005-06-21), pages 1374 - 1382, XP055087508, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kei023 *

Also Published As

Publication number Publication date
GB201222554D0 (en) 2013-01-30
WO2014016584A2 (en) 2014-01-30
GB201213012D0 (en) 2012-09-05

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