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WO2013175395A3 - Procédé amélioré pour la préparation de saxagliptine et de ses sels - Google Patents

Procédé amélioré pour la préparation de saxagliptine et de ses sels Download PDF

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Publication number
WO2013175395A3
WO2013175395A3 PCT/IB2013/054167 IB2013054167W WO2013175395A3 WO 2013175395 A3 WO2013175395 A3 WO 2013175395A3 IB 2013054167 W IB2013054167 W IB 2013054167W WO 2013175395 A3 WO2013175395 A3 WO 2013175395A3
Authority
WO
WIPO (PCT)
Prior art keywords
saxagliptin
salts
preparation
improved process
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/054167
Other languages
English (en)
Other versions
WO2013175395A2 (fr
Inventor
Ganesh Varanasi
Prabhakar Macharla
Chandrasekhar Vempati
Rakeshwar Bandichhor
Vilas Hareshwar Dahanukar
Javed Iqbal
Srinivas ORUGANTI
Rajesh Kumar Rapolu
Munaswamy Sekhar Nariyam
Srinivasan Neti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of WO2013175395A2 publication Critical patent/WO2013175395A2/fr
Publication of WO2013175395A3 publication Critical patent/WO2013175395A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des procédés améliorés de préparation de saxagliptine ou de son sel et des intermédiaires correspondants.
PCT/IB2013/054167 2012-05-21 2013-05-21 Procédé amélioré pour la préparation de saxagliptine et de ses sels Ceased WO2013175395A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2012CH2012 2012-05-21
IN2012/CHE/2012 2012-05-21
IN250/CHE/2013 2013-01-18
IN250CH2013 2013-01-18

Publications (2)

Publication Number Publication Date
WO2013175395A2 WO2013175395A2 (fr) 2013-11-28
WO2013175395A3 true WO2013175395A3 (fr) 2014-01-30

Family

ID=49624449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/054167 Ceased WO2013175395A2 (fr) 2012-05-21 2013-05-21 Procédé amélioré pour la préparation de saxagliptine et de ses sels

Country Status (1)

Country Link
WO (1) WO2013175395A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104109100A (zh) * 2014-05-29 2014-10-22 上海应用技术学院 一种金刚烷氨基酸酯化合物的合成方法
CN105315189A (zh) * 2014-05-29 2016-02-10 上海医药工业研究院 一种制备（5s）-5-氨基羰基-4,5-二氢-1h-吡咯-1-羧酸-1（1,1-二甲基乙基）酯的方法
CN104098487A (zh) * 2014-07-31 2014-10-15 天津民祥生物医药科技有限公司 一种n-叔丁氧羰基-3-羟基-1-金刚烷基甘氨酸的制备方法
CN105503698A (zh) * 2014-09-26 2016-04-20 深圳翰宇药业股份有限公司 一种合成沙格列汀及其中间体的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052850A2 (fr) * 2002-12-09 2004-06-24 Bristol-Myers Squibb Company Procedes et composes pour produire des inhibiteurs de la dipeptidyle-peptidase et leurs intermediaires
WO2006020664A2 (fr) * 2004-08-11 2006-02-23 Bristol-Myers Squibb Company Procede d'ammonolyse destine a la preparation d'intermediaires pour des inhibiteurs iv dpp

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052850A2 (fr) * 2002-12-09 2004-06-24 Bristol-Myers Squibb Company Procedes et composes pour produire des inhibiteurs de la dipeptidyle-peptidase et leurs intermediaires
WO2006020664A2 (fr) * 2004-08-11 2006-02-23 Bristol-Myers Squibb Company Procede d'ammonolyse destine a la preparation d'intermediaires pour des inhibiteurs iv dpp

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU K. K. -C. ET AL.: "Synthetic approaches to the 2009 new drugs", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, 2011, pages 1136 - 1154 *
SAVAGE S. A. ET AL.: "Preparation of Saxagliptin, a Novel DPP-IV Inhibitor", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 13, 2009, pages 1169 - 1176 *

Also Published As

Publication number Publication date
WO2013175395A2 (fr) 2013-11-28

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