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WO2013083910A3 - Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel - Google Patents

Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel Download PDF

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Publication number
WO2013083910A3
WO2013083910A3 PCT/FR2012/052799 FR2012052799W WO2013083910A3 WO 2013083910 A3 WO2013083910 A3 WO 2013083910A3 FR 2012052799 W FR2012052799 W FR 2012052799W WO 2013083910 A3 WO2013083910 A3 WO 2013083910A3
Authority
WO
WIPO (PCT)
Prior art keywords
antalgics
analgesics
retardants
sexual
anaesthetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2012/052799
Other languages
English (en)
Other versions
WO2013083910A2 (fr
Inventor
Mathieu LAZERGES
Philippe ESPEAU
Sylvie Sophie CRAUSTE-MANCIET
Denis Brossard
Yohann CORVIS
Florence AGNELY
Nicolas HUANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Paris Descartes
Original Assignee
Universite Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Paris Descartes filed Critical Universite Paris Descartes
Priority to US14/363,568 priority Critical patent/US20150105426A1/en
Priority to EP12810341.3A priority patent/EP2787976A2/fr
Priority to CA 2858312 priority patent/CA2858312A1/fr
Publication of WO2013083910A2 publication Critical patent/WO2013083910A2/fr
Publication of WO2013083910A3 publication Critical patent/WO2013083910A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouvelles formulations pour l'anesthésie locale topique et pour leur utilisation en tant qu'analgésique, antalgique ou en tant que retardant sexuel,
PCT/FR2012/052799 2011-12-07 2012-12-04 Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel Ceased WO2013083910A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/363,568 US20150105426A1 (en) 2011-12-07 2012-12-04 Topical emulsions based on mixtures of local eutectic anaesthetics and fatty acids as analgesics, antalgics, or as sexual retardants
EP12810341.3A EP2787976A2 (fr) 2011-12-07 2012-12-04 Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel
CA 2858312 CA2858312A1 (fr) 2011-12-07 2012-12-04 Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1161264A FR2983731B1 (fr) 2011-12-07 2011-12-07 Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
FR11/61264 2011-12-07

Publications (2)

Publication Number Publication Date
WO2013083910A2 WO2013083910A2 (fr) 2013-06-13
WO2013083910A3 true WO2013083910A3 (fr) 2013-10-24

Family

ID=47505206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2012/052799 Ceased WO2013083910A2 (fr) 2011-12-07 2012-12-04 Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras en tant qu'analgesique, antalgique ou en tant que retardant sexuel

Country Status (5)

Country Link
US (1) US20150105426A1 (fr)
EP (1) EP2787976A2 (fr)
CA (1) CA2858312A1 (fr)
FR (1) FR2983731B1 (fr)
WO (1) WO2013083910A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3057771A1 (fr) 2016-10-26 2018-04-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Emulsions topiques de lidocaine et d'acides gras utiles en tant qu'analgesique, antalgique ou retardant sexuel
BR112019013192A2 (pt) * 2016-12-26 2019-12-10 Cellix Bio Private Ltd composto e composição farmacêutica
EP3593801A4 (fr) * 2017-03-06 2021-01-13 Maruishi Pharmaceutical Co., Ltd. Composition d'émulsion acide contenant un agent anesthésique local
GB201913456D0 (en) * 2019-09-18 2019-10-30 Queens Univ Of Belfast Polymer-comprising medical devices and uses thereof

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031217A1 (fr) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Compositions de tocopherol destinees a l'apport d'agents biologiquement actifs
WO1996024355A1 (fr) * 1995-02-06 1996-08-15 Astra Aktiebolag Nouvelle combinaison pharmaceutique
WO1998016212A1 (fr) * 1996-10-14 1998-04-23 Kowa Company, Ltd. Anesthesique local a usage externe
US5814659A (en) * 1996-04-23 1998-09-29 Dtr Dermal Therapy (Barbados) Inc. Topical analgesic composition
WO2003066130A2 (fr) * 2002-02-07 2003-08-14 Massachusetts Institute Of Technology Systemes d'administration transdermique d'un medicament
US20040109893A1 (en) * 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
EP1576953A1 (fr) * 2002-12-06 2005-09-21 Otsuka Pharmaceutical Factory, Inc. Emulsions grasses contenant du propofol
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use
WO2011130455A1 (fr) * 2010-04-13 2011-10-20 Najib Babul Compositions pharmaceutiques dermiques de 1-méthyl-2',6'-pipécoloxylidide et méthode d'utilisation
US20120213869A1 (en) * 2011-02-23 2012-08-23 Miss Smarty Pants Enterprises, Inc. Pain Relieving Composition
JP2012214412A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 油性製剤
WO2012151196A1 (fr) * 2011-05-03 2012-11-08 Orthocon, Inc. Compositions d'administration de médicament et procédés d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7713618L (sv) * 1977-12-01 1979-06-02 Astra Laekemedel Ab Lokalanestetisk blandning
US7476400B2 (en) * 2001-11-13 2009-01-13 Ferndale Ip, Inc. High-concentration lidocaine compositions and methods for their preparation

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031217A1 (fr) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Compositions de tocopherol destinees a l'apport d'agents biologiquement actifs
WO1996024355A1 (fr) * 1995-02-06 1996-08-15 Astra Aktiebolag Nouvelle combinaison pharmaceutique
US5814659A (en) * 1996-04-23 1998-09-29 Dtr Dermal Therapy (Barbados) Inc. Topical analgesic composition
WO1998016212A1 (fr) * 1996-10-14 1998-04-23 Kowa Company, Ltd. Anesthesique local a usage externe
WO2003066130A2 (fr) * 2002-02-07 2003-08-14 Massachusetts Institute Of Technology Systemes d'administration transdermique d'un medicament
US20040109893A1 (en) * 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
EP1576953A1 (fr) * 2002-12-06 2005-09-21 Otsuka Pharmaceutical Factory, Inc. Emulsions grasses contenant du propofol
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use
WO2011130455A1 (fr) * 2010-04-13 2011-10-20 Najib Babul Compositions pharmaceutiques dermiques de 1-méthyl-2',6'-pipécoloxylidide et méthode d'utilisation
US20120213869A1 (en) * 2011-02-23 2012-08-23 Miss Smarty Pants Enterprises, Inc. Pain Relieving Composition
JP2012214412A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 油性製剤
WO2012151196A1 (fr) * 2011-05-03 2012-11-08 Orthocon, Inc. Compositions d'administration de médicament et procédés d'utilisation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BICA K ET AL: "Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation", CHEMICAL COMMUNICATIONS, vol. 47, no. 8, 28 February 2011 (2011-02-28), pages 2267 - 2269, XP002677207, Retrieved from the Internet <URL:http://pubs.rsc.org/en/content/articlepdf/2011/cc/c0cc04485g> [retrieved on 20120605] *
CHO CHEONG-WEON; CHOI JUN-SHIK; SHIN SANG-CHUL: "Enhanced Local Anesthetic Efficacy of Bioadhesive Ropivacaine Gels", BIOMOLECULES AND THERAPEUTICS, vol. 19, no. 3, 31 July 2011 (2011-07-31), pages 357 - 363, XP002698111 *
DATABASE WPI Section Ch Week 201278, Derwent World Patents Index; Class B05, AN 2012-P60960, XP002698110, YAMASHITA M: "Oil-based formulation used in body care products, comprises fatty acid including hydrocarbon liquid and lidocaine" *
DEW N ET AL: "Catanionic aggregates formed from drugs and lauric or capric acids enable prolonged release from gels", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 323, no. 2, 15 July 2008 (2008-07-15), pages 386 - 394, XP022703048, ISSN: 0021-9797, [retrieved on 20080409], DOI: 10.1016/J.JCIS.2008.04.008 *
KANG CHUNG; SHIN SANG-CHUL: "Preparation and evaluation of bioadhesive dibucaine gels for enhanced local anesthetic action", ARCHIVES OF PHARMACAL RESEARCH, vol. 33, no. 8, August 2010 (2010-08-01), pages 1277 - 1283, XP002698112 *
NASH R A ET AL: "THE POSSIBILITY OF LIDOCAINE ION PAIR ABSORPTION THROUGH EXCISED HAIRLESS MOUSE SKIN", SKIN PHARMACOLOGY, S. KARGER, BASEL, CH, vol. 5, no. 3, 1 January 1992 (1992-01-01), pages 160 - 170, XP002044700, ISSN: 1011-0283 *

Also Published As

Publication number Publication date
WO2013083910A2 (fr) 2013-06-13
FR2983731A1 (fr) 2013-06-14
EP2787976A2 (fr) 2014-10-15
US20150105426A1 (en) 2015-04-16
CA2858312A1 (fr) 2013-06-13
FR2983731B1 (fr) 2014-04-25

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