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WO2013106766A3 - THERAPEUTIC INDICATIONS OF miR-1291 - Google Patents

THERAPEUTIC INDICATIONS OF miR-1291 Download PDF

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Publication number
WO2013106766A3
WO2013106766A3 PCT/US2013/021307 US2013021307W WO2013106766A3 WO 2013106766 A3 WO2013106766 A3 WO 2013106766A3 US 2013021307 W US2013021307 W US 2013021307W WO 2013106766 A3 WO2013106766 A3 WO 2013106766A3
Authority
WO
WIPO (PCT)
Prior art keywords
mir
methods
therapeutic indications
conditions
human diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/021307
Other languages
French (fr)
Other versions
WO2013106766A2 (en
Inventor
Aiming Yu
Yuzhuo PAN
Jingxin Qiu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Research Foundation of the State University of New York
Original Assignee
Health Research Inc
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc, Research Foundation of the State University of New York filed Critical Health Research Inc
Publication of WO2013106766A2 publication Critical patent/WO2013106766A2/en
Publication of WO2013106766A3 publication Critical patent/WO2013106766A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided herein are compositions and methods for preventing and treating human diseases and/or conditions. The present invention relates to, inter alia, the reconstitution of miR-1291 levels in samples and subjects. Also provided herein are methods for the diagnosis and treatment of human diseases and conditions by assessing miR-1291 expression levels. Methods of treating human cancers by modifying or regulating miRNA pathways are also provided.
PCT/US2013/021307 2012-01-13 2013-01-11 THERAPEUTIC INDICATIONS OF miR-1291 Ceased WO2013106766A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261586446P 2012-01-13 2012-01-13
US61/586,446 2012-01-13

Publications (2)

Publication Number Publication Date
WO2013106766A2 WO2013106766A2 (en) 2013-07-18
WO2013106766A3 true WO2013106766A3 (en) 2013-09-12

Family

ID=48782096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/021307 Ceased WO2013106766A2 (en) 2012-01-13 2013-01-11 THERAPEUTIC INDICATIONS OF miR-1291

Country Status (1)

Country Link
WO (1) WO2013106766A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7026440B2 (en) 2014-05-28 2022-02-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Hybrid tRNA / premiRNA molecules and usage
US10422003B2 (en) 2015-03-23 2019-09-24 The Regents Of The University Of California Methods for detection of RNase activity
CN105106959B (en) * 2015-08-16 2018-07-17 深圳市倍昂生物科技有限公司 Application and a kind of pharmaceutical composition of the cordycepin in the drug of preparation and radiotherapy and/or chemotherapy synergistic treatment tumour
JP6842779B2 (en) * 2016-10-31 2021-03-17 国立大学法人岐阜大学 Double-stranded nucleic acid molecules and their uses
CN118512469A (en) * 2019-02-26 2024-08-20 首尔大学校产学协力团 Pharmaceutical composition for preventing or treating cancer comprising terminal uridyl transferase 4/7 expression regulatory factor
CN114891742B (en) * 2022-06-23 2024-06-04 杭州中赢生物医疗科技有限公司 Culture medium of NK cells with strong killing property and in-vitro amplification method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165659A1 (en) * 2002-11-13 2006-07-27 Carlo Croce Compositions and methods for cancer diagnosis and therapy
US20060189557A1 (en) * 2004-09-02 2006-08-24 Yale University Regulation of oncogenes by microRNAs
WO2009149182A1 (en) * 2008-06-04 2009-12-10 The Board Of Regents Of The University Of Texas System Modulation of gene expression through endogenous small rna targeting of gene promoters
KR20100009268A (en) * 2008-07-18 2010-01-27 국립암센터 Anti-cancer composition comprising microrna molecules
WO2010139810A1 (en) * 2009-06-05 2010-12-09 Febit Holding Gmbh Mirna fingerprint in the diagnosis of lung cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165659A1 (en) * 2002-11-13 2006-07-27 Carlo Croce Compositions and methods for cancer diagnosis and therapy
US20060189557A1 (en) * 2004-09-02 2006-08-24 Yale University Regulation of oncogenes by microRNAs
WO2009149182A1 (en) * 2008-06-04 2009-12-10 The Board Of Regents Of The University Of Texas System Modulation of gene expression through endogenous small rna targeting of gene promoters
KR20100009268A (en) * 2008-07-18 2010-01-27 국립암센터 Anti-cancer composition comprising microrna molecules
WO2010139810A1 (en) * 2009-06-05 2010-12-09 Febit Holding Gmbh Mirna fingerprint in the diagnosis of lung cancer

Also Published As

Publication number Publication date
WO2013106766A2 (en) 2013-07-18

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