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WO2013045650A3 - Infusion imaging method - Google Patents

Infusion imaging method Download PDF

Info

Publication number
WO2013045650A3
WO2013045650A3 PCT/EP2012/069246 EP2012069246W WO2013045650A3 WO 2013045650 A3 WO2013045650 A3 WO 2013045650A3 EP 2012069246 W EP2012069246 W EP 2012069246W WO 2013045650 A3 WO2013045650 A3 WO 2013045650A3
Authority
WO
WIPO (PCT)
Prior art keywords
imaging
vivo
imaging method
optical
infusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/069246
Other languages
French (fr)
Other versions
WO2013045650A2 (en
Inventor
Andrew Healey
Grethe Tang DALSGAARD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of WO2013045650A2 publication Critical patent/WO2013045650A2/en
Publication of WO2013045650A3 publication Critical patent/WO2013045650A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a method of optical imaging of a mammalian subject in vivo, wherein the imaging agent has been previously administered via intravenous infusion. The imaging agent comprises a peptide which targets c-Met labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are in vivo imaging methods, especially of use in the diagnosis of colorectal cancer (CRC).
PCT/EP2012/069246 2011-09-30 2012-09-28 Infusion imaging method Ceased WO2013045650A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1116862.2A GB201116862D0 (en) 2011-09-30 2011-09-30 Infusion imaging method
GB1116862.2 2011-09-30

Publications (2)

Publication Number Publication Date
WO2013045650A2 WO2013045650A2 (en) 2013-04-04
WO2013045650A3 true WO2013045650A3 (en) 2013-05-23

Family

ID=44994240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/069246 Ceased WO2013045650A2 (en) 2011-09-30 2012-09-28 Infusion imaging method

Country Status (2)

Country Link
GB (1) GB201116862D0 (en)
WO (1) WO2013045650A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139207A2 (en) * 2007-05-16 2008-11-20 Ge Healthcare As Labelled hgf binding peptides for imaging
WO2009016180A2 (en) * 2007-07-31 2009-02-05 Ge Healthcare Limited Peptide imaging agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057155A2 (en) 2001-12-27 2003-07-17 Van Andel Research Institute Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor
ES2396368T3 (en) 2003-03-03 2013-02-21 Dyax Corporation Peptides that specifically bind to the HGF receptor (CMET) and uses thereof
NO20034350D0 (en) 2003-09-29 2003-09-29 Amersham Health As Optical imaging of colorectal cancer
US20080249400A1 (en) 2006-10-06 2008-10-09 University Of Rochester Medical Center Intraoperative Imaging Of Hepatobiliary Structures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139207A2 (en) * 2007-05-16 2008-11-20 Ge Healthcare As Labelled hgf binding peptides for imaging
WO2009016180A2 (en) * 2007-07-31 2009-02-05 Ge Healthcare Limited Peptide imaging agents

Also Published As

Publication number Publication date
GB201116862D0 (en) 2011-11-09
WO2013045650A2 (en) 2013-04-04

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