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WO2013048235A2 - Pommade à base d'herbes médicinales - Google Patents

Pommade à base d'herbes médicinales Download PDF

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Publication number
WO2013048235A2
WO2013048235A2 PCT/MY2012/000257 MY2012000257W WO2013048235A2 WO 2013048235 A2 WO2013048235 A2 WO 2013048235A2 MY 2012000257 W MY2012000257 W MY 2012000257W WO 2013048235 A2 WO2013048235 A2 WO 2013048235A2
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WIPO (PCT)
Prior art keywords
oil
radix
solvent extracts
composition according
composition
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Ceased
Application number
PCT/MY2012/000257
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English (en)
Other versions
WO2013048235A3 (fr
Inventor
Yap Cheng HAI
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NAMETA Sdn Bhd
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NAMETA Sdn Bhd
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Publication of WO2013048235A2 publication Critical patent/WO2013048235A2/fr
Publication of WO2013048235A3 publication Critical patent/WO2013048235A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Definitions

  • the present invention relates to a traditional medicine particularly used for treating disorders or illness associated with bones, muscles and joints. More particularly, the present invention provides a herbal ointment containing a formulated combination of natural therapeutic herbs and method for preparing thereof, which can be applied for treating various disorders and illnesses, especially rheumatism, traumatic injury and bone fracture.
  • disorders or illnesses associated with bones, muscles and joints are commonly seen in daily life. These disorders or illnesses are generally resulted from rheumatism, traumatic injury or fracture involving bones and joints, including the connective tissues.
  • Various treatment approaches can be applied depending on the nature of the disorders or illnesses, for example, surgery, physiotherapy, acupuncture, medication and others.
  • traditional medicine as an alternative treatment to bones, muscles and joints-related medical problems, whereby a wide range of natural herbs with known therapeutic functions has been applied in the manufacture of various therapeutic herbal ointments.
  • China patent No. CN 1190007 relates to a plaster consisting of substrate and medicine component, which contains sesame oil extracts of Radix Aconiti, Aconiti, Arisaema congsanguineum, Rhizoma Pinelliae, Rhizoma Atractylodis, as well as fresh ginger, scallion and garlic.
  • the medicine component is obtained by heating the medicinal ingredients in sesame oil, then the plaster with medicine can be attached onto the affected area of the body.
  • Another China patent No. CN101502615 also relates to a plaster for traumatic injury and bone fracture containing a very wide range of traditional medicines derived from therapeutic plant parts, including musk, crude Aconite root, Kusnezoff Aconite root, common Bletilla pseudobulb, hay, safflower, peach seed, diverse wormwood herbs, frankincense, myrrh, Rhizoma Drynariae, Sappan wood, Catechus, Arisaema saxatile and others. These ingredients are crushed and prepared into paste, which is then coated on cloth or kraft papers. When it is in use, the paste can be baked and applied onto the affected area.
  • a bone regeneration pain-relieving plaster is disclosed in China patent No. CN101229295, wherein some of the therapeutic plant parts as set forth in the preceding existing technologies are applied. Most of these plasters or pastes are applied for treating rheumatism, rheumatoid arthritis or other related illnesses, which focuses on relieving pain.
  • Another patented technology disclosed in China patent No. CN1190019 is a medicinal cream for trauma and fracture including Radix Aconiti, Rhizoma Pinelliae, musk and others.
  • the primary object of the present invention is to provide a herbal ointment containing a formulated combination of natural therapeutic herbs, which can be applied for treating various bones, muscles and joints-related disorders and illnesses, as well as other neuromuscular problems.
  • Another object of the present invention is to provide a low-viscosity, non-oily or non- sticky medicinal liquid composition that can be comfortably used for topical application, which is prepared according to an optimal ratio between the active ingredients and the oil.
  • Yet another object of the present invention is to provide an innovative method for preparing a medicinal herbal ointment using a simple and energy-saving technique.
  • Still another object of the present invention is to provide an evolving herbal ointment which is free from any unacceptable odour contributed by the traditional medicine, or even imparted with an aromatherapeutic effect in addition to pain-relieving.
  • Further object of the present invention is to create another avenue for the commercialization of various useful traditional medicines.
  • At least one of the preceding objects is met, in whole or in part, by the present invention, in which one of the embodiments of the present invention describes a composition of herbal ointment comprising solvent extracts of active ingredients derived from Rhizoma Pinelliae, wild Arisaema, Radix Aconiti, Radix Aconiti Kusnezoffii, Resina Boswelliae carterii, Resina Commiphorae myrrhae, Sappan wood and Radix Linderae, in an oil blend of methyl salicylate, safflower oil and cinnamon oil.
  • composition of herbal ointment can further comprise solvent extracts of Herbasperanskiae Tuberculatae, Rhizoma ligustici Chuanxiong, Radix Stemonae, Radix Ledebouriellae, Radix Achyranthis Bidentatae, Cortex Acanthopanacis or a combination of any two or more thereof.
  • Another preferred embodiment of the present invention is a composition of herbal ointment which further comprises solvent extracts of Flos Rhododendri Mollis, Violet, Rhizoma Zeodariae, Fructus Cnidii, seed of Impatiens balsamina L., Radix Euphorbiae Ebrateolatae, Cortex Lycii Radixis, Pericarpium Zanthoxyli, Falsehellebore Root and Rhizom, Folium Artemisiae Argyi, Senecio palmatus, Os Draconis, Hydnocarpus seeds, Fructus Chebulae, diverse wormwood herbs or a combination of any two or more thereof.
  • the composition further comprises a raw salt, talcum or the combination thereof.
  • the solvent extracts of active ingredients are present in an amount of 50% to 70% by weight of the composition.
  • the oil blend can further comprise sesame oil, eucalyptus oil, mint oil, camphor oil, turpentine oil, white oil or a combination of any two or more thereof.
  • composition of herbal ointment can further comprise a fragrance.
  • composition according to the preceding embodiments is use of a composition according to the preceding embodiments as a topically applied medicinal oil.
  • Another further embodiment of the present invention is a method for preparing a composition of herbal ointment, comprising the steps of obtaining solvent extracts of active ingredients derived from Rhizoma Pinelliae, wild Arisaema, Radix Aconiti, Radix Aconiti Kusnezoffii, Resina Boswelliae carterii, Resina Commiphorae myrrhae, Sappan wood and Radix Linderae; and mixing the solvent extracts in an oil blend of methyl salicylate, safflower oil and cinnamon oil.
  • the solvent extracts and the oil blend are mixed in a weight ratio of 1 to 3: 1.
  • the solvent extracts are obtained by dissolving the active ingredients in ethanol, ether, methanol, hexane or acetone, for a period range of 1 to 3 weeks.
  • the medicinal herbal ointment of the present invention is prepared by a simple and energy-saving technique, in which the use of heat is eliminated during the preparation process. Unlike the traditional pasting technique, heat is also not required upon the application of the ointment onto the affected area.
  • the medicinal herbal ointment is non-sticky, mild, non-alergenic and odourless or even aromatic, it can be widely accepted by the user. Apart from its therapeutic effects in treating various bones, muscles and joints-related disorders and illnesses, as well as other neuromuscular problems, this medicinal herbal ointment can also be used regularly for strengthening bones and muscles, especially for those who practise martial arts.
  • the present invention relates to a traditional medicine particularly used for treating disorders or illness associated with bones, muscles and joints. More particularly, the present invention provides a herbal ointment containing a formulated combination of natural therapeutic herbs and method for preparing thereof, which can be applied for treating various disorders and illnesses, especially rheumatism, traumatic injury and bone fracture.
  • the invention shall be described according to the preferred embodiments of the present invention and by referring to the accompanying description and drawings. However, it is to be understood that limiting the description to the preferred embodiments of the invention and to the drawings is merely to facilitate discussion of the present invention and it is envisioned that those skilled in the art may devise various modifications without departing from the scope of the appended claim.
  • the present invention discloses a composition of herbal ointment for topical application.
  • the composition of the medicinal herbal ointment contains an aqueous solution of active ingredients which is mixed with an oil blend.
  • the active ingredients are a mixture of powdered or ground plant parts derived from a wide variety of traditional medicinal plants, which includes the Rhizoma Pinelliae, wild Arisaema, Radix Aconiti, Radix Aconiti Kusnezoffii, Resina Boswelliae carterii, Resina Commiphorae myrrhae, Sappan wood and Radix Linderae.
  • the oil blend contains methyl salicylate, safflower oil and cinnamon oil.
  • Rhizoma Pinelliae is the tuber of the plant of Pinelia ternata. It is useful for elimination of swelling.
  • wild Arisaema which can be derived from Arisaema eruhescens or Arisaema heterophyllum Blume is also good at eliminating swelling.
  • wild Arisaema extract is also capable of soothing mosquitoes and insects' bites, as well as preventing tetanus.
  • Radix Aconiti and Radix Aconiti Kusnezoffii are respectively derived from the roots of the Aconitum carmichaeli Debx. and Aconitum kusnezoffii Reichb.
  • Resina Boswelliae carterii and Resina Commiphorae myrrhae are respectively obtained from the resineous compounds of the plants of ' Boswellia carterii and Commiphora myrrha. They can be used to improve blood circulation as well as to relieve pain.
  • the Sappan wood is derived from the plant of Caesalpinia sappan L. It also helps in improving blood circulation, eliminating swelling as well as relieving pain.
  • Radix ' Linderae which is also known as Lindera root is mainly included for better pain- relieving effect.
  • composition of herbal ointment can further comprise solvent extracts of Herbasperanskiae Tuberculatae, Rhizoma ligustici Chuanxiong, Radix Stemonae, Radix Ledebouriellae, Radix Achyranthis Bidentatae, Cortex Acanthopanacis or a combination of any two or more thereof.
  • Herba Speranskiae Tuberculatae is also known as garden balsam stem. Similar to Radix Aconiti, it is also good at relieving pain as well as expelling wind and dampness caused by rheumatism. Besides, it is capable of promoting tendon relaxation as well as blood circulation in human body.
  • Rhizoma Ligustici Chuanxiong also helps in improving blood circulation as well as relieving pain.
  • Radix Stemonae or Stemona root works to treat cold and eczema.
  • Radix Ledebouriellae or Ledebouriella root can help in relieving pain as well as expelling wind and dampness; whereas
  • Radix Achyranthis Bidentatae which is also known as Achyranthes root is capable of treating bruises.
  • Cortex Acanthopanacis is derived from the bark of Acanthopanax gracilistylus, which also provides the similar functions as set forth in the foregoing description, including expelling wind and dampness as well as strengthening bones and tendons.
  • the composition of herbal ointment can further comprise solvent extracts of other active ingredients derived from other therapeutic plant parts, including Flos Rhododendri Mollis, Violet, Rhizoma Zeodariae, Fructus Cnidii, seed of Impatie balsamina L., Radix Euphorbiae Ebrateolatae, Corte Lycii Radixis, Pericarpium Zanthoxyli, Falsehellebore Root and Rhizom, Folium Artemisiae Argyi, Senecio palmatus, Os Draconis, Hydnocarpus seeds, Fructus Chebulae, diverse wormwood herbs or a combination of any two or more thereof.
  • the addition of different active ingredients into the composition in various combination can enhance its pain-relieving as well as bone and joints-strengthening properties in various ways.
  • the composition further comprises a raw salt, talcum or the combination thereof.
  • main components of the oil blend are methyl salicylate, safflower oil and cinnamon oil.
  • the content of the oil blend also provides additional therapeutic functions as these oils are also derived from therapeutic plant parts.
  • methyl salicylate or the wintergreen oil is derived from the plant of Gaultheria spp; whereas the safflower oil is derived from the flower of the Cartamus spp.
  • the safflower (Flos Cartami) can also be used as an active ingredient.
  • the cinnamon oil or oleum cinnamomi is derived from the bark of Cinnamomum spp.
  • Methyl salicylate can be used to sooth muscles and joints discomfort; safflower oil can treat blood clogs and bruises; whereas cinnamon oil helps in relieving pain as well as improving blood circulation.
  • the oil blend can further comprise sesame oil, eucalyptus oil, mint oil, camphor oil, turpentine oil, white oil or a combination of any two or more thereof.
  • Sesame oil is a good carrier oil for use in ointment composition as it can easily penetrate through human skin to reach the bones, muscles and joints.
  • Eucalyptus oil is capable of stanching bleeding; while mint oil helps to relieve pain and camphor oil is capable of killing germs.
  • Turpentine oil is preferred especially when the ointment is prepared as a medicament for rheumatism.
  • Common white oil can also be applied according to the formulation.
  • the active ingredients in the form of solvent extracts and the oil blend is preferably mixed in an optimal ratio in order to provide a liquid solution which is non-oily and not-sticky.
  • the solvent extracts of active ingredients are present in an amount of 50% to 70% by weight of the composition.
  • An example of the ointment formulation is further detailed in Example 1.
  • the herbal ointment produced is substantially odourless.
  • the composition of herbal ointment can further comprise a fragrance.
  • the fragrance can be an aroma compound or an essential oil derived from lavender, rose, sandalwood and others. These aroma compound is capable of providing an aromatherapeutic effect to the user.
  • the present invention also provides a method for preparing the composition of herbal ointment, which comprises the steps of obtaining solvent extracts of active ingredients derived from Rhizoma Pinelliae, wild Arisaema, Radix Aconiti, Radix Aconiti Kusnezoffii, Resina Boswelliae carterii, Resina Commiphorae myrrhae, Sappan wood and Radix Linderae; and mixing the solvent extracts in an oil blend of methyl salicylate, safflower oil and cinnamon oil.
  • the active ingredients of the plant parts are prepared in a powdered or ground form. These powdered active ingredients are dissolved in a suitable solvent to obtain the solvent extracts.
  • the solvent used can be ethanol, ether, methanol, hexane or acetone. More preferably, ethanol or methanol is used.
  • the active ingredients are soaked in the solvent for a period range of 1 to 3 weeks. Subsequently, the solvent extracts and the oil blend are mixed in a weight ratio of 1 to 3: 1. In other words, 1 to 3 parts of the extracts can be mixed with every one part of the oil blend. In accordance with the most preferred embodiment, 2 parts of extracts are mixed with every one part of the oil blend.
  • compositions according to the preceding embodiments are use of a composition according to the preceding embodiments as a topically applied medicinal oil.
  • the herbal ointment of the present invention is deemed a multipurpose medicinal oil as it can be used as a medicament for treating disorders or illnesses associated with bones, muscles and joints, especially rheumatism, traumatic injury or bone fracture. Besides, it can also be applied for strengthening bones, muscles and joints, easing muscular aches and stiffness, relieving pain at joints, bones and soles, treating bruises and sprains, as well as soothing bites and stings.
  • Table 1 shows an exemplary formulation of the medicinal herbal ointment of the present invention.
  • the solvent extracts of Table 1 is obtained by dissolving the following amounts of powdered plant parts in methanol:

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • General Chemical & Material Sciences (AREA)
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Abstract

La présente invention concerne une composition de pommade à base d'herbes comprenant des extraits par solvant de principes actifs issus de Rhizoma pinelliae, d'Arisaema sauvage, de Radix aconiti, de Radix aconiti kusnezoffii, de Resina boswelliae carterii, de Resina commiphorae myrrhae, de bois de sappan et de Radix Linderae, dans un mélange d'huiles de salicylate de méthyle, d'huile de carthame et d'huile de cannelle de Chine ; les extraits par solvant et le mélange d'huiles étant mélangés dans un rapport en poids de 1 à 3:1.
PCT/MY2012/000257 2011-09-27 2012-09-27 Pommade à base d'herbes médicinales Ceased WO2013048235A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI2011700143 2011-09-27
MYPI2011700143 2011-09-27

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WO2013048235A2 true WO2013048235A2 (fr) 2013-04-04
WO2013048235A3 WO2013048235A3 (fr) 2013-06-13

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Cited By (26)

* Cited by examiner, † Cited by third party
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CN103263529A (zh) * 2013-06-17 2013-08-28 崔新明 一种治疗骨折的中药组合物
CN103272028A (zh) * 2013-06-22 2013-09-04 昆明赛诺制药有限公司 一种治疗跌打损伤及风湿痹痛的药物
CN103301260A (zh) * 2013-05-27 2013-09-18 布焕景 一种治疗关节炎的外用药物及其制备方法
CN103550421A (zh) * 2013-11-01 2014-02-05 杨献华 一种熏蒸治疗强直性脊柱炎的中药组合物
CN103565969A (zh) * 2013-11-14 2014-02-12 侯亭美 一种治疗软组织损伤和骨折的中药组合物
CN103599213A (zh) * 2013-11-14 2014-02-26 黄海 一种治疗骨折的药物组合物及其制备方法
CN103610790A (zh) * 2013-12-02 2014-03-05 陈有才 一种骨质疾病外用擦液及其制备方法
CN103690644A (zh) * 2013-10-24 2014-04-02 青岛华仁技术孵化器有限公司 促进骨折康复的中药制剂
CN103751362A (zh) * 2014-01-08 2014-04-30 杨文新 一种用于快速康复内伤的药物的制作方法
CN104306835A (zh) * 2014-09-28 2015-01-28 苏州市天灵中药饮片有限公司 一种治疗跌打损伤的中药制剂及其制备方法
CN104547887A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 一种促进骨头愈合和生长的中药配方
CN104622969A (zh) * 2015-01-09 2015-05-20 泰山学院 一种治疗脚部运动扭伤的中药制剂
CN104644710A (zh) * 2013-11-25 2015-05-27 罗顺爱 治疗跌打损伤的草药
CN104840684A (zh) * 2015-05-27 2015-08-19 济南方宇文化传媒有限公司 用于治疗跌打损伤后引起的红肿的药贴及其制备方法
CN104887734A (zh) * 2015-06-15 2015-09-09 吉林万通药业集团梅河药业股份有限公司 复方三七胶囊及其制备方法
CN104958732A (zh) * 2015-07-23 2015-10-07 韩茜娟 一种治疗风湿骨痛的外用中成药及其制备方法
CN104971129A (zh) * 2015-06-30 2015-10-14 广西油情米意农产品有限公司 外用跌打酒及其配制方法
CN104983888A (zh) * 2015-06-17 2015-10-21 广西油情米意农产品有限公司 一种补气补血酒的配制方法
CN105362769A (zh) * 2015-12-10 2016-03-02 青岛大学附属医院 一种骨科护理用中药配方
CN107260912A (zh) * 2017-08-11 2017-10-20 曾德东 一种治疗骨折的外敷药物及其制备方法
CN108272987A (zh) * 2018-04-24 2018-07-13 金寨县鑫和新能源科技有限公司 一种治疗风湿骨痛的中草药擦剂及其制备方法
CN108310154A (zh) * 2018-03-22 2018-07-24 付映瑰 治疗腰间盘突出和骨质增生的中药组合物及其制备方法
CN108355120A (zh) * 2018-05-17 2018-08-03 李民 一种治疗筋骨伤痛的中药膏
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