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WO2013092936A3 - Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne - Google Patents

Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne Download PDF

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Publication number
WO2013092936A3
WO2013092936A3 PCT/EP2012/076524 EP2012076524W WO2013092936A3 WO 2013092936 A3 WO2013092936 A3 WO 2013092936A3 EP 2012076524 W EP2012076524 W EP 2012076524W WO 2013092936 A3 WO2013092936 A3 WO 2013092936A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
derivative
analog
photochemotherapy
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/076524
Other languages
French (fr)
Other versions
WO2013092936A2 (en
Inventor
Philippe Martel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of WO2013092936A2 publication Critical patent/WO2013092936A2/en
Publication of WO2013092936A3 publication Critical patent/WO2013092936A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the use in the field of photodynamic therapy (PDT) of a photosensitizer (PS) combined to the use of a vitamin D analog or derivative for treating acne. Said vitamin d analog or derivative is applied before the PS.
PCT/EP2012/076524 2011-12-20 2012-12-20 Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne Ceased WO2013092936A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161578029P 2011-12-20 2011-12-20
US61/578,029 2011-12-20

Publications (2)

Publication Number Publication Date
WO2013092936A2 WO2013092936A2 (en) 2013-06-27
WO2013092936A3 true WO2013092936A3 (en) 2013-08-15

Family

ID=47435989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/076524 Ceased WO2013092936A2 (en) 2011-12-20 2012-12-20 Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne

Country Status (1)

Country Link
WO (1) WO2013092936A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2981753T3 (en) * 2017-02-06 2024-10-10 3Skin As Sunscreen composition
CN112074505B (en) 2018-03-08 2024-04-05 因赛特公司 Aminopyrazine diol compounds as PI 3K-gamma inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013788A1 (en) * 2000-08-16 2002-02-21 The General Hospital Corporation D/B/A Massachusetts General Hospital Topical aminolevulinic acid-photodynamic therapy for acne vulgaris
WO2006051269A1 (en) * 2004-11-10 2006-05-18 Photocure Asa Treatment of acne using derivatives of 5-aminolevulinic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5422093A (en) 1989-07-28 1995-06-06 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5234940A (en) 1989-07-28 1993-08-10 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5079262A (en) 1989-07-28 1992-01-07 Queen's University At Kingston Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
CZ291132B6 (en) 1995-03-10 2002-12-11 Photocure Asa Esters of 5-aminolevullinic acids and pharmaceutical preparation in which the esters are comprised
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013788A1 (en) * 2000-08-16 2002-02-21 The General Hospital Corporation D/B/A Massachusetts General Hospital Topical aminolevulinic acid-photodynamic therapy for acne vulgaris
WO2006051269A1 (en) * 2004-11-10 2006-05-18 Photocure Asa Treatment of acne using derivatives of 5-aminolevulinic acid

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BISSONNETTE R: "Treatment of acne with photodynamic therapy", MINERVA DERMATOLOGICA, EDIZIONI MINERVA MEDICA, TURIN, IT, vol. 146, no. 6, 24 November 2011 (2011-11-24), pages 445 - 456, XP008163113, ISSN: 0026-4741 *
GARNIER G: "[VITAMIN D2 IN TREATMENT OF ACNE CONGLOBATA]", ARCHIVES BELGES DE DERMATOLOGIE ET SYPHILIGRAPHIE, BRUSSELS, vol. 20, 1 September 1964 (1964-09-01), pages 105 - 108, XP008163083, ISSN: 0003-956X *
MAYTIN E V ET AL: "Nuclear transcription factors: a new approach to enhancing cellular responses to ALA-mediated photodynamic therapy", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING USA, vol. 6139, no. 1, 9 February 2006 (2006-02-09), pages 613909 - 1, XP002699489, ISSN: 0277-786X *
SATO NOBUYUKI ET AL: "Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NATURE PUBLISHING GROUP, GB, vol. 127, no. 4, 1 April 2007 (2007-04-01), pages 925 - 934, XP002519835, ISSN: 0022-202X, [retrieved on 20061019], DOI: 10.1038/SJ.JID.5700595 *

Also Published As

Publication number Publication date
WO2013092936A2 (en) 2013-06-27

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