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WO2013009668A2 - Ensemble échangeur de chaleur jetable pour applications de fabrication de biotechnologie et pharmaceutiques stériles et aseptiques - Google Patents

Ensemble échangeur de chaleur jetable pour applications de fabrication de biotechnologie et pharmaceutiques stériles et aseptiques Download PDF

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Publication number
WO2013009668A2
WO2013009668A2 PCT/US2012/045889 US2012045889W WO2013009668A2 WO 2013009668 A2 WO2013009668 A2 WO 2013009668A2 US 2012045889 W US2012045889 W US 2012045889W WO 2013009668 A2 WO2013009668 A2 WO 2013009668A2
Authority
WO
WIPO (PCT)
Prior art keywords
heat exchanger
disposable
bag
exchanger assembly
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/045889
Other languages
English (en)
Other versions
WO2013009668A3 (fr
Inventor
Julie VICKERS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP12811029.3A priority Critical patent/EP2732230A4/fr
Publication of WO2013009668A2 publication Critical patent/WO2013009668A2/fr
Publication of WO2013009668A3 publication Critical patent/WO2013009668A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F01—MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
    • F01C—ROTARY-PISTON OR OSCILLATING-PISTON MACHINES OR ENGINES
    • F01C19/00—Sealing arrangements in rotary-piston machines or engines
    • F01C19/10—Sealings for working fluids between radially and axially movable parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
    • F28D9/00—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
    • F28D9/0031—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
    • F28D9/00—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
    • F28D9/0031—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other
    • F28D9/0043—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other the plates having openings therein for circulation of at least one heat-exchange medium from one conduit to another
    • F28D9/0056—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other the plates having openings therein for circulation of at least one heat-exchange medium from one conduit to another with U-flow or serpentine-flow inside conduits; with centrally arranged openings on the plates
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F2265/00—Safety or protection arrangements; Arrangements for preventing malfunction
    • F28F2265/20—Safety or protection arrangements; Arrangements for preventing malfunction for preventing development of microorganisms

Definitions

  • the invention relates generally to biotechnology and pharmaceutical manufacturing applications where disposable components are utilized for sterile and aseptic cell culture or protein purification processing.
  • Disposable bags and tubing assemblies are sometimes used in lieu of metallic equipment and piping for aseptic or sterile processing. Disposable bags and tubing assemblies are used because they do not require cleaning or steaming in place as do metallic equipment and piping to maintain cleanliness and/or sterility. The disposable components are preferred because they can be sterilized via gamma-irradiation and discarded after use.
  • Another object of the present invention is to provide a disposable heat exchanger system integrating a sterile disposable bag assembly with a heat exchanger manifold assembly .
  • Still another object of the present invention is to provide an improved method and apparatus that in accordance with the foregoing objects and that provides enhanced quality and yield in cell culture and protein purification applications.
  • a disposable heat exchanger system comprised of a sterile disposable bag assembly and sets of modular stainless steel heating/cooling plates.
  • the sterile disposable bags are manifolded together via disposable tubing and are installed and filled in place with cell culture or protein containing process fluid within the stainless steel heating/cooling plates.
  • the stainless steel heating/cooling plates are manifolded together in a modular fashion with stainless steel tubing.
  • Both the disposable bag assemblies and the heating/cooling plates are configured to have a serpentine flow pattern.
  • the process fluid within the sterile disposable bag assembly and heating/cooling fluid within the modular stainless steel heating/cooling plates flow in opposite directions in order to provide counter-current flow for efficient heating or cooling.
  • the sterile disposable bag assemblies are filled in place within the plates via the bottom process inlet port on the first bag in the disposable bag manifold series.
  • the disposable bags are filled in place from bottom to top with process fluid where all air within the bags is displaced as they fill. Once the first bag of the bag manifold series is filled, the disposable interconnecting tubing allows the process fluid to cascade to the next bag in the series.
  • FIG. 1 illustrates typical sterile or aseptic cell culture processing schemes and shows how the disposable heat exchanger of the present invention is used in such applications;
  • FIG. 2 illustrates typical sterile or aseptic protein purification processing schemes and shows how the disposable heat exchanger of the present invention is used in such applications;
  • FIG. 3A is a front view of a disposable bag
  • FIG. 3B is a front view of a heat exchanger shell
  • FIG. 3C is a perspective view of a disposable bag manifold assembly with the bags considered as empty;
  • FIG. 3D is a perspective view of a heat exchanger shell manifold assembly
  • FIG. 3E is a cross-sectional view through one of the plate members.
  • FIG. 3F is a side view of the completed disposable heat exchanger assembly. DETAILED DESCRIPTION OF THE INVENTION
  • FIGS. 1 and 2 demonstrate typical cell culture and protein purification block flow diagrams with corresponding examples of typical disposable equipment configurations.
  • the top diagram depicts a typical upstream cell culture block flow diagram
  • FIG. 2 the top diagram depicts a typical downstream protein purification block flow diagram.
  • the middle diagrams in both FIGS. 1 and 2 depict the respective "Problem” configuration.
  • the "Problem” equipment configuration in each figure shows typical equipment configurations using existing disposable technology.
  • the bottom diagrams in both FIGS. 1 and 2 depict the respective "Solution” configuration.
  • the “Solution” equipment configurations demonstrate how the invention herein may be applied to solve such problems by providing efficient heat transfer and optimal temperature control using disposable features.
  • the "Problem" equipment configuration shows there is currently no method to efficiently heat cell culture media prior to bioreactor inoculation or during a perfusion cell culture process .
  • cold or room temperature media is stored in a Disposable Media Hold Station and transferred to a Disposable Bioreactor where the media is heated prior to inoculation.
  • the heating of media in the Disposable Bioreactor takes several hours and is far less efficient than heating with a heat exchanger.
  • the invention herein would be applied to save time in heating media prior to inoculation.
  • cell culture media is continuously added to the Disposable Bioreactor as the cell culture grows and/or protein is harvested.
  • Adding cold or room temperature media directly to the Disposable Bioreactor is not optimal for the cell culture process as it may affect cell culture growth and/or protein production.
  • the invention herein would be applied to heat the cell culture media as it is transferred into the Disposable Bioreactor to promote optimal cell growth and protein production.
  • the "Problem" equipment configuration shows there is currently no method to efficiently cool harvested protein using existing disposable technology.
  • Existing technology is limited to large disposable mixing totes or stainless steel heat exchangers.
  • Large disposable mixing totes are not optimal as they are not efficient for heat transfer in a continuous process and have excessive hold-up volume where expensive product is wasted, ultimately affecting yield.
  • Stainless steel heat exchangers are not preferred because they must be cleaned and steamed in or out of place for aseptic and/or sterile use and must be maintained for cleanliness and sterility.
  • the invention herein would be applied to efficiently cool the harvested protein in an efficient, disposable fashion with minimal hold-up volume.
  • the "Problem" equipment configuration shows there is currently no disposable method of controlling temperature for harvested protein and buffers required for various protein purification steps.
  • the protein containing harvest fluid and buffers are typically left at room temperature prior to most purification steps.
  • the invention herein would be applied to efficiently regulate the temperature of the harvested protein and/or buffers in an efficient, disposable fashion.
  • the "Problem" equipment configuration shows there is currently no disposable method of efficiently cooling the bulk drug substance intermediate prior to freezer storage.
  • bulk drug substance intermediates are left at ambient or uncontrolled temperatures for long periods of time, they lose their strength and efficacy very quickly.
  • cooling disposable bulk intermediate containers in a freezer is an inefficient heat transfer method.
  • the invention herein would be applied to efficiently cool the bulk drug substance intermediate prior to freezer storage potentially preserving the yield, strength and efficacy of the product.
  • FIG. 3 illustrates the disposable heat exchanger assembly constructed in accordance with the principles of this invention.
  • the disposable heat exchanger assembly comprises a series of stainless steel sealed plate members 1 each with internal welds W to form a serpentine pathway with a dimpled heat transfer surface.
  • the arrows Al indicate this serpentine flow path.
  • the welds W extend substantially in parallel and are spaced apart leaving gaps to define this serpentine flow pattern.
  • the stainless steel sealed plate members 1 are joined together by a stainless steel interconnecting tubing 9 to form the heat exchanger shell manifold assembly 2, as depicted in FIG. 3D.
  • the disposable heat exchanger assembly also comprises a series of disposable bags 4 seal welded to also form a serpentine flow pattern. Refer in FIGS. 3A and 3C to the weld lines X. Also refer to the arrows A2 that depict the serpentine flow path as well as the direction of flow.
  • the disposable bags 4 are joined together via disposable interconnecting tubing 6 in order to form the complete disposable bag manifold assembly 5 such as illustrated in the perspective view of FIG. 3C.
  • FIG. 3E illustrates the construction of one of the stainless steel plate members 1.
  • Each stainless steel plate member 1 within the heat exchanger shell manifold assembly 2 is comprised of a dimpled heat transfer plate surface 1A on one side spot welded at each dimple D against a flat stainless steel plate IB on the opposite side.
  • the dimpled heat transfer surface (plate 1A) and the flat surface (plate IB) are sealed around all edges with stainless steel.
  • supports S may be provided for holding the plate members in place. Supports S are shown in FIG.
  • heating/cooling fluid is therefore allowed to flow between the voids of the dimpled heat transfer and flat stainless steel plates 1A, IB, and couple from plate member to plate member (via tubing 9) .
  • Each disposable bag 4 in the disposable bag manifold assembly 5 is intended to be installed between the stainless steel plate members 1 as part of the heat exchanger shell manifold assembly 2.
  • the disposable bag manifold assembly 5 is filled in place where the cell culture or protein purification process fluid enters from the bottom process inlet port 8A of the first disposable bag 4 in the disposable bag manifold assembly 5 series.
  • the process fluid flows from bottom to top in a serpentine pathway to fill the first disposable bag 4 then cascades via interconnecting disposable tubing 6 to the bottom of the second disposable bag 4 in the disposable bag manifold assembly 5.
  • This cascade of filling each disposable bag 4 in series continues through all bags in the custom disposable bag manifold assembly 5 until all disposable bags 4 are filled.
  • FIG. 3F shows the completed assembly with the disposable bags 4 filled and flowing in place and disposed between adjacent plate members.
  • the heating /cooling fluid enters the top stainless steel heat transfer fluid inlet port 3A on the last plate in the heat exchanger shell manifold assembly 2.
  • the heat transfer fluid flows through the dimpled stainless steel plate member 1 in a serpentine pathway from top to bottom and cascades to the next plate in the series via the stainless steel interconnecting tubing 9. The flow continues through the entire series of stainless steel plate members 1 and exits out the bottom stainless steel heat transfer outlet port 3B.
  • the internal welds within the stainless steel plate members 1 are identical in dimension to the seal welds provided on the disposable bags 4 when filled.
  • the serpentine pathways are hence identical dimensionally but flow in opposite directions to achieve counter-current flow and effective heat transfer.
  • the heat exchanger shell manifold assembly 2 is supported with mechanical plate supports S so that the stainless steel plate members 1 stay rigid such as illustrated in the side view of FIG 3F.
  • FIG. 3D shows a base heat exchanger manifold assembly 2 with a three plate member 1 configuration with an additional three plate members shown in dotted outline for possible future expansion of the heat exchanger.
  • the heat exchanger shell manifold assembly 2 may be constructed with as many plates as desired to add or remove heat based on the initial application. All heat exchanger manifold shell assemblies 2 are constructed such that additional plates may be added by connecting them with the stainless steel interconnecting tubing 9 via a mechanical joint. The joints may be sanitary, flanged, threaded or weld connections depending on the end user' s preference .
  • the disposable bag manifold assembly 5 is customized depending on the heat exchanger shell manifold assembly.
  • the disposable bag manifold assembly 5 is configured with as many disposable bags as desired, and as depicted in FIG. 3C . All disposable bag manifold assemblies 5 may be gamma-irradiated for sterility as an assembly once the final configuration is determined. Sterile tube welding or the use of aseptic connection devices at the process inlets and outlets 8 and between the bags at the disposable interconnecting tubing 6 to join multiple sterile bag assemblies is also possible.
  • the disposable tubing manifold assemblies 5 may be configured with heat sealed ends or aseptic connection devices as those skilled in the art can appreciate based on the end user' s preference for further expansion options .
  • the entire heat exchanger as depicted in the drawings, is preferably also covered or surrounded with a certain amount of insulation.
  • This insulation is preferably sealed with a stainless steel sheathing (not shown) .
  • the insulation as well as the sheathing is intended to be removable so that it can be placed at each end of the modular heat exchanger shell assembly 2.
  • the insulation may take on many different forms. This may be based on the end user's preference.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention porte sur un système d'échangeur de chaleur jetable, lequel système comprend un ensemble de sacs jetables stériles et des jeux d'ensembles de plaques de chauffage/refroidissement en acier inoxydable modulaires. Les sacs jetables stériles sont réunis les uns avec les autres à l'aide d'une tubulure jetable et sont installés et remplis en place, un fluide de traitement contenant une culture de cellules ou une protéine étant à l'intérieur des plaques de chauffage/refroidissement en acier inoxydable. Les plaques de chauffage/refroidissement en acier inoxydable sont réunies les unes avec les autres d'une façon modulaire à l'aide d'une tubulure en acier inoxydable. L'ensemble de sacs jetables stériles et les plaques de chauffage/refroidissement sont tous deux configurés de façon à avoir un motif d'écoulement en serpentin. Le fluide de traitement à l'intérieur de l'ensemble de sacs jetables stériles et le fluide de chauffage/refroidissement à l'intérieur des plaques de chauffage/refroidissement en acier inoxydable modulaires s'écoulent dans des directions opposées afin de produire un écoulement à contre-courant pour un chauffage ou un refroidissement efficaces.
PCT/US2012/045889 2011-07-14 2012-07-09 Ensemble échangeur de chaleur jetable pour applications de fabrication de biotechnologie et pharmaceutiques stériles et aseptiques Ceased WO2013009668A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12811029.3A EP2732230A4 (fr) 2011-07-14 2012-07-09 Ensemble échangeur de chaleur jetable pour applications de fabrication de biotechnologie et pharmaceutiques stériles et aseptiques

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161507837P 2011-07-14 2011-07-14
US61/507,837 2011-07-14
US13/331,083 US9284841B1 (en) 2011-07-14 2011-12-20 Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications
US13/331,083 2011-12-20

Publications (2)

Publication Number Publication Date
WO2013009668A2 true WO2013009668A2 (fr) 2013-01-17
WO2013009668A3 WO2013009668A3 (fr) 2013-06-13

Family

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PCT/US2012/045889 Ceased WO2013009668A2 (fr) 2011-07-14 2012-07-09 Ensemble échangeur de chaleur jetable pour applications de fabrication de biotechnologie et pharmaceutiques stériles et aseptiques

Country Status (3)

Country Link
US (1) US9284841B1 (fr)
EP (1) EP2732230A4 (fr)
WO (1) WO2013009668A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9127246B2 (en) 2010-02-22 2015-09-08 Life Technologies Corporation Methods for condensing a humid gas
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
WO2018072313A1 (fr) * 2016-10-18 2018-04-26 四川捷元科技有限公司 Unité d'échange de chaleur et matrice d'échange de chaleur
US10005005B2 (en) 2014-03-21 2018-06-26 Life Technologies Corporation Condenser systems for fluid processing systems
US10688429B2 (en) 2014-03-21 2020-06-23 Life Technologies Corporation Gas filter systems for fluid processing systems
US11268056B2 (en) 2015-12-29 2022-03-08 Life Technologies Corporation Flexible bioprocessing container with partial dividing partition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240009446A1 (en) * 2022-07-06 2024-01-11 Cardioquip, Llc Heat exchange apparatus and method of operation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2582871A (en) * 1948-07-31 1952-01-15 Pfaudler Co Inc Heat exchanger
US3842617A (en) 1974-01-28 1974-10-22 H Chase Disposable refrigerated container and refillable refrigerant supply vessel
US4177816A (en) * 1978-03-27 1979-12-11 Sci-Med Life Systems, Inc. Heat exchanger for blood
US4258784A (en) * 1978-04-07 1981-03-31 The Boeing Company Heat exchange apparatus and method of utilizing the same
US4731072A (en) * 1981-05-11 1988-03-15 Mcneilab, Inc. Apparatus for heating or cooling fluids
US4744414A (en) * 1986-09-02 1988-05-17 Arco Chemical Company Plastic film plate-type heat exchanger
US4907308A (en) * 1988-11-21 1990-03-13 Kinetic Concepts, Inc. Heat exchange system for inflatable patient support appliances
US5254094A (en) * 1989-07-17 1993-10-19 Starkey David L Physiological fluid warmer
US4982785A (en) * 1990-03-06 1991-01-08 Inter-City Products Corporation (Usa) Serpentine heat exchanger
US5287918A (en) * 1990-06-06 1994-02-22 Rolls-Royce Plc Heat exchangers
US5245693A (en) 1991-03-15 1993-09-14 In-Touch Products Co. Parenteral fluid warmer apparatus and disposable cassette utilizing thin, flexible heat-exchange membrane
AU706388B2 (en) * 1995-09-13 1999-06-17 Manitowoc Foodservice Group, Inc. Apparatus for cooling fluids
US6673098B1 (en) * 1998-08-24 2004-01-06 Radiant Medical, Inc. Disposable cassette for intravascular heat exchange catheter
US6572641B2 (en) * 2001-04-09 2003-06-03 Nxstage Medical, Inc. Devices for warming fluid and methods of use
US6882797B2 (en) * 2003-03-26 2005-04-19 Gaymar Industries, Inc. Multiple plate fluid warmer unit
US8038639B2 (en) * 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
WO2005093335A1 (fr) * 2004-03-25 2005-10-06 Noritz Corporation Dispositif de chauffage
US7629167B2 (en) * 2004-06-04 2009-12-08 Xcellerex, Inc. Disposable bioreactor systems and methods
ITMI20051899A1 (it) * 2005-10-10 2007-04-11 Cardionova S R L Dispositivo di scambio termico ad uso medicale
EP2586472B1 (fr) * 2006-04-14 2017-08-16 DEKA Products Limited Partnership Système de pompage de fluide
WO2007122765A1 (fr) * 2006-04-24 2007-11-01 Rinnai Corporation Machine de source de chaleur composée tubulaire unique
US7588549B2 (en) * 2006-08-03 2009-09-15 Terumo Cardiovascular Systems Corporation Thermoelectric temperature control for extracorporeal blood circuit
US20080262409A1 (en) 2007-04-23 2008-10-23 Joel Brian Derrico High flow rate disposable cassette heat exchanger
US8057423B2 (en) * 2007-07-05 2011-11-15 Baxter International Inc. Dialysis system having disposable cassette
US20090242173A1 (en) * 2008-03-25 2009-10-01 Peter Mitchell Temperature control system
US8672938B2 (en) * 2009-07-23 2014-03-18 Covidien Lp Active cooling system and apparatus for controlling temperature of a fluid used during treatment of biological tissue
US7833206B1 (en) 2010-02-02 2010-11-16 Peregrine Surgical, Ltd. Method and apparatus for disposable aspirator cassette
US8455242B2 (en) * 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None
See also references of EP2732230A4

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10711233B2 (en) 2010-02-22 2020-07-14 Life Technologies Corporation Heat exchanger system with flexible bag
US9284524B2 (en) 2010-02-22 2016-03-15 Life Technologies Corporation Heat exchanger system with flexible bag
US12012579B2 (en) 2010-02-22 2024-06-18 Life Technologies Corporation Heat exchanger system with flexible bag
US9528083B2 (en) 2010-02-22 2016-12-27 Life Technologies Corporation Heat exchanger system with flexible bag
US11492582B2 (en) 2010-02-22 2022-11-08 Life Technologies Corporation Heat exchanger system with flexible bag
US9127246B2 (en) 2010-02-22 2015-09-08 Life Technologies Corporation Methods for condensing a humid gas
US11229855B2 (en) 2014-03-21 2022-01-25 Life Technologies Corporation Condenser systems for processing a fluid
US11554335B2 (en) 2014-03-21 2023-01-17 Life Technologies Corporation Methods for gas filteration in fluid processing systems
US12285713B2 (en) 2014-03-21 2025-04-29 Life Technologies Corporation Condenser bag for processing a fluid
US12076681B2 (en) 2014-03-21 2024-09-03 Life Technologies Corporation Methods for gas filtration in fluid processing systems
US10005005B2 (en) 2014-03-21 2018-06-26 Life Technologies Corporation Condenser systems for fluid processing systems
US11717768B2 (en) 2014-03-21 2023-08-08 Life Technologies Corporation Condenser bag for processing a fluid
US10688429B2 (en) 2014-03-21 2020-06-23 Life Technologies Corporation Gas filter systems for fluid processing systems
US11685886B2 (en) 2014-10-07 2023-06-27 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
US10822582B2 (en) 2014-10-07 2020-11-03 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
US12188000B2 (en) 2014-10-07 2025-01-07 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
US10059916B2 (en) 2014-10-07 2018-08-28 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
US11268056B2 (en) 2015-12-29 2022-03-08 Life Technologies Corporation Flexible bioprocessing container with partial dividing partition
US12226561B2 (en) 2015-12-29 2025-02-18 Life Technologies Corporation Magnetic particle separation system with flexible bioprocessing container
WO2018072313A1 (fr) * 2016-10-18 2018-04-26 四川捷元科技有限公司 Unité d'échange de chaleur et matrice d'échange de chaleur

Also Published As

Publication number Publication date
WO2013009668A3 (fr) 2013-06-13
EP2732230A4 (fr) 2015-03-04
US9284841B1 (en) 2016-03-15
EP2732230A2 (fr) 2014-05-21

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