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WO2013115329A1 - Système de pose d'articles de rétention in vivo - Google Patents

Système de pose d'articles de rétention in vivo Download PDF

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Publication number
WO2013115329A1
WO2013115329A1 PCT/JP2013/052248 JP2013052248W WO2013115329A1 WO 2013115329 A1 WO2013115329 A1 WO 2013115329A1 JP 2013052248 W JP2013052248 W JP 2013052248W WO 2013115329 A1 WO2013115329 A1 WO 2013115329A1
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
delivery system
stent
protrusion
vivo indwelling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2013/052248
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English (en)
Japanese (ja)
Inventor
石井　直樹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2013115329A1 publication Critical patent/WO2013115329A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A61F2002/9583—Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves

Definitions

  • the present invention relates to an in-vivo indwelling material delivery system.
  • a stent is an in-vivo indwelling used for improving a stenosis or occlusion occurring in a lumen in a living body.
  • the stent delivery system has an expandable balloon disposed on the outer periphery of the distal end portion of the hollow shaft portion, and the stent is disposed on the outer periphery of the balloon and configured to be expanded by balloon expansion. .
  • the balloon has a raised portion that engages with the stent, and the displacement of the stent relative to the balloon and the separation (separation) are suppressed.
  • the protruding portion of the balloon is formed by projecting a part of the balloon into a space between the linear members constituting the stent and sandwiching (crimping) the linear balloon by the linear members (see, for example, Patent Document 1). .
  • the present invention has been made in order to solve the problems associated with the prior art described above, and the retention force of the in-vivo indwelling material does not decrease even when it passes through the bent portion of the in-vivo lumen, and the retention effect is prolonged. It aims at providing the in-vivo indwelling material delivery system which can be maintained for a period.
  • the present invention provides a hollow shaft portion, an expandable balloon disposed on the outer periphery of the distal end portion of the shaft portion, and disposed on the outer periphery of the balloon and expanded by balloon expansion.
  • An in-vivo indwelling delivery system having an in-vivo indwelling.
  • the balloon has a plurality of protrusions for adhering the indwelling object, and the protrusions are configured to increase the surface area and develop an adhesive force due to van der Waals force.
  • the holding power of the in-vivo indwelling decreases even after passing through the bent portion of the in-vivo lumen. And the retention effect can be maintained for a long time. That is, it is possible to provide an in-vivo indwelling delivery system capable of maintaining the holding effect for a long period of time without reducing the holding power of the in-vivo indwelling even when passing through the bent portion of the in-vivo lumen.
  • the top portion of the projection that contacts the indwelling object is inclined and has directionality. For example, it is possible to incline the top part in the balloon winding direction, or incline toward the axial front end side or the axial base end side of the shaft part.
  • the area of the adhesion part where the protrusion is arranged occupies 5% or more of the area of the straight part of the balloon.
  • the adhesive portion can be arranged in a columnar shape so as to surround the outer periphery of the straight portion end located on the axial front end side of the shaft portion, or can be arranged apart from each other on the outer periphery of the straight portion.
  • the indwelling object When the indwelling object is a stent, it can be used to improve a stenosis (or occlusion) generated in a lumen in a living body.
  • FIG. 3 is a cross-sectional view taken along line III-III in FIG. It is a top view for demonstrating the stent shown by FIG. It is a side view for demonstrating the balloon shown by FIG. It is sectional drawing for demonstrating the protrusion arrange
  • FIG. 11 is a cross-sectional view for explaining a balloon expansion step following FIG. 10.
  • FIG. 12 is a cross-sectional view for explaining a balloon deflation step following FIG. 11.
  • FIG. 13 is a cross-sectional view for explaining a stent placement step subsequent to FIG. 12. It is a top view for demonstrating the modification 1 which concerns on embodiment of this invention. It is a top view for demonstrating the modification 2 which concerns on embodiment of this invention. It is a top view for demonstrating the modification 3 which concerns on embodiment of this invention. It is a top view for demonstrating the modification 4 which concerns on embodiment of this invention.
  • FIG. 1 is a schematic diagram for explaining a stent delivery system according to an embodiment of the present invention.
  • the stent delivery system 100 is a rapid exchange type having a structure in which the guide wire 150 passes through only the distal end portion, and is used to improve a narrowed portion (or occluded portion) generated in a lumen in a living body.
  • the hollow shaft tube 160, the balloon 120 disposed on the outer periphery of the distal end portion of the shaft tube 160, the stent 110 disposed on the outer periphery of the balloon 120, and the shaft tube 160 And a hub 140 located at the base of each.
  • a guide wire port 144 is provided in the middle of the shaft tube 160. The guide wire port 144 is used to introduce the guide wire 150 into the shaft tube 160 and project from the tip.
  • the lumen in the living body is, for example, the coronary artery of the heart, and one of the objectives of improving the stenosis is to prevent restenosis after percutaneous transluminal coronary angioplasty (PTCA).
  • the stent delivery system 100 is not limited to a form applied to a stenosis part generated in the coronary artery of the heart, but can also be applied to a stenosis part generated in other blood vessels, bile ducts, trachea, esophagus, urethra and the like.
  • the stent 110 is an in-vivo indwelling object that holds a lumen by being placed in close contact with the inner surface of the stenosis, and is configured to be expandable.
  • the balloon 120 is expandable and is configured to expand the diameter of the stent 110 disposed on the outer periphery thereof.
  • the hub 140 has a port 141.
  • Port 141 is used, for example, to introduce and expel pressurized fluid that causes balloon 120 to expand.
  • the pressurized fluid is, for example, a liquid such as physiological saline or an angiographic contrast agent.
  • FIG. 2 is a cross-sectional view for explaining the distal end portion of the stent delivery system shown in FIG. 1
  • FIG. 3 is a cross-sectional view taken along line III-III in FIG. 2
  • FIG. 4 is a view for explaining the stent shown in FIG. It is a top view for doing.
  • the stent 110 has an annular body composed of wavy linear members 112 extending in the circumferential direction C and capable of expanding and contracting in the radial direction, juxtaposed in the axial direction A and joined to each other. It is formed by.
  • the stent 110 is not limited to the above configuration.
  • the stent 110 is made of a biocompatible material.
  • the biocompatible material are nickel-titanium alloy, cobalt-chromium alloy, stainless steel, iron, titanium, aluminum, tin, and zinc-tungsten alloy.
  • the balloon 120 is expandable, and as shown in FIG. 3, the balloon 120 is disposed on the outer periphery of the distal end portion of the shaft tube 160 in a folded state (or a contracted state) by winding. Rewinded. Since the balloon 120 is disposed inside the stent 110, the linear member 112 of the stent 110 is expanded by the expansion of the balloon 120.
  • the balloon 120 has an area (MSA) that can contact the stent 110 in the folded state of about 60% and occupies about 20% in the expanded state.
  • the balloon 120 is not limited to a folded form.
  • the material for forming the balloon 120 is preferably flexible.
  • polyolefins polyvinyl chloride, polyamides including nylon, polyamide elastomers, polyurethanes, polyesters such as polyethylene terephthalate (PET), and polyarylenes such as polyphenylene sulfide. Sulfide, silicone rubber, latex rubber.
  • the polyolefin is, for example, polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, or cross-linked ethylene-vinyl acetate copolymer.
  • the shaft tube 160 has an inner tube 162 and an outer tube 164 into which the inner tube 162 is inserted, as shown in FIG.
  • the inner tube 162 communicates with the guide wire port 144 and extends through the balloon 120 to the tip. Accordingly, the guide wire inserted into the guide wire port 144 can protrude from the distal end of the stent delivery system 100. That is, the inside of the inner tube 162 constitutes a guide wire lumen 161.
  • the coiled marker 168 aligned with both ends of the stent 110 is attached to the inner tube 162.
  • the marker 168 is made of a radiopaque material, and a clear contrast image can be obtained under fluoroscopy. Therefore, the position of the stent 110 (the distal end portion of the stent delivery system 100) can be easily confirmed. Is possible.
  • the radiopaque material is, for example, platinum, gold, tungsten, iridium, or an alloy thereof.
  • the outer tube 164 is disposed outside the inner tube 162, and the lumen 163 constituted by a space between the inner peripheral surface of the outer tube 164 and the outer peripheral surface of the inner tube 162 communicates with the port 141 of the hub 140. is doing.
  • the balloon 120 is liquid-tightly fixed to the outer periphery of the distal end portion of the outer tube 164, and the inside of the balloon 120 communicates with the lumen 163. Therefore, the pressurized fluid introduced from the port 141 can pass through the lumen 163 and be introduced into the balloon 120 to expand the balloon 120.
  • a method for fixing the outer periphery of the distal end portion of the outer tube 164 and the balloon 120 is not particularly limited, and for example, an adhesive or heat fusion can be applied.
  • the constituent material of the outer tube 164 is preferably formed of a flexible material, such as polyethylene, polypropylene, polybutene, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, ionomer, or two of these.
  • Polyolefins such as mixtures of at least seeds, soft polyvinyl chloride resins, polyamides, polyamide elastomers, polyesters, polyester elastomers, polyurethanes, thermoplastic resins such as fluororesins, silicone rubbers, latex rubbers.
  • the same material as the outer tube 164 or a metal material can be applied.
  • the metal material include stainless steel, stainless extensible alloy, and Ni—Ti alloy.
  • the constituent material of the hub 140 is, for example, a thermoplastic resin such as polycarbonate, polyamide, polysulfone, polyarylate, or methacrylate-butylene-styrene copolymer.
  • FIG. 5 is a side view for explaining the balloon shown in FIG. 2
  • FIG. 6 is a cross-sectional view for explaining the protrusions arranged at the bonding portion shown in FIG.
  • the balloon 120 has a straight portion 122 and reduced diameter portions 124A and 124B.
  • the straight part 122 is, for example, a columnar shape having an outer diameter of about 3 mm, and has an adhesive part 130 arranged over the entire surface.
  • the reduced diameter portions 124A and 124B have a diameter smaller than the diameter of the straight portion 122 and are located at both ends of the straight portion 122 in the axial direction A.
  • the reduced diameter portion 124A is on the distal end side, and the reduced diameter portion 124B. Is the proximal side.
  • the bonding portion 130 has a plurality of fine frustoconical protrusions 132 in the order of nanometers or micrometers.
  • the protrusion 132 is configured to increase the surface area of the portion of the stent 110 that contacts the linear member 112 and develop an adhesive force due to van der Waals force.
  • the diameter D 1 of the top 136 in contact with the diameter D 2 and the stent 110 of the base 134 of the protrusion 132 is a 5 nm ⁇ 10 [mu] m
  • the height H of the projection 132 is 1 [mu] m ⁇ 30 [mu] m
  • formation density 100 [mu] m is 1 or more per 2
  • minute projections 132 are formed at a high density.
  • a structure for bonding using van der Waals force for example, a fine fibrous structure found on the sole of a gecko is generally known.
  • the protrusion 132 expresses a physical adhesive force by van der Waals force acting between the linear member 112 (stent 110) in contact with the linear member 112, it is in an attached state without requiring a chemical surface treatment or the like. Thus, no pre-treatment for chemical surface treatment is required, and the holding force does not decrease even when passing through the bent portion, and the effect can be maintained for a long time. That is, since the adhesion between the balloon 120 and the stent 110 is based on physical adhesion by van der Waals force, the retention force of the stent 110 is reduced even when passing through a bent portion (for example, an aortic aneurysm) of a living body lumen. And the retention effect can be maintained for a long time.
  • a bent portion for example, an aortic aneurysm
  • the protrusion 132 is not limited to a truncated cone shape, and may be, for example, a cylindrical shape, a columnar shape with a polygonal cross section, or a larger top cross section than the base portion.
  • FIG. 7 is a cross-sectional view for explaining the formation of protrusions by blow molding
  • FIG. 8 is a cross-sectional view for explaining another example of the formation of protrusions by blow molding
  • FIG. 9 is the formation of protrusions by dispensing. It is a side view for demonstrating.
  • the formation method of the protrusion 132 is not particularly limited, and molding or coating can be applied.
  • molding or coating can be applied.
  • a concave portion 172 corresponding to the protrusion 132 is disposed in the cavity of the molding die 170 as shown in FIG. 120 and protrusions 132 can be formed simultaneously.
  • a fine through hole 174 that communicates the recess 172 and the negative pressure source may be provided in the mold 170 to promote the flow of the balloon material (balloon 120) to the recess 172. Is possible.
  • Coating is dispensing or inkjet.
  • a solution 184 containing a solvent and a non-volatile composition constituting the protrusion 132 is added to the dispenser 182 according to the shape and arrangement pattern of the protrusion 132 as shown in FIG.
  • the protrusion 132 made of a nonvolatile composition can be formed.
  • the balloon 120 is attached to the holder 186 through the mandrel 187 and the chuck portion 188 in the expanded state, it is rotated by the motor M 1.
  • Retainer 186 is movably configured by the moving means 189 for the motor M 2 and the driving source in two axial directions (two directions perpendicular to the axial direction of the dispenser 182).
  • the inner diameter of the tip of the nozzle portion 183 is appropriately set according to the shape and size of the protrusion 132.
  • a femtosecond laser can be applied as a method of forming the protrusion 132.
  • a femtosecond laser is a laser whose pulse duration is reduced to the order of femtoseconds (1/1000 trillion seconds), and energy (laser) is irradiated in an extremely short time (femtoseconds).
  • the material to be processed can be processed before heat conduction to other than the irradiation point occurs, and fine processing becomes possible. Therefore, it is possible to form a fine structure surface having the protrusion 132 by irradiating the balloon 120 with a femtosecond laser in accordance with the shape and arrangement pattern of the protrusion 132 in a scanning manner.
  • a grating-like structure having a periodic interval similar to the laser wavelength is self-organized due to interference between incident light and scattered light or plasma waves along the surface of the workpiece. It exhibits the characteristics formed. Therefore, by utilizing this characteristic and scanning while linearly polarized femtosecond lasers are overlapped, a microstructured surface having protrusions 132 can be formed in a self-organized manner over the entire area irradiated with the laser. Is possible.
  • the molding, coating, and femtosecond laser, nanoimprint, laser, soft lithography, machining (for example, fine diamond bite) and the like can be applied as a method for forming the protrusion 132. It is appropriately selected depending on conditions such as dimensions and materials.
  • FIG. 10 is a cross-sectional view for explaining the tip insertion step
  • FIG. 11 is a cross-sectional view for explaining the balloon expansion step following FIG. 10
  • FIG. 12 is for explaining the balloon deflation step following FIG.
  • FIG. 13 is a cross-sectional view for explaining the stent placement step subsequent to FIG.
  • the method of using the stent delivery system 100 generally includes a tip insertion step, a balloon expansion step, a balloon deflation step, and a stent placement step.
  • the distal end portion of the shaft tube 160 (inner tube 162) is inserted into the patient's lumen 190, and the guide wire 150 is advanced, while the stenosis as the target site is reached. Move toward part 192.
  • the protrusion 132 of the bonding portion 130 of the balloon 120 expresses a physical bonding force by van der Waals force acting between the linear member 112 (stent 110) in contact with the linear member 112 and contacts the linear member 112. Even if it passes through a bent portion (for example, an aortic aneurysm), the retention force of the stent 110 does not decrease, and the retention effect can be maintained for a long time.
  • the guide wire 150 is inserted into the inner tube 162 via the guide wire port 144 and protrudes from the end surface of the inner tube 162.
  • the stent 110 when the stent 110 is positioned at the stenosis 192 as the target site, pressurized fluid is introduced from the port 141 and passes through the lumen 163 (see FIG. 2).
  • the balloon 120 is introduced into the balloon 120, and the balloon 120 is expanded (inflated).
  • the stent 110 located on the outer periphery of the balloon 120 is also expanded and is in close contact with the surface of the narrowed portion 192.
  • the positioning of the stent 110 is performed accurately, quickly and easily by visually recognizing the position of the marker 168 (FIG. 2) aligned with both ends of the stent 110 by X-ray irradiation.
  • the pressurized fluid is discharged from the port 141 via the lumen 163, and the balloon 120 is deflated.
  • the stent 110 is plastically deformed, and the physical adhesion due to the protrusion between the balloon 120 and the stent 110 is easily detached from the stent 110 when the balloon 120 is deflated. 110 is not accompanied by the deflation of the balloon 120. As a result, the stent 110 is separated from the balloon 120.
  • the distal end portion of the shaft tube 160 from which the stent 110 is separated is retracted and removed from the lumen 190.
  • the bonding part 130 of the balloon 120 is not limited to a form in which the bonding part 130 is disposed over the entire straight part of the balloon 120, and may be partially disposed as necessary.
  • the adhesive portion 130 is 5% or more of the length of the straight portion 122, preferably 10% or more, and more preferably 25% or more.
  • the adhesive portion 130 may be configured by a plurality of regions as necessary, and may be spaced apart (discontinuously).
  • the adhesive part 130 is divided into two parts and arranged near both ends of the straight part 122, or as shown in FIG. 16, the adhesive part 130 is configured by a plurality of ring-shaped regions, It is also possible to arrange them at predetermined intervals along the axial direction A, or as shown in FIG. 17, the bonding portion 130 can be constituted by a plurality of circular regions and arranged on the outer periphery of the straight portion 122 at equal intervals. is there. In this case, the entire area of the bonding part 130 is 5% or more, preferably 10% or more, more preferably 25% or more of the area of the straight part 122.
  • 18 to 20 are cross-sectional views for explaining modifications 5 to 7 according to the embodiment of the present invention.
  • the apex 136 that contacts the stent 110 in the protrusion 132 of the bonding portion 130 is not limited to a flat shape, and may have directionality. For example, as shown in FIG. 18, when the top 136 is inclined in the winding direction with respect to the circumferential direction, the contact area between the top 136 and the stent 110 is reduced when the balloon 120 is expanded in the balloon expansion step. When the balloon 120 is deflated in the balloon deflation step, the apex 136 is reduced in diameter while sliding on the inner surface of the stent in the winding direction, so that the balloon 120 is easily peeled off from the stent 110.
  • the inclination angle is not particularly limited, and is appropriately set according to conditions such as the shape, size, material, and the like of the protrusion 132.
  • FIG. 21 is a cross-sectional view for explaining a modification 8 according to the embodiment of the present invention.
  • the protrusion 132 is not limited to the form formed from the same material as the balloon 120, and may be formed from a different material.
  • a paint containing a material (non-volatile composition) different from the material constituting the balloon 120 and a solvent is applied to the balloon 120 according to the shape and arrangement pattern of the protrusions 132, and thereafter
  • the protrusion 132 made of a different material (nonvolatile composition) can be formed by volatilizing a solvent from the coating film.
  • FIG. 22 is a cross-sectional view for explaining a modification 9 according to the embodiment of the present invention.
  • the stent 110 can be engaged with a balloon 120 sandwiched between the stents 110 as necessary.
  • the balloon 120 has an adhesive portion 130, and it is easy to ensure the stent holding force (fixing strength), and the force when the stent 110 is sandwiched (crimped) and engaged is small. Therefore, the generation of pinholes due to the pinching force is suppressed.
  • FIG. 23 is a plan view for explaining the modified example 10 according to the embodiment of the present invention.
  • the stent delivery system 100 is not limited to the rapid exchange type, and can be applied to an over-the-wire (OTW) type as shown in FIG. 23, for example.
  • OGW over-the-wire
  • Reference numeral 142 denotes an injection port used for introducing and discharging a pressurized fluid that expands the balloon 120, for example.
  • Reference numeral 144 inserts a guide wire, passes through the shaft tube 160, and the distal end portion.
  • Figure 3 shows a guidewire port used to protrude from a.
  • the balloon and the indwelling object are bonded by physical bonding based on van der Waals force. It is possible to maintain the holding effect for a long time without reducing the holding power of the indwelling material. That is, it is possible to provide a stent delivery system in which the retention force of the stent does not decrease even when it passes through the bent portion of the living body lumen, and the retention effect can be maintained for a long time.
  • the in-vivo indwelling material is not limited to a stent, and for example, a pessary can be applied.
  • 100 stent delivery system 110 stent, 112 linear member, 120 balloon, 122 Straight part, 124A, 124B reduced diameter part, 130 bonding part, 132 protrusions, 134 base, 136 top, 140 hubs, 141 ports, 142 injection port, 144 Guide wire port, 150 guide wire, 160 shaft tube, 161 lumens, 162 inner pipe, 163 lumens, 164 outer tube, 168 markers, 170 mold, 172 recess, 174 through hole, 182 dispenser, 183 nozzle part, 184 solution, 186 holder, 187 Mandrel, 188 chuck part, 189 moving means, 190 lumen, 192 Stenosis, A axis direction, C circumferential direction, D 1 , D 2 diameter, H height, M 1 and M 2 motors.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/JP2013/052248 2012-01-31 2013-01-31 Système de pose d'articles de rétention in vivo Ceased WO2013115329A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012-018852 2012-01-31
JP2012018852A JP2015077156A (ja) 2012-01-31 2012-01-31 生体内留置物デリバリーシステム

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WO2013115329A1 true WO2013115329A1 (fr) 2013-08-08

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527285A (ja) * 2001-02-16 2004-09-09 コーディス・コーポレイション リッジを備えたバルーンカテーテルステントデリバリシステム
JP2004534555A (ja) * 2000-11-28 2004-11-18 サイメッド ライフ システムズ，インコーポレーテッド 生体活性物質を管腔に送達するための医療装置
JP2008532726A (ja) * 2005-03-21 2008-08-21 ボストン サイエンティフィック リミテッド 医療器具において使用するためのコーティング
US20100312324A1 (en) * 2009-06-04 2010-12-09 Nina Adden Implantation device for stents with a functionally structured surface

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004534555A (ja) * 2000-11-28 2004-11-18 サイメッド ライフ システムズ，インコーポレーテッド 生体活性物質を管腔に送達するための医療装置
JP2004527285A (ja) * 2001-02-16 2004-09-09 コーディス・コーポレイション リッジを備えたバルーンカテーテルステントデリバリシステム
JP2008532726A (ja) * 2005-03-21 2008-08-21 ボストン サイエンティフィック リミテッド 医療器具において使用するためのコーティング
US20100312324A1 (en) * 2009-06-04 2010-12-09 Nina Adden Implantation device for stents with a functionally structured surface

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