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WO2014086453A8 - Azaheterobicyclic compounds - Google Patents

Azaheterobicyclic compounds Download PDF

Info

Publication number
WO2014086453A8
WO2014086453A8 PCT/EP2013/003356 EP2013003356W WO2014086453A8 WO 2014086453 A8 WO2014086453 A8 WO 2014086453A8 EP 2013003356 W EP2013003356 W EP 2013003356W WO 2014086453 A8 WO2014086453 A8 WO 2014086453A8
Authority
WO
WIPO (PCT)
Prior art keywords
azaheterobicyclic
compounds
diseases
inflammatory
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/003356
Other languages
French (fr)
Other versions
WO2014086453A1 (en
Inventor
Kai Schiemann
Frank Stieber
Christina Esdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Cancer Research Technology Ltd
Original Assignee
Merck Patent GmbH
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH, Cancer Research Technology Ltd filed Critical Merck Patent GmbH
Publication of WO2014086453A1 publication Critical patent/WO2014086453A1/en
Publication of WO2014086453A8 publication Critical patent/WO2014086453A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides novel substituted azaheterobicyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.
PCT/EP2013/003356 2012-12-07 2013-11-07 Azaheterobicyclic compounds Ceased WO2014086453A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12008195.5 2012-12-07
EP12008195 2012-12-07

Publications (2)

Publication Number Publication Date
WO2014086453A1 WO2014086453A1 (en) 2014-06-12
WO2014086453A8 true WO2014086453A8 (en) 2014-08-21

Family

ID=47325770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/003356 Ceased WO2014086453A1 (en) 2012-12-07 2013-11-07 Azaheterobicyclic compounds

Country Status (2)

Country Link
AR (1) AR093841A1 (en)
WO (1) WO2014086453A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY36390A (en) * 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BR112017008809A2 (en) 2014-11-05 2017-12-19 Flexus Biosciences Inc immunoregulatory agents
SMT202400141T1 (en) * 2015-12-17 2024-05-14 Merck Patent Gmbh 8-cyano-5-piperidino-quinolines as tlr7/8 antagonists and their uses for treating immune disorders
WO2017122754A1 (en) * 2016-01-12 2017-07-20 日本ケミファ株式会社 Voltage-dependent t-type calcium channel inhibitor
ES2944573T3 (en) 2016-08-08 2023-06-22 Merck Patent Gmbh TLR7/8 antagonists and uses thereof
KR20190063745A (en) * 2017-11-30 2019-06-10 (주)인핸스드바이오 NEW COMPOUNDS FOR INHIBITING BINDING BETWEEN p34 PROTEIN AND NEDD4-1 PROTEIN AND USE THEREOF
EP3962907A1 (en) * 2019-05-02 2022-03-09 Constellation Pharmaceuticals, Inc. Modulators of trex1

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1165283A (en) * 1967-01-17 1969-09-24 Science Union & Cie New Purine Derivatives and processes for prepararing them
EP1067123B1 (en) * 1998-03-31 2011-01-19 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
AU2002336462A1 (en) * 2001-09-06 2003-03-24 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds
ES2878130T3 (en) * 2006-04-25 2021-11-18 Astex Therapeutics Ltd Derivatives of purine and deazapurine as pharmaceutical compounds
CA2660114A1 (en) * 2006-08-09 2008-02-14 Merck Frosst Canada Ltd. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
JP2010537998A (en) * 2007-08-27 2010-12-09 ワイス・エルエルシー Imidazopyridine analogs and their use as agonists of the Wnt-β catenin cell message transduction system
GB0818241D0 (en) * 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
CN102822169A (en) * 2009-12-30 2012-12-12 艾科尔公司 Substituted naphthyl-pyrimidine compounds

Also Published As

Publication number Publication date
AR093841A1 (en) 2015-06-24
WO2014086453A1 (en) 2014-06-12

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