Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
  • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
  • C07C249/14—Separation; Purification; Stabilisation; Use of additives

Definitions

• the present invention relates to a process for purification of the cyclohexanone oxime dissolved in an organic medium.
• Oximes in particular cyclohexanone oxime, can be produced in a process in which a buffered, aqueous reaction medium containing buffer acids or acidic salts, for example phosphate buffers, and buffer salts derived from these acids, is continuously recycled between a hydroxylammonium synthesis zone and an cyclohexanone oxime synthesis zone.
• a buffered, aqueous reaction medium containing buffer acids or acidic salts for example phosphate buffers, and buffer salts derived from these acids
• hydroxylammonium synthesis zone hydroxylammonium may be formed by catalytic reduction of nitrate ions or nitric oxide with hydrogen.
• hydroxylammonium formed in the hydroxylammonium synthesis zone may react with cyclohexanone to form cyclohexanone oxime.
• the cyclohexanone oxime can then be separated from the aqueous reaction medium which is recycled to the hydroxylammonium zone.
• the first reaction is catalyzed heterogeneously.
• the catalyst is present as finely divided solids as a disperse phase in a liquid reaction mixture.
• cyclohexanone oxime may be prepared by countercurrently contacting an aqueous medium comprising hydroxylammonium in water with an organic medium comprising cyclohexanone dissolved in an organic solvent, e.g. toluene or benzene.
• An organic solution comprising the formed cyclohexanone oxime dissolved in organic solvent may be withdrawn from the reaction zone, and distilled to recover cyclohexanone oxime.
• the inorganic process liquid may comprise neutral species e.g. hydroxylamine or ammonia which may also be protonated e.g. hydroxylammonium or ammonium.
• neutral species e.g. hydroxylamine or ammonia which may also be protonated e.g. hydroxylammonium or ammonium.
• hydroxylamine and hydroxylammonium may be read as hydroxylamine and/or hydroxylammonium
• ammonia and ammonium may be read as ammonia and/or ammonium.
• the inorganic liquid leaving the oximation synthesis zone has to be purified thoroughly to protect the catalyst in the hydroxylammonium synthesis zone. This is done in an inorganic liquid extraction section with a solvent, e.g. toluene.
• a solvent e.g. toluene.
• the inorganic liquid leaving the extraction section is for further purification fed to a stripping section and a carbon adsorption section.
• WO 2004/067497 relates to a process for treating an organic solution comprising cyclohexanone oxime, cyclohexanone and an organic solvent.
• an organic product solution comprising cyclohexanone oxime and cyclohexanone dissolved in organic solvent [toluene] is discharged from the cyclohexanone oxime synthesis zone.
• the organic product solution is, preferably after having been washed with water or an aqueous solution, fed to a distillation column. But a specified washing process is not disclosed in this application.
• the present invention provides a continuous purification process for the organic product solution by washing.
• organic product solution washing is to recover almost all inorganic process liquid (I PL) salts from the organic product solution.
• This washing is based on the physical property that I PL salts dissolve better in water than in the organic product solution. Therefore, according to the present invention there is provided a continuous process for purifying organic product solution comprising oxime dissolved in an organic medium comprising:
• a fraction of the aqueous medium contained in the organic product solution from oxime synthesis section [I] is separated out in a liquid-liquid separator [II] before the organic product solution being introduced to the liquid-liquid mixing section [III] and the aqueous bottom layer of the liquid-liquid separator [II] is introduced to the oxime synthesis section [I].
• the organic top layer obtained in the liquid-liquid separator [IV] is sent to the liquid-liquid separator [V] before the oxime is recovered therefrom in the oxime recovery section and the liquid-liquid separator [V] may be a coalescer.
• the organic top layer obtained from the liquid-liquid separator [IV] is subjected to at least one rewash section before being introduced to oxime recovery section.
• the organic top layer obtained from the liquid-liquid separator [IV] is subjected to two rewash sections before being introduced to the oxime recovery section.
• the organic top layer of the liquid-liquid separator [IV] is introduced into a liquid-liquid separator [V] before being introduced into the rewash section.
• the rewash section comprises:
• the organic top layer obtained in the liquid-liquid separator [IV a ] is sent to a liquid-liquid separator [V a ] before the oxime is recovered in the oxime recovery section and the liquid-liquid separator [V a ] may be a coalescer.
• Equipment for the purification of oxime comprises at least one liquid- liquid mixer and at least one liquid-liquid separator.
• the liquid-liquid separator [IV] or the liquid-liquid separator [IV a ] is a gravity liquid-liquid settler.
• the liquid-liquid mixing section [III] or the liquid-liquid mixing section [III 3 ] preferably contains a stirrer and/or a static mixer, preferably a stirrer.
• the aqueous solution in line [7] comprises demineralized water and/or steam condensate.
• the aqueous solution may also contain a small amount of ammonia.
• the amount of the ammonia is preferably less than 30 wt%, more preferably less than 5 wt% and most preferably less than 1 wt%.
• the aqueous solution in line [14] comprises demineralized water and/or steam condensate.
• the aqueous solution in line [14] may also contain a small amount of ammonia.
• the amount of the ammonia is preferably less than 30 wt%, more preferably less than 5 wt% and most preferably less than 1 wt%.
• the aqueous solution in line [19] comprises demineralized water and/or steam condensate.
• the aqueous solution in line [19] may also contain a small amount of ammonia.
• the amount of the ammonia is preferably less than 30 wt%, more preferably less than 5 wt% and most preferably less than 1 wt%.
• the aqueous bottom layer of liquid-liquid separator [IV] is fed to the oxime synthesis section [I]; optionally a fraction of which is fed back into the liquid-liquid mixing section [III].
• a fraction of the aqueous bottom layer of liquid-liquid separator [IV] is introduced into the liquid-liquid mixing section [III] and the remainder is sent to the oxime synthesis section [I].
• the amount of the aqueous bottom layer being introduced to the liquid-liquid mixing section [III] is more than 80 wt%, more preferably more than 90 wt% and most preferably more than 95 wt%.
• a fraction or all of the aqueous bottom layer of liquid-liquid separator [IV a ] is fed into oxime synthesis section [I] and/or into the liquid-liquid mixing section [III] and/or into liquid-liquid mixing section [III 3 ]. More preferably, a fraction of the aqueous bottom layer of liquid-liquid separator [IV a ] is introduced to the liquid-liquid mixing section [III 3 ] and the remainder is sent into the liquid-liquid mixing section [III] and/or is disposed off.
• the amount of the aqueous bottom layer being introduced to the liquid-liquid mixing section [III 3 ] is more than 80 wt%, more preferably more than 90 wt% and most preferably more than 95 wt%.
• the organic top layer obtained from the liquid-liquid separator [IV] is subjected to two or more rewash sections before being introduced to oxime recovery section.
• a fraction or all of aqueous bottom layer of the liquid-liquid separator of each rewash process can be introduced into the oxime synthesis section [I] and/or any one or more previous liquid-liquid mixing sections and/or be disposed off.
• the organic top layer obtained from each rewash process can be introduced into a liquid-liquid separator before being introduced into next rewash process.
• the liquid-liquid separator is a coalescer.
• a fraction or all of the aqueous bottom layer obtained in the liquid-liquid separator is introduced into the oxime synthesis section [I] and/or any one or more previous liquid- liquid mixing section and the remainder is disposed off.
• the oxime is cyclohexanone oxime.
• the organic solution is toluene.
• the temperature in the liquid-liquid mixing section [III] is in the range of from 30°C to 90 °C, more preferably in the range of from 40°C to 80 °C and most preferably in the range of from 50°C to 70 °C.
• the temperature in the liquid-liquid mixing section [III 3 ] is in the range of from 30°C to 90 °C, more preferably in the range of from 40°C to 80 °C and most preferably in the range of from 50°C to 70 °C.
• Another advantage is that less fouling will occur in the oxime recovery section.
• Figures 1 -4 represents a schematic overview of a process for purifying cyclohexanone oxime dissolved in an organic medium.
• Figure 1
• FIG. 1 A preferred embodiment of the process according to the invention is schematically illustrated in figure 1.
• cyclohexanone oxime is produced in the cyclohexanone oxime synthesis section [I].
• an aqueous medium containing hydroxylammonium and inorganic ions in water is contacted with an organic medium comprising cyclohexanone and organic solvent, preferably toluene.
• hydroxylammonium reacts with cyclohexanone to form cyclohexanone oxime.
• the aqueous medium and the organic medium are supplied to the cyclohexanone oxime synthesis section [I] via lines [1 ] and [2], respectively.
• the resulting aqueous layer is discharged from the cyclohexanone oxime synthesis section [I] via line [3].
• An organic product solution comprising cyclohexanone oxime and cyclohexanone dissolved in organic solvent (toluene) is discharged from the cyclohexanone oxime section [I] via line [4] at a discharge level for an organic product solution.
• This organic product solution which contains some water, hydroxylammonium and inorganic ions, is supplied via line [4] to liquid-liquid mixing section [III].
• the liquid- liquid mixing section [III] might contain a stirrer and/or a static mixer, preferably a stirrer. Water or an aqueous solution, is supplied to the liquid-liquid mixing section [III] via line [7].
• a mixture of an aqueous medium and an organic medium is discharged from the liquid-liquid mixing section [III] via line [8] and is supplied to the liquid-liquid separator [IV].
• liquid-liquid separator [IV] an organic top layer and an aqueous bottom layer are formed.
• the aqueous bottom layer is discharged from the liquid-liquid separator [IV] via line [9].
• a fraction of the aqueous bottom layer discharged from the liquid-liquid separator [IV] is supplied to liquid-liquid mixing section [III] via line [9A], while the remainder is discharged via line [9B] to the cyclohexanone oxime synthesis section [I].
• the organic top layer is discharged via line [10].
• This organic top layer which contains some remaining water, hydroxylammonium and inorganic ions, can be directly discharged to the cyclohexanone oxime recovery section in which a product comprising mainly cyclohexanone oxime is obtained.
• FIG. 1 A preferred embodiment of the process according to the invention is schematically illustrated in figure 2.
• cyclohexanone oxime is produced in the cyclohexanone oxime synthesis section [I].
• an aqueous medium containing hydroxylammonium and inorganic ions in water is contacted with an organic medium comprising cyclohexanone and organic solvent, preferably toluene.
• hydroxylammonium reacts with cyclohexanone to form cyclohexanone oxime.
• the aqueous medium and the organic medium are supplied to the cyclohexanone oxime synthesis section [I] via line [1 ] and [2], respectively.
• the resulting aqueous layer is discharged from the cyclohexanone oxime synthesis section [I] via line [3].
• An organic product solution comprising cyclohexanone oxime and cyclohexanone dissolved in organic solvent (toluene) is discharged from the cyclohexanone oxime section [I] via line [4] at a discharge level for an organic product solution.
• This organic product solution which contains some water, hydroxylammonium and inorganic ions, is via line [4B] supplied to a liquid-liquid separator [II], and/or via line [4A] supplied to liquid-liquid mixing section [III].
• liquid-liquid separator [II] an organic top layer and an aqueous bottom layer are formed.
• the aqueous bottom layer is discharged from the liquid-liquid separator [II] via line [5].
• this aqueous bottom layer is supplied to the cyclohexanone oxime synthesis section [I].
• the organic top layer is discharged via line [6] and is supplied to liquid-liquid mixing section [III].
• the liquid-liquid mixing section [III] might contain a stirrer and/or a static mixer, preferably a stirrer. Water or an aqueous solution, preferably
• demineralized water or an aqueous NH 3 solution is supplied to the liquid-liquid mixing section [III] via line [7].
• a mixture of an aqueous medium and an organic medium is discharged from the liquid-liquid mixing section [III] via line [8] and is supplied to the liquid-liquid separator [IV].
• liquid-liquid separator [IV] an organic top layer and an aqueous bottom layer are formed. The aqueous bottom layer is discharged from the liquid-liquid separator [IV] via line [9].
• a fraction of the aqueous bottom layer discharged from the liquid-liquid separator [IV] is supplied to liquid-liquid mixing section [III] via line [9A], while the remainder is discharged via line [9B] to the cyclohexanone oxime synthesis section [I].
• the organic top layer is discharged via line [10].
• This organic top layer which contains some remaining water, hydroxylammonium and inorganic ions, can be directly discharged to the cyclohexanone oxime recovery section via line [10A] in which a product comprising mainly cyclohexanone oxime is obtained or can be fed into a liquid-liquid separator [V] via line [10B] before being introduced into the cyclohexanone oxime recovery section.
• liquid-liquid separator [V] an organic top layer and an aqueous bottom layer are formed.
• the aqueous bottom layer is discharged from the liquid-liquid separator [V] via line [12].
• this aqueous bottom layer is supplied to the cyclohexanone oxime synthesis section [I].
• the organic top layer from liquid-liquid separator [IV] is fed into a liquid-liquid mixing section [III 3 ] via line [10].
• Water or an aqueous solution is fed into the liquid-liquid mixing section [III 3 ] via line [14].
• an aqueous solution originating from liquid-liquid separator [IV 3 ] and/or an aqueous solution originating from liquid-liquid separator [V 3 ] are fed into the liquid-liquid mixing section [III 3 ] via lines [13A] and [17A], respectively.
• the water and/or aqueous solution is mixed with the organic top layer in the liquid-liquid mixing section [III 3 ] and the obtained mixture is introduced into a liquid-liquid separator [IV 3 ] via line [15].
• the organic top layer is separated from the aqueous bottom layer in the liquid-liquid separator [IV 3 ] and the aqueous bottom layer is discharged from liquid-liquid separator [IV 3 ] via line [13].
• a fraction of the aqueous bottom layer is fed back into the liquid-liquid mixing section [III 3 ] via line [13A] and the remainder is introduced into the liquid-liquid mixing section [III] via line [13B] and/or is introduced into oxime synthesis section [I] via line [13C] and/or disposed off via line [13D].
• the organic top layer of the liquid-liquid separator [IV 3 ] can be
• the organic top layer of the liquid-liquid separator [IV 3 ] can also be introduced into a liquid-liquid separator [V 3 ] via line [16B] to separate the water or aqueous solution contained in the organic top layer.
• the aqueous bottom layer of the liquid-liquid separator [V 3 ] is introduced into cyclohexanone oxime synthesis section [I] via line [17C] and/or the liquid-liquid mixing section [III] via line [17B] (figure 1 ) and/or liquid-liquid mixing section [III 3 ] via line [17A] and/or disposed off via line [17D].
• the organic top layer of the liquid-liquid separator [V 3 ] is directly introduced into the cyclohexanone oxime recovery section via line [18] in which a product comprising mainly cyclohexanone oxime is obtained.
• Figure 4 represents a schematic overview of a process for purifying cyclohexanone oxime dissolved in an organic medium comprising two rewashing steps.
• Example 3 For details please refer to Example 3. The invention will be further elucidated by means of the following examples without being limited thereto.
• the organic product solution (toluene/cyclohexanone oxime mixture), fresh demiwater and an aqueous recycle stream were fed to the liquid-liquid mixing section [III].
• the liquid- liquid mixing section [III] was operated with the organic phase as the continuous phase.
• the liquid-liquid separator [IV] consisted of a gravity settler and was equipped with 4 baffles.
• the obtained aqueous bottom layer was divided into a fraction that was sent to the cyclohexanone oxime synthesis section [I] and a fraction that was returned to the liquid-liquid mixing section [III].
• the obtained organic top layer was sent to a liquid- liquid coalescer [V] with glass fiber as coalescing media.
• Average temperature in the range of from 50 to 60 °C
• Cyclohexanone oxime content ca. 43.3 wt%
• the aqueous phase that was returned to the cyclohexanone oxime reactor contained:
• the organic product solution (toluene/cyclohexanone oxime mixture), fresh demineralized water, aqueous phase recovered in liquid-liquid separator [IV] and aqueous phase recovered in the coalescer [V] were fed to the liquid-liquid mixing section [III].
• the liquid-liquid mixing section [III] was operated with the organic phase as the continuous phase.
• the liquid-liquid separator section [IV] consisted of a gravity settler and was equipped with 4 baffles.
• the obtained aqueous bottom layer was divided into a fraction that was sent to the cyclohexanone oxime synthesis section [I] and a fraction that was returned to the liquid-liquid mixing section [III].
• the obtained organic phase was sent to a liquid-liquid coalescer [V] with glass fiber as coalescing media.
• the aqueous phase recovered in the coalescer [V] was sent to the liquid-liquid mixing section [III].
• Average temperature in the range of from 50 to 60 °C
• Cyclohexanone oxime content ca. 42.8 wt%
• the phosphate concentration in the toluene/cyclohexanone oxime flow leaving the top of the cyclohexanone oxime reactor was ca. 828 ppm (wt/wt).
• the obtained purified toluene/cyclohexanone oxime flow that was recovered in the coalescer did contain ca. 284 ppm (wt/wt) phosphate. Due to this purification of the toluene/cyclohexanone oxime approx. 20 kg phosphate per hour could be recovered.
• the cyclohexanone oxime in the purified toluene/cyclohexanone oxime flow that was recovered in the coalescer [V] was further purified by rewashing.
• This rewashing consisted of a liquid-liquid mixing section [III 3 ], a liquid-liquid separator [IV a ], a liquid-liquid mixing section [lll b ], a liquid-liquid separator [IV b ], and a coalescer [V b ].
• the liquid-liquid mixing section [III 3 ] consisted of a cylindrical mixing box and was equipped with a turbine stirrer.
• the organic phase recovered in the coalescer [V] toluene/cyclohexanone oxime mixture
• an aqueous bottom layer of the liquid-liquid separator [IV b ] were fed to the liquid-liquid mixing section [III 3 ] via lines [1 1 ], [21 B], [23] and [13A].
• Both the liquid- liquid separator [IV 3 ] and [IV b ] consisted of gravity settlers.
• the aqueous bottom layer obtained in the liquid-liquid separator [IV 3 ] was divided into a fraction that was returned to the liquid-liquid section [III 3 ] via line [13A] and a fraction that was disposed off via line [13B].
• the obtained organic top layer in the liquid-liquid separator [IV a ] was sent to the liquid-liquid mixing section [lll b ] via line [16].
• the liquid-liquid mixing section [lll b ] consisted of a series of in-line static mixers. In this section the organic phase was mixed with fresh demineralized water via line [19] and an aqueous recycle stream. The obtained mixture was fed to the liquid-liquid separator [IV b ] via line [20].
• the aqueous bottom layer obtained in the liquid-liquid separator [IV b ] was divided into a fraction that was sent to the liquid-liquid mixing section [III 3 ] via line [21 B] and a fraction that was returned to the liquid-liquid mixing section [lll b ] via line [21A].
• the obtained organic top layer was sent to a coalescer [V b ] via line [22] with glass fiber as coalescing media.
• the purified toluene/cyclohexanone oxime flow that was recovered in coalescer [V b ] was sent to a distillation section via line [24] in order to separate cyclohexanone oxime from toluene.
• the obtained cyclohexanone oxime was used for the production of ⁇ - caprolactam.
• Average temperature in the range of from 50 to 60 °C

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• 2013
  • 2013-04-30 TW TW102115409A patent/TW201350463A/zh unknown
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