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WO2013188016A3 - Thérapie utilisant des surfactants pour exposition à un rayonnement ionisant - Google Patents

Thérapie utilisant des surfactants pour exposition à un rayonnement ionisant Download PDF

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Publication number
WO2013188016A3
WO2013188016A3 PCT/US2013/039592 US2013039592W WO2013188016A3 WO 2013188016 A3 WO2013188016 A3 WO 2013188016A3 US 2013039592 W US2013039592 W US 2013039592W WO 2013188016 A3 WO2013188016 A3 WO 2013188016A3
Authority
WO
WIPO (PCT)
Prior art keywords
ionizing radiation
exposure
surfactant
pulmonary
surfactant therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/039592
Other languages
English (en)
Other versions
WO2013188016A2 (fr
Inventor
Robert Segal
Melpo Christofidou-Solomidou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Windtree Therapeutics Inc
Original Assignee
Discovery Laboratories Inc
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Discovery Laboratories Inc, University of Pennsylvania Penn filed Critical Discovery Laboratories Inc
Publication of WO2013188016A2 publication Critical patent/WO2013188016A2/fr
Publication of WO2013188016A3 publication Critical patent/WO2013188016A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des thérapies pour le traitement ou la prévention d'états résultant d'une exposition directe ou indirecte du tissu pulmonaire à un rayonnement ionisant. En particulier, des régimes de traitement ou de prévention d'états résultant d'une exposition directe ou indirecte du tissu pulmonaire à un rayonnement ionisant impliquent l'administration de surfactants pulmonaires. Dans certains modes de réalisation, le surfactant pulmonaire est un surfactant KL4.
PCT/US2013/039592 2012-05-04 2013-05-04 Thérapie utilisant des surfactants pour exposition à un rayonnement ionisant Ceased WO2013188016A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261642856P 2012-05-04 2012-05-04
US61/642,856 2012-05-04
US201361794036P 2013-03-15 2013-03-15
US61/794,036 2013-03-15

Publications (2)

Publication Number Publication Date
WO2013188016A2 WO2013188016A2 (fr) 2013-12-19
WO2013188016A3 true WO2013188016A3 (fr) 2014-04-10

Family

ID=48875145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/039592 Ceased WO2013188016A2 (fr) 2012-05-04 2013-05-04 Thérapie utilisant des surfactants pour exposition à un rayonnement ionisant

Country Status (1)

Country Link
WO (1) WO2013188016A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190067150A (ko) * 2016-06-07 2019-06-14 더 트러스티즈 오브 더 유니버시티 오브 펜실베니아 이식과 관련된 허혈/재관류 손상으로부터 장기를 보호하기 위한 조성물 및 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078506A1 (en) * 2004-05-20 2006-04-13 Ralph Niven Methods, systems and devices for noninvasive pulmonary delivery
WO2006055532A2 (fr) * 2004-11-15 2006-05-26 Discovery Laboratories, Inc. Procedes de production de formulations de tensioactifs pulmonaires par lyophilisation et formulations et utilisations correspondantes
WO2007005672A2 (fr) * 2005-06-30 2007-01-11 The Scripps Research Institute Traitement et prevention de maladies et de situations respiratoires
US20100317565A1 (en) * 2007-06-04 2010-12-16 Rentschler Beteiligungs Gmbh Novel Peptides and Their Use for the Treatment of Edema
EP1558273B1 (fr) * 2002-04-25 2011-08-17 The Scripps Research Institute Traitement et prevention d'affections pulmonaires
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US502495A (en) 1893-08-01 klijsel
US574325A (en) 1896-12-29 Joseph s
US5840527A (en) 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
US4659805A (en) 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4918161A (en) 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
EP0383837B1 (fr) 1987-11-04 1998-02-04 Byk Gulden Lomberg Chemische Fabrik GmbH Proteines a effet tensio-actif alveolaire
US6013619A (en) 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
SE8803713D0 (sv) 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5238920A (en) 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
DE69125750D1 (de) 1990-05-21 1997-05-28 Abbott Lab Fettsäure-Oberflächenaktives-Lungenprotein Konjate
US5272252A (en) 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE69332654T2 (de) 1992-04-10 2003-09-25 Abbott Laboratories, Abbott Park Fragmente eines oberflächenaktiven lungenproteins
US5302481A (en) 1993-06-07 1994-04-12 Xerox Corporation Toner compositions with negative charge enhancing complexes
ES2189825T3 (es) 1993-12-08 2003-07-16 Mitsubishi Pharma Corp Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio.
DE4418936A1 (de) 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
DE4434629C1 (de) 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
WO1997035882A1 (fr) 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Compositions lyophilisees de peptides tensioactifs pulmonaires
WO1997035559A2 (fr) 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Preparation de liposomes et de complexes lipoproteiques par injection d'ethanol et evaporation en couche mince
US6013764A (en) 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
US6573253B2 (en) 1997-02-12 2003-06-03 Medimmune Oncology Inc. Methods for the administration of amifostine and related compounds
US6660833B1 (en) 2000-02-29 2003-12-09 Harbor-Ucla Research And Education Institute Respiratory distress syndrome therapy with peptide analogs of human SP-B
US7040314B2 (en) 2002-09-06 2006-05-09 Philip Morris Usa Inc. Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols
WO2009102818A1 (fr) 2008-02-11 2009-08-20 Cleveland Biolabs, Inc. Procédé de réduction des effets de la chimiothérapie à l’aide de polypeptides associés à la flagelline
HRP20160258T1 (hr) 2008-03-17 2016-04-22 Discovery Laboratories, Inc. Adapter za cijevni sustav ventilacije i proksimalni sustav za dovođenje aerosola
JP2012503014A (ja) 2008-09-19 2012-02-02 マキシジェン， インコーポレイテッド マルチ−ｐｅｇ化顆粒球コロニー刺激因子（ｇ−ｃｓｆ）変異体の投与による放射線誘発好中球減少症の処置のための方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1558273B1 (fr) * 2002-04-25 2011-08-17 The Scripps Research Institute Traitement et prevention d'affections pulmonaires
US20060078506A1 (en) * 2004-05-20 2006-04-13 Ralph Niven Methods, systems and devices for noninvasive pulmonary delivery
WO2006055532A2 (fr) * 2004-11-15 2006-05-26 Discovery Laboratories, Inc. Procedes de production de formulations de tensioactifs pulmonaires par lyophilisation et formulations et utilisations correspondantes
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
EP1833503B1 (fr) * 2004-12-23 2013-07-31 Discovery Laboratories, Inc. Formulations de tensioactif pulmonaire
WO2007005672A2 (fr) * 2005-06-30 2007-01-11 The Scripps Research Institute Traitement et prevention de maladies et de situations respiratoires
US20100317565A1 (en) * 2007-06-04 2010-12-16 Rentschler Beteiligungs Gmbh Novel Peptides and Their Use for the Treatment of Edema

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Discovery Laboratories 10-K 2013", 15 March 2013 (2013-03-15), pages 1 - 133, XP055101943, Retrieved from the Internet <URL:http://www.wikinvest.com/stock/Discovery_Laboratories_(DSCO)/Filing/10-K/2013/F107474757> [retrieved on 20140213] *
ANONYMOUS: "Discovery Labs Initiates Research Projects with Leading Research Institutions and US Government Agencies to Assess KL4 Surfactant Utility in Acute Lung Injury", 27 September 2012 (2012-09-27), pages 1 - 3, XP055093034, Retrieved from the Internet <URL:http://www.discoverylabs.com/2012pr/092712-PR.pdf> [retrieved on 20131212] *
ANONYMOUS: "form10q.htm", 14 November 2012 (2012-11-14), pages 1 - 48, XP055093046, Retrieved from the Internet <URL:http://www.sec.gov/Archives/edgar/data/946486/000114036112047325/form10q.htm> [retrieved on 20131212] *
ANONYMOUS: "KL4 Surfactant to Mitigate Radiation-Induced Lung Injury | SBIR.gov", 2012, pages 1 - 2, XP055093121, Retrieved from the Internet <URL:http://www.sbir.gov/sbirsearch/detail/399806> [retrieved on 20131212] *
ANONYMOUS: "Project Information - 1R43AI102308-01 - Details", 19 June 2012 (2012-06-19), pages 1, XP055093058, Retrieved from the Internet <URL:http://projectreporter.nih.gov/project_info_details.cfm?aid=8393586&icde=0> [retrieved on 20131212] *
ANONYMOUS: "Project Information - 1R43AI102308-01", 19 June 2012 (2012-06-19), pages 1 - 2, XP055093053, Retrieved from the Internet <URL:http://projectreporter.nih.gov/project_info_description.cfm?aid=8393586&icde=0> [retrieved on 20131212] *
KRISHNAN RAGHAVENDRAN ET AL: "Surfactant Therapy for Acute Lung Injury and Acute Respiratory Distress Syndrome", CRITICAL CARE CLINICS, vol. 27, no. 3, 1 July 2011 (2011-07-01), pages 525 - 559, XP055093032, ISSN: 0749-0704, DOI: 10.1016/j.ccc.2011.04.005 *

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