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WO2013030635A2 - Compositions pour des périodes prolongées d'hydratation de la peau - Google Patents

Compositions pour des périodes prolongées d'hydratation de la peau Download PDF

Info

Publication number
WO2013030635A2
WO2013030635A2 PCT/IB2012/001080 IB2012001080W WO2013030635A2 WO 2013030635 A2 WO2013030635 A2 WO 2013030635A2 IB 2012001080 W IB2012001080 W IB 2012001080W WO 2013030635 A2 WO2013030635 A2 WO 2013030635A2
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
skin
upto
coconut oil
emulsifiers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2012/001080
Other languages
English (en)
Other versions
WO2013030635A3 (fr
Inventor
Avani MAINKAR
Agarwal NIDHI
Manisha KHARKAR
Sudhakar MHASKAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARICO Ltd
Original Assignee
MARICO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARICO Ltd filed Critical MARICO Ltd
Publication of WO2013030635A2 publication Critical patent/WO2013030635A2/fr
Publication of WO2013030635A3 publication Critical patent/WO2013030635A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the invention relates to coconut oil containing compositions for moisturisation of the skin for extended periods.
  • the climatic conditions in tropical countries, particularly in the Asian and African continent cause conditions of dry skin wherein the level of moisture falls below 10%, leading to extensive use of skin conditioning agents.
  • the challenge lies in providing compositions the enable the retention of moisture in the skin for extended periods. If water is lost more rapid than it is received from the lower layers of the epidermis, the skin becomes dehydrated and loses flexibility. Moisturising skin to enabling the restoration of water in skin is addressed in three ways namely occlusion, humectancy and restoration of deficient materials to the skin. Petroleum based formulations have been most popular.
  • compositions also contain mineral oil or vegetable oils, actives like glycerine, propylene glycol, urea, NMFs or lipids like ceramides or amino acids like glycine.
  • Moisturisation provided by such formulations either have relatively short retention periods, making frequent multiple applications of the product an essential feature or need a combination of multiple moisturizing agents to achieve the desired retention effects.
  • EP2051691 discloses skin treatment composition containing: a) 0. 1 to 10 % by weight of a mixture consisting of: a: 1) 10 to 80 % by weight of a mixture of at least two ceramides with the provison that at least one of these ceramides contains a long alkyl, alkenyl or acyl side chain with 20 to 26 carbon atoms and that less than 40 % by weight has a side chain larger than 26 carbon atoms; a:2) 10 to 45 % by weight of cholesterol; a:3) 10 to 45 % by weight of free fatty acids with C 12 to C30 alkyl-, alkenyl, alkadienyl, alkatrienyl or alkapolyenyl chains or combinations thereof; b) 0.5 to 10 % by weight of a nonionic emulsifier or a nonionic emulsifier mixture with a combined HLB value of 12 to 19; c) > 40 % by weight of water and optionally; d) 0.1
  • US patent no 5578312 describes a skin care system that incorporates mixture of water, dried herbs, leaves, fruits, roots and or flowers, plant extracts and oil with non irritating lipids, binders, surfactants, emulsifiers and preservatives.
  • US patent no 4235889 describes a pharmaceutical composition consisting of palm kernel oil, coconut oil, extract of Laurus nobilis and an emulsifier for the treatment of skin conditions like Psoriasis, Tinea and eczema.
  • the composition have 30-50% by weight of coconut oil, 30-50% by weight of palm kernel oil, 5- 15 percent by weight of an extract of Laurus nobilis and 5- 15% by weight of an emulsifier.
  • US patent application no 2010/0021563 relates to natural and homeopathic compositions comprising coconut oil as an active agent and atleast one additional active agent having homeopathic, medicinal, pharmaceutical and cosmetic properties. It further describes composition containing 40-80% by weight of unrefined coconut oil, 20-60% of cosmetic grade shea butter, optionally containing other pharmaceutically or cosmetically acceptable adjuvants.
  • Compositions described in prior art disclose compositions in which coconut oil has been used in fairly high quantities of in combination with other oils and agents to achieve moisturizing benefits. The use of high amounts of coconut oil makes the product sticky and sensorially unacceptable to consumers. We have surprisingly found that it is possible to achieve sensorially superior moisturing benefit over extended periods despite the use of relatively low levels of coconut oil singly in combination with excipients and without the use of additional moisturizing agents.
  • the main object of the invention is to provide coconut oil containing compositions for extended periods of skin moisturization. Another object of the invention is to provide such coconut oil containing compositions wherein the percentage of coconut oil does not exceed 30 % exhibiting the desired extended period of moisture retention by the skin.
  • Another object of the invention is to provide such compositions that are non sticky with high sensorial acceptability.
  • Another object of the invention is to provide the said compositions without the use of commonly used emollient oils such as liquid paraffin.
  • Another object of the invention is to provide compositions that provide superior moisturisation in a short time
  • Another object of the invention is to provide the said compositions to retain moisture in the skin for extended periods thereby reducing the frequency of application.
  • the present composition comprise an emulsion with upto 30% of coconut oil as a single active, excipients like emulsifiers, surfactants, water and fragrance.
  • compositions of the present invention are prepared by process comprising steps:
  • the process comprises:
  • step i) and ii) are upto 70°C where as the heating in step iv) is carried upto 50 °C
  • Emulsifiers in the compositions at 0.5 to 5.0% are selected from polyetheylene glycol stearyl ethers, addition products of ethylene oxide and/or propylene oxide, and linear fatty alcohols having 8 to 22 carbon atoms or fatty acids having 12 to 22 carbon atoms, glycerol mono- and diesters of saturated fatty acids having 6 to 22 carbon atoms and ethylene oxide addition products.
  • Structurants in the composition at 0.1 to 10.0% are selected from fatty alcohols, stabilizing polymers and thickeners
  • the thickening agent is selected from carbomer, acrylic acid polymers which may be homopolymers, copolymers and cross-polymers, cross linked polyacrylic acid salts, cross linked acrylic copolymers, carboxymethyl cellulose, carboxy vinyl polymers, Hydroxy ethyl cellulose, Hydroxy propyl cellulose, methyl cellulose, Xanthan gum, Carrageenan, Alginic acid salts, Pectin , Gum Arabic, Gatch gum, Karaya gum, Tragacanth gum, Agar powder, Bentonite.
  • the preferred thickeners are Carbomer, Cross linked acrylic coplymers and Xanthan gum.
  • sensory modifiers are preferably used.
  • the sensory modifiers are selected from esters (e.g. Isopropyl Myristate, Isopropyl Palmitate, Heptyl undecylenate, Neopentyl glycol Dihetanoate), ester ethers such as fatty acid esters of ethoxylated fatty alcohols, Silicones (eg. Cyclomethicone, Dimethicone etc).
  • the present invention results in a sensorially superior product using coconut oil as a single moisturizing agent in fairly low quantities.
  • These compositions enable the use of a single active to provide desired moisturizer levels and eliminates additional costs and unwarranted use of undesirable synthetic moisturizing actives.
  • the invention is illustrated by non-limiting examples.
  • Example 1 Composition with 7% coconut oil
  • Example 2 Composition with 3% coconut oil
  • Example 3 Composition with liquid paraffin.
  • compositions described above were tested on healthy human volunteers to access the extended skin moisture retention. Healthy human volunteers with visibly dry skin were recruited for the tests. Volunteers were made to wash their arms with surfactant solution and acclimatized in a temperature and humidity controlled chamber for 30 minutes. Trans-epidermal water loss (TEWL) was used as an indicator of any disruption in the barrier properties of the skin. Higher the TEWL, more is the compromise in the barrier properties causing dryness of the skin.
  • TEWL Trans-epidermal water loss
  • phase 1 of the test protocol TEWL was measured at the start of the test ("time 0") for each volunteer. This was taken as the baseline. Then a specified amount of the formulation 1 and formulation 2 was applied on one forearm of each volunteer. Formulation 3 was applied on the other forearm of each volunteer. The applications were repeated twice daily for 4 days. At the end of 4 days the TEWL was measured once again.
  • phase 2 of the test protocol no product application was done and TEWL was measured after 7 days.
  • Moisturizers have been thought to induce only a transient moistening effect of the skin surface.
  • effective moisturizers produce changes even in the deep layers of the stratum corneum as well as in the superficial layers.
  • Their repeated application on the skin produces an enhancement of skin surface hydration state that lasts for several days after cessation of the treatment, depending on their efficacy.
  • compositions were stopped after 10 days and hydration was again measured on the 14 th , 16 th and 20 th day to monitor the level of hydration after cessation of the application.
  • compositions containing upto 10% coconut oil addition of sensory modifiers is optional .
  • compositions containing 10-30% of coconut oil addition of sensory modifier is preferable to obtain a sensorially acceptable product.
  • the present invention results in a sensorially superior product using coconut oil as a single moisturizing agent in fairly low quantities.
  • These compositions enable the use of a single active to provide desired moisturizer levels and eliminates additional costs and unwarranted use of undesirable synthetic moisturizing actives.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des compositions d'hydratation de la peau comprenant jusqu'à 30% d'huile de noix de coco comme principe actif unique et des excipients acceptables au niveau cosmétique, de l'eau et facultativement des modificateurs sensoriels dans lesquelles lesdites compositions conservent l'hydratation pendant des périodes sensiblement prolongées. Les excipients sont des émulsifiants, des agents structurants et des épaississants. Les modificateurs sensoriels sont de préférence inclus dans les compositions contenant l'huile de noix de coco à raison de 10-30%. L'invention divulgue aussi un procédé pour la préparation de compositions hydratantes comprenant les étapes de préparation d'une phase aqueuse en mélangeant de l'eau et des conservateurs suivie par l'addition d'épaississant avec chauffage jusqu'à 70°C; la préparation d'une phase huileuse en mélangeant de l'huile de noix de coco, des émulsifiants et des agents structurants avec chauffage jusqu'à 70°C; l'addition de la phase d'huile chauffée à la phase aqueuse chauffée suivie par l'homogénéisation à des températures jusqu'à 50°C; l'addition d'agent neutralisant suivie par l'addition facultative d'un modificateur sensoriel avec chauffage jusqu'à 50°C.
PCT/IB2012/001080 2011-09-02 2012-06-05 Compositions pour des périodes prolongées d'hydratation de la peau Ceased WO2013030635A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2450/MUM/2011 2011-09-02
IN2450MU2011 2011-09-02

Publications (2)

Publication Number Publication Date
WO2013030635A2 true WO2013030635A2 (fr) 2013-03-07
WO2013030635A3 WO2013030635A3 (fr) 2013-12-19

Family

ID=46634468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/001080 Ceased WO2013030635A2 (fr) 2011-09-02 2012-06-05 Compositions pour des périodes prolongées d'hydratation de la peau

Country Status (3)

Country Link
SA (1) SA112330815B1 (fr)
TW (1) TW201315487A (fr)
WO (1) WO2013030635A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458075B2 (en) 2016-10-17 2022-10-04 Colgate-Palmolive Company Oral care composition having enhanced appearance and form

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7046095B2 (ja) * 2017-04-03 2022-04-01 ロレアル 化粧料組成物を形成するためのシステムおよびスキンケア管理システム

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235889A (en) 1979-04-25 1980-11-25 Pharmazeutische Fabrik Evers & Co. Therapeutic agent for the external treatment of psoriasis, tinea and eczemas
US5578312A (en) 1993-05-05 1996-11-26 Parrinello; Vincene M. Skin care system and method for improving moisture retention in skin
EP2051691A1 (fr) 2006-10-13 2009-04-29 Evonik Goldschmidt GmbH Composition de traitement cutané
US20100021563A1 (en) 2008-07-24 2010-01-28 Paul Levesque Compositions comprising coconut oil and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL157814A (en) * 2003-09-08 2007-12-03 Lev Bar Ltd Cosmetic composition comprising camel milk or components thereof
JP5295642B2 (ja) * 2008-05-30 2013-09-18 中野製薬株式会社 毛髪化粧料
WO2010052072A2 (fr) * 2008-11-07 2010-05-14 Unilever Plc Composition
KR101031543B1 (ko) * 2009-04-01 2011-04-27 주식회사 비앤원 클랜징 및 각질제거, 보습용 천연화장품의 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235889A (en) 1979-04-25 1980-11-25 Pharmazeutische Fabrik Evers & Co. Therapeutic agent for the external treatment of psoriasis, tinea and eczemas
US5578312A (en) 1993-05-05 1996-11-26 Parrinello; Vincene M. Skin care system and method for improving moisture retention in skin
EP2051691A1 (fr) 2006-10-13 2009-04-29 Evonik Goldschmidt GmbH Composition de traitement cutané
US20100021563A1 (en) 2008-07-24 2010-01-28 Paul Levesque Compositions comprising coconut oil and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458075B2 (en) 2016-10-17 2022-10-04 Colgate-Palmolive Company Oral care composition having enhanced appearance and form

Also Published As

Publication number Publication date
WO2013030635A3 (fr) 2013-12-19
TW201315487A (zh) 2013-04-16
SA112330815B1 (ar) 2015-12-07

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