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WO2013058527A3 - 류코트리엔 길항제와 에피나스틴의 복합제제 - Google Patents

류코트리엔 길항제와 에피나스틴의 복합제제 Download PDF

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Publication number
WO2013058527A3
WO2013058527A3 PCT/KR2012/008458 KR2012008458W WO2013058527A3 WO 2013058527 A3 WO2013058527 A3 WO 2013058527A3 KR 2012008458 W KR2012008458 W KR 2012008458W WO 2013058527 A3 WO2013058527 A3 WO 2013058527A3
Authority
WO
WIPO (PCT)
Prior art keywords
epinastine
leukotriene antagonist
combined formulation
active ingredients
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/008458
Other languages
English (en)
French (fr)
Other versions
WO2013058527A2 (ko
Inventor
이창규
박상근
최현주
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navipharm Co Ltd
Original Assignee
Navipharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020120069220A external-priority patent/KR101278572B1/ko
Application filed by Navipharm Co Ltd filed Critical Navipharm Co Ltd
Priority to CN201280051128.XA priority Critical patent/CN103889424A/zh
Publication of WO2013058527A2 publication Critical patent/WO2013058527A2/ko
Publication of WO2013058527A3 publication Critical patent/WO2013058527A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 류코트리엔 길항제와 에피나스틴을 유효성분으로 포함하되, 이들 두 유효성분 중 적어도 어느 하나는 다른 하나의 유효성분과 분리된 환경을 갖는 약제학적 유닛(pharmaceutical unit)으로 이루어지는 것을 특징으로 하는 류코트리엔 길항제와 에피나스틴의 복합제제 및 그 제조방법에 관한 것이다. 상기 복합제제는 류코트리엔 길항제의 용출율 및 생체 이용율이 우수하고, 나아가 두 유효성분들이 서로 상승적인 호산구(Eosinophil) 감소 또는 기도 과민성 억제 효과를 발휘함으로써 기관지 천식의 예방 또는 치료용으로 매우 유용하게 사용될 수 있다.
PCT/KR2012/008458 2011-10-18 2012-10-17 류코트리엔 길항제와 에피나스틴의 복합제제 Ceased WO2013058527A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280051128.XA CN103889424A (zh) 2011-10-18 2012-10-17 白三烯拮抗剂和依匹斯汀的复合制剂

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20110106382 2011-10-18
KR10-2011-0106382 2011-10-18
KR1020120069220A KR101278572B1 (ko) 2011-10-18 2012-06-27 류코트리엔 길항제와 에피나스틴의 복합제제
KR10-2012-0069220 2012-06-27

Publications (2)

Publication Number Publication Date
WO2013058527A2 WO2013058527A2 (ko) 2013-04-25
WO2013058527A3 true WO2013058527A3 (ko) 2013-06-20

Family

ID=48141524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/008458 Ceased WO2013058527A2 (ko) 2011-10-18 2012-10-17 류코트리엔 길항제와 에피나스틴의 복합제제

Country Status (1)

Country Link
WO (1) WO2013058527A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101230178B1 (ko) 2010-06-10 2013-02-06 주식회사 네비팜 골다공증 예방 또는 치료용 조성물 및 이의 제조방법
CN103251563A (zh) * 2013-05-22 2013-08-21 北京科源创欣科技有限公司 依匹斯汀或其盐酸盐的稳定的颗粒状药物组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100737710B1 (ko) * 1997-12-23 2007-07-11 쉐링 코포레이션 하나 이상의 류코트리엔 길항제와 데스카보에톡실로라티딘를 포함하는 호흡기 질환 및 피부 질환 치료용 조성물
KR20080016621A (ko) * 2005-06-09 2008-02-21 바이올리폭스 에이비 염증성 질병 치료용 조성물 및 방법
KR20090103810A (ko) * 2008-03-28 2009-10-01 코와 가부시키가이샤 정제
US20110189274A1 (en) * 2008-10-06 2011-08-04 Swati Mukherjee Stable Pharmaceutical Compositions Of Montelukast Or Its Salts Or Solvates Or Hydrates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100737710B1 (ko) * 1997-12-23 2007-07-11 쉐링 코포레이션 하나 이상의 류코트리엔 길항제와 데스카보에톡실로라티딘를 포함하는 호흡기 질환 및 피부 질환 치료용 조성물
KR20080016621A (ko) * 2005-06-09 2008-02-21 바이올리폭스 에이비 염증성 질병 치료용 조성물 및 방법
KR20090103810A (ko) * 2008-03-28 2009-10-01 코와 가부시키가이샤 정제
US20110189274A1 (en) * 2008-10-06 2011-08-04 Swati Mukherjee Stable Pharmaceutical Compositions Of Montelukast Or Its Salts Or Solvates Or Hydrates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALISE REICIN ET AL.: "Montelukast, a Leukotriene Receptor Antagonist, in Combination With Loratadine, a Histamine Receptor Antagonist, in the Treatment of Chronic Asthma", ARCHIVES INTERNAL MEDICINE, vol. 160, 2000, pages 2481 - 2488 *

Also Published As

Publication number Publication date
WO2013058527A2 (ko) 2013-04-25

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