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WO2013052482A1 - Système laser modulable destiné à la thérapie photodynamique - Google Patents

Système laser modulable destiné à la thérapie photodynamique Download PDF

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Publication number
WO2013052482A1
WO2013052482A1 PCT/US2012/058459 US2012058459W WO2013052482A1 WO 2013052482 A1 WO2013052482 A1 WO 2013052482A1 US 2012058459 W US2012058459 W US 2012058459W WO 2013052482 A1 WO2013052482 A1 WO 2013052482A1
Authority
WO
WIPO (PCT)
Prior art keywords
laser
light
sources
core unit
modules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/058459
Other languages
English (en)
Inventor
Thomas H. Foster
Timothy M. BARAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of WO2013052482A1 publication Critical patent/WO2013052482A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N2005/002—Cooling systems
    • A61N2005/005—Cooling systems for cooling the radiator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A61N2005/0627—Dose monitoring systems and methods
    • A61N2005/0628—Dose monitoring systems and methods including a radiation sensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres

Definitions

  • the present invention is directed to photodynamic therapy (PDT) of cancer and other localized diseases, such as macular degeneration, microbial infections, and acne.
  • PDT photodynamic therapy
  • the problems in the art include the lack of commercially available laser systems suitable for clinical photodynamic therapy and the lack of flexibility offered by the FDA-approved, commercially available systems. That situation is a major impediment to the more widespread adoption of PDT. In cancer applications, that lack of flexibility typically constrains physicians to work with Photofrin. Looking forward, as more PDT drugs become available, laser systems emitting one wavelength will impose a significant financial burden on PDT centers because each photosensitizer is optimally activated by a different laser wavelength. Thus, centers would be forced to purchase several expensive individual systems.
  • the present invention is directed to a system including a core unit and multiple interchangeable laser modules.
  • Each laser module preferably has multiple diode lasers and fibers that are fused or otherwise coupled into a single fiber.
  • each module may have a single diode laser, as there are commercial sources of diodes with a single output sufficient for some clinical applications.
  • An important aspect of the present invention is the ability to enable different modules to be controlled by a common core unit.
  • the present invention would enable a PDT center to purchase one system, with additional, relatively inexpensive plug-in laser modules available to deliver light at multiple clinically relevant wavelengths. That will greatly reduce the cost to the hospital or outpatient clinic and facilitate more widespread clinical dissemination of that important therapy. Because the user interface would be the same for each laser module, that single system would facilitate clinical acceptance by eliminating the need for technologists to learn to operate several different laser systems.
  • Figure 1 is a diagram of a laser module according to the preferred embodiment.
  • Figure 2 is a block diagram of a system using multiple laser modules of Figure 1.
  • the laser module 100 of Figure 1 comprises two or more commercially available diode lasers 102.
  • the number of those diodes is determined by the power emitted by each and the total power required for PDT treatment.
  • Each of those diode lasers 102 is equipped with a standard SMA optical fiber termination.
  • the output of each of the individual diodes is coupled to the fiber termination 104 of a leg 106 of a custom optical fiber in which the cores of the legs are fused at a fusion point 108 into a common 200 - 400 micron core diameter optical fiber 110 having a fiber termination 112.
  • a single diode laser 102 can be used instead if it has sufficient output for the purpose, in which case the fusion point 108 is not needed.
  • FIG. 1 Shown in Figure 1 is a bifurcated fused fiber optic arrangement, enabling the coupling of two diode lasers. More lasers can be added to increase the total power by creating a fused arrangement with more than two legs or by linking together a series of bifurcated fibers. The final output would be SMA coupled to the FDA-approved PDT treatment fiber. That part of the laser system can be packaged as a module. Those modules would be sold separately and would enable PDT to be performed at any desired treatment wavelength.
  • a system 200 for photodynamic therapy includes multiple laser modules 100a, 100b, 100c configured like the laser module 100 of Figure 1.
  • the laser modules 100a, 100b, 100c can include laser modules having different wavelength characteristics for use with different photosensitizers or other treatment modalities.
  • One or more of the laser modules 100a, 100b, 100c can be plugged into the core unit 202.
  • the core unit 202 is configured to allow such plugging in; otherwise, its construction will be familiar to those skilled in the art and will therefore not be described in detail here.
  • the user determines the type of photodynamic therapy to be performed, selects one or more of the laser modules 100a, 100b, 100c accordingly, plugs them into the core unit 202, and performs the photodynamic therapy.
  • the diode laser controller 204, the thermoelectric cooling controllers 206, and sensors 208 for measuring the power emitted from the treatment fiber are included in the core unit 202.
  • the laser controller and power measurement hardware are controlled by a laptop computer 210 or similar device (e.g., a netbook or tablet).
  • a touch pad interface could be used.
  • the software interface would be written to be easily operated by a clinical technologist. Plugging in the various laser modules would be straightforward using color coding or clearly marked ports on the housing of the core unit 202.
  • the laser diodes 102 all emit at the same wavelength and are coupled to increase the optical power into the downstream optical fiber 110.
  • Another variation of the preferred embodiment accommodates new photosensitizers for photodynamic therapy that are excited by near infrared laser light, namely, in the 700 - 800 nm range. Those wavelengths are not seen by the human eye and so can present a danger. It would therefore be preferable to implement some way to report to the user that the device is on and emitting near infrared light.
  • one or more of the diodes 102 can be near infrared, but one can be a different wavelength - a visible wavelength (such as blue, green, red) - which would serve as an indicator that the system was on and emitting the near infrared. That additional wavelength would be "piped" down the fiber but would not interfere with the PDT light dose for two reasons: (1) it could be very low power but still visible at the end of the fiber, and (2) its emission would not correspond to the absorption of the photosensitizer.
  • a visible wavelength such as blue, green, red
  • a system can be made up of replicates of the elements described above. That is, the core elements would be the same as disclosed above, but such a system would incorporate a number of them, each delivering light to a different treatment fiber. Therefore, the present invention should be construed as limited only by the appended claims.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un système destiné à la thérapie photodynamique qui comporte un système principal et un système laser modulable dont l'utilisateur peut se servir pour obtenir une lumière ayant une longueur d'onde adaptée. Ledit système laser modulable comprend une ou plusieurs diodes lasers ainsi que des fibres. Dans le cas de multiples diodes lasers, les fibres sont amalgamées ou par ailleurs couplées afin de se présenter sous la forme d'une seule fibre.
PCT/US2012/058459 2011-10-03 2012-10-02 Système laser modulable destiné à la thérapie photodynamique Ceased WO2013052482A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161542445P 2011-10-03 2011-10-03
US61/542,445 2011-10-03

Publications (1)

Publication Number Publication Date
WO2013052482A1 true WO2013052482A1 (fr) 2013-04-11

Family

ID=48044109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/058459 Ceased WO2013052482A1 (fr) 2011-10-03 2012-10-02 Système laser modulable destiné à la thérapie photodynamique

Country Status (1)

Country Link
WO (1) WO2013052482A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20163480A1 (it) * 2016-05-16 2017-11-16 Winform Medical Eng S R L Dispositivo medicale perfezionato per laserterapia.
DE102023004548A1 (de) 2023-11-07 2025-05-08 Biolitec Research Gmbh Vorrichtung und Verfahren zur Behandlung von Tumoren
DE102023004549A1 (de) 2023-11-07 2025-05-08 Biolitec Research Gmbh Vorrichtung und verfahren zur behandlung von dysplasien
WO2025098655A1 (fr) * 2023-11-07 2025-05-15 Biolitec Holding Gmbh & Co Kg Dispositif de traitement de dysplasie, de tumeurs et/ou d'infections bactériennes et virales

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479499A (en) * 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
US5304167A (en) * 1988-11-10 1994-04-19 Premier Laser Systems, Inc. Multiwavelength medical laser method
US20040133191A1 (en) * 2002-12-27 2004-07-08 Masayuki Momiuchi Laser device for medical treatment system
US20060224148A1 (en) * 2005-04-05 2006-10-05 Cho George E System and method for laser lipolysis
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
WO2011072472A1 (fr) * 2009-12-14 2011-06-23 武汉奇致激光技术有限公司 Appareil multifonctionnel de thérapie laser

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479499A (en) * 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
US5304167A (en) * 1988-11-10 1994-04-19 Premier Laser Systems, Inc. Multiwavelength medical laser method
US20040133191A1 (en) * 2002-12-27 2004-07-08 Masayuki Momiuchi Laser device for medical treatment system
US20060224148A1 (en) * 2005-04-05 2006-10-05 Cho George E System and method for laser lipolysis
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
WO2011072472A1 (fr) * 2009-12-14 2011-06-23 武汉奇致激光技术有限公司 Appareil multifonctionnel de thérapie laser

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20163480A1 (it) * 2016-05-16 2017-11-16 Winform Medical Eng S R L Dispositivo medicale perfezionato per laserterapia.
EP3246069A1 (fr) 2016-05-16 2017-11-22 Winform Medical Engineering S.r.l. Dispositif médical amélioré de thérapie laser
DE102023004548A1 (de) 2023-11-07 2025-05-08 Biolitec Research Gmbh Vorrichtung und Verfahren zur Behandlung von Tumoren
DE102023004549A1 (de) 2023-11-07 2025-05-08 Biolitec Research Gmbh Vorrichtung und verfahren zur behandlung von dysplasien
WO2025098655A1 (fr) * 2023-11-07 2025-05-15 Biolitec Holding Gmbh & Co Kg Dispositif de traitement de dysplasie, de tumeurs et/ou d'infections bactériennes et virales

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