WO2013023560A1 - Dispensing method of powder for injection and dispensing device thereof - Google Patents

Abstract

a dispensing method of powder for injection and a dispending device thereof, comprising: establishing an enclosed replacing channel between a medicine bottle(b) and a liquid bottle(B); generating pumping force in the replacing channel by a external-force-driving device; pumping liquid from the liquid bottle(B) into the medicine bottle(b) for dissolving medicinal powder and refilling a medicinal powder dissolved solution back into the liquid bottle(B); pumping air into the medicine bottle(b), and discharging the medicinal powder dissolved solution remained in the medicine bottle(b) and the replacing channel into the liquid bottle(B) to a maximum extent, so as to finish the dispensing process of completely transferring the medicinal powder from the medicine bottle(b) to the liquid bottle(B). The dispensing device comprises a driving device(11) and a dispenser, the dispenser is composed of a displacement rod(1) and an elastic flexible pipe(2), alternatively, the dispenser can be a double-channel or single-channel replacing needle, which completes the dispensing process via gas-liquid replacement between the two sterile spaces, i.e. the medicine bottle(b) and the liquid bottle(B), without communicating with the environment air, so it can avoid the air contamination effectively during the dispensing process, meanwhile the powder for injection in the medicine bottle(b) can be completely dissolved and displaced so as to reduce the medicine wasting, simplify the dispensing process, and improve the dispensing efficiency.

Description

 Powder injection preparation method and dispensing device thereof

TECHNICAL FIELD The present invention relates to the field of medical devices, and provides a method for dispensing a powder injection and a dispensing device therefor.

BACKGROUND OF THE INVENTION In the domestic and international medical treatments for input liquids, a disposable syringe is used to inject a small amount of liquid into a powdered vial, and the powder is fully dissolved and then pumped back into the liquid bottle. The above method has the following disadvantages: First, the drug is wasted, since the syringe can only take a small amount of liquid, the internal space of the powdered medicine bottle is also small, and only a small amount of liquid (usually 2-3 ml) can be injected at a time to dissolve the powder. Even a high concentration of the drug solution has a small amount of drug waste in the vial and syringe (0. 2-0. 3 ml). Therefore, the current dispensing method generally causes about 10% of drug waste. Second, the process is cumbersome. When dispensing the liquid, first use a syringe to pump the liquid → inject the vial (if the positive pressure is generated in the vial, you need to vent) → pull out the syringe → shake the vial to dissolve the powder → use the syringe to pump back The powder injection solution (such as the negative pressure generated in the medicine bottle also needs to be injected with gas) → finally injected into the liquid bottle. If more than one drug is required in a group of liquids, the above process needs to be repeated; if the powder dissolves slowly, the dispensing time will be longer. Third, it is easy to be contaminated. Because the syringe needle is repeatedly exposed to the air during the dosing process and punctures the vial and the liquid bottle stopper, it is possible to inject the gas, and the chance of contamination of the liquid is increased.

Disclosure of the Invention An object of the present invention is to provide a powder injection preparation method which can complete a dispensing process by gas-liquid displacement between a vial and a liquid bottle without communicating with outside air, thereby effectively avoiding air pollution during dispensing.

 Another object of the present invention is to provide a dispensing device for the above dispensing method.

 In order to achieve the above object, the technical solution adopted by the present invention is:

 A powder injection preparation method, establishing a sealed replacement passage between a liquid bottle and a vial; driving an external force to promote a suction force inside the displacement passage; sucking the liquid in the liquid bottle into the medicine bottle to dissolve the powder, the powder solution Re-injection into the liquid bottle; pumping air into the vial, maximally dissipating the residual powder solution in the vial and the replacement channel into the liquid bottle, and completely transferring the powder in the vial to the liquid The dispensing process in the bottle.

As a modification of the above-mentioned powder injection method, a closed cycle replacement passage is formed by a displacement rod, an elastic hose, a medicine bottle and a liquid bottle; a suction force is generated in the circulation displacement passage by the peristaltic elastic hose; The liquid in the liquid bottle enters the vial to dissolve the powder, and the powder solution is reinjected into the liquid bottle; the air is sucked into the vial, and the residual powder in the vial and the circulation replacement channel is maximized. Displacement into the liquid bottle, complete the dispensing process of fully transferring the powder in the vial to the liquid bottle. As another improvement scheme Y of the above powder injection method, a closed replacement passage between the medicine bottle and the soft plastic liquid bottle is established, and the soft plastic liquid bottle is placed on the top of the medicine bottle, and the drive is driven by the squeeze soft plastic liquid bottle. Force, squeeze the liquid in the soft plastic liquid bottle into the medicine bottle to dissolve the powder; then pour the medicine bottle over the soft plastic liquid bottle, squeeze the soft plastic liquid bottle again, and inject the air in the soft plastic liquid bottle into the medicine. In the bottle, the liquid in the back-feeding bottle enters the soft plastic liquid bottle; the dispensing process of transferring the powder in the vial to the soft plastic liquid bottle is completed.

 As an improvement scheme Yl of the above scheme, a closed circulation replacement passage between the medicine bottle and the soft plastic liquid bottle is established, and the soft plastic liquid bottle is poured on the top of the medicine bottle, and the driving force is generated by pressing the soft plastic liquid bottle. The liquid in the soft plastic liquid bottle is squeezed into the medicine bottle to dissolve the powder; then the medicine bottle is poured over the soft plastic liquid bottle, and the soft plastic liquid bottle is squeezed again, and the air in the soft plastic liquid bottle is injected into the medicine bottle. The liquid in the back-feeding bottle enters the soft plastic liquid bottle; the dispensing process of transferring the powder in the vial to the soft plastic liquid bottle is completed.

 As another improvement scheme of the above scheme, 建立2, a closed single displacement passage between the medicine bottle and the soft plastic liquid bottle is established, and the soft plastic liquid bottle is placed on the top of the medicine bottle, and the driving force is generated by pressing the soft plastic liquid bottle. The liquid in the extruded soft plastic liquid bottle enters the medicine bottle to dissolve the powder; then the medicine bottle is placed on top of the soft plastic liquid bottle, and the soft plastic liquid bottle is squeezed again to inject the air in the soft plastic liquid bottle into the medicine bottle. The liquid in the back-feeding bottle enters the soft plastic liquid bottle; the dispensing process of transferring the powder in the vial to the soft plastic liquid bottle is completed.

 A dispensing device for realizing the above dispensing method or the improved solution X thereof, comprising a driving device and a dispensing device, the dispensing device consisting of a displacement rod and an elastic hose, the displacement rods are sharp at both ends, and one end is inserted into the liquid bottle end, and is provided with suction The other end is inserted into the vial end, and has an inlet and an outlet. The waist of the displacement rod is provided with two protruding first connecting nozzles and a second connecting nozzle, and the two ends of the elastic hose are respectively connected with the first connection. The first connecting nozzle is connected with the suction hole at one end of the displacement rod, and the second connecting nozzle is connected to the inlet of the other end of the displacement rod, and is connected with the elastic hose to form the first passage, the first passage The elastic hose is adapted to the driving device slot; the outlet hole at one end of the displacement rod and the outlet at the other end directly penetrate to form a second passage.

A dispensing device for realizing the above-mentioned dispensing method or the improvement scheme Y1 or the modified solution Y1 thereof, comprising a double-channel replacement needle having sharp ends at both ends, one end being inserted into the soft plastic liquid bottle end, and provided with a liquid The bottle inlet hole and the liquid bottle outlet hole, and the other end is inserted into the bottle end, and the medicine bottle inlet hole and the medicine bottle outlet hole are provided. The liquid bottle outlet hole and the medicine bottle inlet hole penetrate to form a first passage, and the medicine bottle outlet hole and the liquid bottle inlet hole penetrate to form a second passage.

 An improved solution for realizing the above-mentioned dispensing method or the improved solution Y or Y. The dispensing device of Y2 is composed of a single-channel replacement needle which is sharp at both ends, and the openings at both ends form a channel.

 The above dispensing method and the dispensing device provided by the invention can complete the dispensing process by gas-liquid displacement in two sterile spaces of the medicine bottle and the liquid bottle, and do not need to communicate with the outside air, thereby effectively avoiding the air (especially the ward) when dispensing the medicine. The airborne bacteria are contaminated, and the powder injection in the vial can be fully dissolved and replaced, thereby minimizing waste of the drug, and the operation is simple and the dispensing efficiency is high.

DRAWINGS

 BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the structure of a first embodiment (integrated short rod structure) of a first dispensing device of the present invention.

 Fig. 2 is a schematic view showing the structure of a second embodiment (integral long rod structure) of the first dispensing device of the present invention.

 Fig. 3 is a schematic view showing the structure of a third embodiment (separate short rod structure) of the first dispensing device of the present invention.

 Fig. 4 is a schematic view showing the structure of a fourth embodiment (separate long rod structure) of the first dispensing device of the present invention.

 Fig. 5 and Fig. 6 are schematic views showing the dispensing process of the first embodiment (integrated short rod structure) of the first dispensing device of the present invention.

 Fig. 7 and Fig. 8 are schematic views showing the second embodiment of the first dispensing device of the present invention (integrated long rod structure).

 Figure 9 is a schematic view showing the structure of a second dispensing device of the present invention.

 Fig. 9-1, Fig. 9-2, Fig. 9-3, and Fig. 9-4 are schematic diagrams showing the sequence of the dispensing method using the second dispensing device in the dispensing method of the present invention.

 Figure 10 is a schematic view showing the structure of a third dispensing device of the present invention.

 Fig. 10-1, Fig. 10-2, Fig. 10-3, and Fig. 10-4 are respectively schematic diagrams showing the sequence of the dispensing method using the third dispensing device in the dispensing method of the present invention.

In the figure: B-liquid bottle; b-medicine bottle; Z-injector; 1-displacement rod, 101-first displacement rod, 102-second displacement rod; 2-elastic hose; 3-suction hole; One connector; 5-second connector; 6-inlet; 7- Outlet; 8-outlet; 9-first channel; 10-second channel; 11-drive device; 12-first replacement needle; 13-first channel; 14-second channel; 15-liquid bottle inlet; 16-Pill bottle outlet; 17-Pill bottle inlet; 18-Liquid bottle outlet; 19-limit collar; 20-Second replacement needle; 21-third channel, 22- vial end opening; - Open the end of the liquid bottle.

DETAILED DESCRIPTION OF THE INVENTION The present invention aims to provide a method for dispensing a powder injection through a gas-liquid displacement between a vial and a liquid bottle, without the need to communicate with the outside air, and effectively avoiding air pollution when dispensing the drug. Firstly, a closed displacement passage between the medicine bottle b and the liquid bottle B is established; the external force is used to drive the suction force inside the displacement passage; the liquid in the liquid bottle B is sucked into the medicine bottle b to dissolve the powder, and the powder solution is returned again. Injecting into the liquid bottle B; pumping air into the vial b, maximally discharging the residual powder solution in the vial b and the replacement channel into the liquid bottle B, and completing the powder in the vial b sufficiently Transfer to the dispensing process in liquid bottle B.

 Further, a closed circulation replacement passage is formed by the displacement rod 1, the elastic hose 2, the vial b, and the liquid bottle B; the suction force is generated in the circulation displacement passage by the peristaltic elastic hose 2; The liquid enters the vial b to dissolve the powder, and the powder solution is reinjected into the liquid bottle B; the suction air enters the vial b, and the drug powder b and the residual powder solution in the circulation replacement channel are squeezed out to the maximum extent. In the liquid bottle B, the dispensing process of sufficiently transferring the powder in the vial b to the liquid bottle B is completed.

 Alternatively, a closed displacement passage between the vial b and the soft plastic liquid bottle B is established, and the soft plastic liquid bottle B is placed on top of the vial b, and the driving force is generated by pressing the soft plastic liquid bottle B to extrude the soft plastic. The liquid in the liquid bottle B enters the vial b to dissolve the powder; then the pill b is placed on top of the soft plastic liquid bottle B, the soft plastic liquid bottle B is squeezed again, and the air in the soft plastic liquid bottle B is injected into the medicine. In the bottle b, the liquid medicine in the sucking bottle b enters the soft plastic liquid bottle B; the dispensing process of transferring the powder in the medicine bottle b to the soft plastic liquid bottle B is completed.

 The sealed displacement passage between the vial b and the soft plastic liquid bottle B may be a closed circulation replacement passage or a closed single displacement passage.

 All of the above-mentioned dispensing methods provided by the present invention establish a closed displacement passage between the two sterile spaces of the medicine bottle and the liquid bottle, and do not communicate with the outside air, and the dispensing process is completed by gas-liquid displacement. Reduce drug waste, simplify the dispensing process, and reduce the risk of contamination of the drug with air (especially in the ward with pathogens) during dispensing.

The technical solutions of the present invention will be further described in detail below in conjunction with the specific embodiments and the accompanying drawings. It should be noted that other equivalent modifications and improvements can be made by those skilled in the art in light of the teachings of the present invention.

 A first dispensing device for carrying out the above dispensing method of the present invention comprises a driving device 11 and a dispensing device, and the driving device 11 can be a peristaltic pump of the prior art; the dispensing device is composed of a displacement rod 1 and an elastic hose 2, a displacement rod 1The ends are sharp, one end is inserted into the B end of the liquid bottle, the suction hole 3 and the outlet hole 8 are provided, the other end is inserted into the b end of the vial, the inlet 6 and the outlet 7 are provided, and the waist of the displacement rod 1 is provided with two protrusions The first connecting nozzle 4 and the second connecting nozzle 5, the two ends of the elastic hose 2 are respectively connected with the first connecting nozzle 4 and the second connecting nozzle 5; the first connecting nozzle 4 and the suction hole at one end of the replacement rod 1 3 penetrates, the second connecting nozzle 5 penetrates with the inlet 6 of the other end of the displacement rod 1, and is connected via the elastic hose 2 to form the first passage 9, the elastic hose 2 and the driving device (peristaltic pump) in the first passage 9 The card slot is adapted; the outlet hole 8 at one end of the displacement rod 1 and the outlet 7 at the other end directly penetrate to form the second channel 10. The specific structure of the dispensing device is various, and it can be either a short rod structure or a long rod structure; it can be either an integral structure or a split structure.

 BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the structure of a first embodiment of a dispenser in a first dispensing device of the present invention. It consists of a displacement rod 1 and an elastic hose 2, which is an integral short rod structure. The displacement rod 1 is sharp at both ends, one end is inserted into the liquid bottle B end, the length of which is smaller than the distance between the liquid surface of the liquid bottle B and the stopper thereof, and the suction hole 3 and the outlet hole 8 are provided; the other end is inserted into the b end of the vial, An inlet 6 and an outlet 7 are provided, and an outlet 7 is provided in the stopper immediately adjacent to the vial b to maximize the displacement of the powdered solution remaining in the vial b and the replacement passage into the liquid bottle B. The waist of the replacement rod 1 is provided with two protruding first connecting nozzles 4 and a second connecting nozzle 5, and two ends of the elastic hose 2 are respectively connected with the first connecting nozzle 4 and the second connecting nozzle 5, and the first connecting nozzle 4 The first port 9 is connected to the inlet 6 of the other end of the displacement rod 1 and the second port 5 is connected to the inlet 6 of the other end of the displacement rod 1 to form a first passage 9, and the elastic hose 2 in the first passage 9 The card slot of the driving device (peristaltic pump) 11 is adapted; the outlet hole 8 at one end of the displacement rod 1 and the outlet 7 at the other end directly penetrate to form the second channel 10.

Figure 2 is a schematic view showing the structure of a second embodiment of the dispenser in the first dispensing device of the present invention. It differs from the first embodiment only in that: the displacement rod 1 is an integral long rod structure, that is, the displacement rod 1 is inserted into one end of the liquid bottle B, the length of which is greater than the liquid bottle B liquid level and its stopper The spacing, the suction hole 3 is below the liquid level of the liquid bottle B, and the outlet hole 8 must be above the liquid level of the liquid bottle B; the displacement rod 1 is inserted into one end of the vial b, and the inlet 6 is disposed adjacent to the vial b Cork. Fig. 3 is a schematic view showing the structure of a third embodiment of the dispenser in the first dispensing device of the present invention. It differs from the first embodiment only in that the displacement rod 1 of the dispenser is a split short rod structure, that is, the first passage 9 and the second passage 10 of the displacement rod 1 are separated by the suction hole 3 and the first connection nozzle. 4. The first passage 9 composed of the elastic hose 2, the second connecting nozzle 5 and the inlet 6 is separately formed into a first displacement rod 101, and the second passage 10 composed of the outlet 7 and the outlet hole 8 is separately made into a second displacement rod. 102; the first displacement rod 101 is inserted into one end of the liquid bottle B, the length of which is smaller than the distance between the liquid surface of the liquid bottle B and the stopper; the second displacement rod 102 is inserted into one end of the medicine bottle b, and the outlet 7 is disposed adjacent to the medicine bottle The cork of b.

 Figure 4 is a schematic view showing the structure of a fourth embodiment of the dispenser in the first dispensing device of the present invention. It differs from the first embodiment only in that the displacement rod 1 of the dispenser is a split-type long rod structure, and the split form is the same as the third embodiment, that is, the first passage 9 and the second passage of the replacement rod 1 are replaced. 10 separation, the first passage 9 composed of the suction hole 3, the first connecting nozzle 4, the elastic hose 2, the second connecting nozzle 5 and the inlet 6 is separately formed into the first displacement rod 101, and is constituted by the outlet 7 and the outlet hole 8. The second passage 10 is separately formed into a second displacement rod 102. The long rod form is the same as the third embodiment. The first displacement rod 101 is inserted into one end of the liquid bottle B, the length of which is greater than the distance between the liquid level of the liquid bottle B and the stopper thereof, and the suction hole 3 is in the liquid of the liquid bottle B. Below the face, the first displacement rod 101 is inserted into one end of the vial b, the inlet 6 is provided at the stopper of the vial; the second displacement rod 102 is inserted into one end of the liquid bottle B, and the outlet 8 is in the liquid bottle B. Above the liquid level.

 That is, the first displacement rod 101 is inserted into one end of the liquid bottle B, the length of which is greater than the distance between the liquid surface of the liquid bottle B and the stopper thereof, and the outlet hole 8 must be above the liquid surface of the liquid bottle B; the second displacement rod 102 is inserted. One end of the vial b, the inlet 6 of which is located immediately adjacent to the stopper of the vial b.

Figures 5 and 6 show the dispensing process of the first embodiment of the dispensing device of the present invention. The displacement rod 1 of the dispenser is an integral short rod structure, and the "short rod" is embodied at one end of the displacement rod 1 inserted into the liquid bottle B, the length of which is smaller than the distance between the liquid surface of the liquid bottle B and its stopper. During dispensing, the two ends of the displacement rod 1 are inserted into the corresponding liquid bottle B and the vial b, and the liquid bottle B bottle is turned upside down, so that the suction hole 3 at one end of the displacement rod 1 is swept into the liquid. When the elastic hose 2 is peristaltic from the liquid bottle B toward the vial b, the liquid in the liquid bottle B constitutes the first through the suction hole 3, the first connecting nozzle 4, the elastic hose 2, the second connecting nozzle 5, and the inlet 6. The passage 9 is injected into the vial b in a large amount, and is returned to the liquid bottle B via the second passage 10 formed by the outlet 7 and the outlet 8 of the displacement rod 1. At this time, while keeping the original connection state unchanged, the position of the liquid bottle B and the vial b is adjusted, and the liquid bottle B bottle mouth is placed upright, and the suction hole originally immersed in the liquid in the inverted liquid bottle B is immersed. 3 will be exposed to the air in the bottle, continue to creep the elastic hose 2, and the self-suction hole 3 is injected into the vial through the first passage 9. b will be the air in the liquid bottle B, and the residual drug solution in the bottle B discharged through the air is returned from the outlet 7 through the second passage 10 to the liquid bottle B to complete the entire dispensing process. Since the outlet 7 is adjacent to the inverted vial b stopper, the liquid residue will be minimized.

 The dispensing process of the third embodiment (separate short rod structure) is the same as the above-described first embodiment (one-piece short rod structure) dispensing process, and will not be described again.

 Fig. 7 and Fig. 8 show the dispensing process of the second embodiment of the dispensing device of the present invention. The displacement rod 1 of the dispenser is an integral long rod structure, and the "long rod" is embodied at one end of the displacement rod 1 inserted into the liquid bottle B, the length of which is greater than the distance between the liquid level of the liquid bottle B and its stopper. When dispensing, the displacement rod 1 is inserted into the liquid bottle B at one end longer, and the suction hole 3 at the top end is directly poured into the liquid, but the outlet hole 8 must be above the liquid level of the liquid bottle B. When the elastic hose 2 is peristaltic from the liquid bottle B toward the vial b, the liquid in the liquid bottle B is largely injected into the vial b from the first passage 9 composed of the suction hole 3, the elastic hose 2 and the inlet 6. Since the outlet 7 is located at the end of the displacement rod 1 and is far from the bottle stopper of the inverted vial b, the injected chemical solution will have a certain amount of accumulation in the vial b to fully dissolve and dilute the powder injection, and then through the discharge rod 1 on the outlet 7 The second passage 10 formed with the outlet 8 is returned to the liquid bottle B. At this time, in the case of leaving the original connection state unchanged, it is only necessary to peristrate the elastic hose 2 from the vial b in the direction of the liquid bottle B, since the outlet hole 8 of the displacement rod 1 located in the liquid bottle B is located in the air inside the bottle. The suction force generated by the reverse peristaltic elastic hose 2 is sucked from the outlet hole 8 into the vial b through the second passage 10, and is discharged by the air. The residual liquid in the vial b passes through the inlet 6 through the first Channel 9 is returned to liquid bottle B. Since the inlet 6 is the final outlet immediately adjacent to the inverted vial b stopper, the liquid residue will be minimized.

 The dispensing process of the fourth embodiment (separate long rod structure) is the same as that of the second embodiment (one-piece long rod structure), and will not be described again.

 The above dispensing method and the first dispensing device provided by the invention can complete all dispensing processes by simply moving the elastic hose after connecting the dispensing device according to requirements, thereby greatly simplifying the complicated and cumbersome operation of the traditional dispensing method; The process is completed in a closed gas and liquid displacement channel, and the gas and liquid replacement principle is flexibly utilized, which greatly reduces the waste of the drug and greatly reduces the probability of contamination of the drug.

In order to improve the above-mentioned dispensing device used in the dispensing method, the present invention proposes a second dispensing device which is simpler in structure as shown in FIG. 9 and can be used for dispensing a soft plastic bottle; the second dispensing device is composed of a special two-channel first replacement needle 12, the first replacement needle 12 is a one-piece structure, and the two ends are pointed Sharp, one end is inserted into the soft plastic liquid bottle B end, there is a liquid bottle inlet hole 15 and a liquid bottle outlet hole 18, and the other end is inserted into the pill bottle end b, with a vial inlet hole 17 and a vial outlet hole 16, liquid The bottle outlet hole 18 and the vial inlet hole 17 penetrate to constitute the first passage 13, and the vial outlet hole 16 and the liquid bottle inlet hole 15 penetrate to form the second passage 14. The waist of the first replacement needle 12 is provided with a limiting convex ring 19, and the limiting convex ring 19 is disposed perpendicular to the first channel 13 and the second channel 14. The limiting convex ring 19 is used to define the two ends of the first replacement needle 12 respectively passing through the bottle. The position at which the plug is inserted into the interior of the vial b and the soft plastic liquid bottle B, that is, the end of the first replacement needle 12 inserted into the soft plastic liquid bottle B is defined, the length of which is smaller than the distance between the liquid surface of the soft plastic liquid bottle B and the stopper thereof; The first replacement needle 12 is defined to be inserted into one end of the vial b, and the vial outlet 16 is provided adjacent to the stopper of the vial b. Compared with the above-mentioned first dispensing device, the dispensing device eliminates the peristaltic pump, the peristaltic hose and the connecting nozzle, and has a simpler structure and lower cost.

Fig. 9-1, Fig. 9-2, Fig. 9-3, and Fig. 9-4 are schematic diagrams showing the sequence of dispensing by the second dispensing device according to the dispensing method of the present invention. When dispensing, insert the two ends of the first replacement needle 12 into the corresponding soft plastic liquid bottle B and the medicine bottle b, so that the medicine bottle outlet hole 16 and the medicine bottle inlet hole 17 are located in the medicine bottle b, so that the liquid bottle is out of the hole. 18 and the liquid bottle inlet 15 are located in the soft plastic liquid bottle B. As shown in Figure 9-1, the vial b is placed first, and the soft plastic liquid bottle B is placed over the vial b, so that the end of the first replacement needle 12 in the soft plastic liquid bottle B is in the soft plastic liquid bottle B. In the liquid, the soft plastic liquid bottle B is squeezed to increase the internal pressure, and the pressure in the soft plastic liquid bottle B will be greater than the pressure in the medicine bottle b, since the position of the medicine bottle inlet hole 17 is lower than the medicine bottle outlet hole 16 In position, the liquid in the soft plastic liquid bottle B is squeezed into the vial b through the first passage 13 to the pressure balance in the two bottles. As shown in Fig. 9-2, when the soft plastic liquid bottle B is released from being squeezed, the pressure in the soft plastic liquid bottle B becomes smaller, and the pressure previously pushed into the liquid pressurized vial b is greater than that of the soft plastic liquid bottle. The pressure in B causes the air in the vial b to enter the second passage 14 through the vial outlet 16 and into the soft plastic liquid bottle B through the second passage 14 to restore the pressure balance in the two vials. Similarly, repeated extrusion and relaxation of the soft plastic liquid bottle B, the above pressure changes and liquid, gas transfer will continue, because the position of the vial outlet 16 is higher than the position of the vial 17 and adjacent to the vial b. The stopper, the above process will maximize the emptying of the air in the vial b until the vial b is filled with liquid. After the powder in the vial b is dissolved, the soft plastic liquid bottle B and the vial b are turned over while the original connection state is maintained, so that the vial b is inverted over the soft plastic liquid bottle B, and the soft plastic liquid bottle B The bottle mouth is up. As shown in Fig. 9-3, at this time, the top end of the first replacement needle 12 inserted into the soft plastic liquid bottle B is placed in the air in the soft plastic liquid bottle B, and the soft plastic liquid bottle B is squeezed to increase the internal pressure thereof. The pressure inside the soft plastic liquid bottle B is greater than the pressure inside the medicine bottle b, Since the position of the vial inlet hole 17 is higher than the position of the vial outlet 16, the air in the soft plastic liquid bottle B enters the first passage 13 through the liquid bottle outlet hole 18 and is squeezed into the vial b. As shown in Figure 9-4, when the soft plastic liquid bottle B is released, the pressure in the soft plastic liquid bottle B becomes smaller, and the pressure in the vial b that has been previously squeezed into the air is greater than the soft plastic liquid bottle B. The internal pressure creates a pressure difference between the two bottles. Under the pressure difference, the liquid medicine in the vial b enters the second passage 14 through the vial outlet 16 and is injected into the soft plastic liquid bottle through the second passage 14. B. Similarly, repeated extrusion and relaxation of the soft plastic liquid bottle B, the above pressure changes and liquid, gas transfer will continue, due to the low position of the vial 16 of the vial and the bottle stopper immediately adjacent to the vial, so that in the vial b The liquid is drained to the maximum extent, reducing the residue of the liquid in the vial b.

 The dispensing device used in the dispensing method is continuously improved and perfected, and under the premise of ensuring the quality of the dispensing, a third dispensing device with a simpler structure and lower cost as shown in FIG. 10 is studied, which is composed of one. The second replacement needle 20 of the single channel is formed. The second replacement needle 20 is of a unitary structure, and the two ends are sharp. One end is inserted into the soft plastic liquid bottle B end, and the liquid bottle end opening 23 is provided; the other end is inserted into the medicine bottle. At the b-end, a vial end opening 22 is provided, and the opening 22, 23 at both ends penetrates to form an axial third passage 21. The waist of the second replacement needle 20 is provided with a limiting convex ring 19, and the limiting convex ring 19 is disposed perpendicular to the third passage 21, and the limiting convex ring 19 is used for defining one end of the second replacement needle 20 inserted into the soft plastic liquid bottle B. The length is less than the distance between the liquid surface of the soft plastic liquid bottle B and its stopper; the second replacement needle 20 is defined to be inserted into one end of the vial b, and the vial end opening 22 is disposed adjacent to the stopper of the vial b.

Fig. 10-1, Fig. 10-2, Fig. 10-3, and Fig. 10-4 are schematic diagrams showing the sequence of the dispensing method using the third dispensing device in the dispensing method of the present invention. When dispensing, insert the two ends of the second replacement needle 20 into the corresponding soft plastic liquid bottle B and the medicine bottle b, so that the medicine bottle end opening 22 is located in the medicine bottle b, and the liquid bottle end opening 23 is located in the soft plastic liquid. Inside the bottle B. As shown in 10-1, the vial b is placed first, and the soft plastic liquid bottle B is placed over the vial b, so that the end of the second replacement needle 20 in the soft plastic liquid bottle B is in the soft plastic liquid bottle B. In the liquid, the soft plastic liquid bottle B is squeezed to increase the internal pressure thereof, and the pressure in the soft plastic liquid bottle B is greater than the pressure of the medicine bottle b, and the liquid in the soft plastic liquid bottle B is squeezed into the medicine bottle through the third passage 21 in. As shown in Fig. 10-2, when the soft plastic liquid bottle B is released from being squeezed, the pressure in the soft plastic liquid bottle B becomes smaller, and the pressure previously pushed into the liquid pressurized vial b is greater than that of the soft plastic liquid bottle. The pressure in B causes air to be injected into the soft plastic liquid bottle B through the third passage 21, and the pressure balance is restored in the two bottles. Similarly, repeated extrusion and relaxation of the soft plastic liquid bottle B, the above pressure changes and liquid and gas transfer will continue. When the medicine powder of the medicine bottle b is dissolved, it is turned over while maintaining the original connection state. Turn the soft plastic liquid bottle B and the pill b so that the pill b is placed upside down on the soft plastic liquid bottle B, and the soft plastic liquid bottle B is up. As shown in Fig. 10-3, at this time, the top end of the second replacement needle 20 inserted into the soft plastic liquid bottle B is placed in the air in the soft plastic liquid bottle B, and the soft plastic liquid bottle B is squeezed to increase the internal pressure thereof. The pressure in the soft plastic liquid bottle B is greater than the pressure in the vial b, and the air in the soft plastic liquid bottle B is pushed into the vial b through the third passage 21. As shown in Figure 10-4, when the soft plastic liquid bottle B is released, the pressure in the soft plastic liquid bottle B becomes smaller, and the pressure in the vial b that has been previously squeezed into the air is greater than the soft plastic liquid bottle B. The pressure inside, a pressure difference between the two bottles, under the action of the pressure difference, the liquid medicine in the vial b is sucked back into the soft plastic liquid bottle B through the third passage 21. Similarly, repeated extrusion and relaxation of the soft plastic liquid bottle B, the above pressure changes and liquid, gas transfer will continue, due to the low position of the vial end opening 22, and close to the vial b stopper, so that the vial b The liquid in the solution is drained to the maximum extent, reducing the residue of the liquid in the vial b.

 Although the dispensing efficiency of the second replacement needle 20 is slightly lower than that of the first replacement needle 12, the structure is simpler, the cost is lower, and the market is more popular. All of the dispensing devices of the present invention, together with other dispensing devices developed by the Applicant, are better able to meet the diverse requirements of clinical dispensing.

Claims

A method for dispensing a powder injection, characterized in that: a closed displacement passage between a vial (b) and a liquid bottle (B) is established; an external force is used to drive a suction force inside the replacement passage; and a liquid bottle is sucked (B) The liquid in the medicine enters the vial (b) to dissolve the powder, and the powder solution is reinjected into the liquid bottle (B); the air is sucked into the vial (b), the vial (b) and the replacement channel are The residual powder solution is pushed out to the liquid bottle (B) to the maximum extent, and the dispensing process of fully transferring the powder in the vial (b) to the liquid bottle (B) is completed.  2. The dispensing method according to claim 1, wherein: the displacement rod (1), the elastic hose (2), the vial (b), and the liquid bottle (B) constitute a closed loop replacement passage; The flexible hose (2) generates a suction force in the circulation displacement passage; the liquid in the suction liquid bottle (B) enters the vial (b) to dissolve the powder, and the powder solution is reinjected into the liquid bottle (B). Pumping air into the vial (b), maximizing the discharge of the powder solution remaining in the vial (b) and the circulation replacement channel into the liquid bottle (B), completing the vial (b) The powder is fully transferred to the dispensing process in the liquid bottle (B).  3. The dispensing method according to claim 1, wherein: a closed displacement passage between the vial (b) and the soft plastic liquid bottle (B) is established, and the soft plastic liquid bottle (B) is placed in the vial ( Above b), use the extruded soft plastic liquid bottle (B) to generate the driving force, and squeeze the liquid in the soft plastic liquid bottle (B) into the vial (b) to dissolve the powder; then invert the vial (b) On top of the soft plastic liquid bottle (B), squeeze the soft plastic liquid bottle (B) again, and inject the air from the soft plastic liquid bottle (B) into the vial (b), back in the vial (b). The liquid enters the soft plastic liquid bottle (B); the dispensing process of transferring the powder in the vial (b) to the soft plastic liquid bottle (B) is completed.  4. The dispensing method according to claim 3, characterized in that: a closed circulation replacement passage between the vial (b) and the soft plastic liquid bottle (B) is established, and the soft plastic liquid bottle (B) is placed in the vial. Above the (b), use the extruded soft plastic liquid bottle (B) to generate the driving force, and the liquid in the soft plastic liquid bottle (B) is extruded into the vial (b) to dissolve the powder; then the vial (b) Pour it over the soft plastic liquid bottle (B), squeeze the soft plastic liquid bottle (B) again, and inject the air from the soft plastic liquid bottle (B) into the vial (b) and back into the vial (b). The liquid enters the soft plastic liquid bottle (B); the dispensing process of transferring the powder in the vial (b) to the soft plastic liquid bottle (B) is completed. 5. The method of dispensing according to claim 3. It is characterized by: a closed single displacement passage between the vial (b) and the soft plastic liquid bottle (B) is established, and the soft plastic liquid bottle (B) is placed over the vial (b), and the soft plastic liquid is squeezed. The bottle (B) generates a driving force to extrude the liquid in the soft plastic liquid bottle (B) Enter the vial (b) to dissolve the powder; then pour the vial (b) over the soft plastic liquid bottle (B), squeeze the soft plastic liquid bottle (B) again, and place the soft plastic liquid bottle (B) The air is injected into the vial (b), and the liquid in the back-feeding bottle (b) enters the soft plastic liquid bottle (B); the transfer of the powder in the vial (b) to the soft plastic liquid bottle (B) The dispensing process in ).  6. A dispensing device for carrying out the dispensing method according to claim 1 or 2, characterized in that it comprises a driving device (11) and a dispensing device, the dispensing device consisting of a displacement rod (1) and an elastic hose (2), Displacement rod (1) Both ends are sharp, one end is inserted into the liquid bottle (B) end, with suction hole (3) and outlet hole (8), and the other end is inserted into the vial (b) end, with inlet (6) and outlet (7), the waist of the displacement rod (1) is provided with two protruding first connecting nozzles and second connecting nozzles (4, 5), and the two ends of the elastic hose (2) are respectively connected with the first connecting nozzle and the second Connecting nozzles (4, 5); the first connecting nozzle (4) and the suction hole at one end of the displacement rod (1) (3) through, the second connecting nozzle (5) is connected to the inlet (6) at the other end of the displacement rod (1), and is connected to the first passage (9) via the elastic hose (2), the first passage (9) The elastic hose (2) in the middle is adapted to the driving device (11); the outlet hole (8) at one end of the displacement rod (1) and the outlet (7) at the other end directly penetrate to form the second passage (10).  7. Dispensing device according to claim 6, characterized in that the displacement rod (1) is an integral short rod structure, and the displacement rod (1) is inserted into one end of the liquid bottle (B), the length of which is smaller than the liquid bottle (B) The distance between the liquid level and its stopper; the displacement rod (1) is inserted into one end of the vial (b) and the outlet (7) is placed next to the stopper of the vial (b).  8. Dispensing device according to claim 6, characterized in that the displacement rod (1) is an integral long rod structure, and the displacement rod (1) is inserted into one end of the liquid bottle (B), the length of which is larger than the liquid bottle (B) the distance between the liquid level and its stopper, the suction hole (3) is below the liquid level of the liquid bottle (B), and the outlet hole (8) is above the liquid level of the liquid bottle (B); (1) Insert one end of the vial (b) and the inlet (6) is placed next to the stopper of the vial (b). 9. Dispensing device according to claim 6, characterized in that the displacement rod (1) is a split short rod structure, ie the first channel (9) and the second channel (10) of the replacement rod (1) Separating, the first passage (9) consisting of the suction hole (3), the first connecting nozzle (4), the elastic hose (2), the second connecting nozzle (5) and the inlet (6) is separately made into the first The displacement rod (101), the second passage (10) composed of the outlet (7) and the outlet hole (8) is separately formed into a second displacement rod (102); the first displacement rod (101) is inserted into the liquid bottle (B) One end, the length is less than the distance between the liquid bottle (B) liquid level and its stopper; the second displacement rod (102) is inserted At one end of the vial (b), the outlet (7) is placed next to the stopper of the vial (b).  10. Dispensing device according to claim 6, characterized in that the displacement rod (1) is a split-type long rod structure, ie the first channel (9) and the second channel (10) of the replacement rod (1) Separating, the first passage (9) consisting of the suction hole (3), the first connecting nozzle (4), the elastic hose (2), the second connecting nozzle (5) and the inlet (6) is separately made into the first The displacement rod (101), the second passage (10) composed of the outlet (7) and the outlet hole (8) is separately formed into a second displacement rod (102); the first displacement rod (101) is inserted into the liquid bottle (B) One end, the length of which is greater than the distance between the liquid surface of the liquid bottle (B) and its stopper, the suction hole (3) is below the liquid level of the liquid bottle (B), and the first displacement rod (101) is inserted into the vial (b) At one end, the inlet (6) is located next to the stopper of the vial (b); the second displacement rod (102) is inserted into one end of the liquid bottle (B), and the outlet (8) is in the liquid bottle (B) Above the liquid level.  11. A dispensing device for realizing the dispensing method according to claim 1 or 3 or 4, wherein: the dispensing device is composed of a double-channel replacement needle, the two-way replacement needle being sharp at both ends, and one end is inserted into a soft plastic liquid bottle (P) end, with liquid bottle inlet (15) and liquid bottle outlet (18), and the other end is inserted into the vial (b) end, there is a medicine bottle inlet hole (17) and a medicine bottle outlet hole (16), and the liquid bottle outlet hole (18) and the medicine bottle inlet hole (17) penetrate to form a first passage (13), the medicine bottle is out The hole (16) penetrates with the liquid bottle inlet hole (15) to form a second passage (14).  12. The dispensing device according to claim 11, wherein: the waist of the two-channel replacement needle is provided with a limiting collar (19), and the two-channel replacement needle is inserted into one end of the soft plastic liquid bottle (P). The length is less than the distance between the liquid surface of the soft plastic liquid bottle (P) and the stopper; the end of the double-channel replacement needle is inserted into the vial (b), and the vial (16) of the vial is placed adjacent to the vial (b) ) at the cork.  13. A dispensing device for carrying out the dispensing method according to claim 1 or 3 or 5, characterized in that it consists of a single-channel replacement needle which is sharp at both ends and has openings at both ends (22, 23) ) through to form a channel.  14. The dispensing device according to claim 13, wherein: the waist of the single-channel replacement needle is provided with a limiting collar (19) defining one end of the single-channel replacement needle inserted into the soft plastic liquid bottle (P), The length is less than the distance between the liquid surface of the soft plastic liquid bottle (P) and its stopper, and the one-channel replacement needle is inserted into one end of the vial (b), and the opening is located at the stopper of the vial (b).