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WO2013007976A1 - Indicateurs de confirmation de traitement de décontamination d'agents de guerre chimiques/biologiques - Google Patents

Indicateurs de confirmation de traitement de décontamination d'agents de guerre chimiques/biologiques Download PDF

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Publication number
WO2013007976A1
WO2013007976A1 PCT/GB2012/051111 GB2012051111W WO2013007976A1 WO 2013007976 A1 WO2013007976 A1 WO 2013007976A1 GB 2012051111 W GB2012051111 W GB 2012051111W WO 2013007976 A1 WO2013007976 A1 WO 2013007976A1
Authority
WO
WIPO (PCT)
Prior art keywords
dye
chemical
chemical indicator
indicator
base substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2012/051111
Other languages
English (en)
Inventor
Guy Matthew TURNER
Neil Richard POMEROY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioquell UK Ltd
Original Assignee
Bioquell UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioquell UK Ltd filed Critical Bioquell UK Ltd
Publication of WO2013007976A1 publication Critical patent/WO2013007976A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/208—Hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
    • A62D3/00—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
    • A62D3/30—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances by reacting with chemical agents
    • A62D3/36—Detoxification by using acid or alkaline reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/228—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for peroxides

Definitions

  • the present invention relates to indicators for
  • WO08/145987 describes a method of rendering harmless chemical/biological warfare agents. This comprises exposing the agents to an atmosphere which includes a peroxide/water vapour, and causing the peroxide vapour to condense on surfaces exposed to the chemical/biological agents; wherein ammonia gas is included in the atmosphere. The ammonia gas is soluble in the condensate to form ammonia hydroxide to react, in conjunction with the peroxide, against the
  • Chemical indicators are already commercially available that change colour when exposed to hydrogen peroxide (the sterilant used in the aforementioned bio-decontamination processes) . Such indicators are able to provide evidence that the "load” (i.e. the surfaces and items within a room/enclosure) has seen the sterilant i.e. verification that at least part of the process has been carried out.
  • the invention therefore provides a chemical indicator for providing visual indication that a decontamination process consisting of a strong oxidant vapour and an
  • said indicator comprising a base substrate, at least one patch of a first dye applied to the base substrate, wherein said dye is initially coloured and is susceptible to nucleophilic attack by a nucleophile, as a result of which the dye becomes colourless, but is
  • the invention relates to the use of specific chemical indicators tuned to the nucleophilic action of a
  • decontamination cycle used to deactivate CWAs such as one utilising a base-activated hydrogen peroxide.
  • the nucleophile is preferably base-activated hydrogen peroxide and the hydrogen peroxide is preferably activated by ammonia.
  • the dye may be an azo dye or a triarylmethane dye.
  • the indicator may further comprise one or more patches of a second dye, said second dye having a different colour to that of the first dye and being susceptible to oxidative attack by an oxidising agent as a result of which the dye becomes colourless.
  • One or more patches of a third dye may also be
  • said third dye having a different colour to that of the first and second dyes and being susceptible to
  • the second and/or third dye may be a triarylmethane dye .
  • the base substrate is preferably a metal plate or a sticky label.
  • the patches are preferably formed by dissolving the dye in a polymer base.
  • Figure 1 is a plan view of an indicator according to the present invention.
  • Figure 2 is a plan view of an alternative embodiment of the present invention.
  • the indicator 10 of the present invention may be provided using a suitable substrate in a convenient form, such as a metal plate (e.g. in the form of a dog tag) or low-tack sticky label.
  • a suitable substrate in a convenient form, such as a metal plate (e.g. in the form of a dog tag) or low-tack sticky label.
  • Applied to a surface of the substrate of the indicator 10 in a suitable manner at least one patches 11 of coloured dye.
  • the patches 11 are formed by dissolving the dye in a polymer, such as polyvinyl alcohol, polyvinylacetate or polyvinylbutyral .
  • An adhesive such as polyvinyl alcohol, is used to affix the patches 11 to the substrate. The adhesive must be applied in a manner so that
  • the patch 11 is preferably labelled with legible identifying indicia 12, such as numbers or letters, although other symbols may be used.
  • legible identifying indicia 12 such as numbers or letters, although other symbols may be used.
  • the patch 11 starts coloured and become colourless when exposed to a previously validated decontamination process for a particular chemical warfare threat, i.e. a process and parameters that have previously been proven by laboratory analysis to be successful in completely destroying a chemical warfare agent.
  • the indicium 12 shown in the embodiment of Figure 1 is the letter N which is indicative of a nerve agent threat, e.g. VX. This is an example of an individual cycle
  • the dye of patch N is a coloured dye (preferably an azo dye) that is susceptible to nucleophilic attack (or
  • nucleophile agent which may or may not be generated in-situ (e.g. HOO ⁇ ) , such as the
  • nucleophilic action of a base-activated hydrogen peroxide cycle used to deactivate CWAs After undergoing nucleophilic attack the dye changes to colourless.
  • the patch N therefore enables an indication to be given only when the indicator has been exposed to an environment consisting of both HPV and NH 3 .
  • the indicator 10 may be enhanced by combining the patch N with other patches which are indicative of other threats, such as those which are described above and are already known in the art per se.
  • An example is shown in Figure 2 which has 3 patches 11 labelled with indicia 12 comprising the letters B, N and H in which: -
  • N is indicative of a nerve agent threat
  • H is indicative of a vesicant threat, e.g. mustard gas.
  • the dye of patch B is a coloured (preferably
  • triarylmethane dye that is susceptible to oxidative attack (or destruction) by an oxidising agent (e.g. hydrogen peroxide) . After undergoing oxidative attack the dye changes from coloured to colourless.
  • an oxidising agent e.g. hydrogen peroxide
  • the dye of patch H is another coloured dye (also preferably a triarylmethane dye) that is also susceptible to oxidative attack (or destruction) by an oxidising agent (e.g. hydrogen peroxide), but which is selected to require a greater exposure than the dye of patch B. After undergoing oxidative attack the dye of patch H also changes from coloured to colourless. The initial hue of this dye is easily distinguishable from the dye of patch B.
  • an oxidising agent e.g. hydrogen peroxide
  • compositions for the dyes of patches B and N are Lissamine Green B, Brilliant Blue R, Brilliant Blue G and Methyl Violet 2b.
  • Suitable compositions for the dye of patch H are Orange I, Orange II and Methyl violet 2B.
  • One or more patches 11 of each dye may be provided on the substrate and other combinations may also be provided indicating other threats.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Emergency Management (AREA)
  • Business, Economics & Management (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

L'invention porte sur des indicateurs de confirmation de traitement de décontamination d'agents de guerre chimiques/biologiques. La présente invention concerne des indicateurs de confirmation que le traitement de décontamination de surfaces qui ont été exposées à des agents de guerre biologiques et/ou chimiques a été achevé de façon réussie. L'indicateur chimique fournit une indication visuelle qu'un processus de décontamination consistant en une vapeur d'oxydant fort et un gaz alcalin s'est produit. L'indicateur comprend un substrat de base et au moins une pièce d'un premier colorant appliqué au substrat de base. Ledit colorant est initialement coloré et est sensible à l'attaque nucléophile par un nucléophile, à la suite de laquelle le colorant devient sans couleur, mais n'est pas affecté par un oxydant fort seul.
PCT/GB2012/051111 2011-07-13 2012-05-17 Indicateurs de confirmation de traitement de décontamination d'agents de guerre chimiques/biologiques Ceased WO2013007976A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1112054.0A GB2492819A (en) 2011-07-13 2011-07-13 Indicators for confirming decontamination treatment of chemical/biological warfare agents
GB1112054.0 2011-07-13

Publications (1)

Publication Number Publication Date
WO2013007976A1 true WO2013007976A1 (fr) 2013-01-17

Family

ID=44586545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/051111 Ceased WO2013007976A1 (fr) 2011-07-13 2012-05-17 Indicateurs de confirmation de traitement de décontamination d'agents de guerre chimiques/biologiques

Country Status (2)

Country Link
GB (1) GB2492819A (fr)
WO (1) WO2013007976A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110538339A (zh) * 2019-09-11 2019-12-06 衡水诺盾生物科技有限公司 一种过氧化氢等离子体五类卡灭菌挑战装置及其制作方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267242B1 (en) 1997-04-17 2001-07-31 Johnson & Johnson Medical Kabushiki Kaisha Chemical indicator sheets and packaging bags for sterilization made with the use of the same
WO2003057262A1 (fr) * 2001-12-31 2003-07-17 3M Innovative Properties Company Indicateurs de peroxyde d'hydrogene et de l'acide peracetique et leurs procedes d'utilisation
WO2005035067A2 (fr) 2003-04-24 2005-04-21 Steris Inc. Traitement a la vapeur active de neutralisation d'agents de guerre
KR20060052833A (ko) 2003-07-22 2006-05-19 스테리스 인코퍼레이티드 증발된 과산화수소용 시각적 검출기
US7102052B2 (en) 2003-04-24 2006-09-05 Steris Inc Activated vapor treatment for neutralizing warfare agents
WO2008006152A1 (fr) * 2006-07-11 2008-01-17 Paul Nigel Brockwell Système indicateur pour déterminer la concentration d'analyte
WO2008145987A1 (fr) 2007-05-30 2008-12-04 Bioquell Uk Limited Décontamination d'agents biologiques et chimiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2085915C1 (ru) * 1993-11-15 1997-07-27 Войсковая часть 61469 Способ количественного определения цианистого калия
US6790411B1 (en) * 1999-12-02 2004-09-14 3M Innovative Properties Company Hydrogen peroxide indicator and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267242B1 (en) 1997-04-17 2001-07-31 Johnson & Johnson Medical Kabushiki Kaisha Chemical indicator sheets and packaging bags for sterilization made with the use of the same
WO2003057262A1 (fr) * 2001-12-31 2003-07-17 3M Innovative Properties Company Indicateurs de peroxyde d'hydrogene et de l'acide peracetique et leurs procedes d'utilisation
WO2005035067A2 (fr) 2003-04-24 2005-04-21 Steris Inc. Traitement a la vapeur active de neutralisation d'agents de guerre
US7102052B2 (en) 2003-04-24 2006-09-05 Steris Inc Activated vapor treatment for neutralizing warfare agents
KR20060052833A (ko) 2003-07-22 2006-05-19 스테리스 인코퍼레이티드 증발된 과산화수소용 시각적 검출기
WO2008006152A1 (fr) * 2006-07-11 2008-01-17 Paul Nigel Brockwell Système indicateur pour déterminer la concentration d'analyte
WO2008145987A1 (fr) 2007-05-30 2008-12-04 Bioquell Uk Limited Décontamination d'agents biologiques et chimiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. OAKES; P. GRATTON: "Kinetic investigations of azo dye oxidation in aqueous media", J. CHEM. SOC., PERKIN TRANS., vol. 2, 1998, pages 1857 - 1864

Also Published As

Publication number Publication date
GB201112054D0 (en) 2011-08-31
GB2492819A (en) 2013-01-16

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