[go: up one dir, main page]

WO2013066145A1 - Système microfluidique et procédé associé - Google Patents

Système microfluidique et procédé associé Download PDF

Info

Publication number
WO2013066145A1
WO2013066145A1 PCT/MY2012/000156 MY2012000156W WO2013066145A1 WO 2013066145 A1 WO2013066145 A1 WO 2013066145A1 MY 2012000156 W MY2012000156 W MY 2012000156W WO 2013066145 A1 WO2013066145 A1 WO 2013066145A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
electrostatic
fluid
microfluidic device
curved sidewall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MY2012/000156
Other languages
English (en)
Inventor
Hing Wah Lee
Chia Sheng Daniel Bien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mimos Bhd
Original Assignee
Mimos Bhd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimos Bhd filed Critical Mimos Bhd
Publication of WO2013066145A1 publication Critical patent/WO2013066145A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0005—Lift valves
    • F16K99/0007—Lift valves of cantilever type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4317—Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • B01F25/43172—Profiles, pillars, chevrons, i.e. long elements having a polygonal cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43197—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F25/431971—Mounted on the wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/60—Pump mixers, i.e. mixing within a pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F04B43/046—Micropumps with piezoelectric drive
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0051—Electric operating means therefor using electrostatic means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves

Definitions

  • the present invention relates to a microfluidic device. More particularly, relates to integration and miniaturization of various fluid manipulation components, particularly a multichannel planar pumping unit, a valve and a mixer onto a single chip for microfluidic applications such as clinical genome analysis, macromolecules separation, enzymatic assays, cell-based assays and any operation that involves a minute volume of fluid samples.
  • Microfluidic systems are well known for manipulating and analysis of fluid samples at sub-millimeter scale. To date, intensive investigations and studies have been conducted to miniaturize and integrate various components su ⁇ ch as pumps, ' valves, filters, mixers, and heater on a single device for a variety of biological and chemical applications. These include drug discovery and development, gene sequencing, immunoassays, in vitro fertilization, and peptide analysis.
  • microfluidic systems that are integrated with various manipulation components on a single device, as understood, provides not only the ease of manipulation of fluids within micrometer-sized channels precisely, they also offers several advantages such as low sample volumes, low chemical consumption, ' fast response time, multiple simultaneous assays, and portability. Furthermore, such microfluidic systems provide a platform for a complete on- chip analysis, where sample preparation, pre-treatment , analytical reaction, detection and results, can be performed within the systems.
  • microfluidic pump includes a pumping chamber positioned between an inlet and an outlet; a plurality of moveable fingers positioned in a wall of said pumping chamber, said fingers being arranged in a row along said wall; and a plurality of thermal bend actuators, each actuator being associated with a respective finger such that actuation of said thermal bend actuator causes movement of said respective finger into said pumping chamber, wherein said pump is configured to provide a peristaltic pumping action in said pumping chamber via movement of said fingers.
  • CMOS circuitry that is- configured to either provide a valve action, a mixing action or a pumping action in the device, by altering an actuation sequence of the finger actuators.
  • This disclosed microfluidic system suffers from several limitations.
  • This single inlet and outlet microfluidic device does not allow parallel introduction and simultaneous or subsequent loading of multiple fluid samples into the device. Contamination of fluid samples to be tested or analyzed in the device is often resulted due to a single input channel is used. For example, during a cleaning process, a cleaning solution would have to be introduced through the same inlet port as the sample to be analyzed, and it thus contaminates the sample in the inlet port. Accordingly, it is the primary object of the present invention to overcome the aforementioned drawbacks.
  • the present invention provides a microfluidic device that allows multiple fluid samples to be independently introduced into the device, and thereby preventing contamination of the fluid samples.
  • It is another object of the present invention to provide a miniaturized microfluidic system comprises a multichannel planar pump unit having a pair of electrostatic-driven membrane electrode for manipulating fluid flow and plurality of mixer structures integrated in the pumping chamber thereof.
  • a microfluidic device having a planar pumping unit integrated with a plurality of mixer structures and a pair of electrostatic- driven membrane electrodes that can be served as fluid flow control valves.
  • said microfluidic device comprises a pumping unit having a pump chamber includes an upper wall, a bottom wall, a first curved sidewall having at least two inlets and a second curved sidewall having at least two outlets, wherein the first curved sidewall and the second curved sidewall are placed in an opposing manner; at least two inflow fluid channels connected to said at least two inlets of the pump chamber for introduction of fluids into the chamber; at least two outflow fluid channels connected to said at least two outlets of the pump chamber for withdrawal of fluid from the chamber; a plurality of mixer structures provided within the cavity of the pump chamber for homogenization of fluids; and a pair of electrostatic-driven membrane electrodes (35a, 35b) disposed within the chamber and configured to manipulate fluid flow in the device
  • Figure 1 illustrates a cross-sectional view
  • microfluidic device of a preferred embodiment accordance to the present invention.
  • Figure 2a-2d illustrates the fluid manipulation process adopted by a microfluidic device of a preferred embodiment with accordance to the present invention.
  • FIG. 1 illustrates a cross-sectional view of microfluidic device (10) constructed in accordance to a preferred embodiment of the present invention.
  • Said microfluidic device (10) includes a planar pumping unit having a pump chamber (15) connected to at least two inflow fluid channels
  • the plurality of mixer structures (25) described herein may be constructed in any configuration and of any materials that assists in enhancing interfacial area between the fluids to be mixed and/or expediting the homogenization of fluids within the chamber (15) .
  • Non-limiting example of mixer structures (25) includes a parallel-plate mixer, a Y- mixer, a planar-type mixer, a spiral-shaped mixer, a circular-shaped mixer and a serpentine type mixer.
  • the plurality of mixer structures (25) have a configuration that is in-plane with the pumping unit.
  • the pump chamber (15) includes an upper wall (15a), a bottom wall (15b), a first curved sidewall (15c) having at least two inlets (30a) and a second curved sidewall (15d) having at least two outlets (30b) .
  • Each inlet (30a) disposed through the first curved sidewall (15c) is connected to a corresponding inflow fluid channel (20a) for introduction of fluid into the chamber (15) .
  • each outlet (30b) disposed through the second curved sidewall (15d) directs fluid to exit from the chamber
  • first sidewall (15c) has a cross-section profile resembling an inverted "L"
  • second curved sidewall- (15d), in cross-section has a substantially "L” shaped profile
  • the second (15d) curved sidewalls may have a substantially “L” shaped an inverted “L” shaped, respectively, in the cross-section profile.
  • the pump chamber (15) further includes a pair of electrostatic-driven membrane electrodes that can be served as flow control valves for manipulating fluid flow in the device (10) .
  • Said pair of electrostatic-driven membrane electrodes include a first membrane electrode (35a) and a second membrane electrode (35b), that are spaced apart to one another and are in proximity to the inner surface of their respective sidewalls (15c, 15d) of the pump chamber (15).
  • These membrane electrodes (35a, 35b) are configured in such a manner that allows fluid flow in an open state and stops fluid flow in a closed state.
  • the open state and the closed state of the membrane electrodes (35a, 35b) in accordance to the preferred embodiment, is controlled by application of voltage.
  • the open state of these membrane electrodes (35a, 35b) is defined . by non-deformed or non-deflected state of the membrane electrode, and in other words, such electrode membrane is in its inactivated state with no voltage supply.
  • the membrane electrodes (35a, 35b) upon application of electrical voltage, will be deformed or deflected towards the curvature surface of the sidewalls (15c, 15d) so that they can seal the inlets (30a) and outlets (30b) of the sidewalls (15c, 15d) , and thereby preventing the flow of fluids from the inlets (30a) or out of the pump chamber (15).
  • each membrane electrode (35a, 35b) is controlled by a respective actuator.
  • the deflection angle of the membrane electrodes (35a, 35b) relative to the curvature surface of the sidewalls (15c, 15d) may be varied with different voltage applied thereto.
  • Inlets (30a) or outlets (30b) provided on the curved surface of the sidewalls (15c, 15d) may not be fully sealed if there is low voltage supplied. These unsealed inlets (30a) or outlets (30b) may thus allow fluids to flow from the inflow (20a) or through the outflow fluid channel (20b) that they communicate with.
  • fluids from different inflow channels (20a) can sequentially be introduced into the chamber (15) .
  • fluids from the pump chamber (15) are also allowed to exit the chamber (15) in a sequential manner through the unsealed outlets (30b).
  • the microfluidic device constructed in accordance to the preferred embodiment may allow multiple fluids from different fluid channels to be independently introduced into the chamber.
  • the pump chamber (15) is associated with a pumping structure for fluid pumping operations and such pumping structure may be operatively coupled with the membrane electrodes (35a, 35b) of the chamber (15) for fluid manipulation.
  • Said pumping structure can be driven by, includes but not limited to electrostatic, thermo-pneumatic, piezoelectric, bimetallic, and shape-memory type actuation. It is preferred that a diaphragm pump is employed as the pumping structure in the microfluidic device (10) of the present invention.
  • a second electrostatic-driven membrane electrode (35b) is actuated to a closed state while a first electrostatic-driven membrane electrode (35a) is actuated to a partially open state with a first inlet (30a') being unsealed for permitting a first fluid sample to flow from the connected first inflow fluid channel (20a') into the chamber (15).
  • a diaphragm pump associated with the chamber (15) is also manipulated to assist the first fluid sample from the unsealed first fluid channel (20a') to the chamber (15) .
  • the first electrostatic-driven membrane electrode (35a) is further actuated to unseal a second inlet (30a") for directing a second fluid sample therethrough into the chamber (15) containing the first fluid sample. Both fluid samples are subsequently homogenously mixed by the plurality of mixer structures (25) disposed within the chamber (15).
  • the second membrane electrode (35b) is then actuated to a fully open state, unsealing the outlets (30b), and in the same time, triggering the diaphragm pump to pump the mixture out of the chamber (15) to the outflow fluid channels (20b) through the outlets (30b). This fluid withdrawal operation is shown in Figure 2c.
  • Figure 2d illustrates the cleaning operation adopted by the microfluidic device (10) ⁇ in accordance to the preferred embodiment of the present invention.
  • the first electrostatic-driven membrane electrode (35a) is actuated to a fully open state.
  • Inlets (30a) provided on the first curved sidewalls are no longer sealed by said first membrane electrode (35a) .
  • Cleaning reagent is then introduced into the chamber (15) through the newly unsealed third inlet (20a"' ) . It should be understood that cleaning agent also can be introduced into the chamber (15) from the first (20a') and the second inlets (20") .
  • the diaphragm pump is triggered to reduce pressure in the chamber, resulting cleaning fluid to be introduced therein via the inlets (20a) . Subsequently, actuating the second membrane electrode (35b) to a fully open state and pumping the cleaning reagent out through the unsealed outlets (30b) by means of the diaphragm pump. Cleaning steps as above may be repeated until a desired level of cleaning is obtained. It should be understood that, upon completion of the cleaning, the first membrane electrode (35a) is actuated to its fully closed state, inhibiting cleaning reagent from entering the pump chamber (15) .

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Reciprocating Pumps (AREA)

Abstract

Un dispositif microfluidique (10) comprend une unité de pompage comprenant un corps de pompe (15) comportant une paroi supérieure (15a), une paroi inférieure (15b), une première paroi latérale incurvée (15c) comportant au moins deux orifices d'admission (30a) et une seconde paroi latérale incurvée (15d) comportant au moins deux orifices d'évacuation (30b), la première paroi incurvée (15c) et la seconde paroi incurvée (15d) étant placées à l'opposé l'une de l'autre ; au moins deux conduits d'arrivée de fluide (20a) reliés audits orifices d'admission (30a) du corps de pompe (15) en vue de l'introduction de fluides dans le corps de pompe (15) ; au moins deux conduits de sortie de fluide (20b) reliés auxdits orifices d'évacuation (30b) du corps de pompe (15) en vue de l'évacuation du fluide présent dans le corps de pompe (15) ; une pluralité de structures de mélange (25) situées au sein de la cavité du corps de pompe (15) et destinées à homogénéiser les fluides ; et une paire d'électrodes membranaires à entraînement électrostatique (35a, 35b), disposées au sein du corps de pompe (15) et conçues pour modifier l'écoulement des fluides dans le dispositif.
PCT/MY2012/000156 2011-11-01 2012-06-28 Système microfluidique et procédé associé Ceased WO2013066145A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2011005274 2011-11-01
MYPI2011005274A MY155726A (en) 2011-11-01 2011-11-01 A microfluidic system and method thereof

Publications (1)

Publication Number Publication Date
WO2013066145A1 true WO2013066145A1 (fr) 2013-05-10

Family

ID=46727520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2012/000156 Ceased WO2013066145A1 (fr) 2011-11-01 2012-06-28 Système microfluidique et procédé associé

Country Status (2)

Country Link
MY (1) MY155726A (fr)
WO (1) WO2013066145A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018009222A1 (fr) * 2016-07-08 2018-01-11 Hewlett-Packard Development Company, L.P. Dispositif microfluidique pour mélange de fluides
EP3503985B1 (fr) * 2016-08-29 2022-09-28 Mott Corporation Mélangeur statique haute performance

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022492A2 (fr) * 2000-09-14 2002-03-21 Mcnc Appareil a soupape electrostatique a membrane souple microelectromecanique et procedes de fabrication associes
US20020086149A1 (en) * 2000-12-28 2002-07-04 Swartz Lars E. Thin laminate film structure for electrostatic or magnetic applications and method for making same
WO2003076331A2 (fr) * 2002-03-08 2003-09-18 Universität Bremen Procede de fabrication de pieces micro-mecaniques et pieces ainsi fabriquees
DE10333741A1 (de) * 2003-07-23 2005-02-17 Festo Ag & Co.Kg Mikroventil mit elektrostatischem Antriebsprinzip
US20060076068A1 (en) * 2004-10-13 2006-04-13 Kionix Corporation Microfluidic pump and valve structures and fabrication methods
US20090317298A1 (en) 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Microfluidic Pump, Mixer or Valve
WO2011122932A1 (fr) * 2010-03-29 2011-10-06 Mimos Berhad Micropompe plane à micromélangeurs passifs intégrés
WO2011133014A1 (fr) * 2010-04-19 2011-10-27 Mimos Berhad Micro-pompe plane comportant des micro-soupapes intégrées

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022492A2 (fr) * 2000-09-14 2002-03-21 Mcnc Appareil a soupape electrostatique a membrane souple microelectromecanique et procedes de fabrication associes
US20020086149A1 (en) * 2000-12-28 2002-07-04 Swartz Lars E. Thin laminate film structure for electrostatic or magnetic applications and method for making same
WO2003076331A2 (fr) * 2002-03-08 2003-09-18 Universität Bremen Procede de fabrication de pieces micro-mecaniques et pieces ainsi fabriquees
DE10333741A1 (de) * 2003-07-23 2005-02-17 Festo Ag & Co.Kg Mikroventil mit elektrostatischem Antriebsprinzip
US20060076068A1 (en) * 2004-10-13 2006-04-13 Kionix Corporation Microfluidic pump and valve structures and fabrication methods
US20090317298A1 (en) 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Microfluidic Pump, Mixer or Valve
WO2011122932A1 (fr) * 2010-03-29 2011-10-06 Mimos Berhad Micropompe plane à micromélangeurs passifs intégrés
WO2011133014A1 (fr) * 2010-04-19 2011-10-27 Mimos Berhad Micro-pompe plane comportant des micro-soupapes intégrées

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018009222A1 (fr) * 2016-07-08 2018-01-11 Hewlett-Packard Development Company, L.P. Dispositif microfluidique pour mélange de fluides
US11439963B2 (en) 2016-07-08 2022-09-13 Hewlett-Packard Development Company, L.P. Microfluidic device for fluid mixture
EP3503985B1 (fr) * 2016-08-29 2022-09-28 Mott Corporation Mélangeur statique haute performance

Also Published As

Publication number Publication date
MY155726A (en) 2015-11-17

Similar Documents

Publication Publication Date Title
Haeberle et al. Microfluidic platforms for lab-on-a-chip applications
US8323887B2 (en) Miniaturized fluid delivery and analysis system
JP5762389B2 (ja) 微小流体装置のための、計量流体ローディングシステムを備える微小流体システム
US9709179B2 (en) Device for controlling fluid flows in lab-on-a-chip systems
Toepke et al. Microfluidic logic gates and timers
US20100104474A1 (en) Micro fluidic device
TWI641823B (zh) 流體整合模組及其適用之多流體系統之流體運作的調控方法
US8309039B2 (en) Valve structure for consistent valve operation of a miniaturized fluid delivery and analysis system
EP3461559A1 (fr) Plaque de puits entraînée par pipette manuelle ou électronique pour le stockage de nano-litres de gouttelettes et procédés d'utilisation associés
WO2011133014A1 (fr) Micro-pompe plane comportant des micro-soupapes intégrées
Chen et al. Manually operatable on-chip bistable pneumatic microstructures for microfluidic manipulations
KR20110037345A (ko) 단일세포 분주용 어레이 장치
JP2011257238A (ja) 微量液滴秤取構造、マイクロ流体デバイス及び微量液滴秤取方法
WO2013066145A1 (fr) Système microfluidique et procédé associé
DK3235568T3 (en) Disposable device for conducting a plurality of simultaneous biological experiments in fluid samples
TWI631069B (zh) 微流體感測系統、方法及相關之非暫態的電腦可讀取媒體
Thakur et al. Programmable microfluidic platform for spatiotemporal control over nanoliter droplets
CN109550527A (zh) 有多数量级浓度稀释功能的微流控芯片装置及其应用方法
CN103586094A (zh) 一种具有环流混合结构的微流控芯片及环流混合方法
CN106999935B (zh) 微流体系统以及分析试样溶液的方法和制造用于分析试样溶液的微流体系统的方法
KR102065300B1 (ko) 미세 주입기를 가진 미세유체분석칩 및 그 제조 방법 및 그 사용 방법
TW557284B (en) Multi-directional logic micro fluid control system and method
US20070111297A1 (en) Portable micro-flow managing system using infinitesimal pressure control
WO2011122932A1 (fr) Micropompe plane à micromélangeurs passifs intégrés
KR101986432B1 (ko) 시료의 흐름을 조절할 수 있는 미세유체분석칩

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12750842

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12750842

Country of ref document: EP

Kind code of ref document: A1