[go: up one dir, main page]

WO2013163246A3 - Polymerization reactions within microfluidic devices - Google Patents

Polymerization reactions within microfluidic devices Download PDF

Info

Publication number
WO2013163246A3
WO2013163246A3 PCT/US2013/037895 US2013037895W WO2013163246A3 WO 2013163246 A3 WO2013163246 A3 WO 2013163246A3 US 2013037895 W US2013037895 W US 2013037895W WO 2013163246 A3 WO2013163246 A3 WO 2013163246A3
Authority
WO
WIPO (PCT)
Prior art keywords
block
monomers
devices
channel
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/037895
Other languages
French (fr)
Other versions
WO2013163246A2 (en
Inventor
Maximilian ZIERINGER
Christian Holtze
David A. Weitz
Joerg Max Georg Erich SIEBERT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Harvard University
Original Assignee
BASF SE
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE, Harvard University filed Critical BASF SE
Publication of WO2013163246A2 publication Critical patent/WO2013163246A2/en
Publication of WO2013163246A3 publication Critical patent/WO2013163246A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/16—Aqueous medium
    • C08F2/22—Emulsion polymerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/01—Processes of polymerisation characterised by special features of the polymerisation apparatus used
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/917—Laminar or parallel flow, i.e. every point of the flow moves in layers which do not intermix
    • B01F2025/9171—Parallel flow, i.e. every point of the flow moves in parallel layers where intermixing can occur by diffusion or which do not intermix; Focusing, i.e. compressing parallel layers without intermixing them
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B01J2219/0084—For changing surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00903—Segmented flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00934—Electromagnetic waves
    • B01J2219/00936—UV-radiations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00961—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00966—Measured properties pH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Graft Or Block Polymers (AREA)

Abstract

The present invention generally relates to polymerization reactions within microfluidic devices. In certain cases, the invention allows for precise control of the polymerization of different types of monomers to form a copolymer by controlling the steps of polymerization and/or controlling the addition of monomers at various time scales within a microfluidic droplet and/or a microfluidic environment, often to a degree that is unattainable by other block polymerization techniques. For example, in one aspect, the present invention is directed to systems and methods for producing polymers such as block copolymers, gradient polymers, random copolymers, etc. For instance, in one set of embodiments, a first monomer contained within a channel, such as a microfluidic channel, is allowed to polymerize to form a first block of a block copolymer. Additional blocks may be added, for example, by flowing the first block and other monomers through a second channel (which may be an extension of the first channel), by polymerizing additional blocks of the copolymer in other channels, by creating droplets containing one or more blocks and allowing the blocks to polymerize, or the like. In some embodiments, a droplet, such as a multiple emulsion droplet, may be creating containing two or more monomers, which are allowed to polymerize together. Still other embodiments of the invention are generally directed to methods of creating such devices, methods of using such devices, kits involving such devices, or the like.
PCT/US2013/037895 2012-04-25 2013-04-24 Polymerization reactions within microfluidic devices Ceased WO2013163246A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261638436P 2012-04-25 2012-04-25
US61/638,436 2012-04-25

Publications (2)

Publication Number Publication Date
WO2013163246A2 WO2013163246A2 (en) 2013-10-31
WO2013163246A3 true WO2013163246A3 (en) 2014-01-03

Family

ID=48227585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/037895 Ceased WO2013163246A2 (en) 2012-04-25 2013-04-24 Polymerization reactions within microfluidic devices

Country Status (1)

Country Link
WO (1) WO2013163246A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US9138381B2 (en) 2013-02-08 2015-09-22 Basf Se Production of inorganic-organic composite materials by reactive spray-drying
US10518241B2 (en) 2014-04-15 2019-12-31 Agilent Technologies, Inc. Creating and harvesting surface-bound emulsion
WO2016085746A1 (en) * 2014-11-24 2016-06-02 President And Fellows Of Harvard College Multiple emulsions comprising rigidified portions
JP5971392B1 (en) * 2015-09-29 2016-08-17 東洋インキＳｃホールディングス株式会社 Method and apparatus for producing vinyl polymer
JP7351150B2 (en) * 2019-09-04 2023-09-27 Jnc株式会社 Merger, microreactor, fluid merging method, and method for preventing blockage in the merger

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089541A2 (en) * 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
WO2010151776A2 (en) * 2009-06-26 2010-12-29 President And Fellows Of Harvard College Fluid injection
CA2681897A1 (en) * 2009-10-08 2011-04-08 National Research Council Of Canada Microfluidic device, composition and method of forming
WO2012037596A1 (en) * 2010-09-22 2012-03-29 Commonwealth Scientific And Industrial Research Organisation Continuous flow polymerisation process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507921A (en) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Method and apparatus for fluid dispersion
WO2004091763A2 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
EP2662136A3 (en) 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for handling and mixing droplets
EP1861194A2 (en) 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089541A2 (en) * 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
WO2010151776A2 (en) * 2009-06-26 2010-12-29 President And Fellows Of Harvard College Fluid injection
CA2681897A1 (en) * 2009-10-08 2011-04-08 National Research Council Of Canada Microfluidic device, composition and method of forming
WO2012037596A1 (en) * 2010-09-22 2012-03-29 Commonwealth Scientific And Industrial Research Organisation Continuous flow polymerisation process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUN-XIA ZHAO ET AL: "Nanoparticle synthesis in microreactors", CHEMICAL ENGINEERING SCIENCE, OXFORD, GB, vol. 66, no. 7, 27 August 2010 (2010-08-27), pages 1463 - 1479, XP028172448, ISSN: 0009-2509, [retrieved on 20100919], DOI: 10.1016/J.CES.2010.08.039 *
JOKE VANDENBERGH ET AL: "Use of a continuous-flow microreactor for thiol-ene functionalization of RAFT-derived poly(butyl acrylate)", POLYMER CHEMISTRY, vol. 3, no. 10, 1 January 2012 (2012-01-01), pages 2739, XP055072935, ISSN: 1759-9954, DOI: 10.1039/c2py20423a *

Also Published As

Publication number Publication date
WO2013163246A2 (en) 2013-10-31

Similar Documents

Publication Publication Date Title
WO2013163246A3 (en) Polymerization reactions within microfluidic devices
SG11201906761PA (en) Method for producing acrylic rubber
MY185219A (en) Thermoplastic elastomers via atom transfer radical polymerization of plant oil
WO2009134665A3 (en) Styrene-butadiene polymers with styrene gradient and methods of making the same
BR112015015394A2 (en) procatalyst, catalyst system, polymerization process and olefin-based polymer
WO2010144386A3 (en) Antimicrobial polymers
DE502007005986D1 (en) METHOD FOR PRODUCING WATER ABSORBING POLYMER PARTICLES BY POLYMERIZATION OF DROPS OF A MONOMER SOLUTION
MX2016000926A (en) Polymerisation initiators.
BR112013009032A2 (en) methods for producing a copolymer dispersion, a polymer modified asphalt, and a polymer modified asphalt emulsion, copolymer, mixture, aqueous dispersion, method, and, polymer modified asphalt composition
MX2016007667A (en) Anti-drumming compounds with high molecular weight emulsion polymers.
MY188161A (en) Pressure sensitive adhesive compositions and methods for preparing same
WO2008019100A3 (en) Living radical polymerization of activated and nonactivated monomers containing electron-withdrawing side groups
MX2017004771A (en) Vinyl acetate-ethylene / acrylic polymer emulsions and products and methods relating thereto.
WO2014046837A3 (en) Microstructured film comprising nanoparticles and monomer comrising alkylene oxide repeat units
MX390862B (en) MULTIPLE GRAFT COPOLYMER SUPERELASTOMERS BY EMULSION POLYMERIZATION.
BR112017024047A2 (en) copolymer, fuel additive package, copolymer preparation method, and use of polymer or additive package
BR112017012639A2 (en) photoreticulable block copolymers for hot melt adhesives
BR112017000044A2 (en) zwitterionic copolymer preparation method, zwitterionic copolymer solution, and scale resistant coating composition
SG11201806520XA (en) Amphiphilic diblock copolymer and use of same for producing polymeric filter membranes
CN106414524A8 (en) Monomers, copolymers and methods of use containing trisubstituted aromatics
MX384775B (en) MULTIPHASE EMULSION POLYMERS FOR WATER-BASED COATING COMPOSITIONS CONTAINING LITTLE OR NO ORGANIC SOLVENTS.
WO2015116916A8 (en) Resin-support emulsion polymerization of hydrophobic monomers
MX393664B (en) POLYSTYRENE MIXES.
MX2017014708A (en) Adhesive composition for reclosable multi-layer film.
WO2008149505A1 (en) Polymer composition

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13719695

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 13719695

Country of ref document: EP

Kind code of ref document: A2