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WO2013150406A3 - Siphonochilone and related compounds and uses thereof - Google Patents

Siphonochilone and related compounds and uses thereof Download PDF

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Publication number
WO2013150406A3
WO2013150406A3 PCT/IB2013/052215 IB2013052215W WO2013150406A3 WO 2013150406 A3 WO2013150406 A3 WO 2013150406A3 IB 2013052215 W IB2013052215 W IB 2013052215W WO 2013150406 A3 WO2013150406 A3 WO 2013150406A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
relates
siphonochilone
amelioration
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/052215
Other languages
French (fr)
Other versions
WO2013150406A2 (en
Inventor
Nigel Peter Gericke
Olga Maria GERICKE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INTEGRAL BIOCEUTICALS Pty Ltd
Original Assignee
INTEGRAL BIOCEUTICALS Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INTEGRAL BIOCEUTICALS Pty Ltd filed Critical INTEGRAL BIOCEUTICALS Pty Ltd
Publication of WO2013150406A2 publication Critical patent/WO2013150406A2/en
Publication of WO2013150406A3 publication Critical patent/WO2013150406A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

This invention relates to the compound (4aαH-3,5α,8aß-trimethyl-4a,9-tetrahydro- naphtho[2,3-b]-furan-8-one) known as siphonochilone, and related compounds, useful in mammals in supporting, promoting and maintaining health, and in the amelioration, prevention and treatment of central nervous system (CNS) disorders or conditions, unit dosages forms containing the compounds, delivery systems for the compounds, and methods for preparing the compounds. More specifically, it relates to plant extracts containing the compounds and uses thereof for the support, promotion and maintenance of health and the amelioration, prevention and treatment of such disorders or conditions. The invention also relates to methods of preparing a plant extract containing the compounds.
PCT/IB2013/052215 2012-04-04 2013-03-20 Siphonochilone and related compounds and uses thereof Ceased WO2013150406A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA201202478 2012-04-04
ZA2012/02478 2012-04-04

Publications (2)

Publication Number Publication Date
WO2013150406A2 WO2013150406A2 (en) 2013-10-10
WO2013150406A3 true WO2013150406A3 (en) 2013-12-05

Family

ID=48428533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/052215 Ceased WO2013150406A2 (en) 2012-04-04 2013-03-20 Siphonochilone and related compounds and uses thereof

Country Status (1)

Country Link
WO (1) WO2013150406A2 (en)

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US20160345631A1 (en) 2005-07-19 2016-12-01 James Monsees Portable devices for generating an inhalable vapor
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
KR102256888B1 (en) 2013-12-23 2021-05-31 쥴 랩스, 인크. Vaporization device systems and methods
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
EP3821735B1 (en) 2014-12-05 2024-11-20 Juul Labs, Inc. Calibrated dose control
CN104800381A (en) * 2015-04-11 2015-07-29 陈彬 Traditional Chinese medicine composition for treating damp-heat and toxin-stasis type stomach cancer and preparation method of traditional Chinese medicine composition
EP3419443A4 (en) 2016-02-11 2019-11-20 Juul Labs, Inc. CARTRIDGES SECURELY FIXED FOR VAPORIZATION DEVICES
MX377347B (en) 2016-02-11 2025-03-07 Juul Labs Inc Fillable vaporizer cartridge and method of filling
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
TWI674894B (en) * 2016-09-23 2019-10-21 大江生醫股份有限公司 Medicament for treating melanoma and uses of the same
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
CN107823527A (en) * 2017-12-06 2018-03-23 韦永朴 A kind of Chinese medicine composition for treating nervous vomiting and preparation method thereof
CN117337188A (en) * 2021-05-21 2024-01-02 三得利控股株式会社 Method for preparing rhizoma Alpiniae Officinarum extract containing 1' -acetoxychavicol acetate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113698A2 (en) * 2006-03-03 2007-10-11 Csir Preventative treatment and remission of allergic diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113698A2 (en) * 2006-03-03 2007-10-11 Csir Preventative treatment and remission of allergic diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"AFRICAN GINGER", 17 September 2011 (2011-09-17), XP002698612, Retrieved from the Internet <URL:http://web.archive.org/web/20110917220651/http://www.bigtreehealth.com/product-information-africanginger.php> [retrieved on 20130611] *
HOLZAPFEL C W ET AL: "Furanoterpenoids from Siphonochilus aethiopicus", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 59, no. 4, 1 February 2002 (2002-02-01), pages 405 - 407, XP004335041, ISSN: 0031-9422, DOI: 10.1016/S0031-9422(01)00402-2 *
MANZINI: "Production of Wild Ginger (Siphonochilus Aethiopicus) Under Protection and Indigenous Knowledge of the Plant from Traditiona Healers", 2005, XP002698611, Retrieved from the Internet <URL:upetd.up.ac.za/thesis/available/etd-02092006.../00dissertation.pdf> [retrieved on 20130611] *
SOBIECKI: "A review of plants used in divination in souther Africa and ther psychoactive effects", SOUTH AFRICAN HUMANITIES, vol. 20, December 2008 (2008-12-01), pages 333 - 351, XP002698616 *
VILJOEN A M ET AL: "The essential oil composition of the roots and rhizomes of Siphonochilus aethiopicus", SOUTH AFRICAN JOURNAL OF BOTANY - SUID-AFRIKAANS TYDSKRIFT VIRPLANTKUNDE, FOUNDATION FOR EDUCATION, SCIENCE AND TECHNOLOGY, PRETORIA, SA, vol. 68, no. 1, 1 January 2002 (2002-01-01), pages 115 - 116, XP009091476, ISSN: 0254-6299 *

Also Published As

Publication number Publication date
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