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WO2013018075A1 - Oxygénateur de liquides organiques pour traiter les patients sous circulation extracorporelle - Google Patents

Oxygénateur de liquides organiques pour traiter les patients sous circulation extracorporelle Download PDF

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Publication number
WO2013018075A1
WO2013018075A1 PCT/IB2012/054005 IB2012054005W WO2013018075A1 WO 2013018075 A1 WO2013018075 A1 WO 2013018075A1 IB 2012054005 W IB2012054005 W IB 2012054005W WO 2013018075 A1 WO2013018075 A1 WO 2013018075A1
Authority
WO
WIPO (PCT)
Prior art keywords
oxygenator
winding
hollow
blood
oxygenator according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2012/054005
Other languages
English (en)
Inventor
Daniele Galavotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rand SRL
Original Assignee
Rand SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rand SRL filed Critical Rand SRL
Publication of WO2013018075A1 publication Critical patent/WO2013018075A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/025—Bobbin units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • B01D63/043—Hollow fibre modules comprising multiple hollow fibre assemblies with separate tube sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/20—Specific housing
    • B01D2313/201—Closed housing, vessels or containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/22—Cooling or heating elements
    • B01D2313/221—Heat exchangers

Definitions

  • the invention relates to an organic fluid oxygenator for extracorporeal circulation treatment of patients, particularly a disposable blood oxygenator, which has a three-dimensional structure and a substantially cylindrical shape, in which blood is submitted to carbon dioxide washout, oxygenation and thermic treatment, as therapeutically needed by patients.
  • Oxygenators Disposable oxygen exchanging devices, known as oxygenators, have been long known and used in the medical field, with the purpose of releasing oxygen to blood and removing excess carbon dioxide during extracorporeal circulation treatment of patients.
  • the latter typically consists of a multitude of hollow fibers, which are arranged in parallel relation to each other and to the longitudinal axis of the cylindrical body, each having a lumen as large as a few hundreds of microns.
  • These hollow fibers are formed of a flexible membrane, which is only gas- and not fluid-permeable.
  • the ends of the hollow fibers are incorporated in two corresponding solid connection elements, known as "pottings", which are typically formed of polyurethane-based glues, and have the purpose of holding the ends in a fixed position.
  • oxygenators have a first blood inlet and outlet pair, with blood being forced to flow in a predetermined path within the oxygenation chamber, and to lap the hollow fibers in a flow direction which, according to the fluidic geometry of the device, may be substantially perpendicular or substantially longitudinal thereto, thereby becoming richer in oxygen and releasing excess carbon dioxide.
  • the cylindrical body also has two covers at the top and bottom ends thereof, in which a second inlet and outlet are formed, designed both for supplying oxygen gas, in pure form or diluted with other gases, such as nitrogen, and for discharging the carbon dioxide released to blood during oxygenation.
  • a second inlet and outlet are formed, designed both for supplying oxygen gas, in pure form or diluted with other gases, such as nitrogen, and for discharging the carbon dioxide released to blood during oxygenation.
  • oxygenator devices can be typically combined with heat exchangers, which are required for temperature control of the blood flowing in the extracorporeal circuit of the patient to be treated, and which require water “treated” by a heating or cooling device, generally known as “heater” or “cooler” or “heater-cooler”, otherwise generally defined as “temperature baths”.
  • a temperature control device may include, according to its geometry, a series of windings of hollow fibers with a temperature-controlled fluid flowing therein, or a flat plate, possibly knurled at its surface, which is equipped with a series of contiguous pleats, designed to be lapped with blood on one side and water on the other, like in the case of oxygenators, or a metal tube bundle.
  • the windings of hollow fibers may be accommodated in a special housing body, which may be separate from the oxygenator, but designed to be coupled thereto for connection to a circuit or, according to a more recent technique, the windings may be arranged in a special compartment defined in the oxygenation chamber of the oxygenator.
  • the blood to be oxygenated that comes from the patient and is carried by a transport conduit shall enter the oxygenation chamber through the inlet therefor, lap the multitude of hollow fibers having oxygen, or a mixture of oxygen and other diluting gases, flowing therein, receive oxygen and simultaneously release carbon dioxide as a result of differential concentrations, and flow out of the outlet in an oxygen-enriched state, to finally reach the patient through a return connection line.
  • Oxygen or the oxygen-containing gas mixture, enters its inlet and is released to blood while carbon dioxide is released by blood to the depleted oxygen that flows in the hollow fibers and us discharged through the outlet.
  • the motion of blood flow that comes from the patient, passes through the oxygenator and goes back to the patient is typically generated and maintained using a pump that may be mounted along an extracorporeal circuit that establishes connection between the patient and the oxygenator.
  • the pump action generates a pressure higher than atmospheric pressure in the oxygenator, which is sufficient to overcome the sum of the mechanical resistances encountered by blood as it flows through the treatment chamber that contains the hollow fibers, through the conduits that connect the various devices and those of the peripheral circulatory system of the patient, and eventually through the temperature control devices, if any, to ensure that circulation is maintained active all along the path defined by the extracorporeal circuit.
  • temperature-controlled oxygenators One requirement to be met by these temperature-controlled oxygenators is to provide an exchange surface area that is optimized for both oxygenation and temperature control, relative to their overall size, which has to be maintained within strict limits both due to bulk limitation and handling requirements, and because a considerable volume of blood has to be removed from the patient to fill and reach steady-state operation of an oxygenator and a temperature control device and the extracorporeal circuit attached thereto, even though it is diluted with suitable salines.
  • This patent provides an oxygenator that has a substantially cylindrical hollow body that defines therein a blood treatment chamber, with an exchange unit arranged therein, comprising a plurality of hollow plastic capillaries spirally wound around an inner cylinder.
  • a further substantially cylindrical body is precision-mounted to the exterior of this first exchange unit, and has an exchange unit thereon, comprising a plurality of microporous capillaries spirally wound around said cylindrical body, to saturation of the gap between the two cylindrical bodies.
  • Both windings are embedded in a polyurethane resin, which simultaneously embeds both ends thereof, thereby simplifying the process of making the device, provided that the materials of the impermeable plastic capillaries of the heat exchanger and the micro-porous capillary fibers of the oxygenator are of the same nature.
  • a top cover and a bottom cover are also provided, with respective blood, oxygen and water supply chambers.
  • Both top and bottom covers are joined to the body of the device by precision-gluing thereof on such body, the top cover being joined to the edge that delimits the boundary between gas and water and the innermost boundary between water and blood, the bottom cover being precision- bounded to the body, at the edge that delimit the boundary between gas and water.
  • the box-like body has an outlet for the blood to be treated, including an annular chamber that has the purpose of collecting the blood that flows in from the inlet, through a special lumen, first into the exchange chamber of the heat exchanger in a substantially longitudinal, downward flow direction and then through radial lumens back into the exchange chamber of the oxygenator, in a substantially longitudinal upward direction.
  • This patent provides an oxygenator whose body is flattened along a first axis, which is formed by successively joining elements having a substantially planar component, with two main containing plates, and three different flow distributing plates or grids.
  • the first winding defines a blood treatment chamber which accommodates an exchange unit comprising a plurality of hollow, impermeable plastic capillaries, wound in successive layers around a flat element.
  • the next compartment accommodates an exchange unit comprising a plurality of micro-porous capillaries wound in successive layers around a flat element, and a plurality of capillaries formed of a micro-porous membrane, which form an additional winding.
  • Both windings are embedded in a polyurethane resin, which simultaneously embeds both ends of the windings, thereby simplifying the process of making the device, provided that the materials of the impermeable plastic capillaries of the heat exchanger and the micro-porous capillary fibers of the oxygenator are of the same nature.
  • Top and bottom covers with oxygen and water supply and depleted gas and water discharge chambers respectively, complement the oxygenator.
  • Both top and bottom covers are joined to the body of the device, by precision-bonding thereof to the structure obtained by coupling the load- bearing elements and their covers on the edges that delimit the boundary between gas and water.
  • the box-like body defined by the two closing plates has a blood inlet and a blood outlet respectively and a series of secondary blood temperature sensing orifices are formed on the plate designed as the blood outlet side.
  • Connections are also provided for drawing cardioplegic blood and for micro-bubble discharge.
  • This patent discloses an oxygenator whose body is flattened along a first axis, wherein a succession of layers of hollow micro-porous fibers are wound on an element or grid, in a double layer crossed geometry.
  • the winding is precision-fitted into a body and the outermost layer is held in contact with the surface of the container body, by means of two opposed longitudinal beams, which are in turn adjacent to the inner surface of the container body or directly formed in the inner surface thereof.
  • Such compression is transferred by the two longitudinal beams to the two lateral areas of the winding, with the purpose of forcing the blood across the above described structure, and throughout its height, with the two beams and the interference mounting arrangement preventing the flowing blood to bypass the above structure without exchanging oxygen and carbon dioxide with the oxygen and gas mixture that flows through the lumens of the micro- porous capillaries of the winding.
  • the structure of the winding is joined to the body using two polyurethane resin pottings.
  • a first drawback is that the increase of pressure losses caused in prior art oxygenators by resistance to blood flow motion damages the red cells membranes and causes hemolysis, i.e. red cell (or erythrocyte) destruction.
  • a second drawback is that prior art oxygenators require their oxygenation and temperature control chambers to be filled with considerable volumes of blood, to be withdrawn and removed from the patient to fill, as mentioned above, the conduits of an extracorporeal circuit and the oxygenation and temperature control compartments, said volumes requiring compensation with additional adequate volumes of blood compatible diluents.
  • a third drawback is that prior art oxygenators tend to be exposed to quick deterioration of gas exchange performance.
  • a fourth drawback is that if prior art oxygenators are not used within a short time from their fabrication and are not stored using criteria that can ensure stable effectiveness thereof, they tend with time to be exposed to degradation of the components mainly made of plastic materials.
  • This degradation may generate deformations of components and thus create undesired gaps or apertures that will act as free passages for blood that will flow through them without previously lapping the hollow fibers and without being adequately oxygenated and washed out of excess carbon dioxide, before reaching back the patient.
  • a fifth drawback is that the bundles of hollow fibers are introduced into their respective housings, both for oxygenation and for temperature control, in a peripherally compressed state, to allow proper fitting thereof without creating gaps through which blood might flow without being adequately treated before reaching back the patient.
  • An object of the invention is to improve the prior art.
  • Another object of the invention is to provide an organic flow oxygenator for extracorporeal circulation treatment of patients, that can prevent reduction of blood and temperature control fluid flows.
  • a further object of the invention is to provide an organic flow oxygenator for extracorporeal circulation treatment of patients, that can incorporate both oxygenation and temperature regulation features for blood or any organic fluid flowing in an extracorporeal circuit, in a single element.
  • a further object of the invention is to provide an organic flow oxygenator for extracorporeal circulation treatment of patients, that can be easily assembled and can maintain a substantially homogeneous pressure on the hollow fibers all over the windings.
  • the invention relates to an organic fluid oxygenator for extracorporeal treatment of patients according to the features of claim 1 .
  • Figure 1 is a perspective view of the oxygenator of the invention
  • Figure 2 is a cross-sectional view of the oxygenator of Figure 1 , as taken along a plane //-// of Figure 1 ;
  • Figure 3 is a partially exploded perspective view of the oxygenator of the invention.
  • Figure 4 is a perspective view of the oxygenator of the invention, with the upper portion partially exploded;
  • Figure 5 is a cross sectional view of Figure 2, with the windings of hollow fibers omitted;
  • FIG. 6 is an exploded perspective view of a frame inserted in the oxygenator of the invention.
  • FIG. 7 is a longitudinal sectional view of the oxygenator of the invention, as taken along a plane VII-VII of Figure 2;
  • Figure 8 is a perspective view of a top cover of the oxygenator of the invention.
  • Figure 9 is a bottom perspective view of the top cover of Figure 8;
  • Figure 10 is a perspective view of a bottom cover of the oxygenator of the invention;
  • Figure 1 1 is a top perspective view of the cover of Figure 10;
  • Figure 12 is a perspective view of a connection element disposed between the top and bottom covers and the body of the oxygenator of the invention.
  • Figure 13 is a bottom perspective view of the connection element of Figure 12.
  • numeral 1 generally designates an oxygenator having a substantially cylindrical box-like body 2 and stiffening ribs at its periphery.
  • the body 2 has a plurality of inlet and outlet ports, that will be described in greater detail below.
  • the body 2 defines therein an inner treatment compartment 4, with a frame 5 being adapted to be precision-fitted therein, and to divide it into a series of hollow seats 6 and 7, as better shown in Figure 5, which are designed to accommodate an oxygenation unit and a temperature control unit for oxygenation and temperature control of an organic fluid to be treated, namely the blood of a patient that flows in an extracorporeal circuit, not shown, which is designed to have the oxygenator 1 mounted thereto.
  • the oxygenator assembly comprises a plurality of first hollow fibers 8, which are wound on rigid central ribs 9, to form a multiplicity of first windings 8 whose peripheral size is slightly larger than the inner size of the seats 6, such that they shall be peripherally elastically compressed beforehand to be introduced therein.
  • This conditions achieves two goals, i.e. affording a substantially even distribution of the residual peripheral pressure over all the hollow fibers of the hollow fiber windings 8 and removing any gap between these and the walls of the seats 6 and 7.
  • the frame 5 is shown to also define a plurality of generally flat parallel diaphragms 10 that separate the seats 6.
  • Each diaphragm 10 comprises a substantially sheet-like central body and two enlarged ends 1 1 , which are shaped to deflect blood flows for the latter to enter the first windings 8 of hollow fibers.
  • high fibers is typically intended to designate a plurality of substantially rectilinear capillaries, which are in parallel integral arrangement, and have open lumens at their ends as small as a few tens of microns.
  • These hollow fibers are formed from liquid-impervious, gas-pervious membranes, whereby a liquid may flow inside or outside them, without mixing with any gas that would lap the exterior or the interior of them, or vice versa.
  • the frame 5 only partially fills the treatment compartment 5 and leaves the above mentioned seats 7 clear.
  • These seats 7 are designed to accommodate a second winding of hollow fibers 12, which are wound around a central rib 13, perpendicular to the ribs 9, and which form the temperature control unit of the oxygenator 1 , as better explained hereinafter.
  • the second winding of hollow fibers 12 has an elongate shape and is oriented perpendicular to the ribs 9, thereby forming two opposed ends 12a and 12b having a rounded shape.
  • the two pottings 1 12a and 1 12b are formed by introducing a liquid- state polyurethane resin, that has been mixed but has not been cured yet, into two channels 200 and 210 specially formed in the inner wall of the treatment compartment 4.
  • the covers 19 and 20 are fixed to their box-like body 2 by using glues or a series of hooking teeth 150, which formed at the periphery of the edge of both ends of the box-like body 2 and are designed to engage with corresponding hooking slots 151 formed at the periphery of the inner contours of the covers 19 and 20.
  • the seal 50 has two stems 51 a and 51 b, which are designed to be temporarily fitted into the two channels 200 and 210 during preparation of two further solid elements 21 and 22, known as pottings, as better described below, through two special holes 61 a and 61 b formed in the connection element 60, and axially aligned with the two stems 51 a and 51 b.
  • the walls of the frame 5 have perforations 14 which, according to the use of the oxygenator 1 , i.e. according to the type of organic fluid to be temperature-controlled and oxygenated, may have predetermined shapes, orders and sizes, in view of not blocking the flows therethrough.
  • the central rib 13 also has perforations and the second winding of hollow fibers 12 is contained between the frame 5 and a retaining wall 15, also perforated, which extends parallel to the central rib 13 and is inserted in the treatment compartment 4, between the wall of the latter and the winding of hollow fibers 12.
  • both the retaining wall 15 and the frame 5 have spacer members 16 and 17 respectively, which are designed to abut against the inner walls of the treatment compartment 4 and keep both slightly spaced therefrom, such that two parallel laminar chambers 18 and 18' are defined, and against the larger walls of the treatment chamber 4.
  • the retaining wall 15 has in turn a pair of hooks 85, located proximate to both ends, which are required to structurally hold the retaining wall 15 to the box-like body 2.
  • the body 2 has two respective closing covers 19 and 20 at the top and bottom ends, and also the windings of hollow fibers 8 have the ends embedded in two additional solid elements 21 and 22, known as pottings, with the one designed to be the upper potting, i.e. the element 21 , having an inclined inner surface 21 a to promote spontaneous outflow of any air collected in the treatment compartment 4.
  • two accumulation chambers 23 and 24 are defined between the two elements 21 and 22 and the inner surfaces of the two covers 19 and 20, whose function will be described below.
  • the inner surfaces of the two covers 19 ad 20 have raised ribs 100 extending into the treatment compartment 4 and forming both the two accumulation chambers 23 and 24 and two housings 23' and 24' contiguous to the latter, which are designed to receive the ends of the second winding of hollow fibers 12 when the oxygenator 1 is in the assembled state.
  • the body 2 has a series of ports for access to the inner treatment compartment 4 from the outside, which include a first inlet port 25 for the organic fluid (blood) to be oxygenated, shaped as a tube segment in which a second accessory port 26 is formed, through which a parameter of the inflowing organic flow is measured, namely venous blood pressure.
  • a first inlet port 25 for the organic fluid (blood) to be oxygenated shaped as a tube segment in which a second accessory port 26 is formed, through which a parameter of the inflowing organic flow is measured, namely venous blood pressure.
  • the body 2 also comprises an outlet port 27 for the organic fluid that has undergone oxygenation, such outlet port also having an accessory port 28 for measuring a parameter of the outflowing organic fluid, namely the pressure of the arterial blood sent back to the patient.
  • ports for bleeding air from the treatment compartment 4 which are referenced 29, 30, 31 and two additional ports 40 and 41 , each formed in one of the covers 19 and 20, and respectively designed for admitting oxygen, or a mixture of oxygen and other gases, into the accumulation chamber 23 and for discharging oxygen or a mixture of oxygen and other gases, once depleted, and the carbon dioxide collected during blood oxygenation in the accumulation chamber 24.
  • Further ports 32 and 33 are also formed in the covers 19 and 29, for discharging water or temperature control fluid respectively into the chamber 23' for collecting water or temperature control fluid and into the chamber 24' for receiving and distributing water or fluid for blood temperature control.
  • the skilled person may decide that all the above communication ports be equipped with standard connectors, such as Luer-lock connectors, or Hansen connectors for the temperature control fluid inlets and outlets, to allow connections with the ends of extracorporeal circuit tubes, for the oxygenator 1 to be quickly and easily mounted or removed to or from the circuits.
  • standard connectors such as Luer-lock connectors, or Hansen connectors for the temperature control fluid inlets and outlets, to allow connections with the ends of extracorporeal circuit tubes, for the oxygenator 1 to be quickly and easily mounted or removed to or from the circuits.
  • the medical staff first carries out a traditional priming step, i.e. fills the oxygenator 1 and the whole extracorporeal circuit with the patient's blood, possibly after diluting it with a blood-compatible saline.
  • a heating or cooling device known as “heater- cooler” is connected to the oxygenator 1 through the inlet 33 and outlet 32 ports, for thermally conditioning the patient's blood to be treated.
  • the venous blood to be treated is directly drawn from the patient through a special drawing line and is introduced into the treatment compartment 4 through the inlet port 25.
  • the value of pressure (or another parameter) of the venous blood is detected through the accessory port 26, prior to its entering the treatment compartment 4 of the oxygenator 1 .
  • temperature-controlled water shall be understood by the skilled person as designating water that may have a temperature above or below blood temperature, temperature control being selected by the medical staff, according to the disease and the desired therapy for the patient.
  • the two pottings 1 12a and 1 12b prevent the venous blood from flowing through the end areas of the second winding of hollow fibers 12, thereby avoiding any flow velocity reduction in these areas, as well as any resulting formation of undesired accumulations, that might be injurious to the patient.
  • Oxygen, or a mixture of oxygen and other gases is caused to axially flow in the hollow fibers of the windings of hollow fibers 8, and is introduced into the oxygenator 1 through the additional port 40, formed in the cover 19, and the accumulation chamber 23.
  • the heated or cooled venous blood transversely laps the hollow fibers 8 of the first windings, and the differential concentration of oxygen flowing in the windings of hollow fibers 8 and venous blood allows the latter to receive oxygen through the gas-pervious structure of the hollow fibers 8 of the first windings and to release its carbon dioxide thereto, to be purified.
  • the liquid imperviousness of the hollow fibers prevents gases from mixing with blood.
  • Blood flow is maintained in the extracorporeal circuit and in the oxygenator 1 , by means of a pump mounted thereto.
  • the hollow fibers of the first windings of hollow fibers 8 release the depleted oxygen, or the depleted mixture of oxygen and other gases, as well as the carbon dioxide they have collected, into the accumulation chamber 24, and such gases are carried from the latter, through the port 41 , out of the oxygenator 1 and collected in special containers provided in the extracorporeal circuit for this purpose.
  • profiles of the central ribs 9 and diaphragms 10 shall be designed to impart a turbulent-wavy motion to blood flows, which is adapted to promote gas exchange.
  • the oxygenator 1 in addition to the advantage of combining both organic fluid oxygenation and temperature control features into a single disposable device, the oxygenator 1 also has the characteristic of being easily assembled and to maintain a low and constant pressure on the hollow fibers 8 and 12 that form the first windings and the second winding, thereby avoiding the presence of uneven hydraulic sections in various areas thereof, which might either slow down and even stop the blood flow or facilitate it to even cause blood to bypass the hollow fibers of the oxygenator and the heat exchanger.
  • the invention is susceptible to changes and variants within the inventive concept.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
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Abstract

L'oxygénateur de liquides organiques ci-décrit, destiné à traiter les patients sous circulation extracorporelle, comprend : un corps tridimensionnel formant récipient (2), comportant un compartiment de traitement interne (4) limité par des parois intérieures ; une unité d'échange de gaz (8) ; une unité d'échange thermique (12) ; l'oxygénateur selon l'invention comprenant en outre un châssis essentiellement rigide (5) qui est conçu pour être introduit dans au moins un premier logement (6) et un second logement (7), qui sont contigus ou séparés l'un de l'autre, servant à loger respectivement ladite unité d'échange de gaz (8) et ladite unité d'échange thermique (12), et qui ont des contours fixes.
PCT/IB2012/054005 2011-08-04 2012-08-06 Oxygénateur de liquides organiques pour traiter les patients sous circulation extracorporelle Ceased WO2013018075A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMO2011A000200 2011-08-04
IT000200A ITMO20110200A1 (it) 2011-08-04 2011-08-04 Un ossigenatore di fluidi organici per trattamenti di pazienti in circolazione extracorporea

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WO2013018075A1 true WO2013018075A1 (fr) 2013-02-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021076437A1 (fr) * 2019-10-15 2021-04-22 Cardiacassist, Inc. Oxygénateur avec membrane de filtration enroulée et diffuseur d'écoulement
CN115708900A (zh) * 2022-11-16 2023-02-24 广州国家实验室 膜式氧合器及制作方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007943A1 (fr) * 1989-01-13 1990-07-26 Minntech Corporation Configuration en coin pour oxygenateurs
EP0346302B1 (fr) 1988-06-07 1994-08-17 SORIN BIOMEDICA CARDIO S.p.A. Appareil pour le traitement du sang
WO1995026488A1 (fr) 1994-03-28 1995-10-05 Minntech Corporation Oxygenateur combine a un echangeur thermique enroule
WO1998008555A1 (fr) * 1996-08-30 1998-03-05 Minntech Corporation Procede d'amorçage ameliore d'un oxygenateur
EP0765683B1 (fr) 1995-09-25 1998-07-01 MEDOS Medizintechnik GmbH Appareil de traitement de liquides, en particulier du sang
EP1557185A1 (fr) * 2004-01-20 2005-07-27 Rand S.r.l. Dispositif de traitement de sang dans un circuit extracorporel
WO2011013075A1 (fr) * 2009-07-28 2011-02-03 Rand S.R.L. Dispositif oxygénateur

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346302B1 (fr) 1988-06-07 1994-08-17 SORIN BIOMEDICA CARDIO S.p.A. Appareil pour le traitement du sang
WO1990007943A1 (fr) * 1989-01-13 1990-07-26 Minntech Corporation Configuration en coin pour oxygenateurs
WO1995026488A1 (fr) 1994-03-28 1995-10-05 Minntech Corporation Oxygenateur combine a un echangeur thermique enroule
EP0765683B1 (fr) 1995-09-25 1998-07-01 MEDOS Medizintechnik GmbH Appareil de traitement de liquides, en particulier du sang
WO1998008555A1 (fr) * 1996-08-30 1998-03-05 Minntech Corporation Procede d'amorçage ameliore d'un oxygenateur
EP1557185A1 (fr) * 2004-01-20 2005-07-27 Rand S.r.l. Dispositif de traitement de sang dans un circuit extracorporel
WO2011013075A1 (fr) * 2009-07-28 2011-02-03 Rand S.R.L. Dispositif oxygénateur

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021076437A1 (fr) * 2019-10-15 2021-04-22 Cardiacassist, Inc. Oxygénateur avec membrane de filtration enroulée et diffuseur d'écoulement
CN115708900A (zh) * 2022-11-16 2023-02-24 广州国家实验室 膜式氧合器及制作方法
CN115708900B (zh) * 2022-11-16 2025-12-02 广州国家实验室 膜式氧合器及制作方法

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