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WO2014063033A3 - Novel probes and targeting comounds for mitochondria - Google Patents

Novel probes and targeting comounds for mitochondria Download PDF

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Publication number
WO2014063033A3
WO2014063033A3 PCT/US2013/065649 US2013065649W WO2014063033A3 WO 2014063033 A3 WO2014063033 A3 WO 2014063033A3 US 2013065649 W US2013065649 W US 2013065649W WO 2014063033 A3 WO2014063033 A3 WO 2014063033A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitochondria
comounds
targeting
novel probes
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/065649
Other languages
French (fr)
Other versions
WO2014063033A2 (en
Inventor
Lanrong Bi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Michigan Technological University
University of Michigan Ann Arbor
Original Assignee
Michigan Technological University
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Technological University, University of Michigan Ann Arbor filed Critical Michigan Technological University
Publication of WO2014063033A2 publication Critical patent/WO2014063033A2/en
Publication of WO2014063033A3 publication Critical patent/WO2014063033A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel compounds which are fluorescent and target the mitochondria and methods of using them.
PCT/US2013/065649 2012-10-19 2013-10-18 Novel probes and targeting comounds for mitochondria Ceased WO2014063033A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261716260P 2012-10-19 2012-10-19
US61/716,260 2012-10-19
US201361778602P 2013-03-13 2013-03-13
US61/778,602 2013-03-13

Publications (2)

Publication Number Publication Date
WO2014063033A2 WO2014063033A2 (en) 2014-04-24
WO2014063033A3 true WO2014063033A3 (en) 2014-06-12

Family

ID=50488900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/065649 Ceased WO2014063033A2 (en) 2012-10-19 2013-10-18 Novel probes and targeting comounds for mitochondria

Country Status (1)

Country Link
WO (1) WO2014063033A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108164509B (en) * 2018-01-17 2020-02-28 浙江大学 A multimodal molecular probe
CN115594713B (en) * 2022-10-14 2025-09-05 西北工业大学 A small molecule probe for extracting and purifying mitochondria and its preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079173A1 (en) * 2001-04-02 2002-10-10 Ciba Specialty Chemicals Holding Inc. Benzotriazoles and their use as uv light stabilisers
US20080200405A1 (en) * 2007-02-16 2008-08-21 Ghanshyam Patil Drug Resistance Reversal In Neoplastic Disease
US20110171677A1 (en) * 2008-05-13 2011-07-14 Rebecca Braslau Fluorescence detection of poison oak oil
EP2134724B1 (en) * 2007-03-12 2011-09-28 Versitech Limited Reagents for detection of hypochlorous acid
WO2012112851A2 (en) * 2011-02-18 2012-08-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeted nitroxide agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079173A1 (en) * 2001-04-02 2002-10-10 Ciba Specialty Chemicals Holding Inc. Benzotriazoles and their use as uv light stabilisers
US20080200405A1 (en) * 2007-02-16 2008-08-21 Ghanshyam Patil Drug Resistance Reversal In Neoplastic Disease
EP2134724B1 (en) * 2007-03-12 2011-09-28 Versitech Limited Reagents for detection of hypochlorous acid
US20110171677A1 (en) * 2008-05-13 2011-07-14 Rebecca Braslau Fluorescence detection of poison oak oil
WO2012112851A2 (en) * 2011-02-18 2012-08-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeted nitroxide agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM 21 April 2008 (2008-04-21), accession no. ID24766484 *
SCHAFER, HJ ET AL.: "Synthesis and Properties of 8-Azido-1,N6-Etheno Adenosine Triphosphate - a Fluorescent and Photosensitive ATP Analog.", NUCLEIC ACIDS RESEARCH, vol. 5, no. 4, April 1978 (1978-04-01), pages 1345 - 1351, Retrieved from the Internet <URL:hftp://www.unboundmedicine.com/medline/citation/26043/Synthesis_and_properties_of_8_azido_1_N6_etheno_adenosine_triphosphatea-fluorescent_and_photosensitive_ATP_analog> [retrieved on 20140320] *
YAPICI, NB ET AL.: "New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl .Radical Identification in Living Cells.", ORGANIC LETTERS, vol. 14, no. 1, 16 December 2011 (2011-12-16), pages 50 - 53, Retrieved from the Internet <URL:http://pubs.acs.org/doi/abs/10.1021/ol202816m> [retrieved on 20140320] *

Also Published As

Publication number Publication date
WO2014063033A2 (en) 2014-04-24

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