[go: up one dir, main page]

WO2013176538A3 - Milieu ténogène de différenciation de cellules souches mésenchymateuses dans une lignée ténogène - Google Patents

Milieu ténogène de différenciation de cellules souches mésenchymateuses dans une lignée ténogène Download PDF

Info

Publication number
WO2013176538A3
WO2013176538A3 PCT/MY2013/000108 MY2013000108W WO2013176538A3 WO 2013176538 A3 WO2013176538 A3 WO 2013176538A3 MY 2013000108 W MY2013000108 W MY 2013000108W WO 2013176538 A3 WO2013176538 A3 WO 2013176538A3
Authority
WO
WIPO (PCT)
Prior art keywords
tenogenic
mesenchymal stem
stem cells
lineage
mscs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MY2013/000108
Other languages
English (en)
Other versions
WO2013176538A2 (fr
Inventor
Tunku Kamarul Zaman Tunku Zainol Abidin MADYA
Sik Loo TAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiti Malaya
Original Assignee
Universiti Malaya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiti Malaya filed Critical Universiti Malaya
Publication of WO2013176538A2 publication Critical patent/WO2013176538A2/fr
Publication of WO2013176538A3 publication Critical patent/WO2013176538A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/066—Tenocytes; Tendons, Ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Les ténocytes sont des cellules hautement différenciées qui présentent un potentiel de réplication limité. Par conséquent, une propagation in vitro de ténocytes peut ne pas fournir encore suffisamment de cellules ensemencées pour une ingénierie tissulaire du tendon. Des cellules souches mésenchymateuses (MSC) de moelle osseuse sont aptes à s'autorenouveler et sont adaptées à se différencier en une lignée multiple comprenant des ténocytes. Il est par conséquent possible que des MSC puissent être utilisées en tant que cellules ensemencées dans l'ingénierie tissulaire du tendon. La présente invention concerne ainsi un procédé et un milieu de culture permettant de favoriser la différenciation de cellules souches mésenchymateuses (MSC) de moelle osseuse humaines dans une lignée ténogène.
PCT/MY2013/000108 2012-05-22 2013-06-13 Milieu ténogène de différenciation de cellules souches mésenchymateuses dans une lignée ténogène Ceased WO2013176538A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2012002249 2012-05-22
MYPI2012002249 2012-05-22

Publications (2)

Publication Number Publication Date
WO2013176538A2 WO2013176538A2 (fr) 2013-11-28
WO2013176538A3 true WO2013176538A3 (fr) 2014-03-06

Family

ID=49624465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2013/000108 Ceased WO2013176538A2 (fr) 2012-05-22 2013-06-13 Milieu ténogène de différenciation de cellules souches mésenchymateuses dans une lignée ténogène

Country Status (1)

Country Link
WO (1) WO2013176538A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110295140A (zh) * 2019-06-04 2019-10-01 河北贝特赛奥生物科技有限公司 一种无血清培养骨髓间充质干细胞的方法
EP3872168A1 (fr) 2020-02-28 2021-09-01 Cline Scientific AB Différenciation de chondrocytes
WO2024000073A1 (fr) * 2022-06-30 2024-01-04 Stemcell Technologies Canada Inc. Milieux, kits et procédés de différenciation de ténocytes ou de chondrocytes
CN120586169B (zh) * 2025-08-08 2025-11-18 四川大学华西医院 一种bme-sis生物膜及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013969A1 (fr) * 2010-07-26 2012-02-02 The University Of Manchester Différenciation ciblée de cellules souches

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013969A1 (fr) * 2010-07-26 2012-02-02 The University Of Manchester Différenciation ciblée de cellules souches

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MAZZOCCA, AUGUSTUS D. ET AL.: "Bone marrow-derived mesenchymal stem cells obtained during arthroscopic rotator cuff repair surgery show potential for tendon cell differentiation after treatment with insulin", ARTHROSCOPY: THE JOURNAL OF ARTHROSCOPIC & RELATED SURGERY, vol. 27, no. 11, 2011, pages 1459 - 1471 *
PARK, ANDREW ET AL.: "Adipose-derived mesenchymal stem cells treated with growth differentiation factor-5 express tendon-specific markers", TISSUE ENGINEERING, vol. 16, no. 9, 2010, pages 2941 - 2951 *
TAN, SIK-LOO ET AL.: "Effect of growth differentiation factor 5 on the proliferation and tenogenic differentiation potential of human mesenchymal stem cells in vitro", CELLS TISSUES ORGANS, vol. 196, no. 4, 30 May 2012 (2012-05-30), pages 325 - 338 *
WANG, XIAOLI ET AL.: "Characterization of mesenchymal stem cells isolated from mouse fetal bone marrow", STEM CELLS, vol. 24, 2006, pages 482 - 493 *
ZHANG, JIANYING ET AL.: "Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes", THE AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 38, no. 12, 2010, pages 2477 - 2486 *

Also Published As

Publication number Publication date
WO2013176538A2 (fr) 2013-11-28

Similar Documents

Publication Publication Date Title
Gaspar et al. Progress in cell-based therapies for tendon repair
MX2017004890A (es) Metodos y composiciones para la generación o el mantenimiento de células pluripotentes.
WO2011139628A8 (fr) Génération d'endoderme de l'intestin antérieur à partir de cellules pluripotentes
PH12014501175A1 (en) Medium composition for rejuvenating stem cells
IN2014MN01680A (fr)
WO2009134532A3 (fr) Homing dans des cellules souches mésenchymateuses
WO2011149762A3 (fr) Procédé de différenciation en nocicepteur de cellules souches embryonnaires humaines et ses utilisations
MX358451B (es) Métodos para purificar células derivadas de células madre pluripotenciales.
WO2013070881A8 (fr) Méthode pour combler les interstices dans le rapprochement de tissus
MY183058A (en) Production method for retinal tissue
MY151979A (en) Method for producing mesenchymal stem cells from human pluripotent stem cells, and mesenchymal stem cells produced by same
GB2485112A (en) Differentiation of human embryonic stem cells
EP2504425A4 (fr) Différenciation de cellules souches embryonnaires humaines et de cellules souches pluripotentes induites
EP4534650A3 (fr) Différenciation de cellules ips humaines en cellules alvéolaires humaines de type ii par endoderme définitif
WO2012092049A8 (fr) Modification des adipocytes bruns
WO2011160055A3 (fr) Néogenèse de follicules pileux
BR112014027783A2 (pt) diferenciação de células-tronco embrionárias humanas em endoderma pancreático
MX2015007361A (es) Produccion mediada por la proteina portadora de acilo de los derivados de acidos grasos.
WO2011043629A3 (fr) Procédé d'induction d'une activité élevée des cellules souches adipeuses humaines et milieu associé
BR112015009229A2 (pt) composição tendo como alvo a expressão de genes para plaquetas, célula tronco hematopoiética, uso da referida célula tronco e método in vitro ou ex vivo para gerar uma célula tronco modificada
AR099557A1 (es) Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejido
EP2596097A4 (fr) Cellules souches mésenchymateuses de moelle osseuse à activité télomérase élevée, procédés pour les produire et produits pharmaceutiques et procédés de traitement basés sur ces cellules
NZ703345A (en) Compositions and methods for reducing frequency and/or severity of headache
WO2012075462A3 (fr) Méthodes et compositions utilisables en vue du traitement de la dystrophie musculaire progressive
WO2014204806A3 (fr) Cellules adipeuses pour des applications de chondrocytes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13793201

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 13793201

Country of ref document: EP

Kind code of ref document: A2