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WO2013175467A1 - Composition fongicide synergétique - Google Patents

Composition fongicide synergétique Download PDF

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Publication number
WO2013175467A1
WO2013175467A1 PCT/IL2013/050431 IL2013050431W WO2013175467A1 WO 2013175467 A1 WO2013175467 A1 WO 2013175467A1 IL 2013050431 W IL2013050431 W IL 2013050431W WO 2013175467 A1 WO2013175467 A1 WO 2013175467A1
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WIPO (PCT)
Prior art keywords
fungicide
rot
mixture
phthalimide
imidazole
Prior art date
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PCT/IL2013/050431
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English (en)
Inventor
Efrat SEGAL
Pietro DI PRIMO
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Adama Makhteshim Ltd
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Makhteshim Chemical Works Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof

Definitions

  • the present invention relates to a fungicidal mixture, and more specifically to a fungicidal mixture for controlling plant diseases.
  • Phytopathogenic fungi may cause a substantial reduction in expected crop yields, quality and profit; further losses can result during storage of harvested crops.
  • agricultural fungicides are chemical compounds used to kill or inhibit fungi or fungal spores.
  • Agricultural fungicides can be used to protect seed grain during storage, shipment and germination and to protect mature crops, berries, seedlings, flowers and grasses in the field, in storage and during shipment. They can be applied to the soil to control fungi that are resident there, to the seed or foliage of the plant to be protected, or to harvested produce to prevent storage losses.
  • Combinations of agricultural fungicides are typically used in order to (i) widen the spectrum of antifungal activity to control several diseases occurring simultaneously in a crop, (ii) use the synergistic interaction between fungicides, by which the overall activity is increased and the concentration of the compounds can be reduced without reduction in activity and (iii) reduce the risk of pathogens developing resistance.
  • Synergism has been defined as an interaction between two or more compounds such that the effect when combined is greater than the predicted effect based on the response to each compound applied separately.
  • the invention relates to a novel synergistic fungicidal mixture comprising a phenyl amide fungicide; an imidazole fungicide; and a phthalimide fungicide.
  • a fungicidal composition comprising a phenyl amide fungicide; an imidazole fungicide; and a phthalimide fungicide in a synergistically effective amount, and an agriculturally acceptable carrier.
  • the phenyl amide fungicide is an acylalanine fungicide.
  • the invention further relates to a method of controlling diseases caused by phytopathogenic fungi on plants or propagation material thereof, which comprises contacting the plants, the locus thereof, or propagation material thereof with a synergistically effective amount of a mixture of a phenyl amide fungicide; an imidazole fungicide; and a phthalimide containing fungicide.
  • the invention also relates to a method of improving the health of a plant, which comprises providing to the plant a synergistically effective amount of a mixture of a phenyl amide fungicide; an imidazole fungicide; and a phthalimide containing fungicide.
  • kits comprising the fungicidal mixture of a phenyl amide fungicide; an imidazole fungicide; and a phthalimide fungicide, in a synergistically effective amount.
  • the invention relates to a fungicidal mixture comprising a phenyl amide fungicide; an imidazole fungicide; and a phthalimide fungicide, in a synergistically effective amount.
  • composition comprising a phenyl amide fungicide; an imidazole fungicide; and a phthalimide containing fungicide and an agriculturally acceptable carrier.
  • the phenyl amide fungicide is an acylalanine fungicide.
  • Suitable non limiting examples of phenyl amides fungicides include benalaxyl, kiralaxyl, furalaxyl, metalaxyl, oxadixyl, ofurace, optical isomers thereof, salts thereof and any combination thereof.
  • the phenyl amide fungicide is an acylalanine fungicide, particularly kiralaxyl.
  • Suitable non limiting examples of imidazole fungicides include climbazole, imazalil, oxpoconazole, prochloraz, triflumizole, salts thereof and any combination thereof.
  • the imidazole fungicide is prochloraz and salts thereof.
  • the imidazole fungicide is zinc prochloraz.
  • Suitable non limiting examples of phthalimide fungicides include captafol, captan, ditalimfos, folpet, thiochlorfenphim, salts thereof and any combination thereof.
  • the phthalimide fungicide is captan.
  • the fungicidal mixture comprises a combination of kiralaxyl; an imidazole fungicide and a phthalimide containing fungicide.
  • the fungicidal mixture can comprise a combination of a phenyl amide fungicide, prochloraz and a phthalimide containing fungicide.
  • the fungicidal mixture can alternatively comprise a combination of a phenyl amide fungicide, an imidazole fungicide and captan.
  • the fungicidal mixture can alternatively comprise a combination of kiralaxyl, prochloraz and a phthalimide containing fungicide.
  • the fungicidal mixture comprises a combination of kiralaxyl, an imidazole fungicide and captan. In yet another embodiment, the fungicidal mixture comprises a combination of a phenyl amide fungicide, prochloraz and captan. In yet another embodiment, the fungicidal mixture comprises a combination of kiralaxyl, prochloraz and captan. Kiralaxyl is described in ATTI Giornate Fitopatologiche, 2004, 2, 67-72, prochloraz is described in Proc. Br. Crop. Prot. Conf. - Pests Dis., 1977, 2, 593 and captan is described in Science, 1952, 115, 84.
  • mixtures and compositions of the present invention may be used for improving the health of a plant.
  • plant health comprises various sorts of improvements of plants that are not connected to the control of pests.
  • advantageous properties are improved crop characteristics including: emergence, crop yields, protein content, oil content, starch content, more developed root system (improved root growth), improved stress tolerance (e.g.
  • the mixtures and compositions of the present invention may be used for improving any combination comprising one or more of the foregoing improvements, optionally together with one or more improvements not named.
  • plant health relates to improved stress tolerance, for example against drought, heat, salt, UV, water and cold.
  • the mixtures and compositions may further comprise one or more insecticides, fungicides, miticides, herbicides, nutrients and/or fertilizers.
  • the ratio (by weight) of the phenyl amide fungicide to the phthalimide fungicide is from about 1 :150 to 150: 1. In another embodiment the ratio is from about 1:50 to 50: 1 and in another embodiment from about 1:30 to 10:1.
  • the ratio of the amount of the phenyl amide fungicide to the amount of the phthalimide fungicide is about 1 : 90.
  • the ratio of the amount of the phenyl amide fungicide to the amount of the phthalimide fungicide is about 1:45.
  • the ratio of the amount of the phenyl amide fungicide to the amount of the phthalimide fungicide is about 1 :20.
  • the ratio (by weight) of kiralaxyl to captan is from about 1: 150 to 150: 1. In another embodiment the ratio is from about 1 :50 to 50:1 and in another embodiment from about 1 :30 to 10: 1.
  • the ratio of the amount of kiralaxyl to the amount of captan is about 1 :90.
  • the ratio of the amount of kiralaxyl to the amount of captan is about 1 :45.
  • the ratio of the amount of kiralaxyl to the amount of captan is about 1 :20.
  • the ratio (by weight) of the phenyl amide fungicide to the imidazole containing fungicide is from about 1 : 100 to 100: 1. In another embodiment, the ratio is from about 1:30 to 10: 1 and in another embodiment, the ratio is from about 1 :5 to 5:1.
  • the ratio of the amount of phenyl amide fungicide to the imidazole fungicide is about 1 :30.
  • the ratio of the amount of phenyl amide fungicide to the imidazole fungicide is about 1 :6.67.
  • the ratio of the amount of phenyl amide fungicide to the imidazole fungicide is about 1 :3.33.
  • the ratio (by weight) of kiralaxyl to prochloraz is from about 1 : 100 to 100: 1. In another embodiment the ratio is from about 1:30 to 10: 1 and in another embodiment the ratio is from about 1 :5 to 5: 1.
  • the ratio of the amount of kiralaxyl to prochloraz is about 1 :30.
  • the ratio of the amount of kiralaxyl to prochloraz is about 1 :6.67.
  • the ratio of the amount of kiralaxyl to prochloraz is about 1 :3.33.
  • the weight ratio between the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide is about 0.5 - 10 : 2 - 50 : 4 - 450, respectively.
  • the weight ratio between the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide is about 0.5 - 5 : 2 - 50 : 10 - 120, respectively.
  • the weight ratio between the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide is about 1 :6.67:45, respectively.
  • the weight ratio between phenyl amide fungicide, imidazole fungicide and phthalimide containing fungicide is about 1 :30:90, respectively.
  • the weight ratio between phenyl amide fungicide, imidazole fungicide and phthalimide containing fungicide is about 1 :3.33:20, respectively.
  • the weight ratio between kiralaxyl, prochloraz and captan in the mixture is about 0.5 - 10 : 2 - 50 : 4 - 450, respectively.
  • the weight ratio between kiralaxyl, prochloraz and captan in the mixture is about 0.5 - 5 : 2 - 50 : 10 - 120, respectively.
  • the weight ratio between kiralaxyl, prochloraz and captan in the mixture is about 1 :30:90, respectively.
  • the weight ratio between kiralaxyl, prochloraz and captan in the mixture is about 1 :6.67:45, respectively.
  • the weight ratio between kiralaxyl, prochloraz and captan in the mixture is about 1 :3.33:20, respectively.
  • the invention further relates to a method for controlling and/or preventing a disease caused by phytopathogenic fungi on plants or propagation material thereof, by contacting the plants, the locus thereof or propagation material thereof, such as seeds, with a synergistically effective amount of a mixture of phenyl amide fungicide, an imidazole fungicide and a phthalimide containing fungicide.
  • contacting refers to applying the compounds, mixtures and compositions of the invention to the plant, to a site of infestation by fungi, to a potential site of infestation by the fungi, which may require protection from infestation, or the environment around the habitat or potential habitat of the fungi.
  • the application may be by methods described in the art such as by spraying, dipping, etc.
  • a method for controlling and/or preventing a disease caused by phytopathogenic fungi in a plant by contacting the useful plants, the locus thereof or propagation material thereof, such as seeds, with a synergistically effective amount of kiralaxyl; captan; and prochloraz is provided.
  • plant includes reference to whole plants, plant organs (e.g. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), or plant cells.
  • plant organs e.g. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.
  • plant propagation material includes all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers, which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil. These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring.
  • the term propagation material denotes seeds.
  • the plants include vegetables, such as tomatoes, peppers, cabbage, broccoli, asparagus, squash, lettuce, spinach, cauliflower, melon, watermelon, cucumbers, carrots, onions, cucurbits and potatoes, tobacco, pome and stone fruits and berries, such as walnuts, kiwi, banana, avocado, olives, passion fruit, almonds, pineapples, apples, pears, raspberry, cherry, plums, peaches, and cherries, table and wine grapes, citrus fruit, such as oranges, lemons, grapefruits and limes, corn, cotton, soybean, oil seed rape, wheat, barley, rye, triticale, oats, maize, sorghum, sunflower, peanuts, rice, sugar beet, fodder beet, coffee, beans, peas, yucca, sugar cane, clover, turf and ornamentals such as roses.
  • vegetables such as tomatoes, peppers, cabbage, broccoli, asparagus, squash, lettuce, spinach, cauliflower, melon, watermelon, cucumbers, carrots,
  • the plant is one or more from soybean, corn or cotton.
  • plants that tolerate the action of herbicides, fungicides or insecticides as a result of breeding, mutagenesis or genetic engineering methods are also included.
  • the invention relates to a fungicidal mixture comprising a phenyl amide fungicide; an imidazole fungicide; and a phthalimide fungicide, in a synergistically effective amount, for controlling diseases caused by phytopathogenic fungi on plants or propagation material thereof which comprises contacting the plants, the locus thereof or propagation material thereof.
  • the phytopathogenic fungi are one or more of the classes Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes, such as Achlya conspicua (Water-mold), Achlya klebsiana (Water-mold), Aecidium cantensis (Deforming rust), Akaropeltopsis sp. (Sooty blotch), Albugo tragopogonis (White rust), Alternaria alternata (Alternaria rot, Black mold rot, Black shoulder, Brown spot and Black pit, Alternaria leaf spot, Alternaria leaf blight, stem spot and head rot, Albinism), Alternaria alternata f.sp.
  • Achlya conspicua Water-mold
  • Achlya klebsiana Water-mold
  • Aecidium cantensis Deforming rust
  • Akaropeltopsis sp. Sooty blotch
  • Lycopersici (Alternaria stem canker), Alternaria brassicae (Alternaria leaf spot), Alternaria brassicicola (Alternaria leaf spot), Alternaria citri (Alternaria leaf spot of rough lemon, Alternaria stem-end rot, Black rot), Alternaria helianthi (Alternaria leaf blight, stem spot and head rot), Alternaria helianthicola (Alternaria leaf blight, stem spot and head rot), Alternaria leucanthemi (Alternaria leaf blight, stem spot and head rot), Alternaria limicola (Mancha foliar de los citricos), Alternaria padwickii (Stackburn), Alternaria solani (Early blight), Alternaria spp.
  • Kernel blight black point
  • Alternaria tenuissima Alternaria leaf blight, stem spot and head rot
  • Alternaria zinnia Alternaria leaf blight, stem spot and head rot
  • Angiosorus solani Thecaphora smut
  • Armillaria tabescens (Clitocybe root rot)
  • Ascochyta graminea Ascochyta leaf spot
  • Ascochyta hordei Ascochyta leaf spot
  • Ascochyta sorghi Ascochyta leaf spot
  • Ascochyta tritici Ascochyta leaf spot
  • Ashbya gossypii Dry rot (fruit))
  • Aspergillus flavus Aspergillus flavus
  • Botryosphaeria disrupta (Branch canker), Botryosphaeria dothidea (Cane blight canker), Botryosphaeria obtuse (Branch canker, Fruit rot), Botryosphaeria quercuum (Branch canker, Fruit rot), Botryosphaeria rhodina (Branch canker, Fruit rot), Botryosphaeria ribis (Cane blight canker, Dothiorella gummosis and rot), Botrytis cinerea (Fruit rot, Gray Mold, Botrytis blight, Botrytis head rot, Botrytis blossom and twig blight, gummosis, Gray mold), Bremia lactucae (Downy mildew), Ceratobasidium oryzae-sativae (Aggregate sheath spot), Cercospora kikuchii (Leaf Blight), Cercospora janseana (Narrow brown
  • Fusarium equiseti Fusarium stalk rot
  • Fusarium graminearum Common root rot, crown rot and seedling blight
  • Puccinia xanthii Rust
  • Pyrenochaeta lycopersici Corky root rot
  • Pyrenophora graminea Barley stripe
  • Pyrenophora teres Net blotch
  • Pyrenophora tritici-repentis Tan spot
  • Pyricularia grisea Blast
  • Pythium aphanidermatum Pythium damping-off and fruit rot, Pythium seedling blight and root rot, Damping-off
  • Pythium arrhenomanes Pythium damping-off and fruit rot, Pythium root rot
  • Pythium debaryanum Pythium damping-off and fruit rot, Pythium seedling blight and root rot, Damping-off
  • Pythium graminicola Pythium root rot
  • Pythium irregular Pythium seedling blight and root rot
  • the phytopathogenic fungi are selected from Aspergillus, Cercospora, Colletotrichum truncatum, Fusarium graminearum, Fusarium spp., Penicillium, Phomopsis, Phytophthora sojae, Pythium spp., Rhizoctonia solani, Sclerotinia sclerotiorum and any combinations comprising one or more thereof.
  • the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide can be applied simultaneously together, separately, or successively. In the case of separate application, the order of applying the fungicides has no effect on the activity of the combination.
  • kiralaxyl, prochloraz and captan can be applied simultaneously, jointly or separately, or in succession.
  • the order of applying the fungicides has no effect on the activity of the combination.
  • the application rates of the combination may vary, depending on the desired effect.
  • the application rates of the mixtures according to the invention are from about 10 g/ha to 2500 g/ha, particularly from about 50 to 1000 g/ha, more particularly from about 100 to 500 g/ha.
  • the applied amounts of the mixture are generally from about 1 to 1000 g/100 kg of seed, particularly from about 1 to 750 g/100 kg and more particularly from about 30 to 300 g/100 kg. In a particular embodiment the applied amounts of the mixture are from about 80 to 150 g/100 kg of seed.
  • the applied amounts of captan are from about 1 to 900 g/ 100 kg seed, from about 1 to 500 g/100 kg seed and particularly from about 20 to 150 g/100 kg seed.
  • the applied amount of captan is about 90 g/100 kg seed.
  • the applied amounts of prochloraz are normally from about 1 to 500 g/100 kg seed, particularly from about 1 to 300 g/ 100 kg seed and more particularly from about 10 to 100 g/100 kg seed.
  • the applied amount of prochloraz is about 30 g/100 kg seed.
  • the applied amounts of kiralaxyl are normally from about 0.01 to 500 g/100 kg seed, particularly from about 0.1 to 100 g/ 100 kg seed and more particularly from about 1 to 50 g/100 kg seed. [00069] In a specific embodiment, the applied amount of kiralaxyl is about 1 g/ 100 kg seed.
  • compositions according to the invention may be formulated in any conventional form, e.g. solutions, emulsions, suspensions, dusts, powders, pastes and granules or any technically feasible formulation in combination with agriculturally acceptable carriers, surfactants or other application promoting adjuvants customarily employed in formulation technology.
  • the application form is governed by the particular purpose; in a specific embodiment is selected to ensure a fine and uniform distribution of the fungicidal mixture according to the invention.
  • the synergistic composition may be applied in various mixtures or combinations of the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide, for example in a concentrate form or a ready-for- use form, or in a combined spray mixture composed from separate formulations of the single active ingredients, such as a "tank-mix" form.
  • ready for use refers to compositions that are not in a concentrate form but rather which may be applied without dilution.
  • surfactant means an agriculturally acceptable material which imparts emulsifiability, stability, spreading, wetting, dispersibility or other surface-modifying properties.
  • suitable surfactants include non-ionic, anionic, cationic and ampholytic types such as lignin sulfonates, fatty acid sulfonates (e.g.
  • phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styrylphenol ethoxylates, condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or of naphthalenesulfonic acid with phenol and formaldehyde, alkylarylsulfonates, ethoxylated alkylphenols and aryl phenols, polyalkylene glycols and ethoxylated fatty alcohols.
  • phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styrylphenol ethoxylates
  • ingredients such as wetting agents, adhesives, thickeners, binders, fertilizers, pigments, dyes or anti-freeze agents, may also be added to the composition including the combination of the fungicides in order to increase the stability, density and viscosity of the composition.
  • the composition of the present invention includes kiralaxyl, captan and prochloraz, obtained by combining the three active ingredients with agriculturally acceptable carriers, a surfactant or any other application-promoting adjuvant customarily employed in formulation technology.
  • the compositions of the invention may be formulated in the form of emulsion concentrates (EC), suspension concentrates (SC), soluble liquid (SL), emulsion in water (EW), micro-emulsion, emulsifiable gel (GL), suspoemulsion (SE), oil dispersion (OD), water dispersible granules (WDG), wettable powders (WP), water soluble powder (SP) and capsule suspension (CS).
  • Such compositions can be formulated with agriculturally acceptable carriers, surfactants or other application-promoting adjuvants customarily employed in formulation technology and formulation techniques that are known in the art.
  • compositions may be formulated in the form of powder for dry seed treatment (DS), gel for seed treatment (GF), water dispersible powder for slurry seed treatment (WS), water soluble powder for seed treatment (SS), solution for seed treatment (LS), emulsion for seed treatment (ES), suspension concentrate (SC), flowable concentrate for seed treatment (FS), capsule suspension (CS), seed coated with a pesticide (PS).
  • DS dry seed treatment
  • GF gel for seed treatment
  • WS water dispersible powder for slurry seed treatment
  • SS water soluble powder for seed treatment
  • LS solution for seed treatment
  • ES emulsion for seed treatment
  • SC suspension concentrate
  • FS flowable concentrate for seed treatment
  • CS capsule suspension
  • PS pesticide
  • compositions for seed treatment may be formulated in the form of emulsions for seed treatment (ES), suspension concentrates (SC), flowable concentrate for seed treatment (FS) and capsule suspension (CS).
  • ES emulsions for seed treatment
  • SC suspension concentrates
  • FS flowable concentrate for seed treatment
  • CS capsule suspension
  • the combined amount of the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide together in the composition is 0.01-99 wt.%.
  • the combined amount of the phenyl amide fungicide, the imidazole fungicide and the phthalimide containing fungicide together in the composition is 0.01-95 wt.%, particularly 30-70 wt.%, based on the total weight of the composition.
  • the combined amount of kiralaxyl, captan and prochloraz in the composition according to the invention is 0.01-99 wt.%. In another embodiment the combined amount is 0.01-95 wt.%, particularly 30-70 wt.%, based on the total weight of the composition.
  • the combined amount of kiralaxyl, captan and prochloraz in the composition according to the invention is 40%-60 wt.%, based on the total weight of the composition.
  • suitable solid carriers include mineral earths such as silica gels, silicates, talc, kaolin, attaclay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, sodium carbonate and bicarbonate, and sodium sulfate, ground synthetic materials, fertilizers, such as, for example, ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and products of vegetable origin, such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders and other solid carriers.
  • mineral earths such as silica gels, silicates, talc, kaolin, attaclay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, sodium carbonate and bicarbonate, and sodium s
  • liquid carriers include water, alcohols such as methanol, cyclohexanol and decanol, ethylene glycol and polypropylene glycol, N,N- dimethylformamide, dimethylsulfoxide, N-alkylpyrrolidone, aromatic hydrocarbons such as alkylbenzenes and alkylnaphthalenes, paraffins, oils of olive, castor, linseed, tung, sesame, corn, peanut, cotton-seed, soybean, rape-seed and coconut, fatty acid esters, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone and the like.
  • alcohols such as methanol, cyclohexanol and decanol
  • ethylene glycol and polypropylene glycol N,N- dimethylformamide, dimethylsulfoxide, N-alkylpyrrolidone
  • aromatic hydrocarbons such as alkylbenzene
  • kits comprising a ternary synergistic fungicidal mixture as described herein, or components thereof.
  • kits may comprise, in addition to the aforementioned active components, one or more additional active and/or inactive ingredients, either within the provided fungicidal mixture to provide a composition, or separately.
  • Certain kits comprise a phenyl amide fungicide, an imidazole fungicide and a phthalimide containing fungicide, each in a separate container, and each optionally combined with a carrier.
  • compositions, kits and methods described herein exhibit a synergistic effect.
  • a synergistic effect exists wherever the action of a combination of active components is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount (or an effective amount of a synergistic composition or combination) is an amount that exhibits greater fungicidal activity than the sum of the fungicidal activities of the individual components.
  • the Wadley Method is a well-known method for determining whether synergy exists. In this method, the synergistic action is determined from the dose response curves.
  • the Wadley formula (Levi et al, EPPO- Bulletin 16, 1986, 651-657 or Wadley, F.M., U.S. Dep. Agric, Agric. Res. Adm., Bur. Entomol. And Plant Quar. ET-223, 1945, 8, incorporated herein by reference in its entirely) describes the theoretical response (EC50 th ) of a two-component mixture as :
  • a and B represent the two components, and a and b represent the absolute amounts of the components in the mixture.
  • A, B and C represent the three components, and a, b and c represent the absolute amounts of the components in the mixture.
  • EC5 0 value represents the effective concentration of fungicide, in ⁇ g/ml, which reduces by 50 % the fungal growth
  • the level of interaction R is calculated as:
  • EC50obs is the observed efficacy value of the specific mixture.
  • Mycelial seed inoculum of Pythium spp. and R. solani strains Two fungal plugs of 5 mm diameter each were taken from the fungal colony margin of each Pythium spp. or R. solani strain. Fungal plugs were then transferred in a 10 ml-Polypropylene tube containing 5 ml of sterile Potato Dextrose Broth (PDB) supplemented with antibiotics. Polypropylen tubes were then incubated at 20°C in darkness with constant shaking (135 r.p.m.). After a 14-days incubation period, mycelium was ground with an Ultra-Turax at 17.000 r.p.m. for 15 seconds. Ground mycelium was diluted in 2 times concentrated Pea Broth (2x PB) supplemented with antibiotics and were used as seed inoculum for the microtitre plate assay.
  • PPB Potato Dextrose Broth
  • each well of a 96-well microtitre plate was poured with 100 ⁇ of sterile distilled water containing a fungicide or not (control). Then, each well was seeded with 100 ⁇ of the calibrated macroconidia suspension (2.10 3 spores/ml) of F. graminearum strain Fgram 1 or 100 ⁇ of the diluted mycelial seed inoculum of each strain of Pythium spp. or R. solani prepared in 2x MM liquid medium. For each fungicide condition tested, 3 replicates were used (3 rows per strain). [00096] The microtitre plates were then incubated in the dark at 20°C.
  • An EC5 0 value represents the effective concentration of fungicide, in ⁇ g/ml, which reduces by 50 % the fungal growth.
  • Four EC5 0 values were obtained in each experiment, one for each fungicide and one for the combination.
  • the EC5 0 values of the single fungicides were placed into the Wadley Formula to calculate the expected EC5 0 of the fungicidal mixture.
  • SF stands for Synergistic Factor.
  • the ternary fungicidal composition was found to exhibit a synergistic effect against the phytopathogenic fungi.
  • the ternary fungicidal composition was found to exhibit a strong synergistic effect against the phytopathogenic fungi.
  • the ternary fungicidal composition was found to exhibit a strong synergistic effect against the phytopathogenic fungi.
  • a "mixture” refers to a combination in any physical form, e.g., blend, solution, alloy, or the like.
  • the endpoints of all ranges directed to the same component or property are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges.
  • the terms “a” and “an” do not denote a limitation of quantity, but rather denote the presence of one or more of the referenced item.
  • the term “or” means "and/or.” In all embodiments of compositions that comprise the named components, it is also contemplated that the compositions consist essentially of the named components; it is also contemplated that all embodiments may consist of the named components.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
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Abstract

La présente invention porte sur un mélange comprenant une association d'un fongicide phénylamide, d'un fongicide imidazole et d'un fongicide contenant un phtalimide, la composition ayant une activité accrue de façon synergétique.
PCT/IL2013/050431 2012-05-24 2013-05-21 Composition fongicide synergétique Ceased WO2013175467A1 (fr)

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WO2020245384A1 (fr) * 2019-06-05 2020-12-10 UPL Corporation Limited Composition fongicide pour lutter contre les infections causées par zymoseptoria dans une plante
JP2023533554A (ja) * 2020-07-08 2023-08-03 アダマ・マクテシム・リミテッド 殺菌・殺カビ性混合物

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CN101322492A (zh) * 2008-07-25 2008-12-17 吉林省农业科学院 一种防治水稻恶苗病和立枯病的农药
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020245384A1 (fr) * 2019-06-05 2020-12-10 UPL Corporation Limited Composition fongicide pour lutter contre les infections causées par zymoseptoria dans une plante
EP4466998A3 (fr) * 2019-06-05 2025-02-26 UPL Corporation Limited Composition fongicide pour lutter contre l'infection par la zymoseptoria dans une plante
US12389908B2 (en) 2019-06-05 2025-08-19 UPL Corporation Limited Fungicide composition for controlling Zymoseptoria infection in plant
JP2023533554A (ja) * 2020-07-08 2023-08-03 アダマ・マクテシム・リミテッド 殺菌・殺カビ性混合物

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