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WO2013025322A3 - Marker-based prognostic risk score in liver cancer - Google Patents

Marker-based prognostic risk score in liver cancer Download PDF

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Publication number
WO2013025322A3
WO2013025322A3 PCT/US2012/048408 US2012048408W WO2013025322A3 WO 2013025322 A3 WO2013025322 A3 WO 2013025322A3 US 2012048408 W US2012048408 W US 2012048408W WO 2013025322 A3 WO2013025322 A3 WO 2013025322A3
Authority
WO
WIPO (PCT)
Prior art keywords
liver cancer
risk score
marker
prognostic risk
based prognostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/048408
Other languages
French (fr)
Other versions
WO2013025322A2 (en
Inventor
Ju-Seog LEE
Soo Mi Kim
In-Sun CHU
Sun-Hee LEEM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2013025322A2 publication Critical patent/WO2013025322A2/en
Publication of WO2013025322A3 publication Critical patent/WO2013025322A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods and compositions for the prognosis and classification of cancer, especially liver cancer, are provided. For example, in certain aspects methods for liver cancer prognosis using expression analysis of selected biomarkers are described. In particular, a risk score may be developed to provide a cancer prognosis.
PCT/US2012/048408 2011-08-15 2012-07-26 Marker-based prognostic risk score in liver cancer Ceased WO2013025322A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161523707P 2011-08-15 2011-08-15
US61/523,707 2011-08-15

Publications (2)

Publication Number Publication Date
WO2013025322A2 WO2013025322A2 (en) 2013-02-21
WO2013025322A3 true WO2013025322A3 (en) 2013-04-11

Family

ID=47715629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/048408 Ceased WO2013025322A2 (en) 2011-08-15 2012-07-26 Marker-based prognostic risk score in liver cancer

Country Status (1)

Country Link
WO (1) WO2013025322A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014173986A2 (en) * 2013-04-25 2014-10-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and monitoring the response to treatment of hepatocellular carcinoma
CN103592438B (en) * 2013-05-29 2015-06-03 首都医科大学附属北京佑安医院 ELISA detection kit of new diagnosis marker regucalcin for liver damage
KR101527283B1 (en) * 2013-08-13 2015-06-10 서울대학교산학협력단 Method for screening cancer marker based on de-glycosylation of glycoproteins and marker for HCC
CN103439516B (en) * 2013-08-15 2016-08-10 中国人民解放军第二军医大学 The application in preparing prognosis in hcc assessment test kit of the HNF4 α albumen
WO2017156594A1 (en) * 2016-03-18 2017-09-21 University Of Melbourne Use of laminins as biomarkers for cancer diagnosis and prognosis
WO2019055648A1 (en) * 2017-09-14 2019-03-21 Tufts Medical Center, Inc. Methods for treating and diagnosing prostate cancer
CN108148835A (en) * 2017-12-07 2018-06-12 和元生物技术（上海）股份有限公司 The sgRNA of CRISPR-Cas9 targeting knock out SLC30A1 genes and its specificity
WO2019115679A1 (en) * 2017-12-13 2019-06-20 Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol A signature to assess prognosis and therapeutic regimen in liver cancer
CN116203142A (en) * 2021-12-01 2023-06-02 中国科学院大连化学物理研究所 Combined marker, application, detection kit and scoring method
CN114107511B (en) * 2022-01-10 2023-10-20 深圳市龙华区人民医院 Marker combination for predicting prognosis of liver cancer and application thereof
CN117165669A (en) * 2023-04-04 2023-12-05 上海交通大学医学院附属仁济医院 Use of marker combinations for detecting liver fibrosis
CN118380153B (en) * 2024-05-06 2024-09-24 重庆市人口和计划生育科学技术研究院 Liver cancer prognosis model based on copper death related gene, construction method and application thereof
CN119560160B (en) * 2025-01-27 2025-10-28 北京大学 Method for constructing cancer assessment model, cancer assessment system, medium and electronic device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030040288A (en) * 2003-04-15 2003-05-22 한국원자력연구소 Microarray for detecting the expression of hepatocellular carcinoma gene and diagnostic method using it
US20100015605A1 (en) * 2005-11-30 2010-01-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Hepatocellular carcinoma classification and prognosis
US20110159498A1 (en) * 2008-04-11 2011-06-30 China Synthetic Rubber Corporation Methods, agents and kits for the detection of cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030040288A (en) * 2003-04-15 2003-05-22 한국원자력연구소 Microarray for detecting the expression of hepatocellular carcinoma gene and diagnostic method using it
US20100015605A1 (en) * 2005-11-30 2010-01-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Hepatocellular carcinoma classification and prognosis
US20110159498A1 (en) * 2008-04-11 2011-06-30 China Synthetic Rubber Corporation Methods, agents and kits for the detection of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEOL, M. A. ET AL.: "Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma", BMC CANCER., vol. 11, 19 February 2011 (2011-02-19), pages 78 *

Also Published As

Publication number Publication date
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