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WO2013047960A1 - Système d'imagerie ultrasonore pour l'obtention d'une image focalisée hifu (ultrason focalisé de haute intensité), et procédé de création d'images ultrasonores à l'aide de celui-ci - Google Patents

Système d'imagerie ultrasonore pour l'obtention d'une image focalisée hifu (ultrason focalisé de haute intensité), et procédé de création d'images ultrasonores à l'aide de celui-ci Download PDF

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Publication number
WO2013047960A1
WO2013047960A1 PCT/KR2012/000339 KR2012000339W WO2013047960A1 WO 2013047960 A1 WO2013047960 A1 WO 2013047960A1 KR 2012000339 W KR2012000339 W KR 2012000339W WO 2013047960 A1 WO2013047960 A1 WO 2013047960A1
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WO
WIPO (PCT)
Prior art keywords
ultrasound
image
signal
transmission signal
ultrasonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/000339
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English (en)
Korean (ko)
Inventor
송태경
유양모
장진호
송재희
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI)
Industry University Cooperation Foundation of Sogang University
Korea Health Industry Development Institute
Original Assignee
KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI)
Industry University Cooperation Foundation of Sogang University
Korea Health Industry Development Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI), Industry University Cooperation Foundation of Sogang University, Korea Health Industry Development Institute filed Critical KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI)
Priority to CN201280047734.4A priority Critical patent/CN104093452B/zh
Publication of WO2013047960A1 publication Critical patent/WO2013047960A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia

Definitions

  • the present invention relates to an ultrasound imaging system, and more particularly, by identifying in advance the position where the high-fu energy is focused, it is possible to prevent the necrosis of the unwanted area by the high-fu procedure, the ultrasound for obtaining a high-fu focus image
  • An imaging system and an ultrasound image generating method using the same are particularly, by identifying in advance the position where the high-fu energy is focused, it is possible to prevent the necrosis of the unwanted area by the high-fu procedure, the ultrasound for obtaining a high-fu focus image
  • Ultrasound is an inaudible vibration sound that is very high, with a vibration frequency of 17,000 to 20,000 Hz or more, which is inaudible to the human ear.
  • ultrasonic waves are sounds, not electromagnetic fields or spectrums. Recently, the range of use of such ultrasound therapy is getting wider.
  • HIFU High Intensity Focused Ultrasound
  • Haifu treatment can lessen the trauma of the patient and realize noninvasive treatment.
  • clinical application of Haifu is rapidly developing.
  • These signs include Liver cancer, Bone sarcoma, Breast cancer, Pancreas cancer, Kidney cancer, Soft tissue tumors and Pelvic tumors. It includes.
  • Ultrasound tumor treatment devices generally employ spherical focusing. Ultrasonic waves emitted from all points are directed to the center of the sphere and become focused ultrasound waves. An emitter on the ultrasound therapy device emits ultrasound from the outside of the body to the inside of the body, which is focused during emission and transmission to form a high energy focus point. Thus, high intensity and continuous ultrasound energy is applied to the target region of the subject.
  • the first problem to be solved by the present invention is to provide an ultrasound imaging system that can determine in advance the position where the Haifu energy is focused using ultrasonic energy in a range that does not affect the human body.
  • the second problem to be solved by the present invention is to provide a method for generating an ultrasound image that can prevent the necrosis of the unwanted portion by the hi-fu procedure by grasping the position where the hy-fu energy is focused in advance.
  • the present invention provides a computer-readable recording medium having recorded thereon a program for executing the above method on a computer.
  • the present invention provides a hi-fu transmit beamformer for focusing and delaying a hi-fu transmit signal having a frequency belonging to a frequency response band of an ultrasound image transducer frequency response band and a hi-pu transducer simultaneously to achieve the first object;
  • a hi-fu transformer for transmitting the transmission focused delayed hi-fu transmission signal to a target object;
  • An ultrasound image converter configured to receive an ultrasound signal received from the target object;
  • An image reception beamformer configured to generate a composite beam by focusing the received ultrasonic signal on a reception delay;
  • an ultrasound image generator for generating an ultrasound image from the generated composite beam.
  • the hi-fu transmission signal preferably has a center frequency of the ultrasound image transducer.
  • the center frequency used by the image receiving beamformer and the ultrasonic image generating unit may be the same as the frequency of the hi-fu transmission signal.
  • the ultrasound image when a harmonic component is generated by the hi-fu transmission signal, the ultrasound image may be generated using the center frequency of the hi-fu transmission signal or the harmonic component.
  • the ultrasound imaging system may transmit the hi-fu transmission signal to a target object in synchronization with the timing of generating the scan line.
  • the hi-fu transmission signal may be transmitted to a target object in synchronization with the time when the ultrasound imaging system generates a frame.
  • a method of performing a second focusing method comprising: focusing delaying a hi-fu transmission signal having a frequency belonging to an ultrasound image transducer frequency response band and a frequency response band of a hi-fu transformer; Transmitting the transmission focus delayed hi-fu transmission signal to a target object; Receiving an ultrasonic signal received from the target object; Generating a composite beam by focusing the received ultrasound signal on a reception focusing delay; And generating an ultrasound image from the generated composite beam.
  • the present invention provides a computer-readable recording medium recording a program for executing the above-described method for generating an ultrasound image on a computer.
  • the present invention it is possible to determine in advance the position where the hi-fu energy is focused using ultrasonic energy in a range that does not affect the human body.
  • by grasping in advance the position where the hi-fu energy is focused it is possible to prevent necrosis of the unwanted site by the hi-fu procedure.
  • FIG. 1 is a block diagram of an ultrasound imaging system according to an exemplary embodiment of the present invention.
  • FIG 2 illustrates the frequency response of the hi-fu transducer 110 and the ultrasound image transducer 120 of the ultrasound imaging system according to an embodiment of the present invention.
  • FIG. 3 is a flowchart illustrating an ultrasound image generating method according to an exemplary embodiment of the present invention.
  • An ultrasound imaging system comprises: a hi-fu transmit beamformer for focusing and delaying a hi-fu transmit signal having a frequency belonging to an ultrasound image transducer frequency response band and a frequency response band of a hi-fu transformer; A hi-fu transformer for transmitting the transmission focused delayed hi-fu transmission signal to a target object; An ultrasound image converter configured to receive an ultrasound signal received from the target object; An image reception beamformer configured to generate a composite beam by focusing the received ultrasonic signal on a reception delay; And an ultrasound image generator configured to generate an ultrasound image from the generated composite beam.
  • the present invention is to propose a method of confirming the position of the focus of the hi-fu transmission signal through the ultrasound image before transmitting the hi-fu transmission signal having a strong energy.
  • FIG. 1 is a block diagram of an ultrasound imaging system according to an exemplary embodiment of the present invention.
  • the ultrasound imaging system includes a hi-fu transmit beamformer 100, a hi-fu transducer 110, an ultrasound image transducer 120, an image receive beamformer 130, and an ultrasound image.
  • the generation unit 140, the display unit 150, the focus control unit 160, and the input unit 170 are configured.
  • the hi-fu transmit beamformer 100 applies a variable delay time to the hi-fu transmit signal for each hi-fu transformer 110 according to a position of focusing the hi-fu transmit signal in the target object.
  • the hi-fu transmit beamformer 100 preferably delays the focusing delay of the hi-fu transmit signal having the center frequency of the ultrasound image transducer 120.
  • the hi-fu transformer 110 transmits a transmission focus delayed hi-fu transmission signal to a target object, that is, the lesion site.
  • the hi-fu transmitted signal transmitted to the object is back scattered.
  • the frequency of the hi-fu transmission signal must be simultaneously within the frequency band of the ultrasound image transducer 120 and the frequency band of the hi-fu transducer.
  • the length of the hi-fu transmit signal pulse is as short as possible (for example, within 5 cycles) to ensure axial resolution. It is desirable that the maximum amplitude of the hi-fu transmit signal pulses be as low as possible so as not to harm the tissue of the hi-fu transmit signal focusing position. In other words, it is essential to know in advance the position where the hi-fu energy is focused using ultrasonic energy (for example, 200 W / cm 2 or less) in a range that does not affect the human body.
  • ultrasonic energy for example, 200 W / cm 2 or less
  • the ultrasound image transducer 120 receives an ultrasonic signal scattered back from the target object.
  • the image reception beamformer 130 generates a composite beam by applying a variable delay time to the received ultrasound signal for each ultrasound image transducer 120.
  • the ultrasound image generator 140 generates an ultrasound image from the generated synthesis beam.
  • the center frequency used by the ultrasound imaging system for image and signal processing is equal to the frequency of the hi-fu transmission signal (f 0 : fundamental frequency).
  • the focus image may be acquired using not only the fundamental frequency component but also the harmonic component.
  • the display unit 150 displays the generated ultrasound image.
  • the display unit 150 displays an image generated by receiving a signal from the ultrasound image generator 140 on the screen.
  • the display unit 150 may be a liquid crystal display (LCD), a plasma display panel (PDP), an organic light emitting device (OLED), or the like.
  • the focus control unit 160 compares the position treated by the hi-fu signal from the ultrasound image generated by the ultrasound image generating unit 140 with the target position originally intended to be treated, and transmits the hi-fu signal of the hi-fu transmission beamformer 100. Control to change the focusing position, ie focus.
  • the input unit 170 receives a focus change signal from the user to change the focus by judging from the display unit 150 a difference between a position treated by the hi-fu signal and a target position originally intended to be treated.
  • a synchronization method for constructing an ultrasound image from a hi-fu transmission signal is as follows.
  • the apparatus transmits a hi-fu transmission signal, receives an ultrasound signal, and uses the same to form a hi-fu focus image of one frame.
  • the hi-fu focus image means an image that transmits a hi-fu signal and receives and focuses an ultrasonic signal.
  • a method of transmitting a hi-fu transmission signal to a target object in synchronization with the time when the ultrasound imaging system generates a frame is a method of transmitting a hi-fu transmission signal to a target object in synchronization with the time when the ultrasound imaging system generates a frame.
  • the number of scanning lines necessary for the ultrasound image may be configured to configure the high-fu focus image of one frame.
  • FIG 2 illustrates the frequency response of the hi-fu transducer 110 and the ultrasound image transducer 120 of the ultrasound imaging system according to an embodiment of the present invention.
  • the frequency response of the hi-fu transducer 110 and the frequency response of the ultrasound image transducer 120 are illustrated.
  • the center frequency of the Haifu transmission signal for lesion formation is 1.1 MHz, and the center frequency of the ultrasound transmission signal for obtaining a general ultrasound image is 3.3 MHz.
  • the resonance frequency of the hi-fu transmit transducer 110 is designed to be 1.1 MHz
  • the resonance frequency of the ultrasound image transducer 120 is designed to be 3.3 MHz.
  • the frequency of the hi-fu transmission signal must be simultaneously in the frequency band of the ultrasound image transducer 120 and the frequency band of the hi-fu transducer, and particularly preferably, the frequency ranges from 1.1 MHz to 3.3 MHz.
  • the high-fu transmit signal is preferably 3.3 MHz, which is the center frequency of the ultrasound image transducer 120.
  • a hi-fu transmission signal having a center frequency equal to the center frequency (3.3 MHz) of the ultrasound image transducer 120 should be transmitted.
  • the frequency response of the hi-fu transformer 110 suppresses the signal of 3.3 MHz, the weak hi-fu transmission signal is transmitted.
  • the ultrasound image converter 120 may receive an ultrasound signal and obtain an ultrasound image through a signal processing process.
  • an ultrasound signal having a center frequency equal to that of an ultrasound image transducer is transmitted and received using the ultrasound image transducer.
  • the ultrasound image transducer 120 is There is a difference in obtaining a hi-fu focus image by receiving an ultrasonic signal.
  • FIG. 3 is a flowchart illustrating an ultrasound image generating method according to an exemplary embodiment of the present invention.
  • the ultrasound image generating method according to the present exemplary embodiment includes steps that are processed in time series in the ultrasound imaging system illustrated in FIG. 1. Therefore, even if omitted below, the above description of the ultrasound imaging system illustrated in FIG. 1 is applied to the ultrasound image generating method according to the present embodiment.
  • the ultrasound imaging system focuses and delays a hi-fu transmission signal having a frequency belonging to an ultrasound image transducer frequency response band and a frequency response band of the hi-fu transducer.
  • the ultrasound imaging system transmits the transmission focused delayed hi-fu transmission signal to a target object.
  • a hi-fu transmission signal having a center frequency equal to the center frequency (3.3 MHz) of the ultrasound image transducer 120.
  • the ultrasound imaging system receives an ultrasound signal received from the target object.
  • the ultrasound imaging system In operation 330, the ultrasound imaging system generates a composite beam by focusing the received ultrasound signal on a reception focusing delay.
  • the ultrasound imaging system In operation 340, the ultrasound imaging system generates an ultrasound image from the generated composite beam.
  • the ultrasound image includes a color image or a B mode image.
  • the ultrasound image generator 140 generates an ultrasound image of a treatment area of a patient.
  • the ultrasound image generator 140 may use the video codec to generate a continuous image in which the treatment region moves.
  • the ultrasound image generator 140 may generate a color video signal by receiving the ultrasound signal reflected from the treatment site and providing a spatial and temporal change of the treatment area by using a depth difference according to the progress of the treatment.
  • the average Doppler frequency or average phase value is measured to derive the spatial and temporal changes of the treatment site.
  • Different colors may be preset and stored using the average phase value as a variable, and the average phase value at each image point is converted into a color according to its size and direction and displayed on the screen. That is, the ultrasonic Doppler system is used, and the Doppler phenomenon is a physical phenomenon in which the frequency of the received sound wave changes in proportion to the speed of the movement when there is a relative movement between the sound source and the receiver.
  • the depth difference according to the course of treatment in the subject may be examined in real time to form a color image using the same.
  • the ultrasound image generator 140 may form a B mode image at an image point determined to have a small difference in depth according to the progress of the treatment.
  • the B mode (Brigtness mode) is a mode that displays the size of the echo (echo) coming into the human body on the screen, the bright point means that there is a strong reflector inside the human body, the dark point is hypoechoic (hypoechoic) Show that there is a part.
  • the ultrasound image generator 140 may generate an integrated image signal combining the B mode image and the color image.
  • the ultrasound image generator 140 may determine which signal to select by comparing the B mode image signal and the color image signal of each image point. For example, when the power of the color image signal is greater than a predetermined ratio of the magnitude of the B mode image signal, the color image signal may be selected.
  • Embodiments of the present invention may be implemented in the form of program instructions that can be executed by various computer means and recorded in a computer readable medium.
  • the computer readable medium may include program instructions, data files, data structures, etc. alone or in combination.
  • Program instructions recorded on the media may be those specially designed and constructed for the purposes of the present invention, or they may be of the kind well-known and available to those having skill in the computer software arts.
  • Examples of computer-readable recording media include magnetic media such as hard disks, floppy disks, and magnetic tape, optical media such as CDROMs, DVDs, and magneto-optical media such as floppy disks. (magnetooptical media), and hardware devices specifically configured to store and execute program instructions, such as ROM, RAM, flash memory, and the like.
  • Examples of program instructions include not only machine code generated by a compiler, but also high-level language code that can be executed by a computer using an interpreter or the like.
  • the hardware device described above may be configured to operate as one or more software modules to perform the operations of the present invention, and vice versa.

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  • Engineering & Computer Science (AREA)
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Abstract

La présente invention concerne un système d'imagerie ultrasonore comprenant : un dispositif de formation de faisceau d'émission d'ultrasons focalisés de haute intensité (HIFU) émettant, focalisant et retardant des signaux d'émission HIFU par l'intermédiaire de fréquences qui appartiennent à la fois à une bande de réponse de fréquence pour un transducteur d'image ultrasonore et celle pour un transducteur HIFU ; un transducteur HIFU émettant les signaux d'émission HIFU émis/focalisés/retardés à un sujet ; un transducteur d'image ultrasonore recevant les signaux ultrasonores à partir du sujet ; un dispositif de formation de faisceaux de réception d'image recevant, focalisant et retardant les signaux ultrasonores reçus pour créer des faisceaux synthétiques ; et une unité de création d'image ultrasonore créant des images ultrasonores à partir des faisceaux synthétiques générés. Selon la présente invention, l'emplacement focalisé de l'énergie HIFU peut être reconnu préalablement pour empêcher des parties indésirables d'être surutilisées par une chirurgie HIFU.
PCT/KR2012/000339 2011-09-29 2012-01-13 Système d'imagerie ultrasonore pour l'obtention d'une image focalisée hifu (ultrason focalisé de haute intensité), et procédé de création d'images ultrasonores à l'aide de celui-ci Ceased WO2013047960A1 (fr)

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CN201280047734.4A CN104093452B (zh) 2011-09-29 2012-01-13 超声波像系统及超声波像生成方法

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KR10-2011-0099172 2011-09-29
KR1020110099172A KR101317359B1 (ko) 2011-09-29 2011-09-29 하이푸 초점 영상을 얻기 위한 초음파 영상 시스템 및 이를 이용한 초음파 영상 생성 방법

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Cited By (3)

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CN105854186A (zh) * 2016-03-15 2016-08-17 西安邮电大学 基于量子超弦引擎的中晚期癌症治疗设备
CN111970972A (zh) * 2018-01-24 2020-11-20 尼娜医疗有限公司 以超声粒子速度估计器映射的声波场
US12350526B2 (en) * 2016-07-17 2025-07-08 Nina Medical Ltd Doppler guided ultrasound therapy

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WO2015115689A1 (fr) * 2014-01-29 2015-08-06 알피니언메디칼시스템 주식회사 Appareil d'imagerie à ondes ultrasonores, et procédé de visualisation de mise au point l'utilisant
KR101935375B1 (ko) * 2016-02-01 2019-01-07 서강대학교산학협력단 Ｈｉｆｕ와 초음파 영상을 위한 초음파 치료 장치 및 그 제어 방법
KR102174627B1 (ko) 2018-05-11 2020-11-05 서강대학교산학협력단 실시간 초음파 모니터링을 위한 초음파 잡음 제거 장치 및 방법
TWI742785B (zh) * 2020-01-14 2021-10-11 國立臺灣科技大學 高強度聚焦超音波治療系統及其即時監測方法
KR102670070B1 (ko) * 2021-11-01 2024-06-10 주식회사 티비비테크놀로지 초음파를 이용한 장기 인식 및 초음파 조사시스템
KR102536179B1 (ko) 2022-06-02 2023-05-26 이상구 초음파 장치, 초음파 트랜스듀서 모듈의 제어 방법

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KR20070069322A (ko) * 2005-12-28 2007-07-03 주식회사 메디슨 병변조직을 검출하는 초음파 진단 시스템 및 방법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105854186A (zh) * 2016-03-15 2016-08-17 西安邮电大学 基于量子超弦引擎的中晚期癌症治疗设备
US12350526B2 (en) * 2016-07-17 2025-07-08 Nina Medical Ltd Doppler guided ultrasound therapy
CN111970972A (zh) * 2018-01-24 2020-11-20 尼娜医疗有限公司 以超声粒子速度估计器映射的声波场
US20210045714A1 (en) * 2018-01-24 2021-02-18 Nina Medical Ltd Acoustic field mapping with ultrasonic particle velocity estimator

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