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WO2013084945A1 - Suction catheter - Google Patents

Suction catheter Download PDF

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Publication number
WO2013084945A1
WO2013084945A1 PCT/JP2012/081516 JP2012081516W WO2013084945A1 WO 2013084945 A1 WO2013084945 A1 WO 2013084945A1 JP 2012081516 W JP2012081516 W JP 2012081516W WO 2013084945 A1 WO2013084945 A1 WO 2013084945A1
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Prior art keywords
liquid
catheter
suction
suction catheter
catheter shaft
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French (fr)
Japanese (ja)
Inventor
畑優
中川雄司
本間康之
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Terumo Corp
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Terumo Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84Drainage tubes; Aspiration tips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/32Surgical cutting instruments
    • A61B17/320016Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082Catheter tip comprising a tool

Definitions

  • the liquid absorbing portion may be configured to be foldable at least before the liquid is absorbed.
  • the suction catheter 10 includes a hollow catheter shaft 16 and a liquid absorbing portion 18 provided (attached) at the distal end portion of the catheter shaft 16.
  • the catheter shaft 16 is a long tube-shaped member constituting the main body portion of the suction catheter 10, and a liquid absorbing portion 18 is coupled to a distal end portion thereof, and a base end portion thereof is configured to be detachable from the suction device 14.
  • a connector 17 detachably attached to the connection port 15 of the suction device 14 is provided at the proximal end portion of the catheter shaft 16.
  • the suction device 14 may have any configuration as long as it can continuously generate a negative pressure in the lumen 16a of the catheter shaft 16.
  • the suction device 14 includes a vacuum generating means and a liquid recovery unit (container). It may be configured.
  • the vacuum generating means may be a vacuum pump or a pressurized air supply source and an ejector.
  • the liquid absorbing portion 18 is not limited to the two-layer structure, but may be a single-layer structure, a multilayer structure of three or more layers, and the inner side regardless of the single-layer structure or the multilayer structure. A configuration in which the pore diameter gradually decreases toward the surface may be employed. Or the liquid absorption part 18 should just be the structure which can move a liquid to radial direction.
  • the dimensions of the liquid absorbing portion 18 are determined according to the dimensions of the catheter shaft 16, but are preferably 0.1 to 10 cm in total length and 1 to 5 cm in outer diameter.
  • the liquid absorbing portion 18 preferably has a pore diameter of 20 to 2000 ⁇ m and a porosity of 25 to 98%.
  • the thickness in the radial direction of the cylindrical wall portion constituting the liquid absorbing portion 18 is preferably 1 to 100 mm.
  • the dimensions of the operation elongated body 28 are determined according to the dimensions of the catheter shaft 16, but it is preferable that the total length is 5 to 35 cm and the outer diameter is 1 to 20 mm.
  • the dimensions of the tube 26 are determined in accordance with the part of the living body where the suction catheter 10 is used, the dimension of the catheter shaft 16, the dimension of the operation elongated body 28, and the like. For example, the total length is about 1 to 34 cm.
  • the outer diameter is preferably 2 to 22 mm.
  • the suction catheter 10 to which the operation elongate body 28 is connected from the lumen of the sheath 40 or the port, the distal end portion (the liquid absorbing portion 18) thereof is near the cartilage 38, preferably Insert until the cell transplantation site 32 is located (see FIG. 5B).
  • the proximal end portion of the catheter shaft 16 is connected to the suction device 14 (see FIG. 1), and suction is started. Further, after removing the dissection device 34, the suction catheter 10 may be inserted using the port used for the insertion of the dissection device 34.
  • the suction catheter 10 specifically operates as follows.
  • the liquid absorber 18 is brought into contact with the liquid 42 in the knee joint (see FIG. 5B)
  • the liquid 42 is absorbed by the liquid absorber 18 due to the liquid absorbability of the liquid absorber 18.
  • the pore diameter of the liquid absorbing portion 18 is smaller toward the inner layer
  • the absorbed liquid moves toward the radially inner side of the liquid absorbing portion 18 by capillary action.
  • the liquid permeable portion 24 has fine pores 24 a, and the liquid in the inner peripheral portion of the liquid absorbing portion 18 is formed by the negative pressure in the lumen 16 a of the catheter shaft 16 under the action of the suction device 14.
  • the liquid absorption part 18 can always absorb a liquid.
  • the liquid absorbing portion 50 before absorbing the liquid, the liquid absorbing portion 50 can be contracted by folding as shown in FIG. 6A to reduce the outer diameter, and when absorbing the liquid, the liquid absorbing portion 50 expands as shown in FIG. 6B. It is configured. Even when the liquid absorbing portion 50 has a single-layer structure, the outer peripheral portion of the liquid absorbing portion 50 is formed in the same shape as the protrusion 56 described above, so that the structure can be folded as described above. Can do. In the case where the liquid absorbing portion 50 is configured with a multilayer structure of three or more layers, the outermost layer may be formed in the same shape as the above-described protruding portion 56.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

A suction catheter (10) is provided with a hollow catheter shaft (16) and a liquid suction unit (18) comprising a flexible, liquid-absorbent porous body provided to a distal end of the catheter shaft (16). The liquid suction unit (18) comprises an outer layer (20) and an inner layer (22) and has an increasingly smaller pore diameter going inward in the layers, therefore adopting a structure where capillary action generates a force that moves liquid towards the catheter shaft (16) side.

Description

吸引カテーテルAspiration catheter

 本発明は、内視鏡視下手術に用いられる吸引カテーテルであって、吸引用のカテーテル軸と液体吸収可能な先端部とを有する吸引カテーテルに関する。 The present invention relates to a suction catheter for use in endoscopic surgery, and relates to a suction catheter having a suction catheter shaft and a tip capable of absorbing liquid.

 従来、軟骨損傷部の再生治療の一つとして、培養した細胞や採取した骨髄液を濃縮し調整した骨髄由来細胞を関節鏡視下で移植する方法がある。例えば、文献「臨床整形外科」(関矢一郎、Vol.45、No.9、医学書院、2010年9月25日、p.791-795)参照。具体的には、患者から採取した滑膜細胞を2週間培養して得られた培養細胞を含む細胞懸濁液を用意した上で、関節鏡視下で軟骨損傷部位を生理食塩水等の洗浄液で洗浄しながら郭清(シェービング)し、洗浄液を除去した後、軟骨損傷部位に0.5mLの細胞懸濁液を注入する。細胞懸濁液を膝の軟骨損傷部位に移植する際、液体(洗浄液)を十分に除去しなければ、細胞が分散してしまい軟骨損傷部位に選択的に留まらず軟骨再生効果が得られない懸念がある。そこで、針とシリンジを用いて関節内の液体を可能な限り吸引し、除去する必要があるが、針先で軟骨組織を傷つけてしまう危険性があること、除去しても時間が経つと浸出液が染み出してくるため何度もシリンジで吸引する必要があることが課題となる。 Conventionally, as one of the regeneration treatments for cartilage damage, there is a method of transplanting cultured cells and bone marrow-derived cells obtained by concentrating and adjusting collected bone marrow fluid under arthroscopy. For example, see the document “Clinical Orthopedic Surgery” (Sekiya Ichiro, Vol. 45, No. 9, Medical School, 25 September 2010, p. 791-795). Specifically, after preparing a cell suspension containing cultured cells obtained by culturing synovial cells collected from a patient for 2 weeks, a cartilage injury site is washed with a physiological saline solution or the like under arthroscopy Dissect (shave) while washing and remove the washing solution, and then inject 0.5 mL of the cell suspension into the cartilage injury site. When transplanting the cell suspension to the cartilage injury site of the knee, if the liquid (washing solution) is not removed sufficiently, the cells will disperse and will not remain selectively at the cartilage injury site and the cartilage regeneration effect cannot be obtained There is. Therefore, it is necessary to suck and remove as much of the liquid in the joint as possible using a needle and syringe, but there is a risk of damaging the cartilage tissue with the needle tip, and even if the removal takes place over time It is a problem that it is necessary to suck with a syringe many times because of oozing out.

 以上のような課題を考慮すると、針とシリンジではなく、吸引チューブを挿入して灌流液を吸引することが好ましい。これに関連して、特開2006-150052号公報には、管状部の端部に形設されカテーテルの先端に着脱自在に装着される装着部と、管状部の他端部に先端が曲面状に形成された吸引部と、装着部及び管状部、吸引部の内部を貫通する通路部とを備えたカテーテル用吸引補助具が提案されている。上記カテーテル用吸引補助具によると、操作性に優れ、カテーテルの吸引力の減少を予防できる。しかし、関節内等のように、組織同士が密着しているような使用部位では、吸引に伴い、カテーテル用吸引補助具の先端が組織を吸い込んでしまい、詰まってしまうこと、さらに細胞移植を行う際には移植した細胞を吸引してしまう恐れがある。 Considering the above problems, it is preferable to suck the perfusate by inserting a suction tube instead of a needle and a syringe. In relation to this, Japanese Patent Application Laid-Open No. 2006-150052 discloses a mounting portion that is formed at the end of the tubular portion and is detachably attached to the distal end of the catheter, and a tip that is curved at the other end of the tubular portion. There has been proposed a suction assisting tool for a catheter comprising a suction part formed in the above, a mounting part and a tubular part, and a passage part penetrating the inside of the suction part. The catheter suction assisting tool is excellent in operability and can prevent a reduction in suction force of the catheter. However, at the site where the tissues are in close contact, such as in a joint, the tip of the catheter suction aid sucks in the tissue due to suction and becomes clogged, and further performs cell transplantation. In some cases, the transplanted cells may be aspirated.

 本発明はこのような課題を考慮してなされたものであり、内視鏡視下手術に際し、組織を傷付けず、液体の持続的な吸引が可能であり、移植した細胞の吸引を防止できる吸引カテーテルを提供することを目的とする。 The present invention has been made in consideration of such a problem, and is capable of continuous suction of liquid without damaging tissue and preventing suction of transplanted cells during endoscopic surgery. An object is to provide a catheter.

 上記の目的を達成するため、中空状のカテーテル軸と、前記カテーテル軸の先端部に設けられ、柔軟性及び液体吸収性を有する多孔質体からなる液体吸収部とを備えることを特徴とする。 In order to achieve the above object, the present invention is characterized by comprising a hollow catheter shaft and a liquid absorbing portion provided at a distal end portion of the catheter shaft and made of a porous body having flexibility and liquid absorbability.

 上記の構成によれば、液体吸収部が柔軟性を有するため、内視鏡視下手術に際し組織を傷付けることがないとともに、液体吸収部で吸収した液体をカテーテル軸の内腔に移動させることにより液体の持続的な吸引が可能である。また、特に、本発明の吸引カテーテルを関節鏡視下細胞移植手術に用いた場合、液体吸収部が多孔質体からなるため、移植された細胞を吸引することが有効に防止される。 According to the above configuration, since the liquid absorption part has flexibility, the tissue is not damaged during the endoscopic operation, and the liquid absorbed by the liquid absorption part is moved to the lumen of the catheter shaft. A continuous suction of liquid is possible. In particular, when the suction catheter of the present invention is used for arthroscopic cell transplantation surgery, the liquid absorbing part is made of a porous body, and therefore, it is possible to effectively prevent the transplanted cells from being sucked.

 上記の吸引カテーテルにおいて、前記液体吸収部は、毛細管現象により前記カテーテル軸側への液体の移動力を発生させる構造を有するとよい。 In the above suction catheter, the liquid absorbing portion may have a structure that generates a moving force of the liquid toward the catheter shaft by capillary action.

 上記の構成によれば、液体吸収部内を液体がカテーテル軸に向かって移動し易いので、液体の持続的な吸引を確実に行うことができる。 According to the above configuration, since the liquid easily moves toward the catheter shaft in the liquid absorbing portion, it is possible to reliably suck the liquid.

 上記の吸引カテーテルにおいて、前記液体吸収部は、複数の層からなり、前記複数の層は、前記カテーテル軸に近い層ほどその気孔径が小さいとよい。 In the above-described suction catheter, the liquid absorbing portion may include a plurality of layers, and the plurality of layers may have smaller pore diameters as the layer is closer to the catheter shaft.

 上記の構成によれば、カテーテル軸側に液体の移動力を容易且つ確実に発生させることができる。 According to the above configuration, the liquid moving force can be easily and reliably generated on the catheter shaft side.

 上記の吸引カテーテルにおいて、前記カテーテル軸の先端部には、前記液体吸収部に接触し、前記液体吸収部の気孔径よりも孔径が小さい孔を有する液体透過部が設けられるとよい。 In the above suction catheter, the distal end portion of the catheter shaft may be provided with a liquid permeable portion having a hole that is in contact with the liquid absorbing portion and has a pore diameter smaller than the pore diameter of the liquid absorbing portion.

 上記の構成によれば、液体吸収部に吸収された液体を、液体透過部を介して効率的にカテーテル軸の内腔に浸出させることができる。 According to the above configuration, the liquid absorbed by the liquid absorbing portion can be efficiently leached into the lumen of the catheter shaft via the liquid permeable portion.

 上記の吸引カテーテルにおいて、前記カテーテル軸の内腔又は前記カテーテル軸に沿って設けられたルーメンに操作長尺体を挿入することにより、前記吸引カテーテルの先端部を操作することができるようになっているとよい。 In the above suction catheter, the distal end portion of the suction catheter can be operated by inserting an operation elongated body into the lumen of the catheter shaft or a lumen provided along the catheter shaft. It is good to be.

 上記の構成によれば、操作性に優れ、液体吸収部を所望の位置に容易に配置することができる。 According to the above configuration, the operability is excellent, and the liquid absorbing portion can be easily disposed at a desired position.

 上記の吸引カテーテルにおいて、前記液体吸収部は、少なくとも液体を吸収する前の状態で折り畳み可能に構成されているとよい。 In the above suction catheter, the liquid absorbing portion may be configured to be foldable at least before the liquid is absorbed.

 上記の構成によれば、治療対象部位が存在する空間に向けて吸引カテーテルを挿入する際に、液体吸収部を折り畳むことにより収縮させることができるため、より細い径での挿入が可能となることから、患者に対する侵襲度を低減することができる。また、吸引カテーテルの先端部を組織間に留置した際にずれにくく、安定的に留置することができる。 According to said structure, when inserting a suction catheter toward the space where a treatment object site | part exists, since it can be contracted by folding a liquid absorption part, insertion with a thinner diameter is attained. Therefore, the degree of invasiveness to the patient can be reduced. Further, when the distal end portion of the suction catheter is placed between the tissues, it is difficult to shift and can be stably placed.

 本発明の吸引カテーテルによれば、内視鏡視下手術に際し、組織を傷付けず、液体の持続的な吸引が可能であり、移植した細胞の吸引を防止できる。 According to the suction catheter of the present invention, during the endoscopic surgery, the liquid can be sucked continuously without damaging the tissue, and the suction of the transplanted cells can be prevented.

本発明の一実施形態に係る吸引カテーテルを備えた吸引システムの概略構成図である。It is a schematic block diagram of the suction system provided with the suction catheter which concerns on one Embodiment of this invention. 図1に示した吸引カテーテルの液体吸収部及びその周辺部位の縦断面図である。It is a longitudinal cross-sectional view of the liquid absorption part of the suction catheter shown in FIG. 1, and its peripheral site | part. 図2におけるIII-III線に沿った横断面図である。FIG. 3 is a transverse sectional view taken along line III-III in FIG. 2. 図4Aは、図3におけるIVA-IVA線に沿った縦断面図であり、図4Bは、第1変形例に係る吸引カテーテルの縦断面図である。4A is a longitudinal sectional view taken along line IVA-IVA in FIG. 3, and FIG. 4B is a longitudinal sectional view of an aspiration catheter according to a first modification. 図5Aは、吸引カテーテルの使用方法を説明する第1の図であり、図5Bは、吸引カテーテルの使用方法を説明する第2の図であり、図5Cは、吸引カテーテルの使用方法を説明する第3の図であり、図5Dは、吸引カテーテルの使用方法を説明する第4の図である。FIG. 5A is a first diagram illustrating a method of using a suction catheter, FIG. 5B is a second diagram illustrating a method of using a suction catheter, and FIG. 5C illustrates a method of using a suction catheter. FIG. 5D is a fourth diagram illustrating a method of using the suction catheter. 図6Aは、第2変形例に係る吸引カテーテルの液体吸収部(収縮時)を示す横断面図であり、図6Bは、第2変形例に係る吸引カテーテルの液体吸収部(膨張時)を示す横断面図である。FIG. 6A is a cross-sectional view showing a liquid absorption part (when contracted) of the suction catheter according to the second modification, and FIG. 6B shows a liquid absorption part (when expanded) of the suction catheter according to the second modification. It is a cross-sectional view. 第3変形例に係る吸引カテーテルの先端部を示す縦断面図である。It is a longitudinal cross-sectional view which shows the front-end | tip part of the suction catheter which concerns on a 3rd modification.

 以下、本発明に係る吸引カテーテルについて好適な実施形態を挙げ、添付の図面を参照しながら説明する。なお、説明の都合上、個々の図面における構成要素同士の寸法の比率、及び複数の図面における同一の構成要素同士の寸法の比率は適宜変更されており、必ずしも現実の比率とは一致しないものとする。 Hereinafter, preferred embodiments of the suction catheter according to the present invention will be described with reference to the accompanying drawings. For convenience of explanation, the ratio of dimensions between components in individual drawings and the ratio of dimensions between identical components in a plurality of drawings are appropriately changed and do not necessarily match the actual ratio. To do.

 図1は、本発明の一実施形態に係る吸引カテーテル10を備えた吸引システム12の概略構成図である。この吸引システム12は、吸引カテーテル10と、吸引カテーテル10が接続される吸引装置14とを備え、吸引カテーテル10の先端部(液体吸収部18)で吸収した液体を、吸引カテーテル10のチューブ(カテーテル軸16)により吸引し、吸引装置14に回収するように構成されている。 FIG. 1 is a schematic configuration diagram of a suction system 12 including a suction catheter 10 according to an embodiment of the present invention. The suction system 12 includes a suction catheter 10 and a suction device 14 to which the suction catheter 10 is connected. The liquid absorbed by the distal end portion (liquid absorption portion 18) of the suction catheter 10 is a tube (catheter of the suction catheter 10). It is configured to be sucked by the shaft 16) and collected by the suction device 14.

 図1に示すように、吸引カテーテル10は、中空状のカテーテル軸16と、カテーテル軸16の先端部に設けられた(取り付けられた)液体吸収部18とを備える。カテーテル軸16は、吸引カテーテル10の本体部分を構成する長尺なチューブ状の部材であり、その先端部には液体吸収部18が結合され、その基端部が吸引装置14に着脱可能に構成されている。具体的には、カテーテル軸16の基端部には、吸引装置14の接続ポート15に着脱可能なコネクタ17が設けられている。 As shown in FIG. 1, the suction catheter 10 includes a hollow catheter shaft 16 and a liquid absorbing portion 18 provided (attached) at the distal end portion of the catheter shaft 16. The catheter shaft 16 is a long tube-shaped member constituting the main body portion of the suction catheter 10, and a liquid absorbing portion 18 is coupled to a distal end portion thereof, and a base end portion thereof is configured to be detachable from the suction device 14. Has been. Specifically, a connector 17 detachably attached to the connection port 15 of the suction device 14 is provided at the proximal end portion of the catheter shaft 16.

 吸引装置14は、カテーテル軸16の内腔16aに陰圧を持続的に発生させることが可能なものであればどのような構成でもよく、例えば、真空発生手段と液体回収部(容器)とにより構成されてもよい。真空発生手段は、真空ポンプでも、加圧空気供給源とエジェクタとにより構成されたものでもよい。 The suction device 14 may have any configuration as long as it can continuously generate a negative pressure in the lumen 16a of the catheter shaft 16. For example, the suction device 14 includes a vacuum generating means and a liquid recovery unit (container). It may be configured. The vacuum generating means may be a vacuum pump or a pressurized air supply source and an ejector.

 液体吸収部18は、カテーテル軸16の先端部に設けられ、柔軟性及び液体吸収性を有する多孔質の部材である。図2は、液体吸収部18及びその周辺部位の縦断面図であり、図3は、図2におけるIII-III線に沿った横断面図である。図2及び図3に示すように、本実施形態における液体吸収部18は、多孔質体からなり径方向に積層した複数の層により構成され、内側の層ほど気孔径(気孔サイズ)が小さい。具体的には、液体吸収部18は、円筒状の多孔質体からなる外層20と内層22から構成され、内層22の気孔径(気孔22aの孔径)は、外層20の気孔径(気孔20aの孔径)よりも小さい。内層22の内側には液体透過部24が配置されている。 The liquid absorbing portion 18 is a porous member that is provided at the distal end portion of the catheter shaft 16 and has flexibility and liquid absorbability. FIG. 2 is a longitudinal sectional view of the liquid absorbing portion 18 and its peripheral portion, and FIG. 3 is a transverse sectional view taken along line III-III in FIG. As shown in FIGS. 2 and 3, the liquid absorbing portion 18 in the present embodiment is composed of a plurality of layers made of a porous material and stacked in the radial direction, and the inner layer has a smaller pore diameter (pore size). Specifically, the liquid absorbing portion 18 includes an outer layer 20 and an inner layer 22 made of a cylindrical porous body, and the pore diameter of the inner layer 22 (pore diameter of the pores 22a) is equal to the pore diameter of the outer layer 20 (of the pores 20a). Smaller than the pore diameter). A liquid permeable portion 24 is disposed inside the inner layer 22.

 このように、液体吸収部18は、複数の層からなり内側の層ほど気孔径が小さいので、毛細管現象により、外側から内側に向かって液体が移動し易い構造となっている。すなわち、液体吸収部18は、毛細管現象によりカテーテル軸16側への液体の移動力を発生させる構造を有する。 As described above, the liquid absorbing portion 18 is composed of a plurality of layers, and the inner layer has a smaller pore diameter, so that the liquid easily moves from the outside to the inside due to capillary action. In other words, the liquid absorbing portion 18 has a structure that generates a liquid moving force toward the catheter shaft 16 by capillary action.

 なお、液体吸収部18は、2層構造に限らず、単層構造であってもよいし、3層以上の多層構造であってもよいし、単層構造、多層構造に関わらず、内側に向かって傾斜的に気孔径が小さくなる構成でもよい。或いは、液体吸収部18は、径方向に液体を移動可能な構成であればよい。 The liquid absorbing portion 18 is not limited to the two-layer structure, but may be a single-layer structure, a multilayer structure of three or more layers, and the inner side regardless of the single-layer structure or the multilayer structure. A configuration in which the pore diameter gradually decreases toward the surface may be employed. Or the liquid absorption part 18 should just be the structure which can move a liquid to radial direction.

 液体吸収部18の輪郭形状は円形に限らず、その他の形状(例えば、楕円形、四角形、三角形)を採用し得る。 The contour shape of the liquid absorbing portion 18 is not limited to a circle, and other shapes (for example, an ellipse, a quadrangle, and a triangle) can be adopted.

 図4Aは、図3におけるIVA-IVA線に沿った断面図である。図4Aに示すように、カテーテル軸16に沿ってチューブ26が配設されている。チューブ26は、その先端部が液体吸収部18内に埋設され、液体吸収部18から基端側に突出し、カテーテル軸16に沿ってカテーテル軸16の途中位置まで延在している。チューブ26の基端には挿入用開口部27が設けられ、当該挿入用開口部27から操作長尺体28を挿入することが可能となっている。チューブ26の先端は、開口していても閉塞していてもどちらでも構わない。後述する吸引カテーテル10の使用方法において、操作長尺体28の先端部が液体吸収部18内に来る位置まで、操作長尺体28をチューブ26のルーメン26aに挿入し、手元側で操作長尺体28を操作することによって、吸引カテーテル10の先端部を任意の位置に調整することができる。また、チューブ26は硬質体でもよく、その場合操作長尺体28を用いずに吸引カテーテル10の先端部を任意の位置に調整することができる。 FIG. 4A is a cross-sectional view taken along the line IVA-IVA in FIG. As shown in FIG. 4A, a tube 26 is disposed along the catheter shaft 16. The distal end portion of the tube 26 is embedded in the liquid absorbing portion 18, protrudes from the liquid absorbing portion 18 to the proximal end side, and extends to the middle position of the catheter shaft 16 along the catheter shaft 16. An insertion opening 27 is provided at the proximal end of the tube 26, and an operation elongated body 28 can be inserted from the insertion opening 27. The tip of the tube 26 may be open or closed. In the method of using the suction catheter 10 described later, the operation elongate body 28 is inserted into the lumen 26a of the tube 26 until the distal end of the operation elongate body 28 comes into the liquid absorbing portion 18, and the operation elongate is performed on the hand side. By operating the body 28, the distal end portion of the suction catheter 10 can be adjusted to an arbitrary position. Further, the tube 26 may be a hard body, and in this case, the distal end portion of the suction catheter 10 can be adjusted to an arbitrary position without using the operation long body 28.

 なお、チューブ26は必須ではなく、無くてもよい。チューブ26を省略する場合、図4Bに示す第1変形例に係る吸引カテーテル10aのように、カテーテル軸16の基端から操作長尺体28を挿入することにより吸引カテーテル10aを操作することができる。すなわち、操作長尺体28の先端部が液体吸収部18内に来る位置まで、カテーテル軸16の内腔16aに操作長尺体28を挿入し、手元側で操作長尺体28を操作することによって、吸引カテーテル10aの先端部を任意の位置に調整することができる。 The tube 26 is not essential and may be omitted. When the tube 26 is omitted, the suction catheter 10a can be operated by inserting the operation elongated body 28 from the proximal end of the catheter shaft 16 like the suction catheter 10a according to the first modification shown in FIG. 4B. . That is, the operation elongate body 28 is inserted into the lumen 16a of the catheter shaft 16 until the distal end of the operation elongate body 28 comes into the liquid absorbing portion 18, and the operation elongate body 28 is operated on the hand side. Thus, the distal end portion of the suction catheter 10a can be adjusted to an arbitrary position.

 図2に示すように、カテーテル軸16の先端部には、液体吸収部18に接触し、液体吸収部18の気孔径よりも孔径が小さい多数の気孔24aを有する液体透過部24が設けられている。本実施形態において、液体透過部24は、カテーテル軸16の内腔16aに連通する内腔24bを有し、先端部が閉じた有底の中空筒状をなし、その外周部が液体吸収部18の内周部(内層22の内周部)に接触している。すなわち、液体透過部24は、液体吸収部18の内側に配置されている。図5A~図5Dに示す構成の液体吸収部18は、先端部が液体吸収部18の先端から露出しているが、先端部が液体吸収部18で覆われていてもよい。 As shown in FIG. 2, the distal end portion of the catheter shaft 16 is provided with a liquid permeable portion 24 that is in contact with the liquid absorbing portion 18 and has a large number of pores 24 a that are smaller than the pore diameter of the liquid absorbing portion 18. Yes. In the present embodiment, the liquid permeable portion 24 has a lumen 24b that communicates with the lumen 16a of the catheter shaft 16, has a bottomed hollow cylindrical shape with the distal end closed, and the outer peripheral portion thereof is the liquid absorbing portion 18. Is in contact with the inner peripheral portion (the inner peripheral portion of the inner layer 22). That is, the liquid permeable part 24 is disposed inside the liquid absorbing part 18. 5A to 5D, the liquid absorption part 18 having the configuration shown in FIGS. 5A to 5D is exposed from the front end of the liquid absorption part 18, but the front end part may be covered with the liquid absorption part 18.

 吸引装置14により、カテーテル軸16の内腔16a、及び当該内腔16aに連通する液体透過部24の内腔24bを陰圧にすると、液体吸収部18に吸収された液体は、液体透過部24の気孔24aを通して内腔24b内に浸出させられる。従って、液体吸収部18に吸収された液体を効率的にカテーテル軸16側に移動させることができる。 When the suction device 14 applies negative pressure to the lumen 16a of the catheter shaft 16 and the lumen 24b of the liquid permeable portion 24 communicating with the lumen 16a, the liquid absorbed by the liquid absorbing portion 18 is liquid permeable portion 24. Is leached into the lumen 24b through the pores 24a. Therefore, the liquid absorbed by the liquid absorption part 18 can be efficiently moved to the catheter shaft 16 side.

 続いて、本実施形態に係る吸引カテーテル10の各部の材質について説明する。カテーテル軸16は、適度の剛性と可撓性を有するのが好ましく、その構成材料としては、例えば、ポリエチレン、ポリプロピレン、ポリ塩化ビニル、ポリブタジエン、フッ素系樹脂、ポリウレタン、ポリエステル、ポリアミド、ポリウレタンエラストマー、スチレン-エチレン-ブチレン-スチレン共重合体(SEBS)、スチレン-エチレン-プロピレン-スチレン共重合体(SEPS)などの熱可塑性エラストマー、ナイロン、PET、ゴム、シリコーンエラストマー等の各種材料が挙げられる。カテーテル軸16の先端部に設けられた、液体吸収部18の内周部と接する液体透過部24の構成材料としては、例えば、PVDF、ポリエーテルスルホン、ポリスルホン、PTFE、ポリエチレン、フッ素樹脂、酢酸セルロース、トリアセテート、ポリプロピレン、ポリアクリロニトリル、ナイロン等の硬質材料が挙げられる。 Subsequently, the material of each part of the suction catheter 10 according to this embodiment will be described. The catheter shaft 16 preferably has moderate rigidity and flexibility, and examples of the constituent material thereof include polyethylene, polypropylene, polyvinyl chloride, polybutadiene, fluorine resin, polyurethane, polyester, polyamide, polyurethane elastomer, and styrene. -Various materials such as thermoplastic elastomers such as ethylene-butylene-styrene copolymer (SEBS) and styrene-ethylene-propylene-styrene copolymer (SEPS), nylon, PET, rubber and silicone elastomer. For example, PVDF, polyethersulfone, polysulfone, PTFE, polyethylene, fluororesin, cellulose acetate may be used as the constituent material of the liquid permeable portion 24 provided at the distal end of the catheter shaft 16 and in contact with the inner peripheral portion of the liquid absorbing portion 18. , Hard materials such as triacetate, polypropylene, polyacrylonitrile, and nylon.

 チューブ26の構成材料としては、例えば、カテーテル軸16の構成材料として上記に例示したものから選択することができる。カテーテル軸16とチューブ26とは、構成材料が同じでも異なっていてもよい。 The constituent material of the tube 26 can be selected from those exemplified above as the constituent material of the catheter shaft 16, for example. The catheter shaft 16 and the tube 26 may be made of the same material or different materials.

 液体吸収部18の構成材料は、柔軟性及び液体吸収性を有するものであれば特に限定されないが、例えば、綿、コットン、ガーゼ、レーヨン等の天然素材、もしくは、ポリエステル、ポリアミド、PVDF、PVA、ウレタン、ポリエーテルスルホン、ポリスルホン等の合成素材が挙げられる。 The constituent material of the liquid absorbent portion 18 is not particularly limited as long as it has flexibility and liquid absorbency. For example, natural materials such as cotton, cotton, gauze, rayon, or polyester, polyamide, PVDF, PVA, Synthetic materials such as urethane, polyethersulfone, and polysulfone are listed.

 操作長尺体28の構成材料は、吸引カテーテル10に操作長尺体28を挿入することによって吸引カテーテル10の特に先端部を操作することが可能であるように適度の剛性を有することが好ましく、例えば、ステンレス鋼、鉄又は鉄合金、アルミニウム又はアルミニウム合金、チタン又はニッケルチタン合金のような金属材料、又はポリエチレン、ポリプロピレン、エチレン-酢酸ビニル共重合体等のポリオレフィン、ポリ塩化ビニル、ポリメチルメタクリレート、ポリカーボネート、ポリブタジエン、ポリアミド、ポリエステル等の各種ポリマーが挙げられる。 The constituent material of the operation elongate body 28 preferably has an appropriate rigidity so that the distal end portion of the suction catheter 10 can be operated by inserting the operation elongate body 28 into the suction catheter 10. For example, stainless steel, iron or iron alloy, aluminum or aluminum alloy, metal material such as titanium or nickel titanium alloy, or polyolefin such as polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polyvinyl chloride, polymethyl methacrylate, Examples include various polymers such as polycarbonate, polybutadiene, polyamide, and polyester.

 続いて、本実施形態に係る吸引カテーテル10の寸法について説明する。吸引カテーテル10の寸法は、それが使用される生体内の部位に応じて適宜選択されるが、特に、後述するような膝関節での関節鏡視下手術に使用される場合には、カテーテル軸16の全長が5~1000cmとされ、外径が1~30mmとされることが好ましい。 Subsequently, the dimensions of the suction catheter 10 according to this embodiment will be described. The size of the suction catheter 10 is appropriately selected according to the site in the living body in which it is used. In particular, when used for arthroscopic surgery at the knee joint as described later, the catheter shaft Preferably, the total length of 16 is 5 to 1000 cm and the outer diameter is 1 to 30 mm.

 液体吸収部18の寸法は、カテーテル軸16の寸法に応じて決定されるが、全長が0.1~10cm、外径が1~5cmとされることが好ましい。液体吸収部18の気孔径は、20~2000μm、気孔率は25~98%とされることが好ましい。液体吸収部18を構成する筒状壁部の径方向の厚さ(外周径と内周径との差)は、1~100mmとされることが好ましい。本実施形態のように液体吸収部18が外層20と内層22からなる場合、外層20の気孔径は、700~2000μmとされることが好ましく、外層20を構成する壁部の径方向の厚さは、1~99mmとされることが好ましく、内層22の気孔径は、50~700μmとされることが好ましく、内層22を構成する壁部の径方向の厚さは、1~99mmとされることが好ましい。 The dimensions of the liquid absorbing portion 18 are determined according to the dimensions of the catheter shaft 16, but are preferably 0.1 to 10 cm in total length and 1 to 5 cm in outer diameter. The liquid absorbing portion 18 preferably has a pore diameter of 20 to 2000 μm and a porosity of 25 to 98%. The thickness in the radial direction of the cylindrical wall portion constituting the liquid absorbing portion 18 (difference between the outer peripheral diameter and the inner peripheral diameter) is preferably 1 to 100 mm. When the liquid absorbing portion 18 is composed of the outer layer 20 and the inner layer 22 as in the present embodiment, the pore diameter of the outer layer 20 is preferably 700 to 2000 μm, and the radial thickness of the wall portion constituting the outer layer 20 Is preferably 1 to 99 mm, the pore diameter of the inner layer 22 is preferably 50 to 700 μm, and the thickness of the wall portion constituting the inner layer 22 in the radial direction is 1 to 99 mm. It is preferable.

 カテーテル軸16の先端部に設けられた液体透過部24の寸法は、カテーテル軸16及び液体吸収部18の寸法に応じて決定されるが、全長が0.1~10cm、外径が1~20mm、壁厚が30~200μm、気孔径が0.1~20μmとされることが好ましい。 The dimensions of the liquid permeable portion 24 provided at the distal end portion of the catheter shaft 16 are determined according to the dimensions of the catheter shaft 16 and the liquid absorbing portion 18, but the overall length is 0.1 to 10 cm and the outer diameter is 1 to 20 mm. The wall thickness is preferably 30 to 200 μm and the pore diameter is preferably 0.1 to 20 μm.

 操作長尺体28の寸法は、カテーテル軸16の寸法に応じて決定されるが、全長が5~35cm、外径が1~20mmとされることが好ましい。チューブ26の寸法は、吸引カテーテル10が使用される生体内の部位、カテーテル軸16の寸法、操作長尺体28の寸法等に応じて決定されるが、例えば、全長が1~34cm程度とされることが好ましく、外径が2~22mmとされることが好ましい。 The dimensions of the operation elongated body 28 are determined according to the dimensions of the catheter shaft 16, but it is preferable that the total length is 5 to 35 cm and the outer diameter is 1 to 20 mm. The dimensions of the tube 26 are determined in accordance with the part of the living body where the suction catheter 10 is used, the dimension of the catheter shaft 16, the dimension of the operation elongated body 28, and the like. For example, the total length is about 1 to 34 cm. The outer diameter is preferably 2 to 22 mm.

 本実施形態に係る吸引カテーテル10は、基本的には以上のように構成されるものであり、以下、その作用及び効果について説明する。以下では、吸引カテーテル10の代表的な用途である関節鏡視下手術での膝関節軟骨損傷部への培養細胞移植を例に挙げて説明する。本例による吸引カテーテル10の使用方法は、以下の工程(a)~(d)からなる。 The suction catheter 10 according to the present embodiment is basically configured as described above, and the operation and effect thereof will be described below. Hereinafter, a cultured cell transplantation to a knee joint cartilage damaged part in arthroscopic surgery, which is a typical use of the suction catheter 10, will be described as an example. The method of using the suction catheter 10 according to this example includes the following steps (a) to (d).

 (a) 処置対象部位である軟骨損傷部位30が存在する膝関節内に生理食塩水等の液体を注入して作業空間を確保し、膝関節の一方側から郭清器34を挿入し、膝関節の他方側から関節鏡36を挿入する(図5A参照)。そして、生理食塩水等を洗浄液として用い、関節鏡視下で、膝関節内を洗浄しながら、郭清器34により軟骨損傷部位30を郭清(シェービング)する。なお、図5A~図5Dにおいて、参照符号38は、処置対象の軟骨である。以下、郭清された軟骨損傷部位30を「細胞移植部位32」と呼ぶ。その後、膝関節内の液体(洗浄液等)を関節鏡視下手術用の吸引器やシリンジと注射針を用いてある程度除去する。 (A) A working space is secured by injecting a liquid such as physiological saline into the knee joint where the cartilage damage site 30 as the treatment target site is present, and the dissection device 34 is inserted from one side of the knee joint. The arthroscope 36 is inserted from the other side (see FIG. 5A). Then, the cartilage damage site 30 is dissected (shaved) by the dissecting device 34 while the inside of the knee joint is cleaned under the arthroscopy using physiological saline or the like as a cleaning solution. In FIG. 5A to FIG. 5D, reference numeral 38 is a cartilage to be treated. Hereinafter, the dissected cartilage damage site 30 is referred to as a “cell transplant site 32”. Thereafter, the liquid in the knee joint (cleaning liquid or the like) is removed to some extent by using an aspirator or a syringe and an injection needle for arthroscopic surgery.

 (b) 注射針を膝関節から抜去し、注射針を挿入していた孔(切開部)を通してシース40又はポートを関節内に挿入する。なお、注射針の内腔がシース40又はポートの外径よりも大きい場合には、シリンジを注射針から外し、当該注射針の内腔を通して、シース40又はポートを関節内に挿入した後、注射針を抜去してもよい。シース40又はポートを関節内に挿入したら、前記シース40又はポートの内腔から、操作長尺体28を接続した吸引カテーテル10を、その先端部(液体吸収部18)が軟骨38近傍、好ましくは細胞移植部位32の近傍位置に来るまで挿入する(図5B参照)。カテーテル軸16の基端部を吸引装置14(図1参照)に接続し、吸引を開始する。また、郭清器34を抜去した後、郭清器34の挿入に用いたポートを用いて吸引カテーテル10を挿入してもよい。 (B) The needle is removed from the knee joint, and the sheath 40 or port is inserted into the joint through the hole (incision) where the needle has been inserted. When the lumen of the injection needle is larger than the outer diameter of the sheath 40 or the port, the syringe is removed from the injection needle, the sheath 40 or the port is inserted into the joint through the lumen of the injection needle, and then the injection is performed. The needle may be removed. When the sheath 40 or the port is inserted into the joint, the suction catheter 10 to which the operation elongate body 28 is connected from the lumen of the sheath 40 or the port, the distal end portion (the liquid absorbing portion 18) thereof is near the cartilage 38, preferably Insert until the cell transplantation site 32 is located (see FIG. 5B). The proximal end portion of the catheter shaft 16 is connected to the suction device 14 (see FIG. 1), and suction is started. Further, after removing the dissection device 34, the suction catheter 10 may be inserted using the port used for the insertion of the dissection device 34.

 (c) 吸引カテーテル10に接続した操作長尺体28を操作し、膝関節内と細胞移植部位32周辺の洗浄液等の液体42を吸引する(図5C参照)。この場合、操作長尺体28を操作することにより、液体吸収部18を所望の位置に容易且つ迅速に到達させることができ、操作性に優れ、細胞移植部位32に残った液体42を効率的に除去することができる。また、液体吸収部18が柔軟性を有するため、軟骨や周辺組織を傷付けることがない。 (C) The operation elongate body 28 connected to the suction catheter 10 is operated to suck a liquid 42 such as a washing solution in the knee joint and around the cell transplant site 32 (see FIG. 5C). In this case, by operating the operation elongate body 28, the liquid absorbing portion 18 can be easily and quickly reached the desired position, and the liquid 42 remaining at the cell transplant site 32 is efficiently obtained with excellent operability. Can be removed. Moreover, since the liquid absorption part 18 has a softness | flexibility, a cartilage and a surrounding tissue are not damaged.

 液体42の吸引において、吸引カテーテル10は具体的には以下のように作用する。液体吸収部18を膝関節内の液体42(図5B参照)に接触させると、液体吸収部18の液体吸収性によって液体42が液体吸収部18に吸収される。本実施形態の場合、液体吸収部18は、内側の層ほど気孔径が小さいので、吸収された液体は毛細管現象により液体吸収部18の径方向内側に向かって移動する。また、液体透過部24は微細な気孔24aを有しており、吸引装置14の作用下にカテーテル軸16の内腔16aが陰圧となることで、液体吸収部18の内周部にある液体は、液体透過部24を介してカテーテル軸16の内腔16aへと移動し、カテーテル軸16の内腔16aを通って吸引装置14に回収される。これにより、液体吸収部18は常に液体を吸水することが可能となっている。 In the suction of the liquid 42, the suction catheter 10 specifically operates as follows. When the liquid absorber 18 is brought into contact with the liquid 42 in the knee joint (see FIG. 5B), the liquid 42 is absorbed by the liquid absorber 18 due to the liquid absorbability of the liquid absorber 18. In the case of the present embodiment, since the pore diameter of the liquid absorbing portion 18 is smaller toward the inner layer, the absorbed liquid moves toward the radially inner side of the liquid absorbing portion 18 by capillary action. Further, the liquid permeable portion 24 has fine pores 24 a, and the liquid in the inner peripheral portion of the liquid absorbing portion 18 is formed by the negative pressure in the lumen 16 a of the catheter shaft 16 under the action of the suction device 14. Moves to the lumen 16a of the catheter shaft 16 via the liquid permeable portion 24, and is collected by the suction device 14 through the lumen 16a of the catheter shaft 16. Thereby, the liquid absorption part 18 can always absorb a liquid.

 (d) 吸引カテーテル10による吸引により細胞移植部位32の液体を完全に除去できたら、液体吸収部18を細胞移植部位32側の長骨、すなわち大腿骨又は脛骨と、周辺滑膜又は筋肉組織との間に挟むことにより固定(留置)する。液体吸収部18を固定できたら、吸引カテーテル10から操作長尺体28を抜去する。吸引装置14は、細胞移植が終了するまで稼動を続ける。操作長尺体28を抜去したら、関節鏡視下で、シース40又はポートの内腔を通して注入用チューブ44を挿入し、当該注入用チューブ44の先端に設けられた開口部を細胞移植部位32の近傍(細胞移植部位32の上方)に配置する。この注入用チューブ44の基端部には、培養細胞(細胞懸濁液)が充填された注入具(例えば、シリンジ)が接続されている。注入用チューブ44の開口部を上述した位置に配置したら、前記注入具を操作することにより注入用チューブ44の開口部から培養細胞を流出させ、細胞移植部位32に注入する(図5D参照)。細胞移植部位32への培養細胞46の注入後、所定時間(例えば、10分間)静置する。当該所定時間が経過したら、吸引装置14を止め、吸引カテーテル10、シース40及び関節鏡36を膝関節から抜去する。 (D) When the liquid in the cell transplant site 32 can be completely removed by suction with the suction catheter 10, the liquid absorbing portion 18 is moved to the long bone on the cell transplant site 32 side, that is, the femur or tibia, and the peripheral synovial membrane or muscle tissue. It is fixed (detained) by sandwiching between the two. When the liquid absorbing portion 18 can be fixed, the operation elongated body 28 is removed from the suction catheter 10. The suction device 14 continues to operate until the cell transplant is completed. After the operation elongate body 28 is removed, the injection tube 44 is inserted through the lumen of the sheath 40 or the port under arthroscopy, and the opening provided at the distal end of the injection tube 44 is inserted into the cell transplant site 32. It arrange | positions in the vicinity (above the cell transplant site | part 32). An injection tool (for example, a syringe) filled with cultured cells (cell suspension) is connected to the proximal end portion of the injection tube 44. When the opening of the injection tube 44 is disposed at the above-described position, the cultured cells are caused to flow out of the opening of the injection tube 44 by operating the injection tool and injected into the cell transplantation site 32 (see FIG. 5D). After the cultured cells 46 are injected into the cell transplant site 32, the cells are allowed to stand for a predetermined time (for example, 10 minutes). When the predetermined time has elapsed, the suction device 14 is stopped, and the suction catheter 10, the sheath 40, and the arthroscope 36 are removed from the knee joint.

 以上の工程(a)~(d)により、培養細胞の細胞移植部位32への移植が完了する。 Through the above steps (a) to (d), the transplantation of the cultured cells to the cell transplantation site 32 is completed.

 なお、図4Bに示した第1変形例に係る吸引カテーテル10aを用いる場合、上記工程(b)~(d)に代えて、下記工程(e)~(g)を実施する。 When the suction catheter 10a according to the first modification shown in FIG. 4B is used, the following steps (e) to (g) are performed instead of the steps (b) to (d).

 (e) 上記(b)で述べたのと同様の方法でシース40又はポートを膝関節内に挿入する。シース40又はポートを膝関節内に挿入したら、カテーテル軸16を吸引装置14から外した状態で、カテーテル軸16の内腔16aに操作長尺体28を挿入し、手元側で操作長尺体28を操作することにより液体吸収部18を細胞移植部位32に配置する。次に、操作長尺体28を吸引カテーテル10aから抜去した後に、カテーテル軸16の基端部を吸引装置14に接続し、吸引を開始する。 (E) The sheath 40 or port is inserted into the knee joint in the same manner as described in (b) above. When the sheath 40 or the port is inserted into the knee joint, the operation elongated body 28 is inserted into the lumen 16a of the catheter shaft 16 with the catheter shaft 16 removed from the suction device 14, and the operation elongated body 28 is inserted on the proximal side. Is disposed at the cell transplantation site 32. Next, after the operation elongated body 28 is removed from the suction catheter 10a, the proximal end portion of the catheter shaft 16 is connected to the suction device 14, and suction is started.

 (f) 吸引カテーテル10aによる吸引により細胞移植部位32の液体を完全に除去できたら、吸引装置14を停止させ、カテーテル軸16の基端部と吸引装置14との接続を解除した後に、カテーテル軸16の内腔16aに操作長尺体28を再び挿入して操作長尺体28を操作することにより、液体吸収部18を細胞移植部位32側の長骨、すなわち大腿骨又は脛骨と、周辺滑膜又は筋肉組織との間に挟むことにより固定(留置)する。液体吸収部18を固定できたら、吸引カテーテル10aから操作長尺体28を抜去し、カテーテル軸16の基端部を再び吸引装置14に接続する。吸引装置14は、細胞移植が終了するまで稼動を続ける。 (F) When the liquid in the cell transplant site 32 can be completely removed by aspiration with the aspiration catheter 10a, the aspiration device 14 is stopped, the connection between the proximal end portion of the catheter shaft 16 and the aspiration device 14 is released, and then the catheter shaft By operating the operation elongate body 28 again by inserting the operation elongate body 28 into the 16 lumens 16a, the liquid absorbing portion 18 is moved to the long bone on the cell transplant site 32 side, that is, the femur or tibia, and the peripheral slide. Fix (dwell) by sandwiching between membrane or muscle tissue. When the liquid absorbing portion 18 can be fixed, the operation elongated body 28 is removed from the suction catheter 10a, and the proximal end portion of the catheter shaft 16 is connected to the suction device 14 again. The suction device 14 continues to operate until the cell transplant is completed.

 (g) その後、上記(d)で述べたのと同様の方法により、関節鏡視下で、注入用チューブ44を関節内に挿入し、注入用チューブ44の基端部に接続された注入具を操作して細胞移植部位32に培養細胞46を注入し、所定時間経過後、吸引装置14を止め、吸引カテーテル10a、シース40及び関節鏡36を膝関節から抜去する。 (G) After that, by the same method as described in (d) above, the injection tube 44 is inserted into the joint under arthroscopy and connected to the proximal end of the injection tube 44 Is operated to inject cultured cells 46 into the cell transplant site 32. After a predetermined time has elapsed, the suction device 14 is stopped, and the suction catheter 10a, the sheath 40, and the arthroscope 36 are removed from the knee joint.

 以上の説明から了解されるように、本発明に係る吸引カテーテル10又は吸引カテーテル10aを用いれば、次のような液体吸引方法を実施することができる。すなわち、当該液体吸引方法は、中空状のカテーテル軸16の先端部に、柔軟性及び液体吸収性を有する多孔質体からなる液体吸収部18が設けられた吸引カテーテル10又は吸引カテーテル10aを用意する工程と、前記カテーテル軸16の内腔16aを陰圧にした状態で、前記液体吸収部18を液体に接触させることにより液体を吸引する工程とを含むことを特徴とする。 As will be understood from the above description, the following liquid suction method can be implemented by using the suction catheter 10 or the suction catheter 10a according to the present invention. That is, in the liquid suction method, the suction catheter 10 or the suction catheter 10a in which the liquid absorbing portion 18 made of a porous body having flexibility and liquid absorbability is provided at the distal end portion of the hollow catheter shaft 16 is prepared. And a step of sucking the liquid by bringing the liquid absorbing portion 18 into contact with the liquid in a state where the lumen 16a of the catheter shaft 16 is set to a negative pressure.

 以上説明したように、本実施形態に係る吸引カテーテル10又は吸引カテーテル10aによれば、以下の作用効果が得られる。 As described above, according to the suction catheter 10 or the suction catheter 10a according to the present embodiment, the following operational effects can be obtained.

 (1) 内視鏡視下手術に際し、液体吸収部18が柔軟性を有するため組織を傷付けることがないとともに、液体吸収部18で吸収した液体をカテーテル軸16の内腔16aに移動させることにより液体の持続的な吸引が可能である。また、特に、本発明の吸引カテーテル10又は吸引カテーテル10aを関節鏡視下細胞移植手術に用いた場合、液体吸収部18が多孔質であるため、移植した細胞を吸引することがない。 (1) During endoscopic surgery, the liquid absorbing portion 18 has flexibility, so that the tissue is not damaged, and the liquid absorbed by the liquid absorbing portion 18 is moved to the lumen 16a of the catheter shaft 16 A continuous suction of liquid is possible. In particular, when the suction catheter 10 or the suction catheter 10a of the present invention is used for cell transplant surgery under arthroscopy, the liquid absorbing portion 18 is porous, so that the transplanted cells are not sucked.

 (2) 本実施形態の場合、液体吸収部18は、毛細管現象により前記カテーテル軸16側への液体の移動力を発生させる構造を有することから、液体吸収部18内を液体がカテーテル軸16に向かって移動し易いので、液体の持続的な吸引を確実に行うことができる。特に、本実施形態の場合、液体吸収部18は、複数の層(外層20及び内層22)からなり、複数の層は、前記カテーテル軸16に近い層ほどその気孔径が小さいので、カテーテル軸16側に液体の移動力を容易且つ確実に発生させることができる。 (2) In the case of this embodiment, since the liquid absorption part 18 has the structure which generates the moving force of the liquid to the said catheter shaft 16 side by a capillary phenomenon, a liquid becomes the catheter shaft 16 in the liquid absorption part 18 inside. Since it is easy to move toward the surface, the liquid can be sucked continuously. In particular, in the case of the present embodiment, the liquid absorbing portion 18 is composed of a plurality of layers (the outer layer 20 and the inner layer 22), and the plurality of layers are closer to the catheter shaft 16 and have a smaller pore diameter. The liquid moving force can be easily and reliably generated on the side.

 (3) また、本実施形態の場合、カテーテル軸16の先端部には、液体吸収部18に接触し、液体吸収部18の気孔径よりも小さい気孔24aを有する液体透過部24が設けられることから、液体吸収部18に吸収された液体を、液体透過部24を介してカテーテル軸16の内腔16aに確実に浸出させることができるため、液体の持続的な吸引を一層効果的に行うことができる。 (3) In the case of the present embodiment, the distal end portion of the catheter shaft 16 is provided with a liquid permeable portion 24 that contacts the liquid absorbing portion 18 and has pores 24 a smaller than the pore diameter of the liquid absorbing portion 18. Therefore, the liquid absorbed in the liquid absorption part 18 can be surely leached into the lumen 16a of the catheter shaft 16 through the liquid transmission part 24, so that the continuous suction of the liquid can be performed more effectively. Can do.

 (4) 吸引カテーテル10の場合、カテーテル軸16に沿って設けられたチューブ26のルーメン26aに操作長尺体28を挿入することにより、吸引カテーテル10の先端部を操作することができるようになっているので、操作性に優れ、液体吸収部18を所望の位置に容易且つ迅速に到達させることができる。第1変形例に係る吸引カテーテル10aの場合、カテーテル軸16の内腔16aに操作長尺体28を挿入することにより、吸引カテーテル10aの先端部を操作することができるようになっているので、操作性に優れ、液体吸収部18を所望の位置に容易且つ迅速に到達させることができる。 (4) In the case of the suction catheter 10, the distal end portion of the suction catheter 10 can be operated by inserting the operation elongated body 28 into the lumen 26 a of the tube 26 provided along the catheter shaft 16. Therefore, the operability is excellent, and the liquid absorbing portion 18 can be easily and quickly reached the desired position. In the case of the suction catheter 10a according to the first modification, the distal end portion of the suction catheter 10a can be operated by inserting the operation elongated body 28 into the lumen 16a of the catheter shaft 16. The operability is excellent, and the liquid absorbing portion 18 can be easily and quickly reached the desired position.

 図6A及び図6Bは、第2変形例に係る吸引カテーテル10bの液体吸収部50の横断面図である。なお、吸引カテーテル10bにおいて、上述した吸引カテーテル10と同様の構成部分には同一符号を付している。この液体吸収部50は、折り畳み可能に構成されている。具体的には、液体吸収部50の外層52は、内層22の外周部に放射状に設けられ、周方向に並べられた複数の突起部56を備える。各突起部56は、径方向外側に向かって先細る形状を有し、周方向に弾性変形して折れ曲がり可能に構成されている。従って、液体吸収部50は、液体を吸収する前は図6Aに示すように折り畳むことにより収縮して外径を小さくすることができ、液体を吸収すると、図6Bに示すように膨張するように構成されている。なお、液体吸収部50が単層構造である場合にも、液体吸収部50の外周部を上記の突起部56と同様の形状に形成することにより、上記のような折り畳み可能な構造とすることができる。液体吸収部50が3層以上の多層構造で構成される場合は、最も外側の層を上記の突起部56と同様の形状に形成すればよい。 6A and 6B are cross-sectional views of the liquid absorbing portion 50 of the suction catheter 10b according to the second modification. In addition, in the suction catheter 10b, the same code | symbol is attached | subjected to the component similar to the suction catheter 10 mentioned above. This liquid absorption part 50 is comprised so that folding is possible. Specifically, the outer layer 52 of the liquid absorber 50 includes a plurality of protrusions 56 that are provided radially on the outer periphery of the inner layer 22 and are arranged in the circumferential direction. Each protrusion 56 has a shape that tapers outward in the radial direction, and is configured to be elastically deformable and bendable in the circumferential direction. Therefore, before absorbing the liquid, the liquid absorbing portion 50 can be contracted by folding as shown in FIG. 6A to reduce the outer diameter, and when absorbing the liquid, the liquid absorbing portion 50 expands as shown in FIG. 6B. It is configured. Even when the liquid absorbing portion 50 has a single-layer structure, the outer peripheral portion of the liquid absorbing portion 50 is formed in the same shape as the protrusion 56 described above, so that the structure can be folded as described above. Can do. In the case where the liquid absorbing portion 50 is configured with a multilayer structure of three or more layers, the outermost layer may be formed in the same shape as the above-described protruding portion 56.

 上記のように構成された吸引カテーテル10bによれば、処置対象部位が存在する空間(上記の例で、膝関節内)に向けて吸引カテーテル10bを挿入する際に、液体吸収部50を折り畳むことにより収縮させることができるため、より細い径での挿入が可能となる。すなわち、吸引カテーテル10bを挿通させるシース40(図5B等参照)を細径化することができることから、患者に対する侵襲度を有効に低減することができる。また、液体吸収部50は放射状に並んだ複数の突起部56を有するので、吸引カテーテル10bの先端部を膝関節内の隙間に挟んだ際にずれにくく、所望の場所に安定的に留置することができる。 According to the suction catheter 10b configured as described above, when the suction catheter 10b is inserted toward the space where the treatment target site exists (in the above example, in the knee joint), the liquid absorbing portion 50 is folded. Therefore, insertion with a smaller diameter becomes possible. That is, since the diameter of the sheath 40 (see FIG. 5B and the like) through which the suction catheter 10b is inserted can be reduced, the degree of invasiveness to the patient can be effectively reduced. Moreover, since the liquid absorption part 50 has the some protrusion part 56 located in a line, it is hard to slip | deviate when the front-end | tip part of the suction catheter 10b is pinched | interposed into the clearance gap in a knee joint, and it can be stably placed in a desired place. Can do.

 図7は、第3変形例に係る吸引カテーテル10cの先端部及びその周囲の縦断面である。なお、図7において、図1等に示した吸引カテーテル10と同様の構成部分には同一の符号を付している。図7に示すように、カテーテル軸16の先端には、液体吸収部18により吸収された液体をカテーテル軸16へと移動させる流路を形成する液体透過部60が設けられている。この液体透過部60は、カテーテル軸16の先端に結合され、多数の側孔61を有する管状部62と、この管状部62内に配置された中空糸64とを備える。 FIG. 7 is a longitudinal sectional view of the distal end portion of the suction catheter 10c according to the third modification and the periphery thereof. In FIG. 7, the same components as those of the suction catheter 10 shown in FIG. As shown in FIG. 7, the distal end of the catheter shaft 16 is provided with a liquid permeable portion 60 that forms a flow path for moving the liquid absorbed by the liquid absorbing portion 18 to the catheter shaft 16. The liquid permeable portion 60 includes a tubular portion 62 coupled to the distal end of the catheter shaft 16 and having a large number of side holes 61, and a hollow fiber 64 disposed in the tubular portion 62.

 管状部62の先端は閉じており、管状部62に設けられた側孔61は、管状部62の内外を貫通する細孔であり、管状部62の側壁において軸線方向及び周方向に間隔をおいて多数設けられている。側孔61の孔径は、液体吸収部18の気孔(具体的には、内層22の気孔22a)の孔径よりも小さい。中空糸64を構成する管壁は、多数の微細な気孔を有し、多数本の中空糸64が管状部62内で束になって管状部62の軸線に沿って配置されている。中空糸64における微細な気孔の孔径は、管状部62の側孔61の孔径よりも小さい。 The distal end of the tubular portion 62 is closed, and the side holes 61 provided in the tubular portion 62 are pores that penetrate the inside and outside of the tubular portion 62, and are spaced apart in the axial direction and the circumferential direction on the side wall of the tubular portion 62. Many are provided. The hole diameter of the side hole 61 is smaller than the hole diameter of the pores of the liquid absorbing portion 18 (specifically, the pores 22a of the inner layer 22). The tube wall constituting the hollow fiber 64 has a large number of fine pores, and a large number of hollow fibers 64 are bundled in the tubular portion 62 and arranged along the axis of the tubular portion 62. The hole diameter of the fine pores in the hollow fiber 64 is smaller than the hole diameter of the side hole 61 of the tubular portion 62.

 上記のように構成された吸引カテーテル10cによれば、カテーテル軸16の先端部には、管状部62と中空糸64とを有する液体透過部60が設けられているので、吸引装置14の作用下にカテーテル軸16の内腔16aが陰圧となることで、液体吸収部18の内周部にある液体は、液体透過部60を介してカテーテル軸16の内腔16aへと移動し、カテーテル軸16の内腔16aを通って吸引装置14(図1参照)に回収される。これにより、液体吸収部18は常に液体を吸水することが可能となっている。 According to the suction catheter 10c configured as described above, the liquid permeable portion 60 having the tubular portion 62 and the hollow fiber 64 is provided at the distal end portion of the catheter shaft 16, so that the suction device 14 is operated. Since the inner lumen 16a of the catheter shaft 16 becomes negative pressure, the liquid in the inner peripheral portion of the liquid absorbing portion 18 moves to the inner lumen 16a of the catheter shaft 16 via the liquid permeable portion 60, and the catheter shaft It is collected by the suction device 14 (see FIG. 1) through the 16 lumens 16a. Thereby, the liquid absorption part 18 can always absorb a liquid.

 特に、吸引カテーテル10cの場合、液体吸収部18の内周部に接する管状部62に設けられた側孔61の孔径が内層22の気孔22aの孔径より小さく、管状部62内に配置された中空糸64の気孔径が管状部62の側孔61の孔径よりも小さいので、毛細管現象により、液体吸収部18の内周部にある液体をカテーテル軸16へと容易に移動させることができる。従って、液体吸収部18に吸収された液体を、液体透過部60を介してカテーテル軸16の内腔16aに確実に浸出させることができるため、液体の持続的な吸引を一層効果的に行うことができる。 In particular, in the case of the suction catheter 10 c, the hollow diameter disposed in the tubular portion 62 is smaller in the diameter of the side hole 61 provided in the tubular portion 62 in contact with the inner peripheral portion of the liquid absorbing portion 18 than the pore diameter of the pore 22 a in the inner layer 22. Since the pore diameter of the thread 64 is smaller than the hole diameter of the side hole 61 of the tubular portion 62, the liquid in the inner peripheral portion of the liquid absorbing portion 18 can be easily moved to the catheter shaft 16 by capillary action. Therefore, since the liquid absorbed by the liquid absorption part 18 can be reliably leached into the lumen 16a of the catheter shaft 16 via the liquid permeable part 60, continuous suction of the liquid can be performed more effectively. Can do.

 上記において、本発明について好適な実施形態を挙げて説明したが、本発明は前記実施形態に限定されるものではなく、本発明の要旨を逸脱しない範囲において、種々の改変が可能なことは言うまでもない。例えば、上記実施形態では吸引カテーテル10、10a~10cの用途として膝関節での関節鏡視下細胞移植手術を挙げたが、本発明はこれに限定されるものではない。すなわち、本発明に係る吸引カテーテル10、10a~10cは、液体を排出することを伴う手術方法であればいかなるものにも適用することができる。例えば、本発明に係る吸引カテーテル10、10a~10cは、脳内、腹腔内、手根管、肩関節、肘関節、脊椎などの内視鏡視下手術や胸水、腹水の水抜に使用することができる。 In the above description, the present invention has been described with reference to preferred embodiments. However, the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the scope of the present invention. Yes. For example, in the above-described embodiment, the arthroscopic cell transplantation operation at the knee joint is given as an application of the suction catheter 10, 10a to 10c, but the present invention is not limited to this. In other words, the suction catheters 10, 10a to 10c according to the present invention can be applied to any surgical method that involves discharging a liquid. For example, the suction catheters 10, 10a to 10c according to the present invention are used for endoscopic surgery such as in the brain, intraperitoneal cavity, carpal tunnel, shoulder joint, elbow joint, spine, pleural effusion and ascites drainage. Can do.

Claims (6)

 中空状のカテーテル軸(16)と、
 前記カテーテル軸(16)の先端部に設けられ、柔軟性及び液体吸収性を有する多孔質体からなる液体吸収部(18、50)とを備える、
 ことを特徴とする吸引カテーテル(10、10a、10b、10c)。
A hollow catheter shaft (16);
A liquid absorbing part (18, 50) made of a porous body provided at the distal end of the catheter shaft (16) and having flexibility and liquid absorbability;
A suction catheter (10, 10a, 10b, 10c) characterized in that.
 請求項1記載の吸引カテーテル(10、10a、10b、10c)において、
 前記液体吸収部(18、50)は、毛細管現象により前記カテーテル軸(16)側への液体の移動力を発生させる構造を有する、
 ことを特徴とする吸引カテーテル(10、10a、10b、10c)。
The suction catheter (10, 10a, 10b, 10c) according to claim 1,
The liquid absorbing portion (18, 50) has a structure for generating a liquid moving force toward the catheter shaft (16) by capillary action.
A suction catheter (10, 10a, 10b, 10c) characterized in that.
 請求項2記載の吸引カテーテル(10、10a、10b、10c)において、
 前記液体吸収部(18、50)は、複数の層からなり、
 前記複数の層は、前記カテーテル軸(16)に近い層ほどその気孔径が小さい、
 ことを特徴とする吸引カテーテル(10、10a、10b、10c)。
The suction catheter (10, 10a, 10b, 10c) according to claim 2,
The liquid absorption part (18, 50) is composed of a plurality of layers,
The plurality of layers have smaller pore diameters as the layer is closer to the catheter shaft (16).
A suction catheter (10, 10a, 10b, 10c) characterized in that.
 請求項1~3のいずれか1項に記載の吸引カテーテル(10、10a、10b、10c)において、
 前記カテーテル軸(16)の先端部には、前記液体吸収部(18、50)に接触し、前記液体吸収部(18、50)の気孔径よりも孔径が小さい孔を有する液体透過部(24、60)が設けられる、
 ことを特徴とする吸引カテーテル(10、10a、10b、10c)。
The suction catheter (10, 10a, 10b, 10c) according to any one of claims 1 to 3,
The distal end portion of the catheter shaft (16) is in contact with the liquid absorbing portion (18, 50) and has a liquid permeable portion (24 having a pore diameter smaller than the pore diameter of the liquid absorbing portion (18, 50)). 60) are provided,
A suction catheter (10, 10a, 10b, 10c) characterized in that.
 請求項1~3のいずれか1項に記載の吸引カテーテル(10、10a、10b、10c)において、
 前記カテーテル軸(16)の内腔又は前記カテーテル軸(16)に沿って設けられたルーメンに操作長尺体(28)を挿入することにより、前記吸引カテーテル(10、10a、10b、10c)の先端部を操作することができるようになっている、
 ことを特徴とする吸引カテーテル(10、10a、10b、10c)。
The suction catheter (10, 10a, 10b, 10c) according to any one of claims 1 to 3,
By inserting the operating elongated body (28) into the lumen of the catheter shaft (16) or the lumen provided along the catheter shaft (16), the suction catheter (10, 10a, 10b, 10c) The tip can be operated.
A suction catheter (10, 10a, 10b, 10c) characterized in that.
 請求項1~3のいずれか1項に記載の吸引カテーテル(10b)において、
 前記液体吸収部(50)は、少なくとも液体を吸収する前の状態で折り畳み可能に構成されている、
 ことを特徴とする吸引カテーテル(10b)。
The suction catheter (10b) according to any one of claims 1 to 3,
The liquid absorption part (50) is configured to be foldable at least before absorbing liquid.
A suction catheter (10b) characterized in that.
PCT/JP2012/081516 2011-12-07 2012-12-05 Suction catheter Ceased WO2013084945A1 (en)

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WO2015032866A1 (en) * 2013-09-06 2015-03-12 Medaxis Ag Handpiece for cleaning wounds
JP2015211828A (en) * 2014-04-14 2015-11-26 国立大学法人 岡山大学 Apparatus, system, and method for controlling local penetration and diffusion of solutes and / or solvents
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GB2603124B (en) * 2021-01-22 2024-08-14 Cambridge Univ Hospitals Nhs Foundation Trust Vacuum Therapy Devices and Methods
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JP2016510632A (en) * 2013-03-14 2016-04-11 ケーシーアイ ライセンシング インコーポレイテッド Multi-porous conduit
WO2015032866A1 (en) * 2013-09-06 2015-03-12 Medaxis Ag Handpiece for cleaning wounds
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CN105611954B (en) * 2013-09-06 2019-02-26 美达克西斯股份公司 Handpiece for cleaning wounds
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