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WO2014013547A1 - Instrument pour administration de liquide - Google Patents

Instrument pour administration de liquide Download PDF

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Publication number
WO2014013547A1
WO2014013547A1 PCT/JP2012/068102 JP2012068102W WO2014013547A1 WO 2014013547 A1 WO2014013547 A1 WO 2014013547A1 JP 2012068102 W JP2012068102 W JP 2012068102W WO 2014013547 A1 WO2014013547 A1 WO 2014013547A1
Authority
WO
WIPO (PCT)
Prior art keywords
rail
cover
liquid
slider
administration device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/068102
Other languages
English (en)
Japanese (ja)
Inventor
学 有延
正臣 今井
滋晃 冨家
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to PCT/JP2012/068102 priority Critical patent/WO2014013547A1/fr
Publication of WO2014013547A1 publication Critical patent/WO2014013547A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3271—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position
    • A61M5/3272—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position having projections following labyrinth paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body

Definitions

  • the present invention relates to a liquid administration device.
  • a prefilled syringe in which a liquid preparation is filled aseptically and the liquid preparation can be administered (see, for example, Patent Document 1).
  • the prefilled syringe described in Patent Document 1 is filled in a space surrounded by a syringe outer cylinder having a mouth portion for discharging a liquid preparation, a gasket that can slide in the syringe outer cylinder, and the syringe outer cylinder and the gasket.
  • a plunger that is connected to the proximal end of the gasket and that discharges the liquid preparation from the mouth by pressing the gasket toward the distal end.
  • this prefilled syringe is an unused state, and the mouth part of the syringe outer cylinder is liquid-tightly sealed with a cap.
  • a cap is removed from the mouth part of a syringe outer cylinder, and an injection needle is attached to the mouth part from which the cap is removed.
  • the living body is punctured with the injection needle, and the plunger is pressed in this punctured state.
  • a liquid formulation will be discharged from a mouth part with a gasket, Therefore The said liquid formulation can be administered to a biological body via an injection needle.
  • the prefilled syringe can normally press the plunger at any timing of the user if the cap is removed, the plunger is erroneously pressed before the living body is punctured with the injection needle. There was a risk of problems. In this case, the liquid preparation leaked unintentionally from the injection needle, or the amount of the liquid preparation was insufficient, and it was difficult to administer a sufficient amount of the liquid preparation to the living body.
  • An object of the present invention is to provide a liquid administration device that can reliably prevent an operation member from operating erroneously.
  • a cylindrical main body having a cylindrical shape and having a mouth filled with liquid and having the liquid discharged at a tip thereof, and the mouth sealed liquid-tightly and having elasticity
  • a cylinder having a portion
  • a gasket that can slide in the cylindrical body
  • a needle tube that is disposed on the distal end side of the sealing portion, is supported so as to be movable along the axial direction of the cylindrical body, and has a sharp distal needle tip at the distal end and a proximal proximal needle tip at the proximal end;
  • the needle tube can be moved to a separated position where the proximal needle tip is separated from the sealing portion, and to a piercing position where the proximal needle tip penetrates the sealing portion and communicates with the cylinder.
  • a supporting member that supports An operation member connected to a proximal end side of the gasket, and performing a pressing operation of pressing the gasket toward a distal direction to discharge the liquid from the needle tube;
  • a first position that covers at least the distal tip of the needle tube, and a cover that is retractable from the first position in the proximal direction and is movable to a second position where the distal tip is exposed.
  • the cover When the cover moves from the first position to the second position, the cover has a pressing portion that contacts the support member and presses the support member together with the needle tube in the proximal direction.
  • the liquid administration device according to (1) or (2) above.
  • the cover includes a cylindrical cover body, and a cylindrical regulating member that is supported on the inner peripheral side of the cover body so as to be rotatable about its central axis and can regulate the movement of the cover body.
  • the liquid administration device according to any one of (1) to (3) above.
  • the cover is movable in the distal direction from the second position and is movable to a third position that covers at least the distal needle tip again.
  • the operating member is disposed on the outer peripheral side of the regulating member, and has a curved piece curved along the circumferential direction thereof.
  • One of the outer peripheral portion of the restricting member and the inner peripheral portion of the curved piece is provided with a slider portion, and the other is provided with a rail portion on which the slider portion slides.
  • a first longitudinal rail formed along the other axial direction, and spaced apart from the first longitudinal rail in the other circumferential direction, along the other axial direction.
  • a second vertical rail formed, and a third vertical rail formed along the other axial direction and spaced apart from the second vertical rail in the other circumferential direction.
  • a first inclined rail formed to be inclined with respect to the second vertical rail and the first rail.
  • a second inclined rail which is disposed between the second vertical rail and the second vertical rail and the third vertical rail, and is inclined with respect to the other axial direction.
  • the slider portion includes the first vertical rail, the first inclined rail, the second vertical rail, and the second (4), in which the slider portion slides on the third longitudinal rail in the process of sliding the inclined rails in order and moving the cover from the second position to the third position. Liquid dosing device.
  • the rail portion is provided on the third longitudinal rail, and when the cover is moved to the third position, the rail portion is engaged with the slider portion from its proximal end side, and the base of the cover
  • the liquid administration device according to the above (5) which has an engagement portion that restricts movement in the end direction.
  • the slider portion is configured by a protruding projection
  • the rail portion is configured by a groove into which the slider portion is inserted.
  • the support member has a cylindrical shape, is disposed between an outer peripheral portion of the cylindrical body and an inner peripheral portion of the restricting member, and is rotatable with the restricting member.
  • One of the outer peripheral part of the cylindrical body and the inner peripheral part of the support member is provided with an inner slider part located inside the slider part, and the inner slider part slides on the other.
  • An inner rail portion is provided, and the inner rail portion is arranged to be inclined with respect to the other axial direction, and is disposed on a proximal end side of the inner inclined rail, An inner longitudinal rail that is continuous and formed along the other axial direction; Any one of the above (5) to (9), in which the inner slider portion sequentially slides on the inner inclined rail and the inner longitudinal rail in the process of moving the needle tube from the separated position to the piercing position.
  • a liquid administration device according to 1.
  • the inner slider portion stays on the inner inclined rail when the slider portion slides on the first vertical rail, and the slider portion slides on the first inclined rail. Slides on the inner inclined rail, and when the slider portion slides on the second vertical rail, the slider portion slides on the inner vertical rail, and the slider portion moves on the second inclined rail,
  • the inner rail portion is provided on the inner longitudinal rail, and when the needle tube moves to the piercing position, the inner rail portion engages with the inner slider portion from the distal end side thereof, toward the distal end direction of the needle tube.
  • the sealing state of the sealing portion with respect to the mouth portion of the cylindrical body is maintained or released. Then, when the sealed state is maintained, the pressing operation by the operation member is prohibited, and when the sealed state is released, the pressing operation by the operation member becomes possible. Thereby, for example, when the cover member is in the first position, the unsealed release of the sealed state is prevented, and as a result, the operation member can be reliably prevented from operating erroneously.
  • FIG. 1 is a side view (a partially cutaway view) sequentially illustrating an operating state when the liquid administration device of the present invention is used.
  • FIG. 2 is a side view (a partially cutaway view) sequentially illustrating the operating state when the liquid administration device of the present invention is used.
  • FIG. 3 is a side view (a partially cutaway view) sequentially illustrating the operating state when the liquid administration device of the present invention is used.
  • FIG. 4 is a side view (a partially cutaway view) sequentially illustrating the operating state when the liquid administration device of the present invention is used.
  • FIG. 5 is a side view (a partially cutaway view) sequentially illustrating an operating state when the liquid administration device of the present invention is used.
  • FIG. 6 is a side view (a partially cutaway view) sequentially illustrating the operating state when the liquid administration device of the present invention is used.
  • FIG. 7 is a longitudinal sectional view of the liquid administration device in the state shown in FIG.
  • FIG. 8 is a longitudinal sectional view of the liquid administration device in the state shown in FIG.
  • FIG. 9 is a longitudinal sectional view of the liquid administration device in the state shown in FIG. 10 is a longitudinal sectional view of the liquid administration device in the state shown in FIG.
  • FIG. 11 is a longitudinal sectional view of the liquid administration device in the state shown in FIG. 12 is a longitudinal sectional view of the liquid administration device in the state shown in FIG. FIG.
  • FIG. 13 is an exploded perspective view showing the positional relationship between the operation member and the regulating member provided in the liquid administration device of the present invention.
  • FIG. 14 is an exploded perspective view showing the positional relationship between the inner cylinder and the support member provided in the liquid administration device of the present invention.
  • FIG. 15 is an exploded perspective view showing the positional relationship between the support member and the regulating member provided in the liquid administration device of the present invention.
  • FIG. 16 is an exploded vertical sectional view showing the positional relationship between the cover main body and the regulating member provided in the liquid administration device of the present invention.
  • FIGS. 1 to 6 are side views (partially cutaway views) sequentially illustrating the operating state of the liquid administration device of the present invention
  • FIGS. 7 to 12 are FIGS. 1 to 6, respectively.
  • FIG. 13 is an exploded perspective view showing the positional relationship between the operation member and the regulating member provided in the liquid administration device of the present invention
  • FIG. 14 is provided in the liquid administration device of the present invention.
  • FIG. 15 is an exploded perspective view showing the positional relationship between the support member and the regulating member provided in the liquid administration device of the present invention
  • FIG. 16 is the liquid according to the present invention.
  • a liquid administration device 10 shown in FIGS. 1 to 12 is a medical instrument used when a liquid Q is administered (injected) to a living body B.
  • the liquid Q is appropriately selected according to the purpose of use.
  • hematopoietic agents, vaccines, hormone preparations, antirheumatic agents, anticancer agents, anesthetics, blood coagulation inhibitors, etc. Chemicals to be used.
  • the liquid administration device 10 is connected to an inner cylinder (cylinder body) 1, a puncture needle 50 attached to the inner cylinder 1, a gasket 3 that can slide in the inner cylinder 1, and a proximal end side of the gasket 3.
  • the operating member 11, a cover 70 that can cover the double-ended needle 2, and a coil spring 60 as an urging means that urges the cover 70 are provided.
  • the puncture needle 50 is composed of two parts (in the present embodiment, the double-ended needle 2 and the support member 9), and is composed of an assembly formed by assembling these parts. Yes. In this assembly, the double-ended needle 2 is fixed to the support member 9.
  • the operation member 11 is also composed of two parts (in this embodiment, the operation member main body 8 and the holding member (gripping part) 7), and these parts are assembled together. It consists of a solid. In this assembly, the gripping member 7 is fixed to the operation member main body 8.
  • the cover 70 is also composed of two parts (in this embodiment, the cover body 6 and the regulating member 4), and is composed of an assembly formed by assembling these parts.
  • the regulating member 4 is supported so as to be rotatable about its central axis with respect to the cover body 6 having a cylindrical shape.
  • the inner cylinder 1 is composed of a member having a bottom portion 12 and a side wall 13 erected from an edge portion of the bottom portion 12, that is, a member having a bottomed cylindrical shape.
  • the inner cylinder main body 14 is provided.
  • the inner cylinder 1 can be filled with the liquid Q.
  • the bottom portion 12 has a mortar shape, and a mouth portion 121 through which the liquid Q is discharged (passed) is formed at the center thereof.
  • the side wall 13 has a cylindrical shape.
  • the inner cylinder 1 has a sealing member (sealing part) 15 for liquid-tightly sealing the mouth part 121 of the inner cylinder main body 14 and a fixing member 16 for fixing the sealing member 15 from the distal end side. is doing.
  • the sealing member 15 is formed of a disk-shaped elastic piece, and a ring-shaped recess 151 is formed on the base end surface thereof.
  • a ring-shaped convex portion 122 protruding from the mouth portion 121 of the inner cylinder main body 14 can be fitted into the concave portion 151 in a liquid-tight manner.
  • the sealing member 15 can be mounted on the mouth portion 121 of the inner cylinder main body 14 and the mouth portion 121 can be sealed in a liquid-tight manner.
  • the fixing member 16 is a ring-shaped member.
  • the fixing member 16 is fitted to the sealing member 15 from the outer peripheral side, and the sealing member 15 is sandwiched between the fixing member 16 and the convex portion 122, whereby the sealing member 15 is attached to the inner cylinder main body 14. It can be securely fixed. Thereby, the detachment
  • a fixing method of the fixing member 16 a method by adhesion or a method by welding may be used as a fixing method of the fixing member 16.
  • the constituent materials of the inner cylinder main body 14, the fixing member 16, the cover 70, the support member 9, and the operation member 11 are not particularly limited.
  • polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) are preferable because they are easy to mold.
  • Such resin is preferred
  • the elastic material constituting the sealing member 15 and the gasket 3 is not particularly limited.
  • various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber
  • elastic materials such as various thermoplastic elastomers such as polyurethane, polyester, polyamide, olefin, and styrene, and mixtures thereof.
  • the gasket 3 is accommodated in the cylindrical body 14. Note that the space surrounded by the gasket 3 and the cylindrical body 14 (inner cylinder 1) is preliminarily filled with the liquid Q. Then, by moving the gasket 3 toward the distal direction, the liquid Q in the cylindrical body 14 can be pushed out from the double-ended needle 2 in a state communicating with the cylindrical body 14 (see FIGS. 10 and 11). ).
  • the outer shape of the gasket 3 is a disk shape, and two protrusions 31 and 32 are formed on the outer periphery thereof.
  • the protrusion 31 and the protrusion 32 are separated along the axial direction of the gasket 3.
  • each of the protrusions 31 and 32 has a ring shape along the circumferential direction of the gasket 3, and its outer diameter is slightly larger than the inner diameter of the inner cylinder 1 in a natural state where no external force is applied. Thereby, each of the protrusions 31 and 32 can slide while being in close contact with the inner peripheral portion 133 of the side wall 13 of the inner cylinder 1. Can be improved.
  • a puncture needle 50 is attached to the tip of the inner cylinder 1.
  • the puncture needle 50 includes a double-ended needle 2 and a support member 9.
  • the double-ended needle 2 is disposed on the distal end side of the sealing member 15 of the inner cylinder 1.
  • the double-ended needle 2 is a hollow needle tube, has a sharp distal needle tip 21 at the distal end, and a sharp proximal needle tip 23 at the proximal end.
  • the double-ended needle 2 having such a configuration can puncture the living body B with the distal-side needle tip 21 and can pierce the sealing member 15 of the inner cylinder 1 with the proximal-side needle tip 23.
  • the lumen portion (hollow portion) of the double-ended needle 2 communicates with the inner cylinder 1 in the state shown in FIGS. 10 to 12 in which the proximal needle tip 23 penetrates the sealing member 15 of the inner cylinder 1. It functions as a flow path 22 through which the liquid Q from the inner cylinder 1 passes. Then, the liquid Q is injected into the living body B through the flow path 22 in a state where the living body B is punctured from the skin to a predetermined depth with the tip side needle tip 21.
  • constituent material of the double-ended needle 2 is not particularly limited, and examples thereof include a metal material such as stainless steel, aluminum or aluminum alloy, titanium or titanium alloy.
  • the double-ended needle 2 having such a configuration is attached to the inner cylinder 1 via the support member 9.
  • the support member 9 supports the double-ended needle 2 so as to be movable along the central axis direction with respect to the inner cylinder 1.
  • the puncture needle 50 is moved from the separation position (see FIGS. 7 to 9) where the proximal end needle tip 23 is separated from the sealing member 15 of the inner cylinder 1 (or is not pierced and partitioned). 23 can pierce the sealing member 15 and move to a piercing position (see FIGS. 10 to 12) where the double-ended needle 2 communicates with the inside of the inner cylinder 1. Therefore, in the liquid administration device 10, unintentional leakage of the liquid Q from the double-ended needle 2 is prevented until the puncture needle 50 is located at the piercing position.
  • the support member 9 includes a fixed portion (support portion) 91 having a disk shape and a wall portion 92 erected from the edge portion of the fixed portion 91 toward the proximal direction.
  • the fixing portion 91 can support and fix the double-ended needle 2 at the center thereof.
  • the portion supported by the fixing portion 91 of the double-ended needle 2 is in the middle of the double-ended needle 2 in the longitudinal direction.
  • the wall portion 92 is a cylindrical portion along the edge of the fixed portion 91.
  • the ridges 93 are arranged at equal intervals along the circumferential direction of the wall portion 92.
  • Each protrusion 93 is inserted into a guide groove 41 formed on the inner peripheral portion of the regulating member 4 of the cover 70. Thereby, when the puncture needle 50 moves from the separated position to the piercing position, the ridge 93 is guided by the guide groove 41, and thus the movement is performed smoothly.
  • the regulating member 4 is supported so as to be rotatable around the central axis with respect to the cover body 6.
  • the puncture needle 50 can also rotate together with the regulating member 4 because the ridge 93 is inserted into the guide groove 41.
  • an inner slider portion 94 of the puncture needle 50 described later can move in the inner inclined groove 171 of the inner groove portion 17 of the inner cylinder 1 (see FIGS. 1, 2, and 14).
  • the operation member 11 is a member that performs a pressing operation (discharging operation) in which the gasket 3 is pressed toward the distal end to discharge the liquid Q from the double-ended needle 2.
  • the operation member 11 includes an operation member main body 8 connected to the gasket 3 and a grip member (gripping part) 7 gripped when a pressing operation is performed.
  • the operation member main body 8 includes a disk-shaped top plate 81, a plunger 82 that is formed in a cylindrical shape on the bottom surface of the top plate 81, and a projection that is formed on the bottom surface of the top plate 81 And a pair of curved pieces 83 disposed to face each other via a plunger 82.
  • the inner peripheral portion of the cylindrical gripping member 7 can be fitted to the outer peripheral portion of the top plate 81.
  • a plurality of claw portions are formed on one of the outer peripheral portion of the top plate 81 and the inner peripheral portion of the gripping member 7, and a concave portion in which each claw portion is engaged is formed on the other.
  • the operation member main body 8 and the gripping member 7 are fixed to each other by engaging the claw portion with the recess.
  • the index finger to the little finger of one hand is hung on the outer peripheral portion 71 of the gripping member 7, and the thumb is hung on the top plate 81 of the operation member body 8, so that the operation can be reliably performed in one continuous operation with one hand. Can be done.
  • the plunger 82 is provided at the center of the top plate 81.
  • the plunger 82 is inserted (fitted) into a recess 33 whose tip 821 is open on the base end surface of the gasket 3. Thereby, the operation member 11 and the gasket 3 are connected, and therefore, the operation on the gasket 3 can be performed.
  • Each curved piece 83 is curved along the circumferential direction of the plunger 82.
  • the gripping member 7 has a cylindrical shape and is provided so that the inner peripheral portion thereof is separated from the outer peripheral portion of the curved piece 83. 7 to 12, the cover main body 6 of the cover 70 can move between the inner peripheral portion of the gripping member 7 and the outer peripheral portion of the bending piece 83.
  • the cover 70 has a first position (see FIGS. 1 and 7), a second position (see FIGS. 4, 5, 10, and 11), and a third position (see FIGS. 6 and 12). And can move on.
  • the cover 70 can cover at least the tip side needle tip 21 of the double-ended needle 2.
  • the distal side needle tip 21 is sufficiently exposed to puncture the living body B.
  • the living body B can be reliably punctured with the tip side needle tip 21.
  • At the third position moved from the second position toward the distal direction at least the distal side needle tip 21 can be covered again.
  • the cover 70 includes a cylindrical cover body 6 and a cylindrical regulating member 4 that is disposed concentrically with the cover body 6 on the inner peripheral side of the cover body 6. ing.
  • the cover body 6 has a tip wall 63 at the tip.
  • the tip wall 63 is a ring-shaped part along the circumferential direction of the cover body 6. As shown in FIGS. 7 to 10, the tip wall 63 abuts on the fixing portion 91 of the support member 9 when the cover 70 moves from the first position to the second position, and the support member 9. Functions as a pressing portion that presses the double-ended needle 2 toward the proximal direction. By this pressing, the puncture needle 50 can be moved from the separated position to the piercing position.
  • a protrusion 651 protrudes from the inner peripheral portion 65 of the cover body 6 at a position spaced from the tip wall portion 63.
  • the protrusion 651 forms a gap with the tip wall 63, and a claw 46 of the regulating member 4 described later is inserted into the gap.
  • the cover body 6 and the regulating member 4 are engaged at the third position, and the movement of the cover body 6 toward the proximal direction is restricted.
  • FIGS. 7 to 11 the engagement between the cover body 6 and the restricting member 4 is released until the cover 70 reaches the third position.
  • the claw portion 46 of the regulating member 4 is separated from the gap between the protrusion 651 and the tip wall portion 63.
  • a plurality (four in this embodiment) of ribs 641 are formed to protrude from the outer peripheral portion 64 of the cover body 6.
  • the ribs 641 are arranged at equal intervals along the circumferential direction.
  • Each rib 641 formed in this way is inserted into a groove 721 (see FIGS. 9 and 10) formed in the inner peripheral portion 72 of the gripping member 7 along the axial direction thereof.
  • the regulating member 4 is a member that can regulate the movement of the cover main body 6 (cover 70), and is supported so as to be rotatable about the central axis of the cover main body 6.
  • the claw portion 46 described above is formed at the distal end portion of the regulating member 4.
  • the claw portion 46 has a tip portion of the wall portion of the regulating member 4 missing, thereby moving toward the rotation direction of the regulating member 4, that is, toward the circumferential direction of the regulating member 4 (left direction in FIG. 16). It is a protruding part.
  • the cover 70 is urged by the urging force of the coil spring 60 in the direction of moving from the second position to the first position (third position).
  • the coil spring 60 is housed between the plunger 82 and the bending piece 83 of the operation member 11 in a compressed state.
  • the coil spring 60 has a distal end 601 in contact with the base end surface of the regulating member 4 and a base end 602 in contact with the top plate 81 of the operation member 11. And between these, the coil spring 60 is compressed.
  • the cover 70 can be reliably urged in the direction from the second position toward the first position.
  • the tip side needle tip 21 of the puncture needle 50 can be covered with the cover body 6 before and after the liquid administration device 10 is used. Can be reliably prevented.
  • the constituent material of the coil spring 60 is not particularly limited, and for example, a metal material such as stainless steel can be used.
  • the pressing operation prohibited state shown in FIGS. 1 and 7 the pressing operation possible state shown in FIGS. 4, 5, 10, and 11, and FIGS.
  • the cover movement prohibition state shown can be taken.
  • the puncture needle 50 is moved to the piercing position as the cover 70 is moved.
  • the sealing state of the sealing member 15 with respect to the portion 121 is released, and the pressing operation by the operation member 11 is enabled.
  • the cover movement prohibited state is a state in which when the cover 70 is moved from the second position to the third position after the pressing operation is completed, the re-movement of the cover 70 from the third position is prohibited.
  • the regulating member 4 is provided with a pair of outer slider portions (slider portions (outer follower portions)) 42 at the distal end portion of the outer peripheral portion thereof.
  • a pair of curved pieces 83 of the operation member 11 (operation member main body 8) are disposed on the outer peripheral side of the regulating member 4.
  • Each curved piece 83 is provided with an outer groove portion (outer cam groove) 84 as an outer rail portion (rail portion) on which one outer slider portion 42 slides.
  • each outer slider portion 42 is disposed on the opposite sides with respect to the central axis of the regulating member 4.
  • each outer slider portion 42 is configured by a protrusion that protrudes from the outer periphery of the regulating member 4.
  • each outer groove 84 Since the configuration of each outer groove 84 is the same, only one outer groove 84 will be described as a representative.
  • the outer groove portion 84 is a through-hole penetrating the bending piece 83 in the thickness direction, and the outer slider portion 42 is inserted therein.
  • the outer groove 84 includes a first outer vertical groove (first vertical rail) 841, a second outer vertical groove (second vertical rail) 842, and a third outer vertical groove (third Vertical rail) 843, first outer inclined groove (first inclined rail) 844, second outer inclined groove (second inclined rail) 845, outer engaging portion (engaging portion) 846, It consists of
  • the first outer longitudinal groove 841 is formed along the central axis direction of the operation member 11, that is, in the direction in which the cover 70 moves from the first position to the second position.
  • the second outer longitudinal groove 842 is located along the central axis direction of the operating member 11 at a position spaced from the first outer longitudinal groove 841 in the circumferential direction of the operating member 11 (curved piece 83), that is, 1 in the same direction as the outer longitudinal groove 841.
  • the third outer longitudinal groove 843 is located at a position spaced apart from the second outer longitudinal groove 842 in the circumferential direction of the operation member 11 along the central axis direction of the operation member 11, that is, the cover 70 is second. It is formed in the direction moving from the position to the third position.
  • the first outer vertical groove 841, the second outer vertical groove 842, and the third outer vertical groove 843 are arranged in this order along the circumferential direction of the operation member 11.
  • the first outer inclined groove 844 is formed between the first outer vertical groove 841 and the second outer vertical groove 842 so as to be inclined with respect to the central axis direction of the operation member 11.
  • the first outer inclined groove 844 has a distal end portion intersecting the proximal end portion of the first outer longitudinal groove 841 and a proximal end portion intersecting the distal end portion of the second outer longitudinal groove 842. .
  • the second outer inclined groove 845 is formed to be inclined with respect to the central axis direction of the operation member 11 between the second outer vertical groove 842 and the third outer vertical groove 843.
  • the distal end portion of the second outer inclined groove 845 intersects with the proximal end portion of the second outer longitudinal groove 842, and the proximal end portion intersects with the proximal end portion of the third outer longitudinal groove 843.
  • the first outer vertical groove 841, the second outer vertical groove 842, the third outer vertical groove 843, the first outer inclined groove 844, and the second outer inclined groove 845 formed as described above are adjacent grooves. They communicate with each other and form a single continuous groove as a whole.
  • the outer slider portion 42 has the first outer longitudinal groove 841, the first outer inclined groove 844, and the second outer longitudinal groove 842.
  • the second outer inclined groove 845 can smoothly slide in order.
  • the outer slider portion 42 can smoothly slide in the third outer longitudinal groove 843.
  • the outer engaging portion 846 is an elastic piece configured by a part of the curved piece 83 that defines the third outer longitudinal groove 843.
  • the outer engagement portion 846 is disposed at the distal end portion of the third outer longitudinal groove 843 and can be engaged with the outer slider portion 42 from the distal end side when the cover 70 is moved to the third position ( (See FIG. 6). Further, the outer engagement portion 846 formed of an elastic piece can be elastically deformed, and thus the engagement state with the outer slider portion 42 is reliably maintained. Thereby, it can restrict
  • the support member 9 of the puncture needle 50 is provided with a pair of inner slider portions (inner follower portions) 94 at the proximal end portion of the inner peripheral portion thereof.
  • a cylindrical body 14 (inner cylinder 1) is disposed on the inner peripheral side of the support member 9.
  • the cylindrical body 14 is provided with an inner groove portion (inner cam groove) 17 as an inner rail portion on which each inner slider portion 94 slides at the distal end portion of the outer peripheral portion thereof.
  • the pair of inner slider portions 94 are located on the inner side of the outer slider portion 42 and are disposed to face each other with the central axis of the support member 9 interposed therebetween.
  • each inner slider portion 94 is configured by a protruding portion that protrudes from the inner peripheral portion of the support member 9.
  • each inner groove part 17 is the same, only one inner groove part 17 will be described as a representative.
  • the inner slider portion 94 is inserted into the inner groove portion 17.
  • the inner groove portion 17 includes an inner inclined groove (inner inclined rail) 171, an inner vertical groove (inner vertical rail) 172, a first inner engagement portion 173, and a second inner engagement portion (inner engagement). Part) 174.
  • the inner inclined groove 171 is formed to be inclined with respect to the central axis direction of the cylindrical body 14.
  • the inner longitudinal groove 172 is formed on the proximal end side of the inner inclined groove 171 along the central axis direction of the cylindrical body 14, that is, in the direction in which the puncture needle 50 moves from the separated position to the piercing position. Yes.
  • the inner longitudinal groove 172 has a distal end intersecting the base end of the inner inclined groove 171.
  • the inner inclined groove 171 and the inner vertical groove 172 communicate with each other to form one continuous groove. Therefore, in the process in which the puncture needle 50 moves from the separated position to the piercing position, the inner slider portion 94 can smoothly slide in the inner inclined groove 171 and the inner vertical groove 172 in order.
  • the first inner engagement portion 173 is a portion from which a part of the wall portion of the cylindrical body 14 that defines the inner inclined groove 171 protrudes.
  • the first inner engagement portion 173 is disposed at the distal end portion of the inner inclined groove 171 and is temporarily engaged with the inner slider portion 94 from the proximal end side when the puncture needle 50 is in the separated position. (See FIGS. 1 and 2).
  • the unintentional movement of the puncture needle 50 is reliably restricted until the puncture needle 50 is pressed toward the proximal direction by the distal end wall portion 63 of the cover 70, that is, the puncture needle. 50 can remain securely in the spaced position.
  • the second inner engaging portion 174 is a portion from which a part of the wall portion of the cylindrical body 14 that defines the inner longitudinal groove 172 protrudes.
  • the second inner engagement portion 174 is disposed at the proximal end portion of the inner longitudinal groove 172, and engages the inner slider portion 94 from the distal end side when the puncture needle 50 moves to the piercing position ( (See FIGS. 4 to 6). Thereby, the puncture needle 50 is moved in the distal direction, that is, the puncture needle 50 is restricted from returning to the separated position, so that the distal end needle tip 21 can be reliably covered with the cover 70 in the third position. it can.
  • the puncture needle 50 can rotate together with the restricting member 4.
  • the position of the outer slider portion 42 provided on the regulating member 4 with respect to the outer groove portion 84 that is, which groove of the plurality of grooves that the outer slider portion 42 constitutes the outer groove portion 84 is determined.
  • the inner slider portion 94 provided on the puncture needle 50 (supporting member 9) can move in the inner groove portion 17 depending on (in conjunction with) the movement.
  • the inner slider portion 94 when the outer slider portion 42 slides in the first outer longitudinal groove 841, the inner slider portion 94 remains in the inner inclined groove 171. Further, as shown in FIG. 3, when the outer slider portion 42 slides in the first outer inclined groove 844, the inner slider portion 94 slides in the inner inclined groove 171. As shown in FIG. 4, when the outer slider portion 42 slides in the second outer longitudinal groove 842, the inner slider portion 94 slides in the inner longitudinal groove 172. As shown in FIGS. 5 and 6, when the outer slider portion 42 sequentially slides in the second outer inclined groove 845 and the third outer longitudinal groove 843, the inner slider portion 94 remains in the inner longitudinal groove 172. .
  • the liquid administration device 10 can pass through the pressing operation prohibited state, the pressing operation enabled state, and the cover movement prohibited state in this order. The detail about this is demonstrated with the usage method of the following liquid administration devices 10, and the operation state at the time of the use.
  • the liquid administration device 10 is in a pressing operation prohibited state.
  • the cover 70 In the pressing operation prohibition state, the cover 70 is in the first position, and the outer slider portion 42 of the regulating member 4 constituting a part of the cover 70 is moved to the first outer longitudinal groove 841 of the outer groove portion 84 of the operation member 11. Is located.
  • the puncture needle 50 is in a separated position, and the inner slider portion 94 of the support member 9 constituting a part of the puncture needle 50 is positioned in the inner inclined groove 171 of the inner groove portion 17 of the inner cylinder 1. Yes.
  • the puncture needle 50 since the puncture needle 50 is in the separated position, the sealing state of the sealing member 15 with respect to the mouth portion 121 is maintained in the inner cylinder 1. Thereby, while pressing operation by the operation member 11 is prohibited, the aseptic state of the liquid Q can be maintained until the administration of the liquid Q is started.
  • the inner slider portion 94 is engaged with the first inner engagement portion 173 in the inner inclined groove 171. As a result, the unintentional movement of the puncture needle 50 in the proximal direction is restricted, so that the sealed state can be reliably maintained.
  • the tip side needle tip 21 of the double-ended needle 2 is covered by the cover 70 in the first position. Thereby, the erroneous puncture by the tip side needle tip 21 can be prevented reliably.
  • the outer slider portion 42 of the cover 70 slides to a position intersecting the first outer inclined groove 844 of the first outer longitudinal groove 841 of the operation member 11.
  • the inner slider portion 94 of the puncture needle 50 is in a state of being engaged with the first inner engagement portion 173 in the inner inclined groove 171 and therefore remains at that position (see FIG. 2). Thereby, the puncture needle 50 is still in the separated position.
  • the distal wall 63 of the cover 70 presses the support member 9 of the puncture needle 50 toward the proximal direction.
  • the puncture needle 50 can move the inner slider portion 94 to the proximal end portion of the inner longitudinal groove 172 (see FIG. 4), and thus communicates with the inner cylinder 1 at the piercing position ( (See FIG. 10).
  • the sealing state of the sealing member 15 with respect to the mouth portion 121 in the inner cylinder 1 is released, so that the pressing operation by the operation member 11 can be performed, and the administration of the liquid Q is started.
  • the liquid administration device 10 is separated from the living body B.
  • the cover 70 is urged toward the distal end by the urging force of the coil spring 60, and the outer slider portion 42 moves through the third outer longitudinal groove 843 to the third position. it can.
  • the liquid administration device 10 is in a cover movement prohibited state.
  • the outer slider portion 42 is engaged with the outer engaging portion 846, and the engagement prevents the cover 70 from moving again toward the proximal direction. Incorrect puncture by the distal needle tip 21 is prevented.
  • the inner slider portion 94 of the puncture needle 50 engages with the second inner engagement portion 174 and remains in the inner longitudinal groove 172. Thereby, the puncture needle 50 will continue to be located at the piercing position.
  • the pressing operation for ejecting the liquid Q by the operating member 11 is prohibited, and the distal needle tip 21.
  • a pressing operation can be performed. Thereby, before the puncture with respect to the biological body B is performed, it is possible to reliably prevent the pressing operation by the operation member 11 from being performed erroneously.
  • liquid administration device of the present invention has been described above with respect to the illustrated embodiment. However, the present invention is not limited to this, and each component constituting the liquid administration device can have any function that can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.
  • the outer slider portion is provided on the restriction member of the restriction member and the curved piece of the operation member, and the outer rail portion is provided on the curved piece of the operation member.
  • An outer rail part may be provided in a control member, and the outer slider part may be provided in the curved piece of the operation member.
  • the inner slider portion is provided on the support member of the support member and the cylindrical body, and the inner rail portion is provided on the cylindrical body.
  • the inner side slider part may be provided in a cylinder main body, and the inner side rail part may be provided in the supporting member.
  • outer rail portion and the inner rail portion are each configured with a groove in the above embodiment, but the outer slider portion and the inner slider portion are not limited to this as long as the outer slider portion and the inner slider portion can slide along the rail. You may be comprised by the protruding item
  • the liquid administration device of the present invention has a cylindrical shape, the inside of which is filled with liquid, and a cylindrical body having a mouth part through which the liquid is discharged at the tip part, and the mouth part is sealed in a liquid-tight manner,
  • a cylindrical body provided with a sealing portion having elasticity, a gasket that can slide in the cylindrical body, and disposed on the distal end side of the sealing portion, and supported so as to be movable along the axial direction of the cylindrical body,
  • a needle tube having a sharp distal end needle tip and a proximal proximal needle point at the distal end; a separation position where the proximal needle tip is spaced from the sealing portion; and the proximal end.
  • a side needle tip pierces the sealing portion and is connected to a support member movably supported to a piercing position communicating with the cylindrical body, and is connected to a proximal end side of the gasket, and the gasket is directed toward the distal direction.
  • An operating member for performing a pressing operation for pressing and discharging the liquid from the needle tube; and at least in front of the needle tube A cover that is movable to a first position that covers the distal needle tip and a second position that retracts from the first position in the proximal direction and exposes the distal needle tip; Is in the separated position, the sealed state of the sealing portion with respect to the mouth portion is maintained, and the cover is moved from the first position to the second position. When moved to the position, the needle tube moves to the piercing position with the movement, and thereby the sealed state is released. Therefore, when it is desired to regulate the operation of the operation member, it is possible to reliably prevent the operation member from operating erroneously.
  • the liquid administration device of the present invention has industrial applicability.
  • Liquid administration device 1 Inner cylinder (tubular body) 12 bottom part 121 mouth part 122 convex part 13 side wall 133 inner peripheral part 14 inner cylinder main body 15 sealing member (sealing part) 151 Recess 16 Fixing member 17 Inner groove (inner cam groove) 171 Inner inclined groove (inner inclined rail) 172 Inner vertical groove (inner vertical rail) 173 First inner engagement portion 174 Second inner engagement portion (inner engagement portion) 2 double-ended needle 21 distal end side needle tip 22 flow path 23 proximal end side needle tip 3 gasket 31, 32 protrusion 33 recess 4 restriction member 41 guide groove 42 outer slider portion (slider portion (outer follower portion)) 46 claw part 6 cover body 63 tip wall part 64 outer peripheral part 641 rib 65 inner peripheral part 651 projecting part 7 gripping member (gripping part) 71 Outer peripheral portion 72 Inner peripheral portion 721 Groove 8 Operation member body 81 Top plate 82 Plunger 821 Tip portion 83 Curved piece 84 Outer groove portion (outer

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PCT/JP2012/068102 2012-07-17 2012-07-17 Instrument pour administration de liquide Ceased WO2014013547A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/068102 WO2014013547A1 (fr) 2012-07-17 2012-07-17 Instrument pour administration de liquide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/068102 WO2014013547A1 (fr) 2012-07-17 2012-07-17 Instrument pour administration de liquide

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WO2014013547A1 true WO2014013547A1 (fr) 2014-01-23

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232457A (en) * 1991-08-05 1993-08-03 Grim John P Medical syringe
WO2010100244A1 (fr) * 2009-03-06 2010-09-10 Sanofi-Aventis Deutschland Gmbh Élément d'étanchéité pour seringue munie d'une aiguille rétractable
JP2011104363A (ja) * 2009-11-13 2011-06-02 Becton Dickinson & Co 薬剤送出ペン用の覆い隠された針を有するハブ・アセンブリ
WO2011095488A1 (fr) * 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Module médicamenteux comportant une double gaine de protection d'aiguille
WO2012000837A1 (fr) * 2010-07-02 2012-01-05 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection doté d'un protecteur d'aiguille
JP2012500063A (ja) * 2008-08-15 2012-01-05 ベクトン・ディキンソン・アンド・カンパニー 安全ペンニードルアセンブリ

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232457A (en) * 1991-08-05 1993-08-03 Grim John P Medical syringe
JP2012500063A (ja) * 2008-08-15 2012-01-05 ベクトン・ディキンソン・アンド・カンパニー 安全ペンニードルアセンブリ
WO2010100244A1 (fr) * 2009-03-06 2010-09-10 Sanofi-Aventis Deutschland Gmbh Élément d'étanchéité pour seringue munie d'une aiguille rétractable
JP2011104363A (ja) * 2009-11-13 2011-06-02 Becton Dickinson & Co 薬剤送出ペン用の覆い隠された針を有するハブ・アセンブリ
WO2011095488A1 (fr) * 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Module médicamenteux comportant une double gaine de protection d'aiguille
WO2012000837A1 (fr) * 2010-07-02 2012-01-05 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection doté d'un protecteur d'aiguille

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