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WO2013011062A3 - Antagonistic antibodies against oscar - Google Patents

Antagonistic antibodies against oscar Download PDF

Info

Publication number
WO2013011062A3
WO2013011062A3 PCT/EP2012/064109 EP2012064109W WO2013011062A3 WO 2013011062 A3 WO2013011062 A3 WO 2013011062A3 EP 2012064109 W EP2012064109 W EP 2012064109W WO 2013011062 A3 WO2013011062 A3 WO 2013011062A3
Authority
WO
WIPO (PCT)
Prior art keywords
oscar
antibodies against
antagonistic antibodies
antagonistic
present disclosure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/064109
Other languages
French (fr)
Other versions
WO2013011062A2 (en
Inventor
Li Guo
Svetlana PANINA
Jesper Pass
Louise Hjerrild ZEUTHEN
Louise Maymann NITZE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of WO2013011062A2 publication Critical patent/WO2013011062A2/en
Publication of WO2013011062A3 publication Critical patent/WO2013011062A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present disclosure relates to therapeutic antagonistic OSCAR antibodies. The present disclosure furthermore relates to use of such antibodies.
PCT/EP2012/064109 2011-07-18 2012-07-18 Oscar antagonists Ceased WO2013011062A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CNPCT/CN2011/001174 2011-07-18
CN2011001174 2011-07-18
US201161524426P 2011-08-17 2011-08-17
US61/524,426 2011-08-17
CNPCT/CN2012/076144 2012-05-28
CN2012076144 2012-05-28
US201261662643P 2012-06-21 2012-06-21
US61/662,643 2012-06-21

Publications (2)

Publication Number Publication Date
WO2013011062A2 WO2013011062A2 (en) 2013-01-24
WO2013011062A3 true WO2013011062A3 (en) 2013-03-21

Family

ID=46513781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/064109 Ceased WO2013011062A2 (en) 2011-07-18 2012-07-18 Oscar antagonists

Country Status (1)

Country Link
WO (1) WO2013011062A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017123642A1 (en) * 2016-01-12 2017-07-20 The Trustees Of The University Of Pennsylvania Methods and uses of osteoclast associated receptor (oscar) for prevention and treatment of osteoarthritis
KR102316299B1 (en) * 2018-11-30 2021-10-22 이화여자대학교 산학협력단 Composition for screening of oscar-collagen interaction inhibitor, kit including the same, and screening method using the same
JP7731596B2 (en) * 2020-12-03 2025-09-01 イムノフォージ カンパニー リミテッド Fusion protein comprising a GLP-1 receptor agonist and an anti-oskar antibody and uses thereof
CN119424633B (en) * 2024-11-07 2025-07-25 浙江赛尔共银生物科技有限公司 Composition containing mesenchymal stem cells for treating degenerative arthritis and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053368A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Single ifn-beta fused to a mutated igg fc fragment
WO2010040998A1 (en) * 2008-10-06 2010-04-15 Cambridge Enterprise Llimited Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
ATE207080T1 (en) 1991-11-25 2001-11-15 Enzon Inc MULTIVALENT ANTIGEN-BINDING PROTEINS
AU7266898A (en) 1997-04-30 1998-11-24 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
JP2007534631A (en) 2003-10-28 2007-11-29 ノボ　ノルディスク　アクティーゼルスカブ Laminin-5γ2 binding peptides, related compositions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053368A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Single ifn-beta fused to a mutated igg fc fragment
WO2010040998A1 (en) * 2008-10-06 2010-04-15 Cambridge Enterprise Llimited Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
E. MERCK ET AL.: "Fc-receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.", BLOOD, vol. 105, no. 9, 1 May 2005 (2005-05-01), USA, pages 3623 - 3632, XP002681827 *
U. BRAND ET AL.: "Influence of extracellular matrix proteins on the development of cultured human dendritic cells.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 5, 1 May 1998 (1998-05-01), Germany, pages 1673 - 1680, XP002403016 *

Also Published As

Publication number Publication date
WO2013011062A2 (en) 2013-01-24

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