WO2013157910A1 - Portable electronic sensor for detecting volatile amines in the exploration of the female genital tract - Google Patents
Portable electronic sensor for detecting volatile amines in the exploration of the female genital tract Download PDFInfo
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- WO2013157910A1 WO2013157910A1 PCT/MX2012/000041 MX2012000041W WO2013157910A1 WO 2013157910 A1 WO2013157910 A1 WO 2013157910A1 MX 2012000041 W MX2012000041 W MX 2012000041W WO 2013157910 A1 WO2013157910 A1 WO 2013157910A1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0047—Organic compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
Definitions
- I. - Medical sector a) .- Medical devices, b) .- Diagnostic tests for office and field.
- Ion Mobility Spectrometer IMS of biogenic amines, product of pathogenic germs of the genital tract, this same graphic equipment and determines these amines by qualifying and quantifying them the problem is that high training and knowledge is required for the personnel that manages the equipment.
- a method that, so to speak, is economical for the diagnosis of infectious diseases of the genital tract has been the "Direct Preparation of the Gout" with a correct diagnosis in 60-70%, which consists of taking with a platinum handle two drops of vaginal discharge, the first one is placed on a slide or lamella and mixed with a drop of physiological serum covering it with a coverslip for observation under a microscope.
- the second drop is also placed on a slide to which a drop of 10% Potassium Hydroxide (KOH) is added, this sample approaches the doctor's nose so that the known amines test is carried out through smell also as a test of Whiff, if in thirty seconds approximately unpleasant odor amines have been released we are faced with an exaggerated growth of pathogenic germs.
- KOH Potassium Hydroxide
- the use of the microscope by means of the microscopic technique of "phase contrast" of the first lamella by means of objectives and condenser “Ph” of 10 and 40 magnifications respectively is a visualization method that allows us to quickly observe the pathogenic germs of the diseases, as well as the state of the genital epithelial cells, also looking for in each microscopic field the number of leukocytes.
- a third drop can be placed on a litmus paper to measure the PH (Acid-Basic) of the genital exudate.
- microscopy is that the gynecologist must be very familiar with what you are seeing and generally prefer to resort to other laboratory studies, resulting in not having the patients the appropriate treatment when not being applied at the same time of the query
- Infectious sexually transmitted diseases are those that are transmitted during sexual intercourse, these are usually asymptomatic and any sexually active person is at risk of acquiring them.
- pathogenic microorganisms that produce them, these can be: fungi that produce mycosis, bacteria, protozoa and viruses.
- Vaginosis is a pathological process that affects the vagina and is considered a syndrome due to alterations of the bacterial flora that results in physical-chemical changes of the vaginal secretions and in which the characteristics of the host and his sexual partner are involved. It is the current term that has been conferred is: a polymicrobial clinical syndrome that is characterized by presenting an abnormal vaginal secretion with, disturbances in the vaginal ecosystem with displacement of the lactobacillus by pathogenic microorganisms.
- Vaginosis and cervicitis continue to be the most common female genital tract disorder in women of reproductive age, having a high economic impact worldwide.
- the amines test or Whiff test the amines (trimethylamine, putrescine and cadaverine) are produced by the vaginal flora combined with pathogenic germs and are detected when the vaginal secretions are mixed with potassium hydroxide in a foil or carrier.
- the smell of amine recalls the fishy smell, this occurs when a drop of vaginal discharge is mixed with a drop of 10% potassium hydroxide. This smell is not produced in the absence of pathogenic germs.
- a sensor is a device that physically measures and detects an amount of something and converts it into a signal, which can be read by an observer or an instrument.
- the invention described and detailed in this document as well as its systems basically comprise an: electronic device that detects the presence and amount of amines (triethylamine, putrescine and cadaverine) that help the doctor determine an accurate diagnosis in the presence of genital tract infections female.
- amines triethylamine, putrescine and cadaverine
- This device also has the option of giving values with visual, numerical and auditory information to the presence and quantity of amines, it also contains a form of registration that facilitates the way of saving data for future research studies and patient history .
- the new portable electronic sensor is composed of several parts that structure your system. To understand we have: mechanical and electronic parts, structuring: I.- Mechanical Assembly:
- the cabinet that is the structure or skeleton, which contains and supports the electronic parts of the equipment, it may be made of bakelite, metal, rigid plastic, PBC or any other material for this purpose.
- the heating resistance fastener At the base of this structure we find the heating resistance fastener.
- the slide holder that enters and leaves the cabinet. Above is the sensor holder. Above this is the air passage regulator as well as the fan holder. In the upper part of the cabinet there are small holes that allow ventilation. Inside and on the sides there are the rails where the electronic circuits are placed. Also the space for the horn or buzzer and the spaces for the mini ammeter, digital numbers and the colored LEDs.
- the solar cells and rechargeable batteries are placed behind the structure. II.- Electronic set:
- the lamella is introduced into the equipment and is heated under induction, raising the temperature of the sample.
- the electronic nose generates the following responses: Numerical, visual and auditory supported by ammeter, LED display, buzzer and digital numbers.
- vaginal speculum can be removed or the gynecological examination can be continued if required.
- the result can be communicated to the patient in an easy and fast way. Description of team activities
- Air dispenser or air passage regulator
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Description
Sensor electrónico portátil para detección de aminas volátiles en la exploración del tracto genital femenino Portable electronic sensor for the detection of volatile amines in the exploration of the female genital tract
Sector de la técnica Technical sector
I. - Sector médico: a).- Dispositivos médicos, b).- Pruebas para diagnóstico para consultorio y de campo. I. - Medical sector: a) .- Medical devices, b) .- Diagnostic tests for office and field.
II. - Sector tecnológico: a).- Equipos sensoriales electrónicos, b).- Detectores de aminas volátiles, c).- Instrumentación médica. II. - Technology sector: a) .- Electronic sensory equipment, b) .- Volatile amines detectors, c) .- Medical instrumentation.
Estado de la técnica State of the art
A partir de la segunda mitad del siglo XIX, las tecnologías de la química, física y electrónica han dado lugar a una plétora de desarrollos científicos y tecnológicos para los diagnósticos y tratamientos médicos, dando como resultado nuevos dispositivos, con los que se ha podido investigar y comprender más la interacción de la instrumentación médica, química, física y electrónica con los tejidos biológicos pertenecientes al campo de la inmuno-histoquímica y patología, así, teniendo como blanco, como en nuestro caso, el estudio, diagnóstico y tratamiento del tracto genital femenino. From the second half of the nineteenth century, the technologies of chemistry, physics and electronics have given rise to a plethora of scientific and technological developments for diagnoses and medical treatments, resulting in new devices, with which it has been possible to investigate and understand more the interaction of medical, chemical, physical and electronic instrumentation with biological tissues belonging to the field of immuno-histochemistry and pathology, thus, having as a target, as in our case, the study, diagnosis and treatment of the genital tract female.
Dado que las enfermedades infecciosas y de trasmisión sexual actualmente se consideran emergentes, como consecuencia ha habido una creciente demanda para resolver las enfermedades del tracto genital de la mujer, dando lugar al desarrollo en los últimos veinte años de nuevos dispositivos médicos, tanto para el diagnóstico como para el tratamiento médico, sin embargo estos nuevos métodos tienen diferentes desventajas, entre ellos el alto costo económico que implica su uso, mismo que en países en vías de desarrollo es casi imposible estar al nivel tecnológico requerido. Since infectious and sexually transmitted diseases are currently considered emergent, as a consequence there has been a growing demand to resolve diseases of the genital tract of women, leading to the development in the last twenty years of new medical devices, both for diagnosis As for medical treatment, however, these new methods have different disadvantages, including the high economic cost involved in their use, even in developing countries it is almost impossible to be at the required technological level.
Como ejemplo de equipos y métodos de tecnología avanzada en países desarrollados para diagnóstico en el área de sensores podemos mencionar: La espectrometría de la movilidad de iones (Ion Mobility Spectrometer IMS) de aminas biogénicas, producto de los gérmenes patógenos del tracto genital, este mismo equipo gráfica y determina a estas aminas cualificándolas y cuantificándolas, el problema está en que se requiere alto entrenamiento y conocimiento para el personal que maneja el equipo. Un método que por decir así es económico para el diagnóstico de las enfermedades infecciosas del tracto genital, ha sido la "Preparación Directa de la Gota" con un diagnóstico correcto en un 60-70%, que consiste en tomar con una asa de platino dos gotas del flujo vaginal, la primera de ella se coloca en un portaobjeto o laminilla y se mezcla con una gota de suero fisiológico cubriéndola con un cubreobjeto para su observación al microscopio. La segunda gota se coloca también en un portaobjeto al cual se le agrega una gota de Hidróxido de Potasio (KOH) al 10%, ésta muestra se acerca a la nariz del médico para que por medio del olfato se realice la prueba de las aminas conocida también como prueba de Whiff, si en treinta segundos aproximadamente se han liberado aminas de olor desagradable nos encontramos ante un crecimiento exagerado de gérmenes patógenos. As an example of advanced technology equipment and methods in developed countries for diagnosis in the area of sensors we can mention: Ion Mobility Spectrometer IMS of biogenic amines, product of pathogenic germs of the genital tract, this same graphic equipment and determines these amines by qualifying and quantifying them, the problem is that high training and knowledge is required for the personnel that manages the equipment. A method that, so to speak, is economical for the diagnosis of infectious diseases of the genital tract, has been the "Direct Preparation of the Gout" with a correct diagnosis in 60-70%, which consists of taking with a platinum handle two drops of vaginal discharge, the first one is placed on a slide or lamella and mixed with a drop of physiological serum covering it with a coverslip for observation under a microscope. The second drop is also placed on a slide to which a drop of 10% Potassium Hydroxide (KOH) is added, this sample approaches the doctor's nose so that the known amines test is carried out through smell also as a test of Whiff, if in thirty seconds approximately unpleasant odor amines have been released we are faced with an exaggerated growth of pathogenic germs.
El uso del microscopio mediante la técnica microscópica de "contraste de fases" de la primera laminilla mediante objetivos y condensador "Ph" de 10 y de 40 aumentos respectivamente es un método de visualización que nos permite observar de una manera rápida los gérmenes patógenos de las enfermedades, así como el estado de las células del epitelio genital buscando además en cada campo microscópico el número de leucocitos. The use of the microscope by means of the microscopic technique of "phase contrast" of the first lamella by means of objectives and condenser "Ph" of 10 and 40 magnifications respectively is a visualization method that allows us to quickly observe the pathogenic germs of the diseases, as well as the state of the genital epithelial cells, also looking for in each microscopic field the number of leukocytes.
Una tercera gota se puede colocar en un papel tornasol para medir el PH (Acido- Básico) del exudado genital. A third drop can be placed on a litmus paper to measure the PH (Acid-Basic) of the genital exudate.
La desventaja de la microscopía es que el ginecólogo debe de estar muy familiarizado con lo que está viendo y generalmente prefiere recurrir a otros estudios de laboratorio, teniendo como consecuencia el no tener las pacientes el tratamiento oportuno al no ser aplicado éste en el mismo momento de la consulta. The disadvantage of microscopy is that the gynecologist must be very familiar with what you are seeing and generally prefer to resort to other laboratory studies, resulting in not having the patients the appropriate treatment when not being applied at the same time of the query
Antecedentes de la invención Background of the invention
Con la finalidad de la cabal comprensión del funcionamiento y los beneficios de este nuevo aparato, se describen primeramente los conceptos requeridos para ello. In order to fully understand the operation and benefits of this new device, the concepts required for it are described first.
Las enfermedades infecciosas de trasmisión sexual (STD) son aquellas que se trasmiten durante el intercurso sexual, éstas por lo general son asintomáticas y cualquier persona sexualmente activa está en riesgo de adquirirlas. Existen diversos tipos de microorganismos patógenos que las producen, éstos pueden ser: hongos productores de micosis, bacterias, protozoarios y virus. Infectious sexually transmitted diseases (STDs) are those that are transmitted during sexual intercourse, these are usually asymptomatic and any sexually active person is at risk of acquiring them. There are several types of pathogenic microorganisms that produce them, these can be: fungi that produce mycosis, bacteria, protozoa and viruses.
La vaginosis es un proceso patológico que afecta la vagina y se considera un síndrome por alteraciones de la flora bacteriana que se traduce en cambios físicoquímicos de las secreciones vaginales y en el que intervienen las características propias del hospedero y su pareja sexual. Es el término actual que se le ha conferido es: un síndrome clínico polimicrobiano que se caracteriza por presentar una secreción vaginal anormal con , disturbios en el ecosistema vaginal con desplazamiento del lactobacilo por microorganismos patógenos. Vaginosis is a pathological process that affects the vagina and is considered a syndrome due to alterations of the bacterial flora that results in physical-chemical changes of the vaginal secretions and in which the characteristics of the host and his sexual partner are involved. It is the current term that has been conferred is: a polymicrobial clinical syndrome that is characterized by presenting an abnormal vaginal secretion with, disturbances in the vaginal ecosystem with displacement of the lactobacillus by pathogenic microorganisms.
En una gran parte de los casos infectados, encontramos la combinación de múltiples patógenos. Las vaginosis y cervicitis continúan siendo el trastorno del tracto genital femenino más frecuente en las mujeres en edad reproductiva, teniendo a escala mundial un alto impacto económico. In a large part of the infected cases, we found the combination of multiple pathogens. Vaginosis and cervicitis continue to be the most common female genital tract disorder in women of reproductive age, having a high economic impact worldwide.
La prueba de aminas o prueba de Whiff, las aminas (trimetilamina, putrescina y cadaverina) son producidas por la flora vaginal combinada con gérmenes patógenos y se detectan cuando las secreciones vaginales se mezclan con hidróxido de potasio en una laminilla o porta- objetos. El olor de amina recuerda el olor a pescado, éste se produce cuando una gota de descarga vaginal se mezcla con una gota de hidróxido de potasio al 10%. No se produce este olor en ausencia de gérmenes patógenos. The amines test or Whiff test, the amines (trimethylamine, putrescine and cadaverine) are produced by the vaginal flora combined with pathogenic germs and are detected when the vaginal secretions are mixed with potassium hydroxide in a foil or carrier. The smell of amine recalls the fishy smell, this occurs when a drop of vaginal discharge is mixed with a drop of 10% potassium hydroxide. This smell is not produced in the absence of pathogenic germs.
La prueba de las aminas empleada sola, predice el diagnóstico de vaginosis en forma exacta en el 94% de las pacientes. The amines test used alone, predicts the diagnosis of vaginosis accurately in 94% of patients.
Un sensor es un dispositivo que mide y detecta físicamente una cantidad de algo y convierte ésta en una señal, misma que puede ser leída por un observador o un instrumento. A sensor is a device that physically measures and detects an amount of something and converts it into a signal, which can be read by an observer or an instrument.
Problemática Problematic
Frecuentemente no son diagnosticadas ni tratadas de manera fácil las enfermedades de etiología infecciosa del tracto genital femenino, por carecer en el ámbito del consultorio de un equipo y pruebas que faciliten de forma sencilla el diagnóstico de éstas, lo cual ocasiona que el ginecólogo tenga que recurrir a pruebas de laboratorio con amplio margen de error, o bien al uso de equipos sofisticados y de alto costo, que requieren de un largo tiempo de entrenamiento para sus usuarios, además que estos equipos están disponibles únicamente en los países industrializados, y no al alcance tecnológico en los países en vías de desarrollo por múltiples factores. Frequently, diseases of infectious etiology of the female genital tract are not diagnosed or treated easily, due to lack in the field of a team's office and tests that facilitate their diagnosis in a simple way, which causes the gynecologist to have to resort to laboratory tests with a wide margin of error, or to the use of sophisticated and high-cost equipment, which require of a long time of training for its users, in addition that these equipments are available only in the industrialized countries, and not to the technological reach in the developing countries by multiple factors.
También se mencionó anteriormente el uso del microscopio mediante la técnica de contraste de fases para la observación de la secreción vaginal, mas sin embargo son muy pocos o escasos los ginecólogos con entrenamiento en técnicas de microscopía (tales como contraste de fases, campo obscuro, contraste diferenciado, etc.), por lo que en la mayoría de los consultorios ginecológicos no existen microscopios. The use of the microscope was also mentioned previously by means of the phase contrast technique for the observation of vaginal secretion, but nevertheless there are very few or few gynecologists with training in microscopy techniques (such as phase contrast, dark field, contrast differentiated, etc.), so that in most gynecological offices there are no microscopes.
La Gran ayuda que nos brinda el exámen de prueba de las aminas es indudable, un bajo costo de la prueba con una alta precisión del diagnóstico, sin embargo existen errores debido a que queda a consideración del olfato del médico, y además de que en las pacientes al ver que el médico acerca a su nariz la muestra que obtuvo de su vagina causa una mala impresión y un malestar psicológico. Todo esto da por resultado en las pacientes, los consecuentes tiempos en espera de los resultados, múltiples consultas, tratamientos no adecuados, malestar psicológico y aumentando por ello los costos para las pacientes, cuando lo ideal es ver y tratar adecuadamente en una sola consulta. Hoy en día en el avance tecnológico de la robótica y electrónica es común ver que existen una gran gama de sensores electrónicos: alarmas de humo, sensores de distancia, sensores de presión y posición, sensores para varios tipos de gases como C02, CO, vapor de alcohol, etc. sin embargo éstos en la practica clínica aún no se han utilizado. The great help that the amines test test gives us is undoubtedly, a low cost of the test with a high precision of the diagnosis, however there are errors because it is considered by the doctor's smell, and in addition to the fact that patients to see that the doctor near his nose the sample he obtained from his vagina causes a bad impression and a psychological malaise. All this results in patients, the consequent waiting times for the results, multiple consultations, inappropriate treatments, psychological distress and therefore increasing costs for patients, when the ideal is to see and treat properly in a single consultation. Nowadays in the technological advancement of robotics and electronics it is common to see that there is a wide range of electronic sensors: smoke alarms, distance sensors, pressure and position sensors, sensors for various types of gases such as C02, CO, steam of alcohol, etc. however these in clinical practice have not yet been used.
Objetivo del presente invento Objective of the present invention
Con la finalidad de dar solución a la problemática mencionada, se ideó la creación de este nuevo invento: "Sensor electrónico portátil para detección de aminas volátiles en la exploración del tracto genital femenino", el cual sirve para realizar el diagnóstico temprano y brindar el tratamiento oportuno en las enfermedades de etiología infecciosa del tracto genital femenino, al ser adquirida por el médico la información requerida de la enfermedad en tiempo real, es decir es un instrumento con el imperativo de "Ver y tratar". In order to solve the aforementioned problem, the creation of this new invention was devised: "Portable electronic sensor for amines detection volatile in the exploration of the female genital tract, "which serves to make the early diagnosis and provide timely treatment in diseases of infectious etiology of the female genital tract, when the required information of the disease is acquired by the doctor in real time, that is to say, it is an instrument with the imperative of "See and treat".
Con el nuevo "Sensor electrónico portátil para detección de aminas volátiles en la exploración del tracto genital femenino" se evita realizar estudios costosos, maniobras molestas para la mujer que causan malestares sicológicos y procedimientos de largo tiempo para tener un resultado altamente confiable en cuanto a la detección y tratamiento de enfermedades de origen infeccioso del tracto genital femenino. With the new "Portable electronic sensor for the detection of volatile amines in the exploration of the female genital tract", costly studies, annoying maneuvers for women that cause psychological distress and long-term procedures are avoided to have a highly reliable result in terms of detection and treatment of diseases of infectious origin of the female genital tract.
Descripción del aparato Description of the equipment
La invención descrita y detallada en este documento así como sus sistemas conforman básicamente un: aparato electrónico que detecta la presencia y cantidad de aminas (trietilamina, putrescina y cadaverina) que ayudan al médico a determinar un diagnóstico preciso en la presencia de infecciones del tracto genital femenino. The invention described and detailed in this document as well as its systems basically comprise an: electronic device that detects the presence and amount of amines (triethylamine, putrescine and cadaverine) that help the doctor determine an accurate diagnosis in the presence of genital tract infections female.
Este aparato también cuenta con la opción de dar valores con información visual, numérica y auditiva a la presencia y cantidad de aminas, al igual contiene una forma de registro que facilita la forma de guardado de datos para futuros estudios de investigación e historial de las pacientes. This device also has the option of giving values with visual, numerical and auditory information to the presence and quantity of amines, it also contains a form of registration that facilitates the way of saving data for future research studies and patient history .
Esta detección es ayudada con sensores y con pantallas de LEDs que determinar con código de colores la presencia de aminas exuberante o pobre. La prueba de las aminas por si sola ha demostrado una exactitud en diagnóstico con un 94% lo que induce que este aparato cubrirá con esa precisión pero a su vez reducción en costos, tiempos y autonomía para el médico que lo utilice. This detection is helped with sensors and LED screens that determine with color coding the presence of exuberant or poor amines. The test of the amines alone has demonstrated an accuracy in diagnosis with 94% which induces that this device will cover with that precision but in turn reduction in costs, times and autonomy for the doctor who uses it.
La reducción en costos, tiempos y autonomía radican en que gracias a la posibilidad de diagnóstico con la nariz electrónica los médicos ya no tienen que esperar el resultado de laboratorio, la pruebas de las aminas en combinación con esta nariz electrónica podrá estar al alcance económico de diversos medios y países, mejorando la precisión del médico en su diagnóstico. The reduction in costs, times and autonomy lies in the fact that thanks to the possibility of diagnosis with the electronic nose, doctors no longer have to wait for the laboratory result, the tests of the amines in combination with this nose electronics may be affordable for various media and countries, improving the accuracy of the doctor in his diagnosis.
Conjuntos de partes en el Sensor electrónico portátil Parts assemblies in the Portable Electronic Sensor
El nuevo Sensor electrónico portátil está integrado por varias partes que estructuran su sistema. Para entender tenemos: partes mecánicas y electrónicas, estructurando: I.- Conjunto Mecánico: The new portable electronic sensor is composed of several parts that structure your system. To understand we have: mechanical and electronic parts, structuring: I.- Mechanical Assembly:
Constituido primeramente por el gabinete que es la estructura o esqueleto, que contiene y sirve de soporte a las partes electrónicas del equipo, éste podrá ser de bakelita, metal, plástico rígido, PBC o cualquier otro material para este fin. En la base de esta estructura encontramos el sujetador de la resistencia calefactor. Firstly constituted by the cabinet that is the structure or skeleton, which contains and supports the electronic parts of the equipment, it may be made of bakelite, metal, rigid plastic, PBC or any other material for this purpose. At the base of this structure we find the heating resistance fastener.
Continuando con el porta laminilla que entra y sale del gabinete. Más arriba está el sujetador del sensor. Por arriba de éste se encuentra el regulador del paso de aire así como el sujetador del ventilador. En la parte superior del gabinete se encuentran pequeños orificios que permiten la ventilación. Por adentro y en los costados existen los rieles donde se colocan los circuitos electrónicos. También el espacio para la bocina o buzzer y los espacios para el mini amperímetro, números digitales y los LEDs de colores. Continuing with the slide holder that enters and leaves the cabinet. Above is the sensor holder. Above this is the air passage regulator as well as the fan holder. In the upper part of the cabinet there are small holes that allow ventilation. Inside and on the sides there are the rails where the electronic circuits are placed. Also the space for the horn or buzzer and the spaces for the mini ammeter, digital numbers and the colored LEDs.
Detrás de la estructura se colocan las Celdas solares y baterías recargables. II.- Conjunto electrónico: The solar cells and rechargeable batteries are placed behind the structure. II.- Electronic set:
Está constituido básicamente por: resistencia térmica, sensor(es), ventilador, circuitos electrónicos, amperímetro, buzzer o zumbador, memoria(s), LEDs de colores, baterías, números digitales, celdas solares e interruptores. Funcionamiento y manejo del Sensor electrónico portátil para detección de aminas volátiles en la exploración del tracto genital femenino It consists basically of: thermal resistance, sensor (s), fan, electronic circuits, ammeter, buzzer or buzzer, memory (s), colored LEDs, batteries, digital numbers, solar cells and switches. Operation and operation of the portable electronic sensor for the detection of volatile amines in the exploration of the female genital tract
El manejo que mostramos a continuación cuando se realiza en la práctica no es restrictivo ya que no es ejemplo limitativo en el uso del aparato, ya que este instrumento está diseñado para múltiples aplicaciones en el presente y a futuro dentro del área médica. The handling that we show below when performed in practice is not restrictive since it is not a limiting example in the use of the device, since this instrument is designed for multiple applications at present and in the future within the medical area.
Procedimiento Process
• Colocar cómodamente a la paciente en posición ginecológica. La duración del estudio es de 10 al 5 minutos. • Comfortably place the patient in gynecological position. The duration of the study is 10 to 5 minutes.
• Introducir un espéculo vaginal. • Introduce a vaginal speculum.
• Se toma la muestra de nuestra paciente. • The sample of our patient is taken.
• Esta se coloca en la laminilla de la nariz electrónica, se le agrega una gota de KOH al 10%. • This is placed in the electronic nose foil, a drop of 10% KOH is added.
• El regulador del paso de aire del equipo es cerrado. • The device air passage regulator is closed.
• La laminilla se introduce en el equipo y es calentada bajo inducción, elevando la temperatura de la muestra. • The lamella is introduced into the equipment and is heated under induction, raising the temperature of the sample.
• El sensor capta las partículas y las cuantifica. • The sensor captures the particles and quantifies them.
• Esta información es transmitida a un sistema electrónico que determina bajo criterio la gravedad de la infección de la muestra. • This information is transmitted to an electronic system that determines under criteria the severity of the sample infection.
• De acuerdo a la gravedad de la infección y al criterio la nariz electrónica genera la siguientes respuestas: Numérica, visual y auditiva apoyada de amperímetro, pantalla de LEDs, buzzer y números digitales. • According to the severity of the infection and the criteria, the electronic nose generates the following responses: Numerical, visual and auditory supported by ammeter, LED display, buzzer and digital numbers.
• Al terminar el equipo da dos pitidos mostrando que ha terminado de examinar el resultado y el dosificador de aire del equipo se abre. • When the equipment is finished it gives two beeps, showing that it has finished examining the result and the equipment's air dispenser opens.
• Al terminar el examinado de la muestra el ventilador es activado y por dosificador de aire, el limpiado de partículas toma lugar dando también frescura al sistema por dentro, quedando listo para la siguiente muestra a examinar. • At the end of the examination of the sample, the fan is activated and by air dispenser, the cleaning of particles takes place giving also freshness to the system inside, being ready for the next sample to examine.
• En este momento se puede retirar el espéculo vaginal o bien continuar con la exploración ginecológica si así lo requiere. • At this time the vaginal speculum can be removed or the gynecological examination can be continued if required.
De una manera fácil y rápida se le puede comunicar a la paciente su resultado. Descripción de actividades del equipo The result can be communicated to the patient in an easy and fast way. Description of team activities
• Interacción de la muestra-sensor. • Sample-sensor interaction.
• Transmisión de datos en forma Analógica y Digital. • Data transmission in Analog and Digital form.
· Resultado de los datos en forma digital: Numérica, visual y auditiva. · Result of the data in digital form: Numerical, visual and auditory.
• Limpieza del equipo de partículas por la ventilación. • Cleaning of particulate equipment by ventilation.
• Y nuevamente al primer paso. • And again to the first step.
Descripción de la figura Description of the figure
Partes: Parts:
1. - Dosificador de aire (o regulador del paso de aire) 1. - Air dispenser (or air passage regulator)
2. - Ventilador 2. - Fan
3.- Números digitales 3.- Digital numbers
4. - Celdas solares 4. - Solar cells
5. - Pantalla de LEDs (intensidad) 5. - LED display (intensity)
6. - Batería recargable 6. - Rechargeable battery
7. - Descanso de la laminilla 7. - Lamella rest
8.- Sistema de inducción de calor de la laminilla 8.- Lamella heat induction system
9. - Amperímetro 9. - Ammeter
10. - Sensor 10. - Sensor
11. - Memoria y sistema de software 11. - Memory and software system
12. - Bocina 12. - Horn
13-Cámara de vapores de la laminilla 13-Lamella vapors chamber
Claims
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2014009852A MX380607B (en) | 2012-04-19 | 2012-04-19 | PORTABLE ELECTRONIC SENSOR FOR DETECTION OF VOLATILE AMINES IN THE EXAMINATION OF THE FEMALE GENITAL TRACT. |
| PCT/MX2012/000041 WO2013157910A1 (en) | 2012-04-19 | 2012-04-19 | Portable electronic sensor for detecting volatile amines in the exploration of the female genital tract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2012/000041 WO2013157910A1 (en) | 2012-04-19 | 2012-04-19 | Portable electronic sensor for detecting volatile amines in the exploration of the female genital tract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013157910A1 true WO2013157910A1 (en) | 2013-10-24 |
Family
ID=49383779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/MX2012/000041 Ceased WO2013157910A1 (en) | 2012-04-19 | 2012-04-19 | Portable electronic sensor for detecting volatile amines in the exploration of the female genital tract |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2013157910A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575920A (en) * | 2013-11-14 | 2014-02-12 | 宋筱亮 | Full-automatic genital tract infection detection system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998161A (en) * | 1998-09-28 | 1999-12-07 | Caillouette; James C. | Amine detection by color change, in human body moisture |
| WO2000042427A1 (en) * | 1999-01-14 | 2000-07-20 | Extraction Systems, Inc. | Detection of base contaminants in gas samples |
| US20050150778A1 (en) * | 2002-11-18 | 2005-07-14 | Lewis Nathan S. | Use of basic polymers in carbon black composite vapor detectors to obtain enhanced sensitivity and classification performance for volatile fatty acids |
| EP1419266B1 (en) * | 2001-08-17 | 2008-01-16 | Osmetech PLC | Detection of bacterial vaginosis |
| WO2012006546A2 (en) * | 2010-07-08 | 2012-01-12 | The Johns Hopkins University | Circuits, devices and sensors for fluid detection |
-
2012
- 2012-04-19 WO PCT/MX2012/000041 patent/WO2013157910A1/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998161A (en) * | 1998-09-28 | 1999-12-07 | Caillouette; James C. | Amine detection by color change, in human body moisture |
| WO2000042427A1 (en) * | 1999-01-14 | 2000-07-20 | Extraction Systems, Inc. | Detection of base contaminants in gas samples |
| EP1419266B1 (en) * | 2001-08-17 | 2008-01-16 | Osmetech PLC | Detection of bacterial vaginosis |
| US20050150778A1 (en) * | 2002-11-18 | 2005-07-14 | Lewis Nathan S. | Use of basic polymers in carbon black composite vapor detectors to obtain enhanced sensitivity and classification performance for volatile fatty acids |
| WO2012006546A2 (en) * | 2010-07-08 | 2012-01-12 | The Johns Hopkins University | Circuits, devices and sensors for fluid detection |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575920A (en) * | 2013-11-14 | 2014-02-12 | 宋筱亮 | Full-automatic genital tract infection detection system |
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