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WO2013059530A3 - Peptidomimetic macrocycles - Google Patents

Peptidomimetic macrocycles Download PDF

Info

Publication number
WO2013059530A3
WO2013059530A3 PCT/US2012/060919 US2012060919W WO2013059530A3 WO 2013059530 A3 WO2013059530 A3 WO 2013059530A3 US 2012060919 W US2012060919 W US 2012060919W WO 2013059530 A3 WO2013059530 A3 WO 2013059530A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
peptidomimetic
disease
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/060919
Other languages
French (fr)
Other versions
WO2013059530A2 (en
Inventor
Noriyuki Kawahata
Carl Elkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of WO2013059530A2 publication Critical patent/WO2013059530A2/en
Anticipated expiration legal-status Critical
Publication of WO2013059530A3 publication Critical patent/WO2013059530A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided are novel peptidomimetic macrocycles and methods of using the macrocycles for the treatment of disease.
PCT/US2012/060919 2011-10-18 2012-10-18 Peptidomimetic macrocycles Ceased WO2013059530A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161548695P 2011-10-18 2011-10-18
US61/548,695 2011-10-18

Publications (2)

Publication Number Publication Date
WO2013059530A2 WO2013059530A2 (en) 2013-04-25
WO2013059530A3 true WO2013059530A3 (en) 2015-06-11

Family

ID=48141627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/060919 Ceased WO2013059530A2 (en) 2011-10-18 2012-10-18 Peptidomimetic macrocycles

Country Status (1)

Country Link
WO (1) WO2013059530A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720306A2 (en) 2006-12-14 2014-02-04 Aileron Therapeutics Inc BIS-SUFIDRIL MACROCYCLING SYSTEMS
CN104086641A (en) 2007-02-23 2014-10-08 爱勒让治疗公司 Triazole macrocycle systems
EP3159352B1 (en) 2007-03-28 2023-08-02 President and Fellows of Harvard College Stitched polypeptides
AU2009294877C1 (en) 2008-09-22 2015-05-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2352507A4 (en) 2008-11-24 2012-04-25 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
JP2012515172A (en) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド Peptidomimetic macrocycle
AU2010298338A1 (en) 2009-09-22 2012-04-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR102104762B1 (en) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
TW201806968A (en) 2011-10-18 2018-03-01 艾利倫治療公司 Peptidomimetic macrocycles
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
BR112015009470A2 (en) 2012-11-01 2019-12-17 Aileron Therapeutics Inc disubstituted amino acids and their methods of preparation and use
MX389354B (en) 2014-09-24 2025-03-20 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF.
KR20170058424A (en) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles and uses thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010317A1 (en) * 2000-03-17 2002-01-24 Wild Carl T. Method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins
US20080242598A1 (en) * 2004-03-19 2008-10-02 The University Of Queensland Alpha Helical Mimics, Their Uses and Methods For Their Production
US20110046043A1 (en) * 2007-12-31 2011-02-24 Deyun Wang Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010317A1 (en) * 2000-03-17 2002-01-24 Wild Carl T. Method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins
US20080242598A1 (en) * 2004-03-19 2008-10-02 The University Of Queensland Alpha Helical Mimics, Their Uses and Methods For Their Production
US20110046043A1 (en) * 2007-12-31 2011-02-24 Deyun Wang Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 27 September 1995 (1995-09-27), accession no. AA7668.1. *
XIE, D. ET AL.: "An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, no. 1, January 2010 (2010-01-01), pages 191 - 196 *

Also Published As

Publication number Publication date
WO2013059530A2 (en) 2013-04-25

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