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WO2013037889A3 - Vaccine - Google Patents

Vaccine Download PDF

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Publication number
WO2013037889A3
WO2013037889A3 PCT/EP2012/067950 EP2012067950W WO2013037889A3 WO 2013037889 A3 WO2013037889 A3 WO 2013037889A3 EP 2012067950 W EP2012067950 W EP 2012067950W WO 2013037889 A3 WO2013037889 A3 WO 2013037889A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
pcsk9
amino acid
acid residues
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/067950
Other languages
French (fr)
Other versions
WO2013037889A2 (en
Inventor
Sylvia Brunner
Gergana Galabova
Bettina Wanko
Markus Windwarder
Gabriele Winsauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affiris AG
Original Assignee
Affiris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020147009735A priority Critical patent/KR101983685B1/en
Priority to CN201280044571.4A priority patent/CN103874504B/en
Priority to JP2014530217A priority patent/JP6054400B2/en
Priority to SG11201400086QA priority patent/SG11201400086QA/en
Priority to EP12759427.3A priority patent/EP2755678B1/en
Priority to US14/344,879 priority patent/US9220762B2/en
Priority to BR112014005756A priority patent/BR112014005756A2/en
Priority to RU2014114506A priority patent/RU2640258C2/en
Priority to SI201230903A priority patent/SI2755678T1/en
Priority to MX2014002879A priority patent/MX346883B/en
Priority to LTEP12759427.3T priority patent/LT2755678T/en
Priority to HRP20170328TT priority patent/HRP20170328T1/en
Priority to NZ621439A priority patent/NZ621439B2/en
Priority to DK12759427.3T priority patent/DK2755678T3/en
Application filed by Affiris AG filed Critical Affiris AG
Priority to CA2848487A priority patent/CA2848487A1/en
Priority to AU2012307348A priority patent/AU2012307348B8/en
Priority to ES12759427.3T priority patent/ES2618796T3/en
Publication of WO2013037889A2 publication Critical patent/WO2013037889A2/en
Publication of WO2013037889A3 publication Critical patent/WO2013037889A3/en
Priority to IL231043A priority patent/IL231043A/en
Anticipated expiration legal-status Critical
Priority to US14/921,485 priority patent/US9669079B2/en
Priority to CY20171100333T priority patent/CY1118856T1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a vaccine comprising at least two fragments of Proprotein convertase subtilisin/kexin type 9 (PCSK9), wherein said at least two fragments comprise at least 8 consecutive amino acid residues of amino acid residues 150 to 170 and 205 to 225 of PCSK9 (SEQ ID No. 9).
PCT/EP2012/067950 2011-09-13 2012-09-13 Vaccine Ceased WO2013037889A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
NZ621439A NZ621439B2 (en) 2011-09-13 2012-09-13 Vaccine
JP2014530217A JP6054400B2 (en) 2011-09-13 2012-09-13 vaccine
SG11201400086QA SG11201400086QA (en) 2011-09-13 2012-09-13 Vaccine
EP12759427.3A EP2755678B1 (en) 2011-09-13 2012-09-13 Pcsk9 vaccine
US14/344,879 US9220762B2 (en) 2011-09-13 2012-09-13 PCSK9 peptide combination vaccine and method of use
BR112014005756A BR112014005756A2 (en) 2011-09-13 2012-09-13 vaccine
RU2014114506A RU2640258C2 (en) 2011-09-13 2012-09-13 Vaccine
SI201230903A SI2755678T1 (en) 2011-09-13 2012-09-13 Pcsk9 vaccine
CN201280044571.4A CN103874504B (en) 2011-09-13 2012-09-13 Vaccine
LTEP12759427.3T LT2755678T (en) 2011-09-13 2012-09-13 Pcsk9 vaccine
HRP20170328TT HRP20170328T1 (en) 2011-09-13 2012-09-13 PCSK9 vaccine
KR1020147009735A KR101983685B1 (en) 2011-09-13 2012-09-13 Vaccine
MX2014002879A MX346883B (en) 2011-09-13 2012-09-13 Vaccine.
DK12759427.3T DK2755678T3 (en) 2011-09-13 2012-09-13 PCSK9-VACCINE
CA2848487A CA2848487A1 (en) 2011-09-13 2012-09-13 Vaccine
AU2012307348A AU2012307348B8 (en) 2011-09-13 2012-09-13 Vaccine
ES12759427.3T ES2618796T3 (en) 2011-09-13 2012-09-13 PCSK9 vaccine
IL231043A IL231043A (en) 2011-09-13 2014-02-19 Vaccine
US14/921,485 US9669079B2 (en) 2011-09-13 2015-10-23 PCSK9 peptide combination vaccine and method of use
CY20171100333T CY1118856T1 (en) 2011-09-13 2017-03-16 Vaccine PCSK9

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11181090.9A EP2570135B1 (en) 2011-09-13 2011-09-13 PCSK9 Vaccine
EP11181090.9 2011-09-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/344,879 A-371-Of-International US9220762B2 (en) 2011-09-13 2012-09-13 PCSK9 peptide combination vaccine and method of use
US14/921,485 Division US9669079B2 (en) 2011-09-13 2015-10-23 PCSK9 peptide combination vaccine and method of use

Publications (2)

Publication Number Publication Date
WO2013037889A2 WO2013037889A2 (en) 2013-03-21
WO2013037889A3 true WO2013037889A3 (en) 2013-05-10

Family

ID=46851983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/067950 Ceased WO2013037889A2 (en) 2011-09-13 2012-09-13 Vaccine

Country Status (24)

Country Link
US (2) US9220762B2 (en)
EP (2) EP2570135B1 (en)
JP (1) JP6054400B2 (en)
KR (1) KR101983685B1 (en)
CN (1) CN103874504B (en)
AU (1) AU2012307348B8 (en)
BR (1) BR112014005756A2 (en)
CA (1) CA2848487A1 (en)
CY (2) CY1117335T1 (en)
DK (2) DK2570135T3 (en)
ES (2) ES2565757T3 (en)
HR (2) HRP20170328T1 (en)
HU (2) HUE028583T2 (en)
IL (1) IL231043A (en)
LT (1) LT2755678T (en)
MX (1) MX346883B (en)
PL (2) PL2570135T3 (en)
PT (1) PT2755678T (en)
RS (1) RS54639B1 (en)
RU (2) RU2017139094A (en)
SG (1) SG11201400086QA (en)
SI (2) SI2570135T1 (en)
SM (1) SMT201600082B (en)
WO (1) WO2013037889A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
EP2703483A1 (en) 2012-08-29 2014-03-05 Affiris AG PCSK9 peptide vaccine
WO2015123291A1 (en) * 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
EP3110439B1 (en) * 2014-02-28 2019-03-27 Affiris AG Pcsk9 vaccines
CN105085684B (en) * 2014-05-14 2020-04-17 上海亨臻实业有限公司 Design and application of PCSK9 targeted recombinant vaccine
CN106822881A (en) * 2016-12-09 2017-06-13 四川大学 A kind of hyperlipoproteinemia vaccine for PCSK9
BR112019020148A2 (en) 2017-04-13 2020-05-05 Cadila Healthcare Ltd peptide
CN107488215A (en) * 2017-07-19 2017-12-19 邱志华 The immunogenicity peptide fragment of people's proprotein convertases subtilisin 9 and its carrier bacterin
WO2021154947A1 (en) * 2020-01-28 2021-08-05 Ubi Ip Holdings Peptide immunogens targeting pcsk9 and formulations thereof for prevention and treatment of pcsk9-mediated disorders
KR20210158693A (en) * 2020-06-24 2021-12-31 바이오스트림테크놀러지스(주) Anti pcsk9 antibody and use thereof
JPWO2022244845A1 (en) * 2021-05-19 2022-11-24
US20250186595A1 (en) 2022-02-28 2025-06-12 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100297A1 (en) * 2008-02-07 2009-08-13 Merck & Co., Inc. 1d05 pcsk9 antagonists
WO2010057242A2 (en) * 2008-11-19 2010-05-27 Affiris Ag Vaccine
WO2011027257A2 (en) * 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ572666A (en) * 2006-05-11 2010-11-26 Alnylam Pharmaceuticals Inc Compositions comprising double stranded rna and methods for inhibiting expression of the pcsk9 gene
WO2008125623A2 (en) * 2007-04-13 2008-10-23 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100297A1 (en) * 2008-02-07 2009-08-13 Merck & Co., Inc. 1d05 pcsk9 antagonists
WO2010057242A2 (en) * 2008-11-19 2010-05-27 Affiris Ag Vaccine
WO2011027257A2 (en) * 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine

Also Published As

Publication number Publication date
EP2570135A1 (en) 2013-03-20
EP2755678B1 (en) 2016-12-21
PL2755678T3 (en) 2017-08-31
SG11201400086QA (en) 2014-03-28
IL231043A (en) 2017-05-29
US9220762B2 (en) 2015-12-29
HRP20170328T1 (en) 2017-05-19
HUE031860T2 (en) 2017-08-28
CN103874504B (en) 2017-05-31
RU2017139094A (en) 2019-02-12
RU2017139094A3 (en) 2019-02-12
MX346883B (en) 2017-04-05
SI2755678T1 (en) 2017-04-26
IL231043A0 (en) 2014-03-31
AU2012307348B8 (en) 2017-04-06
CA2848487A1 (en) 2013-03-21
AU2012307348A8 (en) 2017-04-06
KR20140067118A (en) 2014-06-03
CY1117335T1 (en) 2017-04-26
CY1118856T1 (en) 2018-01-10
EP2755678A2 (en) 2014-07-23
RS54639B1 (en) 2016-08-31
RU2014114506A (en) 2015-10-20
AU2012307348A1 (en) 2014-03-20
NZ621439A (en) 2015-06-26
PT2755678T (en) 2017-03-24
LT2755678T (en) 2017-03-27
DK2570135T3 (en) 2016-02-15
US9669079B2 (en) 2017-06-06
AU2012307348B2 (en) 2017-03-02
US20160106822A1 (en) 2016-04-21
CN103874504A (en) 2014-06-18
JP6054400B2 (en) 2016-12-27
ES2618796T3 (en) 2017-06-22
HUE028583T2 (en) 2016-12-28
RU2640258C2 (en) 2017-12-27
US20150071951A1 (en) 2015-03-12
HRP20160392T1 (en) 2016-05-06
EP2570135B1 (en) 2016-01-27
SI2570135T1 (en) 2016-05-31
KR101983685B1 (en) 2019-05-29
PL2570135T3 (en) 2016-07-29
WO2013037889A2 (en) 2013-03-21
ES2565757T3 (en) 2016-04-06
BR112014005756A2 (en) 2017-03-28
SMT201600082B (en) 2016-04-29
MX2014002879A (en) 2014-04-10
DK2755678T3 (en) 2017-03-13
JP2014527078A (en) 2014-10-09

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