WO2012133295A1 - Bioabsorbable antiadhesive material containing contrast medium - Google Patents

Abstract

Provided is a bioabsorbable antiadhesive material the arrangement state of which can be checked without incising a patient. This bioabsorbable antiadhesive material is made from a bioabsorbable material which contains a contrast medium. Thus, the boiabsorbable antiadhesive material contains a contrast medium. Therefore, the bioabsorbable antiadhesive material is externally detectable, so that the arrangement state of the bioabsorbable antiadhesive material can be checked without incising a patient.

Description

Bioabsorbable anti-adhesion material containing contrast agent

The present invention relates to a bioabsorbable adhesion preventing material containing a contrast agent.

In the clinical field, in order to prevent adhesion of living tissue, an adhesion preventing material that physically separates the affected area from the surrounding tissue is used. On the other hand, it is desirable that the adhesion preventing material is decomposed and absorbed by a living body after exhibiting the above-described adhesion preventing function within a predetermined period. As materials exhibiting such decomposition and absorption properties, for example, polymers and copolymers containing lactide, caprolactone, and the like as constituent monomers are used (Patent Document 1).

However, after the adhesion preventing material is implanted in the living body, the fixation in the living body may be released or may be damaged due to decomposition before the predetermined period elapses. However, the state of the anti-adhesion material in the living body has no means other than confirming by incising the patient, and this confirmation process is very painful for the patient and is a great effort for the doctor.

JP 2006-297064 A

Therefore, an object of the present invention is to provide a new adhesion preventing material capable of confirming the state of the adhesion preventing material without making an incision after the adhesion preventing material is implanted in a patient's body.

The bioabsorbable antiadhesive material of the present invention is a bioabsorbable antiadhesive material formed from a bioabsorbable material, wherein the bioabsorbable material contains a contrast agent.

Since the bioabsorbable anti-adhesion material of the present invention contains a contrast agent, it can be detected from outside the body, for example. For this reason, according to the bioabsorbable anti-adhesion material of the present invention, for example, the arrangement state can be confirmed without incising the patient. Thus, the present invention is extremely useful in the medical field.

1A and 1B are schematic perspective views showing a configuration example of the bioabsorbable adhesion preventing material of the present invention. FIG. 2 is a photomicrograph showing a cross section of the bioabsorbable anti-adhesion material of Example 1. FIG. 3 is a photograph showing the contrast ability of the contrast agent-containing laminated film of Example 1.

As described above, the bioabsorbable adhesion preventing material of the present invention is an adhesion preventing material formed from a bioabsorbable material, and the bioabsorbable material contains a contrast agent.

The bioabsorbable anti-adhesion material of the present invention is not particularly limited as long as the bioabsorbable material contains the contrast agent, and other configurations and shapes are not particularly limited. The bioabsorbable adhesion-preventing material of the present invention may contain, for example, the contrast agent in a part thereof or the contrast agent in the whole.

The contrast agent is not particularly limited, and can be appropriately selected according to, for example, the type of diagnostic imaging method. The diagnostic imaging method is not particularly limited, and examples thereof include an X-ray diagnostic imaging method, a nuclear magnetic resonance imaging (MRI) diagnostic method, and the like. For example, one type of contrast agent may be used, or two or more types may be used in combination. In the latter case, for example, two or more contrast agents for X-ray image diagnosis may be used in combination, two or more contrast agents for MRI diagnosis may be used in combination, or a contrast agent for X-ray image diagnosis. And a contrast medium for MRI diagnosis may be used in combination.

The contrast agent is not particularly limited. Examples include iodo contrast agents such as iodoxamic acid and iodinated poppy oil fatty acid ethyl ester, and barium sulfate. Barium sulfate is preferred. These contrast agents are suitable for detection by the X-ray diagnostic imaging method, for example. For example, the contrast agent may be any one kind or two or more kinds, and the combination and ratio thereof are not particularly limited and can be set as appropriate.

In addition to these, examples of the contrast agent include paramagnetic metals and compounds containing the paramagnetic metals. The metal is suitable for detection by MRI image diagnosis, for example. Examples of the metal include those that exhibit contrast by interaction with nearby nuclei. Examples of the nearby nuclei include hydrogen nuclei. Specific examples of the metal include gadolinium and iron. Examples of the iron include superparamagnetic iron oxide. Examples of the compound containing metal include ammonium iron citrate. The contrast agent may be, for example, any one type or two or more types, and the combination and ratio thereof are not particularly limited and can be set as appropriate.

The concentration of the contrast agent in the bioabsorbable material is not particularly limited, and can be appropriately set according to the type of the contrast agent, for example. In the layer containing the contrast agent of the bioabsorbable anti-adhesion material, for example, 10 to 50% by weight, preferably 30 to 40% by weight.

The bioabsorbable material preferably contains a bioabsorbable polymer, for example. The bioabsorbable polymer is not particularly limited.

The molecular weight of the bioabsorbable polymer is not particularly limited, and is, for example, 5,000 to 2,000,000, preferably 10,000 to 1,500,000, and more preferably 100,000. ~ 1,000,000. The bioabsorbable polymer may be, for example, a homopolymer or a copolymer. The copolymer may be, for example, a random polymer, a block polymer, a graft polymer, or the like.

The bioabsorbable polymer is not particularly limited, and examples thereof include aliphatic polyester, polyvinyl alcohol, polyethylene glycol, polycarbonate, polyamide, and the like, and preferably aliphatic polyester. The monomer constituting the bioabsorbable polymer is not particularly limited, and examples thereof include lactic acid, lactide, lactone, glycolide, glycolic acid, trimethylene carbonate, ethylene oxide, and paradioxanone. The homopolymer can be synthesized, for example, from any monomer, or the copolymer can be synthesized, for example, by a combination thereof. When the bioabsorbable polymer is a copolymer, the combination of the monomers and the ratio thereof are not particularly limited. Examples of the combination of the monomers include lactide and lactone, glycolide and lactone, and preferably lactide and lactone. The lactide is not particularly limited, and for example, L-lactide, D-lactide and a mixture thereof (D, L-lactide) can be used. The lactide may be synthesized from lactic acid, for example. The lactic acid is not particularly limited, and for example, L-lactic acid, D-lactic acid and mixtures thereof (D, L-lactic acid) can be used. Examples of the lactone include butyrolactone, valerolactone, caprolactone, and the like, and caprolactone is preferable. Specific examples of the lactone include γ-butyrolactone, δ-valerolactone, and ε-caprolactone.

The bioabsorbable polymer may be a natural polymer such as collagen, hyaluronic acid, elastin, chitosan, chitin, chondroitin sulfate, or cellulose. The natural polymer is not particularly limited, and may be, for example, an extract from a living tissue or cell, a product of a transformant, or a synthetic product. The natural polymer may be, for example, a product obtained by further modifying or derivatizing the extract, product or synthetic product.

The bioabsorbable polymer may be, for example, any one of the aforementioned polymers, or may include two or more types, and the combination and ratio thereof are not particularly limited and can be set as appropriate.

The bioabsorbable material may contain, for example, other components in addition to the above-described contrast agent and bioabsorbable polymer. The other components are not particularly limited, and examples thereof include hydroxyapatite and titanium.

The shape of the bioabsorbable adhesion preventing material is not particularly limited, and for example, a sheet shape and a tubular shape are preferable, and a sheet shape is more preferable.

The bioabsorbable adhesion preventing material may be, for example, a single layer or a laminate, and preferably a laminate. The laminate may be, for example, a laminate of the layer containing the contrast agent (contrast agent-containing layer), or a layer containing the contrast agent and a layer not containing the contrast agent (contrast agent-free layer). A laminated body may be sufficient. The contrast agent-containing layer is specifically a layer of the bioabsorbable polymer containing a contrast agent, and the contrast agent-free layer is specifically the bioabsorbable polymer not containing a contrast agent. Layer. The contrast agent-containing layer and the contrast agent-free layer may be, for example, porous or non-porous, respectively, and preferably non-porous.

When the bioabsorbable adhesion preventing material is the laminate, the number of layers is not limited. The lower limit of the number of layers is, for example, 2 layers, preferably 3 layers, more preferably 5 layers, and the upper limit is, for example, 10 layers, 9 layers, preferably 7 layers. is there. The range of the number of layers is, for example, 2 to 10 layers, preferably 3 to 7 layers, and more preferably 5 to 7 layers.

The laminate may be, for example, a laminate having the same composition and / or shape, or a laminate having layers having different compositions and / or shapes. In the latter case, for example, the type and concentration of the contrast agent contained in each layer, the type and concentration of the bioabsorbable polymer, and other compositions are not particularly limited.

When the laminate includes the contrast agent-containing layer and the contrast agent-free layer, the number of layers and the order of lamination are not particularly limited. The concentration of the contrast agent in the contrast agent-containing layer is not particularly limited, and is, for example, 10 to 50% by weight, preferably 30 to 40% by weight. Examples of the contrast agent-free layer include a layer that does not substantially contain a contrast agent. A layer that does not substantially contain a contrast agent is, for example, a layer that does not contain a contrast agent, or a layer in which a contrast agent cannot be detected even if a contrast agent is contained (a layer in which the contrast agent concentration is below the detection limit), Examples thereof include a layer having a concentration that does not function as a contrast agent.

The configuration of the laminate is not particularly limited. The bioabsorbable anti-adhesion material is, for example, in the case of a sheet, the lowermost layer and the uppermost layer in the stacking direction are the contrast agent-free layer, and the middle layer located between the lowermost layer and the uppermost layer (Also referred to as an intervening layer) preferably includes the contrast agent-containing layer. The number of intermediate layers between the lowermost layer and the uppermost layer is not particularly limited, and when it has a plurality of intermediate layers, for example, at least one layer may be the contrast agent-containing layer. The lowermost layer is, for example, the outermost layer on the side in contact with the application site (affected site), and the uppermost layer is, for example, the outermost layer on the side opposite to the lowermost layer. The contrast agent-free layer is superior in strength to the contrast agent-containing layer, for example. Thus, for example, if the lowermost layer and the uppermost layer in contact with the tissue in the body are the contrast agent-free layer, the physical strength of the adhesion preventing material can be further improved. For this reason, for example, the influence of decomposition of the adhesion preventing material due to erosion of the body tissue or body fluid can be delayed. As a result, the shape of the adhesion preventing material can be maintained for a longer period of time, for example. Further, if the contrast agent-containing layer is disposed between the lowermost layer and the uppermost layer, for example, decomposition of the contrast agent-containing layer due to erosion of the body fluid can be suppressed. Thereby, for example, the contrast of the adhesion preventing material can be maintained for a longer period.

Examples of the laminate include a configuration in which two contrast agent-free layers are laminated via the contrast agent-containing layer. Specifically, as shown in FIG. 1A, the laminate has a three-layer structure, the lowermost layer 11 and the uppermost layer 13 are the contrast agent-free layers, and the middle layer 12 is the A contrast agent-containing layer is preferred.

In addition, the laminate includes, for example, a structure in which the contrast agent-containing layer and the contrast agent-free layer are alternately laminated one by one, and the lowermost layer and the uppermost layer include the contrast agent. A non-containing layer is preferred. The number of stacked layers is not particularly limited, and for example, a five-layer structure or a seven-layer structure is preferable. An example of the laminate having a five-layer structure is shown in FIG. This laminated body has a structure in which the contrast agent-containing layers 22 and 24 and the contrast agent-free layers 21, 23, and 25 are alternately stacked one by one. The lowermost layer 21 and the uppermost layer 25 Is the contrast agent-free layer.

Thus, in the case of a laminate in which the contrast agent-containing layer and the contrast agent-free layer are alternately laminated, the concentration of the contrast agent in each contrast agent-containing layer is not particularly limited. However, it may be a different concentration. As a specific example, the laminate is, for example, in the order from the lowest layer to the uppermost layer: first layer (contrast medium-free layer) -second layer (contrast medium-containing layer) -third layer (contrast medium-free layer) -4th layer (contrast medium-containing layer)-5th layer (contrast medium-free layer)-6th layer (contrast medium-containing layer)-7th layer (contrast medium-free layer) The contrast agent concentrations in the fourth layer and the sixth layer may be the same or different, for example. When the contrast agent concentration is different, for example, each contrast agent concentration in the second layer and the sixth layer may be lower or higher than the contrast agent concentration in the fourth layer. In the former case, since the contrast agent concentration in the fourth layer is high, for example, higher contrast can be maintained for a relatively long period of time. In the latter case, since the contrast agent concentrations in the second layer and the sixth layer are high, for example, the difference in contrast between the second layer and the sixth layer becomes large before and after the decomposition. For this reason, the progress degree of decomposition | disassembly of an adhesion preventing material can be confirmed more easily.

The method of using the bioabsorbable antiadhesive material in vivo is not particularly limited. For example, the adhesion preventing material may be used as it is in the form of a sheet, or may be used in the form of being wound into a cylindrical shape. The latter is preferable when used for tendons, nerves, fallopian tubes, and the like. The living body is not particularly limited, and examples thereof include mammals. The mammal is not particularly limited, and examples thereof include humans, monkeys, dogs, cats, horses, cows, sheep, goats, pigs, mice, rats, rabbits, and hamsters.

The method for producing the bioabsorbable anti-adhesion material of the present invention is not particularly limited, and a known method can be adopted except that a contrast agent is used. As an example of the bioabsorbable adhesion-preventing material of the present invention, a method for producing a laminate including the contrast agent-containing layer and the contrast agent-free layer will be described below. The following method is an example, and the present invention is not limited to this.

First, the bioabsorbable polymer and a solvent are mixed to prepare a polymer solution. The solvent is preferably one that can dissolve the bioabsorbable polymer, for example, dichloromethane, chloroform, 1,4-dioxane, acetone, toluene, benzene, methyl ethyl ketone, dimethyl carbonate, dimethylformamide, hexafluoroisopropanol, and the like. And organic solvents such as water and aqueous solvents such as water. The solvent may be, for example, any one kind or a mixed solvent of two or more kinds. The solvent may be, for example, a mixed solvent of the organic solvent and the aqueous solvent. In the mixed solvent, the ratio of the solvent to be combined is not particularly limited. The concentration of the bioabsorbable polymer in the polymer liquid is not particularly limited, and is, for example, 1 to 10 w / v%, preferably 3 to 7 w / v%.

Then, the contrast agent is added to the polymer solution to prepare a contrast agent-containing polymer solution. In the contrast agent-containing polymer solution, the ratio of the contrast agent to 100% by weight of the bioabsorbable polymer is not particularly limited, and is, for example, 10 to 50% by weight, preferably 30 to 40% by weight.

Next, a sheet-like base material is prepared. Examples of the sheet-like base material include a silicon sheet. The magnitude | size of the said base material is not restrict | limited in particular, For example, it can set suitably according to the magnitude | size of the adhesion prevention material to manufacture.

Furthermore, the base material is first immersed in a polymer solution not containing the contrast agent. The immersion time is not particularly limited, and is, for example, 1 to 10 seconds, preferably 1 to 5 seconds. The immersion temperature is not particularly limited, and is, for example, 4 to 50 ° C., preferably 10 to 40 ° C., and more preferably 20 to 30 ° C. After the immersion, the substrate is pulled up from the polymer solution and dried. Thereby, the contrast agent-free layer is formed on the surface of the substrate. The drying time is not particularly limited, and is, for example, 10 to 60 minutes, preferably 20 to 40 minutes. The drying temperature is not particularly limited, and is, for example, 4 to 50 ° C., preferably 10 to 40 ° C., and more preferably 20 to 30 ° C. The dipping and drying steps may be performed once, or may be repeated several times until a desired thickness is obtained. The thickness of the contrast agent-free layer is not particularly limited, and is, for example, 10 to 100 μm.

Subsequently, the base material on which the contrast agent-free layer is formed is immersed in the contrast agent-containing polymer solution. The immersion time is not particularly limited, and is, for example, 1 to 10 seconds, preferably 1 to 5 seconds. The immersion temperature is not particularly limited, and is, for example, 4 to 50 ° C., preferably 10 to 40 ° C., and more preferably 20 to 30 ° C. After the immersion, the substrate is pulled up from the polymer solution and dried. Thereby, the contrast agent-containing layer is formed on the contrast agent-free layer. The drying time is not particularly limited, and is, for example, 10 to 60 minutes, preferably 20 to 40 minutes. The drying temperature is not particularly limited, and is, for example, 4 to 50 ° C., preferably 10 to 40 ° C., and more preferably 20 to 30 ° C. The dipping and drying steps may be performed once, or may be repeated several times until a desired thickness is obtained. The thickness of the contrast agent-containing layer is not particularly limited and is, for example, 10 to 100 μm.

Then, the base material is again immersed in a polymer solution not containing the contrast agent, and the contrast agent-free layer is formed in the same manner. As a result, a laminate having a three-layer structure of a contrast agent-free layer-a contrast agent-containing layer-a contrast agent-free layer can be formed. And the bioabsorbable adhesion prevention material of this invention is obtained by peeling the said laminated body from the said base material. The frequency | count and order of the formation process of the said contrast agent non-containing layer and the said contrast agent content layer are not restrict | limited at all, and can be suitably determined according to the structure of a desired adhesion prevention material. The thickness of the adhesion preventing material is not particularly limited, and is, for example, 50 to 400 μm.

In addition to this, the method for producing the bioabsorbable anti-adhesion material of the present invention includes, for example, a method using a heat press. The contrast agent-free layer is formed into a sheet by, for example, hot pressing the bioabsorbable polymer, and the contrast agent-containing layer is formed into a sheet by, for example, hot-pressing a mixture of the bioabsorbable polymer and the contrast agent. To do. And the said anti-adhesion material can be formed by laminating | stacking the obtained sheet-like said contrast agent non-containing layer and the said contrast agent content layer, and also heat-pressing.

Also, examples of the method for producing the bioabsorbable anti-adhesion material of the present invention include a method using a casting method. Specifically, the contrast agent-free layer is produced, for example, as follows. First, the bioabsorbable polymer and a solvent are mixed to prepare a polymer solution. The solvent is not particularly limited, and examples thereof are the same as described above. The concentration of the bioabsorbable polymer in the polymer liquid is not particularly limited, and is, for example, 1 to 10 w / v%, preferably 3 to 7 w / v%. Next, the polymer solution is poured into a mold and the solvent is volatilized to form the bioabsorbable polymer into a sheet. Moreover, the said contrast agent content layer mixes the said bioabsorbable polymer and the said contrast agent, and also mixes the said mixture and a solvent, for example, and prepares a contrast agent containing polymer liquid. The solvent is not particularly limited, and examples thereof are the same as described above. The concentration of the bioabsorbable polymer in the contrast agent-containing polymer liquid is not particularly limited, and is the same as that of the bioabsorbable polymer liquid. Further, the ratio of the contrast agent to 100% by weight of the bioabsorbable polymer is not particularly limited, and is, for example, 10 to 50% by weight, preferably 30 to 40% by weight. And the said contrast agent containing polymer liquid is poured into a casting_mold | template, and the said solvent is volatilized, The said mixture is made into a sheet. And the said anti-adhesion material can be formed by laminating | stacking the obtained sheet-like said contrast agent non-containing layer and the said contrast agent content layer, and also heat-pressing.

Further, the bioabsorbable anti-adhesion material of the present invention can be produced by using, for example, the hot press method and the casting method in combination. For example, one of the contrast agent-free layer and the contrast agent-containing layer is produced by a hot press method and the other is produced by a cast method, and the obtained sheet-like contrast agent-free layer and the contrast agent-containing layer are obtained. And may be laminated by hot pressing. As a specific example, for example, there is a combination in which the contrast agent-free layer is produced by the hot press and the contrast agent-containing layer is produced by a casting method.

The bioabsorbable anti-adhesion material of the present invention may further contain a reinforcing material, for example. By providing the reinforcing material, the bioabsorbable anti-adhesion material of the present invention can further improve the physical strength of the entire anti-adhesion material, for example, without impairing its decomposability.

The type of the reinforcing material is not particularly limited, and is preferably formed from a bioabsorbable material, for example. The bioabsorbable material is not particularly limited and is as described above. The shape of the reinforcing material is not particularly limited, and for example, a mesh-like sheet is preferable. In the bioabsorbable adhesion-preventing material of the present invention, the position of the reinforcing material is not particularly limited, and is preferably included in the contrast agent-containing layer, for example. By including the reinforcing material in the contrast medium-containing layer, for example, decomposition of the contrast medium-containing layer due to erosion of the body fluid can be further suppressed. For this reason, for example, the contrast of the bioabsorbable adhesion preventing material of the present invention can be maintained for a longer period of time.

The arrangement method of the reinforcing material is not particularly limited. For example, the mesh sheet is prepared in advance as a reinforcing material, and the sheet is disposed on the base material or a contrast agent-free layer formed on the base material. And the said base material is immersed in a contrast agent containing polymer liquid, maintaining the state which has arrange | positioned the said sheet | seat. As a result, the contrast agent-containing polymer liquid penetrates into the gaps of the mesh of the sheet. After the immersion, the contrast agent-containing layer containing the reinforcing material can be formed by performing a drying process in the same manner as described above.

The bioabsorbable anti-adhesion material may be produced by, for example, producing a long laminate and then cutting it to a desired length, or directly producing an adhesion prevention material having a desired length. In addition, the bioabsorbable adhesion preventing material of the present invention is not limited to the above-described immersion molding method, heat press method, and cast method, and may be molded using a method such as extrusion molding or injection molding. Moreover, the manufacturing method of the said bioabsorbable adhesion prevention material may further include other processes, such as a sterilization process, for example.

The bioabsorbable adhesion preventing material may be subjected to a surface modification treatment on at least one of the lower surface (exposed surface of the lowermost layer) and the upper surface (exposed surface of the uppermost layer), for example. The surface modification treatment is not particularly limited, and examples thereof include hydrophilic treatment and hydrophobic treatment. The hydrophilic treatment and the hydrophobic treatment are not particularly limited, and conventionally known methods can be employed.

The bioabsorbable anti-adhesion material can be used, for example, disposed in the living body. The arrangement method is not particularly limited, and can be appropriately set according to a target site. For example, the bioabsorbable adhesion preventing material may be sutured together with tissue in the living body. By the suturing, for example, the bioabsorbable anti-adhesion material can be more reliably fixed to the tissue in the living body. The bioabsorbable anti-adhesion material can be easily applied to, for example, a complicated and narrow tissue, and may be disposed at a target site using an endoscope or the like.

The adhesion preventing method of the present invention comprises a step of arranging the bioabsorbable adhesion preventing material of the present invention in a living body, and detecting the contrast agent in the living body at a desired time, thereby It is characterized by confirming. The method of the present invention can be said to be a method for confirming the bioabsorbable anti-adhesion material of the present invention, for example. According to the confirmation step, the shape, remaining rate, and the like of the bioabsorbable adhesion preventing material can be confirmed by detecting the contrast agent.

The medical device of the present invention includes the bioabsorbable adhesion preventing material of the present invention. The medical device may include, for example, an endoscope in addition to the bioabsorbable adhesion preventing material of the present invention.

Next, examples of the present invention will be described. However, the present invention is not limited by the following examples.

Example 1
A sheet-like bioabsorbable anti-adhesion material containing barium sulfate as a contrast agent was prepared.

(1) Production of bioabsorbable adhesion-preventing material A copolymer of L-lactide and ε-caprolactone (hereinafter also referred to as “P (LA / CL)”) was used as a bioabsorbable polymer. The P (LA / CL) had a molecular weight of 360,000 and an L-lactide content of 69 mol%. The P (LA / CL) was hot-pressed at 150 ° C. for 15 minutes to produce a non-porous film-like contrast agent-free layer 1. The thickness of the contrast agent-free layer 1 was 120 μm.

On the other hand, the P (LA / CL) and barium sulfate were mixed at a weight ratio of 100: 40. The said mixture was mixed with dichloromethane so that it might become 3.5 w / v%, and the contrast agent containing polymer liquid was prepared. And the said mixture was formed into a film by the casting method using the said contrast agent containing polymer liquid. The casting method was performed by pouring the contrast agent-containing polymer solution into a mold and volatilizing the dichloromethane. As a result, a non-porous film-like contrast agent-containing layer was produced. The thickness of the contrast agent-containing layer 2 was 30 μm.

Then, the contrast agent-free layer 1, the contrast agent-containing layer 2, the contrast agent-free layer 1, the contrast agent-containing layer 2, and the contrast agent-free layer 1 are laminated in this order, and a five-layer structure The laminated film was hot pressed at 130 ° C. for 2 minutes. In this way, a sheet-like bioabsorbable adhesion-preventing material was produced in which the contrast agent-free layer and the contrast agent-containing layer were alternately laminated (hereinafter also referred to as “contrast agent-containing laminated film”). ). The contrast agent-containing laminated film had a thickness of 240 μm.

(2) Evaluation of contrast agent-containing laminated film The cross section of the contrast agent-containing laminated film was confirmed with a microscope. The result is shown in FIG. FIG. 2 is a photograph showing the result of cross-sectional observation (× 200) of the contrast agent-containing laminated film. As shown in FIG. 2, the contrast agent-containing laminated film is a laminate of all five layers in which the contrast agent-free layer and the contrast agent-containing layer are alternately laminated in order from the lowest layer. It could be confirmed.

Next, the imaging ability of the contrast agent-containing laminated film was confirmed. The result is shown in FIG. 3A is a photograph taken under normal conditions (natural conditions), and FIG. 3B is a photograph taken with X-ray CT. As shown in FIG.3 (b), the shape of the said contrast agent containing laminated | multilayer film was clearly imaged by X-ray CT imaging | photography. From this result, it was confirmed that the contrast agent-containing laminated film had a contrast ability.

As mentioned above, although this invention was demonstrated with reference to embodiment, this invention is not limited to the said embodiment. Various changes that can be understood by those skilled in the art can be made to the configuration and details of the present invention within the scope of the present invention.

This application claims priority based on Japanese Patent Application No. 2011-0756559 filed on Mar. 30, 2011, the entire disclosure of which is incorporated herein.

As described above, since the bioabsorbable anti-adhesion material of the present invention contains a contrast agent, for example, detection from outside the living body is possible. For this reason, according to the bioabsorbable anti-adhesion material of the present invention, for example, the arrangement state can be confirmed without incising the patient. Thus, the present invention is extremely useful in the medical field.

11 Lowermost layer 12 Middle layer 13 Uppermost layer 21 Lowermost layer (contrast medium-free layer)
22, 24 Contrast medium-containing layer 23 Contrast medium-free layer 25 Top layer (contrast medium-free layer)

Claims (9)

A bioabsorbable anti-adhesion material formed from a bioabsorbable material,
A bioabsorbable adhesion preventing material, wherein the bioabsorbable material contains a contrast agent. The bioabsorbable adhesion preventing material according to claim 1, wherein the bioabsorbable material contains a bioabsorbable polymer. The bioabsorbable antiadhesive material according to claim 2, wherein the bioabsorbable polymer comprises a copolymer of lactide and caprolactone. The bioabsorbable anti-adhesion material according to claim 1, wherein the contrast agent is at least one of barium sulfate and an iodine contrast agent. The bioabsorbable adhesion preventing material according to claim 1, wherein the adhesion preventing material is a laminate. The bioabsorbable antiadhesive material according to claim 5, wherein the antiadhesive material is in the form of a sheet. The bioabsorbable adhesion-preventing material according to claim 1, wherein the adhesion-preventing material is a laminate of a layer containing the contrast agent and a layer not containing the contrast agent. The bioabsorbable antiadhesive material according to claim 1, wherein the antiadhesive material is a laminate of three or more layers. The bioabsorbable adhesion-preventing material according to claim 8, wherein in the adhesion-preventing material, two layers that do not contain the contrast agent are laminated via the layer containing the contrast agent.

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