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WO2013048169A3 - Method for preparing taxane derivatives - Google Patents

Method for preparing taxane derivatives Download PDF

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Publication number
WO2013048169A3
WO2013048169A3 PCT/KR2012/007885 KR2012007885W WO2013048169A3 WO 2013048169 A3 WO2013048169 A3 WO 2013048169A3 KR 2012007885 W KR2012007885 W KR 2012007885W WO 2013048169 A3 WO2013048169 A3 WO 2013048169A3
Authority
WO
WIPO (PCT)
Prior art keywords
docetaxel
preparing
taxane derivatives
specific structure
preparing taxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/007885
Other languages
French (fr)
Other versions
WO2013048169A2 (en
Inventor
Young Min Kim
Seong Ho Kim
Jin Suk Cho
Moon Suk Kim
Jong Won Yoon
Ho Joon Choi
Jai Young Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Genexbio Corp
Original Assignee
Samyang Genexbio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Genexbio Corp filed Critical Samyang Genexbio Corp
Priority to JP2014533210A priority Critical patent/JP5870197B2/en
Publication of WO2013048169A2 publication Critical patent/WO2013048169A2/en
Publication of WO2013048169A3 publication Critical patent/WO2013048169A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There is provided a method for preparing docetaxel that is a taxane derivative, and more specifically, a method for preparing docetaxel in which since the docetaxel having high purity can be prepared at a high yield through a simple production method including preparing an intermediate having a specific structure of a steric configuration that is the same type as the docetaxel that is a final product from a taxane compound having a specific structure and then semi-synthesizing the docetaxel using them, the method is very suitable for industrial manufacturing.
PCT/KR2012/007885 2011-09-30 2012-09-28 Method for preparing taxane derivatives Ceased WO2013048169A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014533210A JP5870197B2 (en) 2011-09-30 2012-09-28 Method for producing taxane derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110099780A KR101379694B1 (en) 2011-09-30 2011-09-30 Method for preparing taxane derivatives
KR10-2011-0099780 2011-09-30

Publications (2)

Publication Number Publication Date
WO2013048169A2 WO2013048169A2 (en) 2013-04-04
WO2013048169A3 true WO2013048169A3 (en) 2013-06-13

Family

ID=47996638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/007885 Ceased WO2013048169A2 (en) 2011-09-30 2012-09-28 Method for preparing taxane derivatives

Country Status (3)

Country Link
JP (1) JP5870197B2 (en)
KR (1) KR101379694B1 (en)
WO (1) WO2013048169A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100255460B1 (en) * 1992-10-30 2000-05-01 자끄 사비나 Method for preparing taxane derivatives
KR100297197B1 (en) * 1992-10-05 2001-11-26 자끄 사비나 Manufacturing method of taxane derivative
US20040073044A1 (en) * 2002-05-10 2004-04-15 Sharma Arun Prakash Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
KR20080054986A (en) * 2006-12-14 2008-06-19 한미약품 주식회사 Method for preparing docetaxel and intermediates used therein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100297197B1 (en) * 1992-10-05 2001-11-26 자끄 사비나 Manufacturing method of taxane derivative
KR100255460B1 (en) * 1992-10-30 2000-05-01 자끄 사비나 Method for preparing taxane derivatives
US20040073044A1 (en) * 2002-05-10 2004-04-15 Sharma Arun Prakash Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
KR20080054986A (en) * 2006-12-14 2008-06-19 한미약품 주식회사 Method for preparing docetaxel and intermediates used therein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QI, C. M. ET AL.: "A novel method to synthesize docetaxel and its isomer with high yields.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 42, no. 4, 2005, pages 679 - 684, XP002482597 *

Also Published As

Publication number Publication date
WO2013048169A2 (en) 2013-04-04
JP5870197B2 (en) 2016-02-24
KR101379694B1 (en) 2014-03-31
KR20130035466A (en) 2013-04-09
JP2014528408A (en) 2014-10-27

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