WO2013178065A1 - Amino acid copper complex with effects of preventing alopecia, growing hair and protecting skin, preparation method and application - Google Patents

Description

 Amino acid copper complex for preventing hair loss, hair growth and skin care, preparation method and application thereof

 The invention relates to the field of biomedicine, in particular to an amino acid copper complex, a preparation method thereof and application thereof in preventing hair loss and skin care.

Background technique

 Hair loss, as a common disease of modern people, has been paid more and more attention. According to a survey by the World Health Organization, there are hundreds of millions of patients with hair loss in the world, and hair loss has become a social problem that plagues the world. The moment of hair loss affects people, makes people's pressure more and more, and enters the vicious circle of stress->hair loss->more stress. Book

 Hair growth is inseparable from hair follicles, and the presence of hair follicles is a prerequisite for hair growth replacement. Hair growth is divided into three periods: growth period, regression period and rest period. The growth period of the hair follicles, hair bulbs and dermal papillae are also large, at this time the hair matrix cells are actively dividing, causing hair growth. From the growth phase to the degenerative phase, the hair follicles become shorter, the hair bulbs shrink, the dermal papillas gather into a small group, and at the lower end of the hair bulb, the hair germ cells stop dividing and keratinize, and the hair and hair follicles are not firmly connected. Hair is easy to fall off. At the beginning of the next growth cycle, new hair bulbs and dermal papillae are formed at the lower end of the hair follicle, and new hair is grown. The new hair grows into the original hair follicle, and the old hair is pushed out, and the new hair reaches out to the skin.

 Western medicine for the treatment of hair loss The United States FDA-certified drugs are only finasteride and minoxidil, but both drugs have serious side effects. In addition to these two drugs, methods for treating hair loss include hair transplants recognized by the Western medical community. Although medical treatment and hair transplantation have made great progress, they still have great limitations.

International cosmetics companies have begun to create a whirlwind of copper, because the latest evidence shows that copper is the latest secret weapon for anti-aging. When all the Egyptians used copper as a repairing wound, the idea that copper is good for the skin has been popular for a long time, but when the American biochemist Dr. Loren Pickart discovered the copper peptide in the 1970s, Begin to study it further in science. His early work showed that when copper is combined with protein, some special copper peptides have a good effect on wound healing, hair repair and skin diseases. By promoting the synthesis of collagen, elastin, and other essential skin components, an independent dermatologist in the United States found that copper peptides are effective in preventing damage to common skin free factors and stimulated collagen. In fact, in the lift skin They are more effective than the world's leading anti-aging product, Retin A, in terms of skin firmness. Another study showed that copper peptides also contribute to the recovery of skin integrity after exposure to SLS, a cleaner commonly found in many shampoo, cleaning, washing and laundry products. A large number of scientific studies have shown that: 5-alpha reductase (Dihydrotestosterone (DHT) is the main cause of male degeneration. DHT is produced by testosterone by 5-alpha reductase. After DHT binds to receptors on cells in hair follicles ( The number of receptors is related to heredity, which triggers a series of hair loss reactions that cause baldness. Copper inhibits the action of 5-alpha reductase, re-converts dihydrotestosterone to testosterone, and solves the problem of hair loss from the root. Copper ions also have Enlarging hair follicles, accelerating hair growth, inhibiting the discovery of hair growth, regulating the production of melanin in hair, regulating the energy metabolism of hair follicle cells, and eliminating free radicals on the skin. After a large number of safety tests, no toxicity problems were found, and It also does not cause an increase in copper in the blood during use.

 This series of studies on copper peptides fully demonstrates the advantages of copper peptides, but the price of copper peptide series is quite expensive, which has become a major obstacle in meeting market demand, and we have been surprised by a large number of experiments. A novel copper complex of amino acids against hair loss, hair growth and skin care has been discovered. The copper complex of the amino acid has the same effect as the copper polypeptide, and the copper complex of the amino acid can effectively prevent the normal skin free factor and collagen from being affected. Stimulating damage, restoring the integrity of the skin, acting on the surface of the scalp, then repairing and repairing from the hair follicles of the hair, allowing the hair follicles to gradually return to health, returning the hair to a normal growth cycle, thereby preventing hair loss, hair growth, and skin care. The effect, and the amino acid copper complex is much lower in cost than the copper polypeptide, and is convenient and safe in use without toxic side effects, which is not only a major discovery in anti-hair loss, hair growth, skin care research, but also in application. A big breakthrough, to solve the problem of people who have anti-hair loss, hair growth, skin care needs Annoyed, at the same time can create considerable economic benefits. Summary of the invention

 The first technical problem to be solved by the present invention is to provide an amino acid copper complex having anti-hair loss, hair growth and skin care effects.

 The second technical problem to be solved by the present invention is to provide a method for preparing an amino acid copper complex having anti-hair loss, hair growth and skin care effects.

 A third technical problem to be solved by the present invention is to provide an amino acid copper complex as an anti-hair loss and hair growth preparation.

A fourth technical problem to be solved by the present invention is to provide an application of an amino acid copper complex as a skin care product. In order to solve the above first technical problem, the technical solution of the present invention is:

 An amino acid copper complex for preventing hair loss, hair growth and skin care, which is composed of a divalent copper ion and an amino acid having a structure of a base acid and/or an amino acid structure:

Wherein R ₂ , R ₃ , R ₄ , R ₅ , R ₆ , R ₇ , R ₈ , R ₉ , R ₁₀ , R _u , R ₁₂ and R ₁₃ are different kinds of side chain functional groups or the same side chain functional group, n is an integer greater than or equal to zero.

 In the present invention, the divalent copper ion and the amino acid of the two structures may be complexed in any ratio, wherein the amino acid is a variety of amino acids conforming to the listed amino acid structure 1 and the amino acid structure 2, and the coordination network with the divalent copper ion in a different manner. A raw material capable of freeing out divalent copper ions or reacting with various amino acids conforming to the amino acid structure 1 and amino acid structure 2 of the listed structure to form a copper complex of the amino acid, which can be used as a source of divalent copper ions. .

 1〜10。 The preferred molar ratio of the divalent copper ion to the amino acid in the amino acid copper complex is 1: 0. 1~10.

For convenience of explanation of the amino acid copper complex prepared by the present invention, the following several complex structures of different structures are listed for illustration. In the present invention, the amino acid and the divalent copper ion can be complexed in different ways, and are not limited to the three complex structures listed below, and include other modes of short chain, long chain and other spatial orbital multiple angle coordination. Coordination complexation.

Wherein, R ₂ , R ₃ , R ₄ , R ₅ , R ₆ , R ₇ , R ₈ , R ₉ , R ₁₀ , R _u , R ₁₂ , R ₁₃ represent different kinds of side chain functional groups or the same side chain functional group , n is an integer greater than or equal to 0.

 In order to solve the above second technical problem, the technical solution of the present invention is:

其中， R₂、 R₃、 R₄、 R₅、 R₆、 R₇、 R₈、 R₉、 R₁₀、 R_u、 R₁₂、

A method for preparing an amino acid copper complex having anti-hair loss, hair growth and skin care effects, comprising the steps of: mixing a solution of divalent copper ions with at least one of amino acids satisfying the following structure, and concentrating the reaction solution after complexation reaction Crystallizing or precipitating the complex in the form of crystals using an organic solvent, that is, obtaining the amino acid copper complex for preventing hair loss, hair growth, and skin care;

Wherein R ₂ , R ₃ , R ₄ , R ₅ , R ₆ , R ₇ , R ₈ , R ₉ , R ₁₀ , R _u , R ₁₂ ,

An energy group or the same side chain functional group, n is an integer greater than or equal to zero.

 Preferably, the organic solvent is methanol, ethanol or isopropanol.

 1〜10。 The preferred molar ratio of the divalent copper ion to the amino acid in the amino acid copper complex is 1: 0. 1~10.

 In order to solve the above third technical problem, the technical solution of the present invention is:

 The amino acid copper complex for preventing hair loss, hair growth and skin care is used as an anti-hair loss and hair growth preparation. Preferably, the amino acid copper complex is prepared into a water, ointment, liniment, gel, cream, lotion or spray dosage form, and is adjusted to a suitable pH value for the human body.

 In order to solve the above fourth technical problem, the technical solution of the present invention is:

 Amino acid copper complex for preventing hair loss, hair growth and skin care as a skin care product.

 Preferably, the amino acid copper complex is prepared into a water, ointment, liniment, gel, cream, lotion or spray dosage form, and is adjusted to a suitable pH value for the human body.

 Due to the adoption of the above technical solutions, the beneficial effects of the present invention are:

 The amino acid copper complex prepared by complexing divalent copper ions with an amino acid has the same effect as the copper polypeptide, and not only has a repairing effect on the skin, but also has anti-hair loss and hair growth effects. The amino acid copper complex can be formulated into a liquid preparation, a paste, a liniment, a gel, a cream, an emulsion, a spray, etc., and can be adjusted to a suitable pH value of the human body, and the skin can be effectively prevented from the normal skin free factor. And the stimulation damage caused by collagen, the restoration of the integrity of the skin, the action on the surface of the scalp hair follicle, so that the repair factor directly acts on the scalp hair follicle, effectively penetrate the root of the hair, then activate the hair follicle tissue, promote blood circulation, Promote the full absorption of nutrients by the hair follicles, thus repairing the integrity of the scalp, and finally achieving anti-hair loss, hair growth and skin care effects.

The invention does not cause the rise of copper element in the blood during use, is safe and has no toxic side effects, and is a A more efficient and safer product enriched with a new generation of active copper repair factors that can be used as an alternative to expensive copper peptides. The preparation method has the advantages of simple preparation method and low cost, and is a great discovery in anti-hair loss, hair growth and skin care research, and is also a breakthrough in application, can meet the demand for anti-hair loss products, and solve the troubles caused by hair loss to modern people. At the same time, the application and promotion of the invention can create considerable economic benefits.

detailed description

 The invention is further illustrated below in conjunction with specific embodiments. It is to be understood that the examples are not intended to limit the scope of the invention. It is to be understood that the invention may be modified or modified by those skilled in the art in the light of the scope of the present invention.

 Example 1

 Copper sulfate pentahydrate is used as a source of divalent copper ions, and an amino acid material which is a complex of L-histidine which conforms to the amino acid structure-1 is used. Preparation of amino acid copper complex: Take 9. 00g of water in a beaker, and then weigh 0. 35g of copper sulfate pentahydrate, 0. 65g of L-histidine, added under stirring, fully stirred and completely dissolved That is, a solution of 10.00 g of a structure containing an amino acid copper complex was prepared.

 Example 2

 Copper chloride dihydrate is used as a source of divalent copper ions, and an amino acid raw material which is a complex of L-arginine which conforms to the amino acid structure II is used. Preparation of the amino acid copper complex: Take 9.20g of water in a beaker, and then weigh 0. 15g of copper chloride dihydrate, 0. 65g of L-arginine, add under stirring, fully stirred and fully dissolved After that, a solution of 10.00 g of a structure containing an amino acid copper complex was prepared.

 Example 3

 The copper sulfate pentahydrate is used as a source of divalent copper ions, and the amino acid materials of the complex amino acid structure L-histidine and L-arginine are used as the complex. The agglomerate of the amino acid copper complex: Take 9. 00g of water in a beaker, and then weigh 0. 35g of copper sulfate pentahydrate, 0. 28g L-histidine, 0. 37g L-arginine, under stirring 00克溶液。 The solution containing the structure of the amino acid copper complex was prepared.

 Example 4

Copper hydroxide is used as a source of divalent copper ions, and an amino acid raw material which is a complex of L-histidine which conforms to amino acid structure 1 and L-arginine of structure II is used. Preparation of amino acid copper complex: 0.18g Copper hydroxide was added to a beaker, and 1.00 mol/L of dilute hydrochloric acid was added dropwise to completely dissolve it. After dissolution, water was added to the total mass of the reaction liquid of 9.35 g, and then 0.28 g of histidine and 0.37 g of arginine were weighed separately. After adding, it is fully stirred and uniformly dissolved to prepare a solution of 100.00 g of a structure containing an amino acid copper complex.

 Example 5

 Copper chloride dihydrate is used as a source of divalent copper ions, and an amino acid raw material which is a complex of L-arginine which conforms to the amino acid structure II is used. Preparation of amino acid copper complex: a copper chloride solution and an L-arginine solution according to a molar ratio of copper chloride dihydrate to L-arginine of 1:1, stirred and mixed uniformly, and then complexed, and then Ethanol was added dropwise to the obtained reaction solution, and the complex was precipitated in the form of crystals with ethanol to obtain the amino acid copper complex which was resistant to hair loss, hair growth and skin care.

 Example 6

 Copper sulfate pentahydrate is used as a source of divalent copper ions, and an amino acid material which is a complex of L-arginine which conforms to the amino acid structure II is used. Preparation of amino acid copper complex: The copper sulfate solution and the L-arginine solution are stirred and mixed according to the molar ratio of copper sulfate to L-arginine of 1:8, and then the complex reaction is carried out, and then the reaction is obtained. Methanol was added dropwise to the solution, and the complex was precipitated in the form of crystals with methanol to obtain the amino acid copper complex for preventing hair loss, hair growth and skin care.

 Example 7

 The copper nitrate trihydrate is used as the source of the divalent copper ion, and the amino acid raw materials of the complex amino acid structure L-histidine and L-arginine are used as the complex. Preparation of amino acid copper complex: The solution of copper nitrate and L-histidine, L-arginine according to copper nitrate trihydrate and L-histidine, L-arginine is 1: 0.05 mole The mixture is stirred and mixed uniformly, and the complexation reaction is carried out. Then, isopropanol is added dropwise to the obtained reaction solution, and the complex is precipitated in the form of crystals with isopropanol to obtain the amino acid for preventing hair loss, hair growth and skin care. Copper complex.

 Example 8

 Copper acetate monohydrate is used as a source of divalent copper ions, and L-histidine and L-arginine which are in accordance with amino acid structure 1 and structure 2 are used as amino acid raw materials of the complex. Preparation of amino acid copper complex: a solution of copper acetate monohydrate and L-histidine, L-arginine solution according to copper acetate monohydrate and L-histidine, L-arginine is 1: 3 mole The mixture is stirred and mixed uniformly to carry out a complexation reaction, and then the reaction solution is concentrated and crystallized to obtain the amino acid copper complex which is anti-hair loss, hair growth and skin care.

Example 9 The amino acid copper complex solution prepared in Example 1 was diluted and prepared into a water agent, and adjusted to a suitable pH value of the human body for use as an anti-hair loss and hair growth product.

 Example 10

 The crystals of the amino acid copper complex prepared in Example 5 were respectively added to the anti-hair loss product to allow the use of an auxiliary agent and a carrier to prepare a gelling agent, which was adjusted to a suitable pH value of the human body for use as an anti-hair loss and hair growth product.

 Example 11

 The amino acid copper complex solution prepared in Example 3 is added to a skin care product to allow the use of an auxiliary agent and a carrier to prepare a cream, which is used as a skin care product under a suitable pH value of the human body.

 Example 12

 The crystal of the amino acid copper complex prepared in Example 6 was added to the skin care product to allow the use of an auxiliary agent and a carrier to prepare a spray dosage form, which was adjusted to a suitable pH value of the human body as a skin care product.

 The basic principles, main features and advantages of the present invention are shown and described above. It should be understood by those skilled in the art that the present invention is not limited by the foregoing embodiments, and that the present invention is only described in the foregoing embodiments and the description of the present invention, without departing from the spirit and scope of the invention. Various changes and modifications are intended to fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and their equivalents.

 All changes from the concept of the invention, and structural changes made without creative labor, fall within the scope of the invention.

Claims

Claim An amino acid copper complex for preventing hair loss, hair growth and skin care, characterized in that a divalent copper ion is complexed with an amino acid having the following amino acid structure and/or amino acid structure II:

 Amino acid structure II  Amino acid structure Wherein, R ₂ , R ₃ , R ₄ , R ₅ , R ₆ , R ₇ , R ₈ , R ₉ , R _u , R ₁₂ , R ₁₃ are different kinds of side chain functional groups or the same side chain functional group, n is An integer greater than or equal to 0.  2. The amino acid copper complex for preventing hair loss, hair growth and skin care according to claim 1, wherein: a preferred complex molar ratio of divalent copper ions to said amino acid in said amino acid copper complex For 1: 0. 1~10.  3. A method of preparing an amino acid copper complex for preventing hair loss, hair growth, and skin care according to claim 1, wherein: a solution of divalent copper ions is uniformly mixed with at least one of amino acids having the following structure: After the complexation reaction, the reaction solution is concentrated to crystallize or the complex is precipitated in the form of crystals using an organic solvent to obtain the amino acid copper complex having the functions of preventing hair loss, hair growth and skin care;

Wherein, R ₂ , R ₃ , R ₄ , R ₅ , R ₇ , R ₉ , R _{1 ()} , R _u , R ₁₂ , R ₁₃ are different kinds of side chain functional groups or the same side chain functional group, n Is an integer greater than or equal to 0.  The method for producing an amino acid copper complex for preventing hair loss, hair growth and skin care according to claim 3, wherein the organic solvent is methanol, ethanol or isopropanol. 5. Preparation of amino acid copper complex for preventing hair loss, hair growth and skin care according to claim 3. 1〜10。 The method, wherein the molar ratio of the divalent copper ion in the amino acid copper complex to the amino acid is preferably 1: 0. 1~10.  6. Amino acid copper complex for preventing hair loss, hair growth and skin care as an anti-hair loss and hair growth preparation.  The use of the amino acid copper complex for preventing hair loss, hair growth and skin care according to claim 6, wherein the amino acid copper complex is prepared as a liquid preparation, a paste, or the like. A liniment, gel, cream, lotion or spray formulation.  8. Amino acid copper complex for preventing hair loss, hair growth and skin care as a skin care product.  9. The use of an amino acid copper complex for preventing hair loss, hair growth and skin care according to claim 8, wherein the amino acid copper complex is prepared as a liquid preparation, a paste, a liniment, Gel, cream, lotion or spray form.