[go: up one dir, main page]

WO2013093931A3 - Nouveaux promédicaments de médicaments phénoliques - Google Patents

Nouveaux promédicaments de médicaments phénoliques Download PDF

Info

Publication number
WO2013093931A3
WO2013093931A3 PCT/IN2012/000590 IN2012000590W WO2013093931A3 WO 2013093931 A3 WO2013093931 A3 WO 2013093931A3 IN 2012000590 W IN2012000590 W IN 2012000590W WO 2013093931 A3 WO2013093931 A3 WO 2013093931A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel prodrugs
phenolic drugs
phenolic
drugs
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2012/000590
Other languages
English (en)
Other versions
WO2013093931A2 (fr
Inventor
Jiten Ranchhodbhai Patel
Gopalkumar Chimanlal Patel
Gaurav Sanjivkumar Sheth
Sanjay Nandlalji MANDHANE
Trinadha Rao Chitturi
Rajamannar Thennati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharma Advanced Research Co Ltd
Original Assignee
Sun Pharma Advanced Research Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Research Co Ltd filed Critical Sun Pharma Advanced Research Co Ltd
Publication of WO2013093931A2 publication Critical patent/WO2013093931A2/fr
Publication of WO2013093931A3 publication Critical patent/WO2013093931A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des nouveaux promédicaments de carbamate contenant un groupe hydrazide de médicaments phénoliques de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, ainsi qu'un procédé pour leur préparation.
PCT/IN2012/000590 2011-09-19 2012-09-06 Nouveaux promédicaments de médicaments phénoliques Ceased WO2013093931A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2647/MUM/2011 2011-09-19
IN2647MU2011 2011-09-19

Publications (2)

Publication Number Publication Date
WO2013093931A2 WO2013093931A2 (fr) 2013-06-27
WO2013093931A3 true WO2013093931A3 (fr) 2013-08-08

Family

ID=48050873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000590 Ceased WO2013093931A2 (fr) 2011-09-19 2012-09-06 Nouveaux promédicaments de médicaments phénoliques

Country Status (1)

Country Link
WO (1) WO2013093931A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015099863A1 (fr) * 2013-12-27 2015-07-02 Purdue Pharma L.P. Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
CN104262352B (zh) * 2014-09-01 2018-06-15 中国人民解放军军事医学科学院毒物药物研究所 喜树碱衍生物及其医药用途
WO2020012245A1 (fr) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Promédicaments de thiénothiophène-naltrexone pour compositions injectables à action prolongée
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604463A (en) * 1983-07-14 1986-08-05 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US20090005352A1 (en) * 2004-07-12 2009-01-01 Xenoport, Inc. Prodrugs of Propofol, Compositions and Uses Thereof
WO2010112942A1 (fr) * 2009-04-02 2010-10-07 Shire Llc Nouveaux promédicaments d'opioïdes à base d'acide aminé et de peptide liés à l'acide dicarboxylique et leurs utilisations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230A (en) 1850-04-02 Machine for hoisting
US4551452A (en) 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
WO1996028451A1 (fr) 1995-03-14 1996-09-19 Euroceltique S.A. Morphine-3-esters
US6225321B1 (en) 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
EP2402037B8 (fr) 2006-05-26 2019-12-04 Signature Therapeutics, Inc. Libération contrôlée d'opioïdes phénoliques
EP2064215B1 (fr) 2006-09-22 2015-07-15 Zynerba Pharmaceuticals, Inc. Promédicaments d'opioïdes administrables de façon transdermique, compositions empêchant l'usage abusif de ceux-ci et procédés d'utilisation de promédicaments d'opioïdes
US20090192095A1 (en) 2008-01-18 2009-07-30 Shire Llc Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604463A (en) * 1983-07-14 1986-08-05 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US20090005352A1 (en) * 2004-07-12 2009-01-01 Xenoport, Inc. Prodrugs of Propofol, Compositions and Uses Thereof
WO2010112942A1 (fr) * 2009-04-02 2010-10-07 Shire Llc Nouveaux promédicaments d'opioïdes à base d'acide aminé et de peptide liés à l'acide dicarboxylique et leurs utilisations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. YOON, ET AL.: "Solution and soluble polymer synthesis of 3-aminoimidazoline-2,4-diones", CHEMICAL COMMUNICATIONS, no. 24, December 1998 (1998-12-01), Royal Society of Chemistry, Cambridge, GB, pages 2703 - 2704, XP002162268, ISSN: 0022-4936, DOI: 10.1039/a807067i *
M. SABURI, ET AL.: "Stereochemical studies of metal chelates. VII. The preparation, stereochemistry and circular dichloism of dinitrocobalt(III) complexes with (3S, 8S)-dimethyltriethylenetetramine and related tetramines", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 45, no. 4, 1972, pages 1086 - 1093, XP055067195, ISSN: 0009-2673, DOI: 10.1246/bcsj.45.1086 *
W. ELGER, ET AL.: "Sulfamates of various estrogens are prodrugs with increased systemic and reduced hepatic estrogenicity at oral application", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 55, no. 3-4, December 1995 (1995-12-01), Elsevier Science, Oxford, GB, pages 395 - 403, XP005348960, ISSN: 0960-0760, DOI: 10.1016/0960-0760(95)00214-6 *

Also Published As

Publication number Publication date
WO2013093931A2 (fr) 2013-06-27

Similar Documents

Publication Publication Date Title
WO2013093931A3 (fr) Nouveaux promédicaments de médicaments phénoliques
MY165087A (en) Neprilysin inhibitors
WO2012025944A3 (fr) Sitagliptine, sels et polymorphes de celle-ci
MD20150091A2 (ro) Compuşi antivirali
PH12014502733A1 (en) Neprilysin inhibitors
MY163394A (en) Substituted aminobutyric derivates as neprilysin inhibitors
PH12015500260A1 (en) Neprilysin inhibitors
WO2010092090A3 (fr) Nouveaux sels de la sitagliptine
WO2013098833A3 (fr) Procédés et intermédiaires destinés à la préparation de rivaroxaban
MY187718A (en) Pharmaceutical formulations
MX2015003594A (es) Agente terapeutico o profilactico para sindrome de lisis tumoral.
WO2013100566A8 (fr) Composé de dérivés de carbamate d'alkyle phényle et composition pharmaceutique en contenant
WO2012006474A3 (fr) Composés et procédés pour l'inhibition du transport de phosphate
WO2013004995A8 (fr) Composés pyrimidinones et leur utilisation
WO2011157722A3 (fr) Composition contenant de l'ivabradine solide
WO2013055684A8 (fr) Citramide de rasagiline
WO2010129918A8 (fr) Promédicaments à base de triptolide
HK1200314A1 (en) R(+)-n-methyl-propargyl-aminoindan
WO2012135615A3 (fr) Enopeptines, utilisations de celles-ci, et procédés de synthèse de celles-ci
HK1200315A1 (en) R(+)-n-formyl-propargyl-aminoindan
WO2013109972A3 (fr) Composés thérapeutiques
WO2014062838A3 (fr) Modulateurs de pkm2 et procédés pour les utiliser
WO2013121235A3 (fr) Procédé de préparation de la dronédarone par retrait du groupe hydroxyle
WO2013128379A3 (fr) Formes polymorphes cristallines de linagliptine
PL2865664T3 (pl) Nowy związek mający zdolność hamowania enzymu 11ß-HSD1, lub jego farmaceutycznie dopuszczalna sól, sposób wytwarzania go, i kompozycja farmaceutyczna zawierająca go jako składnik aktywny

Legal Events

Date Code Title Description
122 Ep: pct application non-entry in european phase

Ref document number: 12839219

Country of ref document: EP

Kind code of ref document: A2