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WO2013067358A3 - Detection of osteoarthritis - Google Patents

Detection of osteoarthritis Download PDF

Info

Publication number
WO2013067358A3
WO2013067358A3 PCT/US2012/063334 US2012063334W WO2013067358A3 WO 2013067358 A3 WO2013067358 A3 WO 2013067358A3 US 2012063334 W US2012063334 W US 2012063334W WO 2013067358 A3 WO2013067358 A3 WO 2013067358A3
Authority
WO
WIPO (PCT)
Prior art keywords
osteoarthritis
detection
methods
biomarkers
progression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/063334
Other languages
French (fr)
Other versions
WO2013067358A2 (en
Inventor
John A. Todd
Mukundan Attur
Jeffrey David GREENBERG
Steven Abramson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Singulex Inc
Original Assignee
New York University NYU
Singulex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU, Singulex Inc filed Critical New York University NYU
Publication of WO2013067358A2 publication Critical patent/WO2013067358A2/en
Anticipated expiration legal-status Critical
Publication of WO2013067358A3 publication Critical patent/WO2013067358A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G01N2333/96491—Metalloendopeptidases (3.4.24) with definite EC number
    • G01N2333/96494—Matrix metalloproteases, e. g. 3.4.24.7
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for determining osteoarthritis severity, risk, progression and methods of treatment using biomarkers in biological samples from a patient.
PCT/US2012/063334 2011-11-04 2012-11-02 Detection of osteoarthritis Ceased WO2013067358A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161556158P 2011-11-04 2011-11-04
US61/556,158 2011-11-04

Publications (2)

Publication Number Publication Date
WO2013067358A2 WO2013067358A2 (en) 2013-05-10
WO2013067358A3 true WO2013067358A3 (en) 2015-06-25

Family

ID=48193036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/063334 Ceased WO2013067358A2 (en) 2011-11-04 2012-11-02 Detection of osteoarthritis

Country Status (1)

Country Link
WO (1) WO2013067358A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110218116A1 (en) * 2010-03-05 2011-09-08 The Curators Of The University Of Missouri Biomarkers of osteoarthritis
US20120065094A1 (en) * 2010-09-14 2012-03-15 New York University Methods and kits for diagnosing osteoarthritis and predicting progression

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110218116A1 (en) * 2010-03-05 2011-09-08 The Curators Of The University Of Missouri Biomarkers of osteoarthritis
US20120065094A1 (en) * 2010-09-14 2012-03-15 New York University Methods and kits for diagnosing osteoarthritis and predicting progression

Also Published As

Publication number Publication date
WO2013067358A2 (en) 2013-05-10

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