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WO2013026850A1 - Stylo-injecteur avec piston magnétique sans tige - Google Patents

Stylo-injecteur avec piston magnétique sans tige Download PDF

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Publication number
WO2013026850A1
WO2013026850A1 PCT/EP2012/066270 EP2012066270W WO2013026850A1 WO 2013026850 A1 WO2013026850 A1 WO 2013026850A1 EP 2012066270 W EP2012066270 W EP 2012066270W WO 2013026850 A1 WO2013026850 A1 WO 2013026850A1
Authority
WO
WIPO (PCT)
Prior art keywords
sleeve
pen
injector
cartridge
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/066270
Other languages
English (en)
Inventor
Jürgen Schmidt-Evers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2013026850A1 publication Critical patent/WO2013026850A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button

Definitions

  • the technical field is the injection of a liquid product, especially of a medication, into the human or animal body.
  • Injector Pens are commonly used for the treatment of diabetes by self-injection with Insulin.
  • housing sleeve contains all components
  • the second housing part contains the cartridge and is positioned one after another with the first housing part.
  • Pen-Injectors utilize a rigid piston rod for moving the cartridge piston. This piston rod must, of necessity be at least as long as the moving stroke of the piston in the cartridge. It is clear that such Pen-Injectors cannot be shorter than the total length of the cartridge and the piston rod.
  • EP 0245 312 B1 There were previous attempts to shorten the pens, for example, by using a flexible piston rod, which is guided around the edge of the cartridge (EP 0 901 194 B1 ).
  • the new Pen-Injector does not work with a rigid piston rod.
  • the drive mechanism, the power transmitting means and the dosing means now surround the cartridge concentrically.
  • the power transmitting means include - in place of the stiff piston rod - magnets, one of which is positioned outside of the cartridge and the other within the cartridge.
  • the magnets are kept permanently in an attraction relationship with a strong coupling. A movement of the outer magnet causes a
  • Both magnets are movable to a large extent synchronously at least over a part of the filled section of the cartridge, preferably over the complete filled section. It is possible thereby to move the piston of the cartridge without using a piston rod from outside of the cartridge.
  • DE 20 2005 010 389 U1 discloses a device including a stiff piston rod on which a magnetic member is disposed. If the piston rod is moved along its axis the magnetic member will be moved with the piston rod relative to a second magnetic member.
  • the second magnetic member may be fixedly attached to the housing, or at least so that it does not move with the piston rod as it moves. Both magnetic members cooperate magnetically at least in one position of the piston rod.
  • the target is to reduce or prevent the chance of an overdose of the product to be injected.
  • US 2002/0022807 A1 shows a syringe plunger locking mechanism including a plunger with a plunger support and an actuator for the plunger.
  • the plunger support and the actuator are each provided with a permanent magnet for connecting them. The magnets allow for an easy disengagement.
  • GB 2 342 047 A discloses a syringe with a base body and a plunger longitudinally guided in the base body.
  • An injection needle is attached to the base in the distal direction of the syringe.
  • the base and the plunger rod each have magnets, which interact with each other after an injection so that they magnetically stick together. Pulling back the plunger causes the base with the needle to be pulled back into the syringe base body so that there is no longer any risk of injury by the injection needle.
  • US 4,959,056 discloses a an injecting system including a syringe
  • Figure 1 shows an longitudinal section though a first embodiment of the new Injection Pen in an exploded view (in the scale 1 : 1 if it is printed in the format DIN A4);
  • Figure 2 shows three individual components of the first embodiment
  • Figure 2 (a) a front view onto the cover flange
  • Figure 2 (b) a front view into the threaded element with the outer
  • Figure 3 shows a longitudinal section though the assembled first
  • Figure 4 shows a longitudinal section though the first embodiment (like
  • Figure 5 shows a side view onto the first embodiment at the end of an injection phase or at the beginning of the next dosing phase (like
  • Figure 6 shows the side view and the top view of the outer magnet with an indication of the magnetization
  • Figure 7 shows the side view and the top view of the inner magnet with an indication of the magnetization
  • Figures 8 (a)-(d) show a test arrangement for measuring the offset of the outer magnet relative to the inner magnet as a result of four different load conditions.
  • Figure 10 shows a longitudinal section through a second embodiment of the new Pen Injector at the beginning of the first dosing phase (in the scale 2: 1 if it is printed in the format DIN A4);
  • Figure 1 1 shows a longitudinal section through the second
  • Figure 12 shows a part of the second embodiment during the injection phase (in the scale 2:1 if it is printed in the format DIN A4);
  • Figure 13 shows a longitudinal section though a third embodiment of the new Pen Injector a t the beginning of the first dosing phase (in the scale 2:1 if it is printed in the format DIN A4);
  • Figure 14 shows a longitudinal section through the third embodiment
  • Figure 15 shows a side view onto the third embodiment at the end of an injection phase or at the beginning of the next dosing phase (in the scale 1 :1 if it is printed in the format DIN A4);
  • Figure 16 shows a side view onto a conventional Injector Pen with a rigid piston (in the scale 1 : 1 if it is printed in the format DIN A4).
  • the cartridge which is used here for the first embodiment is a Novo-type cartridge. It is made from glass and contains the injection liquid 1 a, as for example Insulin, and a slideable piston 1 b. The proximal end of the cartridge is closed by an exit element 1 c with an outer thread 1 d. The exit element is closed by an elastic foil.
  • a guide strip 1 e is glued, which extends in the axial direction.
  • the guide strip 1 e is made from hard plastic material and has a thickness of about 0,5 mm. The function of the guide strip 1 e will be explained later.
  • IE Insulin units
  • the housing sleeve 2 is made from plastic and consists of a front
  • the two housing parts 2a, 2b are connected but can be rotated against each other.
  • the means of connection between the two housing parts 2a and 2b is not shown and is indicated only symbolically.
  • the proximal end of the housing sleeve 2 is covered with a front flange 2c, which has a central through hole 2d for the exit element 1 c of the cartridge 1.
  • the central through hole 2d is extended at one point to a slot 2h for receiving the guide strip 1e.
  • Two elastic latches 2e1 , 2e2 with an inward peak are cut out of the wall of the rear housing part 2b and positioned opposite to each other. Further a dose window 2f is cut out of wall of the rear housing part 2b.
  • the drive sleeve 4 is made from plastic and has an inner helical
  • the drive sleeve 4 is provided with an outer helical groove 4e, which has the same pitch as the inner helical groove 4a.
  • the outer helical groove 4e extends between two annular grooves 4f, 4g and cooperates with the two latches 2e whose point grips into the helical groove 4e or one of the annular groves 4f, 4g.
  • the cavity of the drive sleeve 4 is extended at the distal end to a receiving space 4c, whose function is to receive the inner magnet 5 if a new cartridge 1 is inserted.
  • the rear end of the drive sleeve 4 is used as actuation element 9.
  • dosing numbers 4d in the form of a helix are printed on the outer periphery of the drive sleeve 4 . If the drive sleeve 4 is turned the dosing numbers 4e pass one after the other under the dose windows 2f and are therefore
  • the inner magnet 5 is formed cylindrically and adapted to the inner form of the cartridge 1.
  • the axial length of the inner magnet 5 is 8 mm.
  • the air gap between the inner magnet 5 and the wall of the cartridge 1 should be as small as possible but large enough to allow the inner magnet 5 to move axially within the cartridgel .
  • An air gap of 0,1 mm corresponds to this requirements.
  • the inner magnet 5 is in close contact with the piston 1 b but they are not connected.
  • the outer magnet 6 is shaped as a ring and has the same axial length as the inner magnet 5, namely 8 mm. Its wall thickness is 3 mm. The outer magnet 6 surrounds the cartridge 1. The air gap between the outer magnet 6 and the cartridge wall should also be as small as possible but large enough to allow the outer magnet 6 to axially move relative to the cartridge 1. An air gap of 0,1 mm corresponds to this requirements.
  • the outer magnet 6 has on its inner side an axial slot for receiving the guide strip 1 e.
  • the two magnets 5 and 6 are made from a very strong magnetic
  • Both magnets 5 and 6 are axially magnetized, i.e. the poles are aligned in the axial direction of the cylinder respectively the ring. After assembling the pen components opposite poles of the two magnets are adjacent and form a "magnetic trap", which is explained in detail later.
  • the outer magnet 6 is firmly connected to a thread element 7 which is formed as a tube and made from plastic.
  • the thread element 7 is provided with an outer protruding helical rib 7a, which corresponds to the inner helical groove 4a of the drive sleeve 4 and forms a thread connection 4/7.
  • Thread element 7 has on its inner side an axial slot for receiving the guide strip 1 e.
  • Thread element 7 is dispensable if its function is replaced by the outer magnet 6 whose function takes. This requires that the outer magnet must be provided with the outer protruding helical rib 7a. However, it is more difficult to form the threads on the outer magnet 6 in such a way than on the plastic component 7.
  • the cover flange 10 is made from plastic and has a central through hole 10a for the cartridge exit element 1 c.
  • the cover flange is provided with two part-circular bayonet (banana shaped) slots 10b, each slot terminates with a hole 10d (see Figure 2a).
  • the two screws 10c secure element 10 to the front flange 2c of the housing sleeve 2.
  • the needle cap 1 1 When assembled, the needle cap 1 1 is screwed with its inner thread 1 1 b on the outer thread 1 d of the cartridge exit element 1 c.
  • the needle cap 1 1 carries a needle 1 1a.
  • the front end of the needle 1 1 a pierces the elastic foil of the cartridge exit element 1 c and is thereby connected with the liquid volume 1 a of the cartridge 1.
  • the cover flange 10 To remove cartridge 1 from the pen, it is necessary to first unscrew the needle cap 1 1 from the cartridge exit element 1 c. Then the cover flange 10 must be rotated in the appropriate direction until the pan heads of the two screws 10c are lined up with the holes 10d of the banana slots 10b. In this position the cover flange 10 can be removed from the housing sleeve 2. It is now it is possible to remove the cartridge 1 from the pen.
  • the front end of the needle 1 1a can be protected by putting the protection cap 13 onto the front end of the pen.
  • the drive sleeve 4 is intended to serve both for dosing by rotation as also for injecting by axial movement.
  • the thread connection 4/7 between the drive sleeve 4 and the threaded element 7 ensures an accurate dose.
  • the drive sleeve 4 is provided with an outer helical groove 4e which cooperates with the two latches 2e1 , 2e2.
  • the two latches are unique parts of the housing 2.
  • the latches 2e1 , 2e2 are partially cut out of the housing 2 but integrally connected to this. During the dosing phase the peak of both the latches 2e grips into the helical groove 4e or one of the annular groove 4f, 4g and prevents that the drive sleeve 4 can be drawn out of the housing 2.
  • a dosing reset is necessary. This can be effected in that the rear housing part 2b with the both latches 2e1 , 2e2 is rotated relative to the front housing part 2a.
  • the reset action causes the drive sleeve 4 to turn into the initial angle position, which is the basis for a new dosing 4 to turn phase.
  • the helical grove 4e will be brought by the reset rotation in the initial angle position, in which the latch 2e2 can fully dip into the helical groove 4e and in which the dose number "0" appears in the dose window 2f.
  • the essential components for realizing the magnetic trap are the cartridge 1 with the piston 1 b, the inner magnet 5 and the outer magnet 6 with the threaded element 7. As it can be seen from drawings the opposite poles of the two magnets are positioned adjacent to each other when the assembly is completed. The inner magnet 5 is in contact with the piston 1 b, but not connected with it.
  • Figure 8 shows in four phases that an axial force F (in form of a load) is applied onto the outer magnet 6 in the proximal direction.
  • a load of 1 ,1 kg causes an axial displacement of 10 mm ( Figure 8(c)).
  • the magnetic trap also functions in the other (distal) direction. And it functions even when the outer magnet 6 is fixed and the force F is applied onto the inner magnet 5.
  • the graph in Figure 9 shows that the axial displacement s of the outer magnet 6 is dependent on the force F (load), which is applied onto the outer magnet 6.
  • F load
  • the trap area is extended in this special example between a displacement of - 10 mm to + 10 mm, wherein only the stable range between 0 and +10 mm is used.
  • the outer magnet element 6 always returns after a deflection to its neutral position. This is the case even if a force F is applied onto the outer magnet 6, which exceeds the limit value of 10,2 kg, provided that the axial movement of the outer magnet 6 is limited to +10mm. In the present case this can be realized by a corresponding dosing.
  • the offset of the outer magnet 6 relative to the inner magnet 5 is caused by the axial movement of the drive sleeve 4 in the proximal direction during the injection phase.
  • This movement is stopped respectively limited when the drive sleeve 4 reaches its (initial) position, which it had before the dosing action.
  • This means that the drive sleeve 4 can only moved by the distance, which was set before during the dosing phase. And this is independent of the force, which is brought onto the drive sleeve 4 for executing the injection.
  • the maximum piston stroke for the cartridge 1 ("Novo"-Type) is 9,0 mm and therewith smaller than the limit value of the stable range which is 10 mm. Therefore a break of the magnetic coupling between the both magnets 5 and 6 can be safely excluded. The outer magnet 6 remains always trapped in the magnetic trap.
  • the dose number "0" must first appear in the dose window 2f. Then the actuation element 9 must be turned so that the drive sleeve 4 axially moves out of the housing 2 until the selected dose number appears in the dose windows 2f.
  • the rear housing part 2b must be turned relative to the front housing part 2a (either clockwise or counterclockwise), until the latch 2e1 locks fully into the annular groove 4g and the dose number "0" appears again in the dose windows 2f.
  • the piston 1 b, the inner magnet 5, the outer magnet 6 and the threaded element 7 are in their most forward (proximal) position.
  • the drive sleeve 5 abuts against the front flange 2d of the housing 2.
  • the actuation element 9 must be turned opposite to the dosing direction, whereby the drive sleeve 4 remains in contact with the front flange 2c.
  • the threaded element 7, the outer magnet 6 and the inner magnet 5 move backwards until the inner magnet 5 reaches the reception space 4c in the actuation element 9.
  • the needle cap 1 1 and the cover flange 10 must be removed. Now the exchange can be carried out.
  • the magnets which are used here are very strong, and they are - due to the small air gaps - very intensively coupled.
  • the injection force which a user applies shock-like onto the actuation element is always the maximum force with the result that the outer magnet will be immediately displaced by the maximum value.
  • the maximum deviation of the ejected liquid volume from the set dose was 6%.
  • the average deviation was 2,5%.
  • the doses between 1 and 30 units (IE) were completely ejected within 5 seconds.
  • the ejection of the doses 40, 50 and 60 units (IE) was not fully completed within 5 seconds. In each case 5 more drops followed in the next seconds. These 5 further drops correspond to about 2 units (IE). This gives a worst case deviation of 5%.
  • the magnets show the same behaviour. At least in theory, they cannot overcome the small resistance of the static friction between the cartridge wall and the piston. The residual failure is very small because the replacement force which acts onto the piston (more than 1 ,2 kg) is much more higher than the before mentioned resistance of the static friction (about 100 g).
  • the second embodiment includes the following components arranged in a concentric arrangement - from outside to inside ( Figure 10):
  • a housing comprising of a housing sleeve 2 and a cover flange 10, [0096] a dose dial sleeve 12,
  • the cartridge 1 contains the piston 1 b and an inner magnet 5 (with its opposite pole parts 5a, 5b) positioned after another.
  • the cartridge further contains the injection liquid 1a, which is trapped between the cartridge piston 1 b and a cartridge exit 1 c.
  • the inner magnet 5 is axially movable within the cartridge 1 and in touch with the piston 1 b but not fixed to it.
  • the cartridge 1 which is used here is of the so-called "Lilly"-type. This type differs from the Novo-Type with regards to the construction of the exit as well as to some dimensions. The most important difference in the dimensions is the following:
  • the housing sleeve 2 has at its proximal end a front flange 2c, on which other elements are to be fixed.
  • the inner side of the housing sleeve 2 is provided with a helical groove 2k, which forms a thread connection 2/12 with a corresponding helical protruding rib 12b on the outer side of the dose dial sleeve 12.
  • the cartridge reception sleeve 3 is designed to receive the cartridge 1 and has a front flange 3a which is fixed to the front flange 2c of the housing 2.
  • the cartridge reception sleeve 3 further has at is back end a trap basket 3c for receiving the inner magnet 5 when this is moved backward - in case that the pen is used as reusable version - before a new cartridge 1 can be inserted.
  • the cartridge reception sleeve 3 might be replaced by other fixing means for the cartridge 1 if the pen should be used as a disposable pre-filled pen.
  • the drive sleeve 4 has on its inner side a helical groove 4a which forms a thread connection 4/7 with a corresponding helical rib 7a on the outer side of the thread element 7.
  • An outer magnet 6 with an annular shape is positioned between the container reception sleeve 3 and the drive sleeve 4.
  • the outer magnet 6 is fixed to the annular thread element 7.
  • the thread element 7 may be omitted if the outer magnet 6 is provided with the helical rib 7a of the tread element 7.
  • the outer magnet 6 and the thread element 7 can be moved only in an axial direction but not turned. This is due to an axial guide strip 3b on the outside of the cartridge reception sleeve 3 and corresponding axial slots 7b and 6c in the thread element 7 and in the outer magnet 6.
  • the outer magnet 6 and the inner magnet element 5 are adapted to the circular cross shape of the cartridge 1. That means that the inner side of the annular shaped outer magnet 6 is closely fitted to the outer surface of the cartridge 1.
  • the inner magnetic 5 has a cylindrical shape and is closely fitted to the inner surface of the cartridge 1.
  • the air gape between each of the two magnets 5, 6 and the corresponding wall of the cartridge 1 should be made as small as possible, while still allowing the two magnets 5, 6 to easily move in an axial direction.
  • the air gap should be as small as possible, preferably 0,1 mm.
  • the axial length of two magnets 5, 6 should be selected between 5 and 10 mm, preferably 8 mm. A proper strong magnet material for this purpose is available under the trade mark "Neodym".
  • the two magnets 5, 6 should be magnetized axially and so arranged that their opposite poles lie side by side. On this way it is possible to keep the two magnets 5, 6 permanently in a close and strong magnetic contact and to move them synchronously along the axis of the cartridge 1. The force for moving them must be applied only onto the outer magnet element 6. This force is transmitted by the strong magnetic coupling onto the inner magnet element 5, which is thereby able to force the piston 1 b deeper into the cartridge 1 with the result that injection liquid is discharged.
  • the rear end of the pen is formed by a cap-like actuation element 9, which is connected with the drive sleeve 4 by a rotary coupling 4/9.
  • the rotary coupling 4/9 is formed on the one side of a wheel like member 9u, which carries a number of axial extending ribs 9v and on the other side of corresponding grooves 4j on the outer side of the drive sleeve 4.
  • the wheel like member 9u is fixed via a centrally positioned connecting pin 9x to the inner side of the actuation element 9.
  • the rotary coupling 4/9 permits only a common rotation of the actuation element 9, the wheel-like member 9u and the drive sleeve 4, but it permits a free an axial movement of the actuation element 9 and the wheel-like member 9u on one side and the drive sleeve 4 on the other side.
  • the dose dial sleeve 12 is provided on its rear end with a wheel-like member 12a with a central boring.
  • the connecting pin 9x is extending through this central boring.
  • the two wheel-like members 9u and 12a form a friction clutch. They are pressed together by a pressure spring 9y. If an axial pressure is applied onto the actuation element 9, the members 9u and 12a will disengage.
  • the friction clutch therefore can be regarded as a rotary coupling 9/12 which can - if necessary - deactivated.
  • the rotary coupling 9/12 permits - when it is activated - only a common rotation of the coupled elements 9 and 12, whereas they can rotate independently when the rotary coupling is deactivated.
  • the intermediate sleeve 8 is connected to the housing sleeve 2 by a rotary stop means 2/8.
  • This means 2/8 is formed by axial ribs 8c on the outer side of the intermediate sleeve 8 and axial ribs 2n on the inner side of the housing sleeve 2, which ribs 8r and 2n gears into each other.
  • the rotary stop means 2/8 permits an axial movement but no rotation of the intermediate sleeve 8 against the housing sleeve 2.
  • the intermediate sleeve 8 is further connected with the drive sleeve 4 by an axial movement coupling 4/8, which is formed by an annular groove 8s on the inner side of the intermediate sleeve 8 and a corresponding annular rib 4j on the outer side of the drive sleeve 4.
  • This axial movement coupling 4/8 permits only a common axial movement of the drive sleeve 4 and the intermediate sleeve 8 but it allows a free rotation of this elements 4 and 8 against each other.
  • the intermediate sleeve 8 is connected with the dose dial sleeve 12 by a threaded connection 8/12, which is formed by a helical protruding rib 8t on the outer side of the gear sleeve 8 and a corresponding helical groove 12g on the inner side of the dose dial sleeve 12.
  • the pitch p3 of the thread connection 2/12 is greater than the pitch p1 of the thread connection 4/7 (p3 > p1 ).
  • the pitch p3 of the thread connection 2/12 must be selected so that it is not self- blocking, i.e. that the dose dial sleeve 12 can freely rotate if an axial pressure is exerted on the actuation element 9.
  • the pitch depends on the diameter D of the dose dial sleeve 12 and on a friction parameter. It was found that the relationship p/D should preferably 0,75 or larger. In the present case the diameter D of the dose dial sleeve 12 is calculated as being 20 mm.
  • the dose dial sleeve 12 is moved out of the housing sleeve 2 by one turn of the actuation element 9, the movement distance is 15 mm.
  • the intermediate sleeve 8 will follow with an axial movement of 1 1 mm. The axial movement of the intermediate sleeve 8 causes a
  • the front end of the pen is a disc-like formed cover flange 10.
  • the cover flange 10 is designed so that it can be fixed and removed easily.
  • the edge of the cover flange 10 has ribbing 10e to facilitate turning.
  • Cover flange 10 includes two banana shaped slots 10b. Each slot terminates in a hole (see Figure 2a). The diameter of the hole and is a little larger than the two pan head screws 10c.
  • the two screws 10c are also used for connecting the cartridge reception sleeve 3 and the cover flange 10 with the housing sleeve 2.
  • the corresponding cover flange 10 has a cylindrical portion 10i for receiving the exit end 1 c of the cartridge 1.
  • the outer surface of this cylindrical portion 10i is provided with a male tread, which is matched to the female of the needle cap 1 1.
  • the dose numbers are printed onto the outer side of the dose dial sleeve 12 in the form of two columns, which helically wind around the dose dial sleeve 12. Only every second dose number is printed so that each column has 15 numbers.
  • the dose number which has been dialled appears in the dose number window 2b in the housing sleeve 2. With a diameter of 20 mm for the dose dial sleeve 12 and a corresponding circumference of about 60 mm and further with an axial feed rate of 4 mm for each turn a field of 4 x4 mm is available for each printed dose number. This allows for good visibility of the dose numbers.
  • the pen shall be used as a reusable version it must be provided with additional means (not shown) for keeping the clutch 9/12 temporarily in its disengaged position.
  • This additional clutch 9/12 can be realized for example by a motion link mechanism, often used in ball point pens.
  • the actuation element 9 At the beginning of the dosing phase the actuation element 9 is in its proximal position, and in the dose number "0" will appear in the window 2f. For setting a dosing number different from “0” the actuation element 9 must be turned in the dosing direction (for example counterclockwise) until the desired dose number appears in the dose number window 2f.
  • a rotation of the actuation element 9 causes the dose dial sleeve 12 and the rotary coupling 9/12 to be taken along by the actuation element 9. The result is that the dose dial sleeve 12 turns together with actuation element 9 and moves a first distance out of the housing sleeve 2. The rotation of the dose dial sleeve 12 causes an axial movement of the intermediate sleeve 8 out of the housing sleeve 2 but by a second distance which is less than the first distance.
  • the drive sleeve 4 is forced by the coupling 4/7 to turn with the actuation element 9, whereby the threaded element 7 is urged to move axially into the housing sleeve 2 by a third distance, which is the same as the second distance but in the opposite direction.
  • the thread element 7 and thereby also the outer magnet 6 remain in its former position or - in other words - they do not move at all. This also means that the piston 1 b in cartridge 1 does not move.
  • the dialled dose can be corrected - if necessary - by turning the
  • the dose dial sleeve 12 applies a part of the pressure force via the tread connection 8/12 onto the intermediate sleeve 8, which will be moved thereby axially back into the housing sleeve 2. Since the dose dial sleeve 12 and the intermediate sleeve 8 are decoupled during this injecting phase, the drive sleeve 4 will be moved axially back into the housing sleeve 2 without a rotation. This causes the tread 7 and the outer magnetic 6 to move also axially into the housing sleeve 2 by the above mentioned second distance. The outer magnet 6 takes the inner magnet 5 along, whereby the piston 1 b is moved deeper into the cartridge 1 with the result that the predetermined amount of injection liquid 1 a will be discharged though the injection needle 1 1 a.
  • intermediate sleeve 8 and the dose dial sleeve 12 are again in the position they had at the beginning of the dosing phase.
  • the dose number "0" once again appears in the dose number window 2f. A reset is not necessary.
  • the first step is to disengage the clutch 9/12 by pressing onto the actuation element 9 and to activate the means for keeping them temporarily in this disengaged condition. Now the user must turn the actuation element contrary to the dosing direction. Thereby only the drive sleeve 4 will be turned with the result that the thread element 7 is moved backward and it takes the two magnets 5, 6 along until all these elements reach their most backward position.
  • the trap basket 3c prevents the inner magnet 5 from falling out of the end section of the cartridge 1 and from sticking to the outer magnet 6.
  • the fourth embodiment includes the following components - arranged concentrically - from inside to outside ( Figure 13):
  • a cartridge 1 (here again a Lilly-type) with a piston 1 b and the inner magnet element 5 (with its opposite pole parts 5a, 5b), both positioned one after another,
  • the cartridge 1 is a cylindrically shaped glass container containing the injection liquid 1 a, which is trapped between a movable cartridge piston 1 b and a cartridge exit 1 c.
  • a cylindrically shaped inner magnet 5 is positioned in the cartridge 1.
  • the inner magnet 5 is axially movable within the cartridge 1 and in touch with the piston 1 b but not fixed to it.
  • the cartridge reception sleeve 3 is intended to receive the cartridge 1 and has a front flange 3a which is fixed to the front flange 2a of the housing 2.
  • the cartridge reception sleeve 3 has at is back end a trap basket 3c for receiving the inner magnet 6 when a new cartridge 1 is inserted in the pen.
  • the outer magnet 6 and the thread element 7 are positioned - in radial direction - between the container reception sleeve 3 and the drive sleeve 4.
  • the thread element 7 has on its outer side a helical protruding rib 7a, which projects beyond the periphery of the outer magnet 6 and mates with a helical groove 4a on the inner side of the drive sleeve 4 a thread connection 4/7.
  • the outer magnet 6 is fixed to the front side of the annular thread element 7.
  • the thread element 7 may be omitted if the outer magnet 6 is provided with the helical protruding rib 7a of the tread element 7.
  • the outer magnet 6 and the thread element 7 can be moved only in an axial direction but not turned. This is caused by an axial guide strip 3b on the outside of the container reception sleeve 3 and corresponding axial slots 7b and 6c in the threaded element 7 and in the outer magnet 6.
  • the outer magnet 6 and the inner magnet 5 are adapted to the circular cross shape of the cartridge 1. This means that the inner side of the outer magnet 6 is closely fitted to the outer surface of the cartridge 1.
  • the inner magnetic 5 is closely fitted to the inner surface of the cartridge 1.
  • the air gape between each of the two magnets 5, 6 and the corresponding wall of the cartridge 1 should be kept as small as possible, while still permitting magnets 5, 6 to easily move in an axial direction.
  • the air gap should be as small as possible, preferably 0,1 mm .
  • the axial lengths of the both magnets 5, 6 are between 5 and 10 mm, preferably 8 mm. An adequately strong magnet material for this purpose is commercially available under the trademark "Neodym".
  • the two magnets 5, 6 should be magnetized axially. This means that the poles are aligned in the axial direction.
  • the two magnets are arranged such that the opposite poles of the two magnets 5, 6 are positioned side by side. Thereby the two magnets 5, 6 are in a close and strong magnetic contact. They can be moved synchronously to a large extent along the axis of the cartridge 1. The force for moving them axially must be applied onto the outer magnet 6 only. This force is transmitted by virtue of the strong magnetic coupling onto the inner magnet 5, which is thereby able to force the piston 1 b deeper into the cartridge 1 with the result that injection liquid 1 a is discharged.
  • Movement retainer means 2/4(1 ) prevents the drive sleeve 4 from an axial displacement against the housing sleeve 2 but permits a rotation. Retention is obtained by an annual groove 4c in the outer side of the drive sleeve 4, in which a retainer pin 2d projects.
  • the drive sleeve 4 furthermore has on its outer side ratchet means
  • the ratchet means 2/4(2) which acts together with a toothed ring on the inner side of the housing sleeve 2.
  • the teeth have an inclined and a radial projecting flank. They are positioned so that the ratchet means 2/4(2) allows a rotation of the drive sleeve 4 only in that rotary direction, in which the piston 1 b will be moved to the exit 1 c of the cartridge 1.
  • the ratchet means 2/4(2) ensures that there is no operation phase in which air can be sucked into the cartridge.
  • the intermediate sleeve 8 is connected with the drive sleeve 4 by a rotary coupling 4/8, this forces the intermediate sleeve 8 and the drive sleeve 4 to have a common rotation, but it allows that the intermediate sleeve 8 can be axially moved against the drive sleeve 4 and the housing sleeve 2.
  • the rotary drive coupling 4/8 is formed by an axial groove 4b on the outer side of the drive sleeve 4 and by an axial rail 8a, which is guided in the axial groove 4b.
  • the back end section of the intermediate sleeve 8 is terminated by a flange member 8b.
  • the intermediate sleeve 8 is connected with the dose dial sleeve 12 by an axial movement coupling 8/12, which is formed by an annular rib 8d on the outer side of this distal end section of the intermediate sleeve 8 and by an annular groove 12e of the dose dial sleeve 12.
  • This coupling 8/12 forces the intermediate sleeve 8 and the dose dial sleeve to a common axial movement but it allows an independent rotation of these two parts 8 and 12.
  • the dose dial sleeve 12 is connected with the housing sleeve 2 by a threaded connection 2/12, which is formed by a helical protruding rib 2c on the inner side of the housing sleeve 2 and by a helical groove 12b on the outer side of the dose dial sleeve 12.
  • the back end section of the dose dial sleeve 12 is formed with a slightly larger diameter, which serves as a dose dial grip 12c. This diameter is equal to the diameter of housing sleeve 2.
  • the dose dial grip 12c encloses a hollow space, in which a push-button 9 is positioned.
  • the push-button 9 has a central pin 9a, which projects into a recess 8c on the back side of the flange member 8b.
  • the central pin 9a is surrounded by a compression spring 9c, which tries to keep the flange member 8b and the push-button 9 properly spaced.
  • a push-plate 9b is positioned on the back side of the push-button 9.
  • This push-plate 9b carries a pivot pin 9f with a tip and is anchored in a recess 9g of the push-button 9.
  • the push-plate 9b is can rotate freely relative to push-button 9.
  • the dose dial sleeve 12 and the intermediate sleeve 8 on the one side and the push-button 9 on the other side will be coupled by a rotary coupling 8/9/12 for a common rotation.
  • the rotary coupling 8/9/12 is formed by a front toothed sprocket 12f on the dose dial sleeve 12 and a front toothed sprocket 8e on the intermediate sleeve 8 on the one side and a front teeth sprocket 9e on the push- button 9 on the other side.
  • the pitch p2 of the thread connection 2/12 is larger than the pitch p1 of the first thread connection 4/7 (p2 > p1 ).
  • the pitch p2 of the thread connection 2/12 must be selected so that it is not self-blocking, i.e. that the dose dial sleeve 12 can freely rotate if an axial pressure is exerted on the push-button 9.
  • the diameter D of the dose dial sleeve 12 was calculated with 20 mm. That means that the dose dial sleeve 12 will be moved out of the housing sleeve 2 by a maximum distance of 32 mm with two turns. This distance guarantees a comfortable handling of the pen and sufficient place for the dose numbers on the outer side of the dose dial sleeve (to be explained later in detail).
  • the front end of the pen is formed by a disc-like cover flange 10.
  • the cover flange 10 is intended to be easily attached and removed.
  • the edge of cover flange 10 has ribbing 10e to facilitate turning.
  • Cover flange 10 includes two banana shaped slots 10b and 10d ( Figure 8c). Each slot terminates in a hole (see Figure 2a). The diameter of the hole is a little larger than the diameter of the pan head screws 10c.
  • the two screws 10c are also used to connect the cartridge sleeve 3 and the cover flange 10 with the housing sleeve 2.
  • the cover flange 10 has a cylindrical portion 10i for receiving the cartridge exit 1 c.
  • the outer side of this cylindrical portion 10i is provided with a male tread, which is matched to a female thread of the needle cap 1 1.
  • the dose numbers are printed onto the outer side of the dose dial sleeve 12 in the form of two columns, which helically wind around the dose dial sleeve 12. Only every second dose number is printed so that each column has 15 numbers.
  • the dialled dose number appears in the dose number window 2b that is provided in the housing sleeve 2. With a diameter of 20 mm for the dose dial sleeve 12 and a corresponding circumference of about 60 mm and further with an axial feed rate of 4 mm for each turn a field of 4 x4 mm is available for each printed dose number. This allows for good visibility of the dose numbers.
  • the intermediate sleeve 8 and the dose dial sleeve 12 are in their proximal position (start position), and the dose number "0" will appear in the dose number window 2f.
  • the dose dial grip 12a For setting a dose number different from "0" the dose dial grip 12a must be turned in the dosing direction (for example clockwise) until the selected dose number appears in the dose number window 2f.
  • the dose dial sleeve 12 takes - because of the axial movement coupling 8/12 - the intermediate sleeve 8 along with it.
  • the intermediate sleeve 8 can only move axially. It is prevented from rotating by the rotary coupling 4/8.
  • the rotary coupling 4/8 prevents the rotation because drive sleeve 4 cannot rotated clockwise due to the action of ratchet means 2/4(2).
  • the user wishes to reduce the set dose number before an injection, he can turn the dose dial grip 12a counter-clockwise.
  • the result is that that the dose dial sleeve 12 will again turn a corresponding distance into the housing sleeve 2, taking the intermediate sleeve 8 along with it.
  • the intermediate sleeve 8 moves only axially even though ratchet means 2/4(2) would allow a counterclockwise rotation.
  • the primary purpose of the ratchet means 2/4(2) is to prevent air being sucked into the cartridge 1. This is only possible if the piston 1 b is moved backward, away from the cartridge exit 1 c, and this only occurs with a clockwise rotation of the drive sleeve 4.
  • Figure 15 shows the fourth embodiment and below in Figure 16 a
  • the new Pen-Injector has a length (with needle) of about 9 cm.
  • the common pen is has a length of about 15- 16 cm and is therewith longer by 72%.
  • the common pen includes beside the cartridge - a manual operable drive mechanism, power transmitting means and dosing means. All components are positioned in a pen-like housing, which consists of the two housing parts. The two housing parts are connected in longitudinal direction. The first housing part contains all components except the cartridge. The cartridge is positioned in the second housing part.
  • the components include a rigid piston rod for moving the cartridge piston. This piston rod must, of necessity, be at least as long as the length of the piston travel inside the cartridge. It is clear that such Pen-Injectors cannot be shorter than the total length of the cartridge plus the piston rod.
  • the proposed new Pen-Injector does not use a rigid piston rod.
  • the drive mechanism, the power transmitting means and the dosing means now surround the cartridge concentrically.
  • the power transmitting means utilize - in place of a rigid piston rod - magnets, one of which is positioned outside of the cartridge and the other within the cartridge.
  • the magnets form a closed magnetic circuit with strong coupling.
  • a movement of the outer magnet element causes a corresponding movement of the inner magnet element and therewith of the cartridge piston.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un stylo-injecteur destiné à administrer un produit injectable, notamment de l'insuline. Contrairement aux stylos classiques, qui contiennent une tige de piston rigide pour la transmission de l'énergie, le nouveau stylo-injecteur comprend deux aimants (5, 6). L'un (5) des aimants (5, 6) est positionné à l'intérieur de la cartouche (1) en contact avec le piston (1b). L'autre aimant (6) est positionné à l'extérieur de la cartouche, mais en contact magnétique étroit et permanent avec l'aimant intérieur (5). Les deux aimants (5, 6) font partie du moyen d'entraînement pour le déplacement du piston (1b). La force d'entraînement est appliquée à l'aimant extérieur (6) et de celui-ci à l'aimant intérieur (5). En raison de l'absence d'une tige de piston rigide, le nouveau stylo injecteur peut être conçu de manière à ce qu'il soit 40 % plus court que les stylos classiques. Un tel stylo-injecteur court peut être stocké plus facilement qu'un stylo classique dans la poche d'un habit ou dans un sac à main.
PCT/EP2012/066270 2011-08-22 2012-08-21 Stylo-injecteur avec piston magnétique sans tige Ceased WO2013026850A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP11006857.4 2011-08-22
EP11006857 2011-08-22
EP12150115 2012-01-04
EP12150115.9 2012-01-04
EP12152882.2 2012-01-27
EP12152882 2012-01-27
EP12154227.8 2012-02-07
EP12154227 2012-02-07

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063527A1 (fr) * 2013-10-28 2015-05-07 Piros Éva Anna Dispositif d'administration pour l'administration transdermique de préparations médicales liquides, en particulier l'insuline
WO2016069982A1 (fr) * 2014-10-30 2016-05-06 Otomagnetics, Llc Injection magnétique d'agents thérapeutiques par l'addition d'extrusions de matériaux présentant une magnétisation et une perméabilité magnétique différentes
WO2017143285A1 (fr) * 2016-02-19 2017-08-24 Flextronics Ap, Llc Dispositif d'injection automatique comprenant un système d'entraînement magnétique
US9943314B2 (en) 2015-04-14 2018-04-17 Teleflex Innovations S.À.R.L. Magnetically-driven delivery assembly and method
WO2018119055A3 (fr) * 2016-12-21 2018-08-02 Dynamic Magnetics, Llc Dispositif d'entraînement magnétique utilisé pour alimenter un injecteur automatique
WO2019016777A1 (fr) * 2017-07-20 2019-01-24 Barmaimon Eyal Régulateur de débit à mécanisme d'horloge
US10967118B2 (en) 2016-02-19 2021-04-06 Flex, Ltd. Automatic injection device having a magnetic drive system
CN116492541A (zh) * 2023-03-28 2023-07-28 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法
WO2024199257A1 (fr) * 2023-03-28 2024-10-03 卓优医疗(苏州)有限公司 Dispositif d'injection et son procédé de réglage

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US3977402A (en) * 1975-03-25 1976-08-31 William Floyd Pike Injection apparatus and method with automatic aspiration feature
EP0245312B1 (fr) 1985-11-08 1990-05-02 Disetronic Ag Instrument d'injection
US4959056A (en) 1988-06-14 1990-09-25 Wayne State University Digital dispenser
EP0901194B1 (fr) 1997-09-08 2004-03-31 Delphi Automotive Systems Deutschland GmbH Connecteur électrique en deux parties
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063527A1 (fr) * 2013-10-28 2015-05-07 Piros Éva Anna Dispositif d'administration pour l'administration transdermique de préparations médicales liquides, en particulier l'insuline
WO2016069982A1 (fr) * 2014-10-30 2016-05-06 Otomagnetics, Llc Injection magnétique d'agents thérapeutiques par l'addition d'extrusions de matériaux présentant une magnétisation et une perméabilité magnétique différentes
US11484694B2 (en) 2014-10-30 2022-11-01 Otomagnetics, Inc. Magnetic injection of therapeutic agents by addition of material extrusions with differing magnetization and magnetic permeability
US9943314B2 (en) 2015-04-14 2018-04-17 Teleflex Innovations S.À.R.L. Magnetically-driven delivery assembly and method
US10967118B2 (en) 2016-02-19 2021-04-06 Flex, Ltd. Automatic injection device having a magnetic drive system
WO2017143285A1 (fr) * 2016-02-19 2017-08-24 Flextronics Ap, Llc Dispositif d'injection automatique comprenant un système d'entraînement magnétique
CN108697846A (zh) * 2016-02-19 2018-10-23 伟创力有限责任公司 具有磁驱动系统的自动注射装置
CN108697846B (zh) * 2016-02-19 2021-09-10 伟创力有限责任公司 具有磁驱动系统的自动注射装置
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WO2018119055A3 (fr) * 2016-12-21 2018-08-02 Dynamic Magnetics, Llc Dispositif d'entraînement magnétique utilisé pour alimenter un injecteur automatique
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CN115154755A (zh) * 2017-07-20 2022-10-11 E·巴麦农 缆线和滑轮钟表机构流量调节器
CN115154761A (zh) * 2017-07-20 2022-10-11 E·巴麦农 自动注射装置
WO2019016777A1 (fr) * 2017-07-20 2019-01-24 Barmaimon Eyal Régulateur de débit à mécanisme d'horloge
US11517664B2 (en) 2017-07-20 2022-12-06 Flex Ltd. Wire and pulley clock mechanism flow regulator
US11590279B2 (en) 2017-07-20 2023-02-28 Flex Ltd. Clock mechanism flow regulator
CN116492541A (zh) * 2023-03-28 2023-07-28 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法
CN116492541B (zh) * 2023-03-28 2024-06-04 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法
WO2024199257A1 (fr) * 2023-03-28 2024-10-03 卓优医疗(苏州)有限公司 Dispositif d'injection et son procédé de réglage

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