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WO2012129804A1 - Appareil et procédé pour détecter un déplacement, et système d'assistance radiothérapeutique - Google Patents

Appareil et procédé pour détecter un déplacement, et système d'assistance radiothérapeutique Download PDF

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Publication number
WO2012129804A1
WO2012129804A1 PCT/CN2011/072333 CN2011072333W WO2012129804A1 WO 2012129804 A1 WO2012129804 A1 WO 2012129804A1 CN 2011072333 W CN2011072333 W CN 2011072333W WO 2012129804 A1 WO2012129804 A1 WO 2012129804A1
Authority
WO
WIPO (PCT)
Prior art keywords
force
displacement measuring
tissue
displacement
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2011/072333
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English (en)
Chinese (zh)
Inventor
季匡华
田德之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZENSIM ENTERPRISE CO Ltd
Original Assignee
ZENSIM ENTERPRISE CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZENSIM ENTERPRISE CO Ltd filed Critical ZENSIM ENTERPRISE CO Ltd
Priority to PCT/CN2011/072333 priority Critical patent/WO2012129804A1/fr
Publication of WO2012129804A1 publication Critical patent/WO2012129804A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam

Definitions

  • the present invention relates to a displacement measuring device and method, and more particularly to a displacement measuring device and method for tissue application.
  • the invention also relates to a radiation therapy assist system. Background technique
  • Radiation therapy is an extremely important medical treatment for cancer and oncology.
  • the main principle is to give the target individual a certain amount of radiation to directly or indirectly kill cancer cells or tumor cells through the energy released by the action. Achieve the purpose of disease control.
  • the radiation acts on all cells indiscriminately, normal tissue is often accidentally injured during the treatment.
  • tumor localization technology is most commonly applied to tumor radiotherapy in the chest and abdomen to solve the tumor displacement caused by the movement of the chest, the intra-abdominal organs or tissues, especially in lung cancer or liver cancer patients.
  • This condition is more obvious, mainly because the location of the tumor is adjacent to the diaphragm, such as the tip of the lung or the upper edge of the liver, so that the breathing is inevitably affected by the rise or fall of the diaphragm, and with the lungs. Or the liver is displaced, affecting the area where the medical staff fixed the radiation therapy, resulting in poor treatment or side effects on normal tissues.
  • other physiological phenomena such as heartbeat, swallowing, or gastrointestinal motility can also cause changes in the position or shape of the tumor.
  • the object of the present invention is to provide a displacement measuring device, a method and a radiation therapy auxiliary system, It can replace optical monitoring in a way that senses changes in force, overcoming the shortcomings of known means to accurately measure tissue displacement under non-invasive conditions, such as assisted radiation therapy to reduce safety margins and normal tissue The chance of causing side effects, while allowing for an increase in the dose of radiation, enhances the therapeutic effect of the tumor.
  • Another object of the present invention is to provide a displacement measuring device and method capable of accurately measuring a tissue displacement amount in a manner of sensing a change in force, thereby assisting a medical detection system to eliminate, for example, an image scanning or capturing process.
  • a model that is more realistic is established.
  • the present invention can be implemented by the following technical solutions.
  • a displacement measuring device is applied to a tissue, and the displacement measuring device comprises a load member, a pressing member and a force sensing module.
  • the pressing part directly or indirectly resists the tissue.
  • the force sensing module has at least one force reaction component, and the force reaction component is disposed between the load component and the pressing component.
  • the load member receives an external force, and the force sensing module calculates the displacement of the tissue by sensing the force response component.
  • the tissue is a tumor tissue or a cancer tissue.
  • the force-responsive component is a resistive, capacitive or strain gauge force sensor.
  • the force-responsive component is disposed below the load member.
  • the force sensing module includes a strained member and a joint support member.
  • the load member is coupled to one end of the strain member, and the connection support member is connected to the other end of the strain member and the pressing member.
  • the force-responsive component is disposed between the load member and the position at which the connection support member is coupled to the strain member.
  • the load member is coupled to a fixture and the external force is provided by the fixture.
  • the displacement measuring device further includes a display module electrically connected to the power sensing module.
  • a radiation therapy assisting system comprises a displacement measuring device, a supporting device and a driving device having the aforementioned technical features.
  • the support device supports a body.
  • the driving device is coupled to the supporting device, and the supporting device moves the individual according to the displacement amount of the tissue measured by the displacement measuring device.
  • a displacement measuring method is applied to an organization.
  • the tissue displacement measurement method is combined with a displacement measuring device.
  • the displacement measuring device includes a load member, a pressing member, and a force sensing module.
  • the force sensing module has at least one force reaction component, and the force reaction component is disposed between the load member and the pressing member.
  • the displacement measuring method comprises the following steps: pressing the member directly or indirectly against the tissue; when the tissue is displaced, receiving an external force by the load member; and calculating the displacement of the tissue by sensing the force reaction component by the force sensing module the amount.
  • the tissue is a tumor tissue or a cancer tissue.
  • the force-responsive component is a resistive, capacitive or strain gauge force sensor.
  • the force-responsive component is disposed below the load member.
  • the force sensing module includes a strained member and a joint support member.
  • the load member is coupled to one end of the strain member, and the other end of the strain member is coupled to the support member. Resist the parts.
  • the force-responsive component is disposed between the load member and the position at which the connection support member is coupled to the strain member.
  • the load member is coupled to a fixture and the external force is provided by the fixture.
  • the displacement measuring device further includes a display module electrically connected to the power sensing module.
  • the displacement measurement method further includes the following steps: displaying the force sensing module to sense a force obtained by the reaction component in the display module.
  • a displacement measuring device and method can sense a change in force generated by a displacement corresponding to a target tissue through a setting of a force sensing module and a force-responsive component thereof, thereby calculating a The amount of displacement of the tissue is a real-time measurement technique.
  • the pressing member is directly or indirectly pressed against the target tissue, and the load member can be simply fixed, the measurement can be performed, so that even if the target tissue is located in the body cavity of the individual, no additional surgery is required, which is also called A simple and non-invasive measurement technique.
  • the displacement measuring device and method of the present invention provides an alternative to optical monitoring means as compared to known techniques, and this technique does not require indirect access to complex camera systems and tags.
  • the screen does not need to perform a large number of subsequent image analysis through software programs, but instead directly changes the power to avoid possible errors, and at the same time, the device can be simplistic and easy to integrate with existing medical instruments.
  • the control drive can drive the individual to move in the opposite direction, offsetting the displacement of the tumor tissue caused by the individual during breathing, and achieving the goal that the tumor is stationary or almost stationary relative to the radiation therapy device. Therefore, the treatment of high irradiation dose can be concentrated, and the tumor control rate is high, and a better therapeutic effect is obtained.
  • FIG. 1 is a schematic structural view of a displacement measuring device according to a first embodiment of the present invention
  • FIG. 2 is a schematic view showing the structure of the displacement measuring device of FIG. 1 pressed against a chest;
  • FIG. 3 is a system block diagram of a power sensing module according to a first embodiment of the present invention.
  • FIG. 4 is a schematic view showing the appearance of a displacement measuring device according to a second embodiment of the present invention
  • FIG. 5 is a side view showing the displacement measuring device shown in FIG.
  • FIG. 6 is a schematic diagram of a system of a radiation therapy assisting system according to an embodiment of the present invention
  • FIG. 7 is a flow chart showing the steps of a displacement measuring method according to an embodiment of the invention.
  • Processing components 136 Storage component
  • the displacement measuring device 1 is applied to a tissue, and includes a load member 1 1 , a pressing member 12 and a force sensing module 13 . It should be noted, however, that the main structure of the displacement measuring device 1 shown in Fig. 1 is not an integral part, especially the force sensing module 13, and the relevant details will be further explained as follows.
  • the load member 1 1 can be used to load an external structure or an external force, and the pressing member 12 can be directly or indirectly pressed against the tissue.
  • the force sensing module 13 has at least one force reaction component 13 1, and the force reaction component 131 is disposed between the load member 1 1 and the pressing member 12.
  • the force sensing module 13 has only one force reaction component 131, and the force reaction component 13 1 is disposed under the load member 1 1 as an example, but in other embodiments, the force The sensing module 13 can have two or three force-reactive components 13 1 and surround the central axis of the load component 1 1 to increase accuracy for different targets or with average values, respectively.
  • FIG. 2 is a schematic diagram of the displacement measuring device of FIG. 1 pressing against the tissue located in the chest.
  • the tissue T in the chest B and the chest B is inevitably driven at the same time due to the individual inhaling.
  • a displacement external force F D is received by the pressing member 12.
  • the displacement external force F D should be lifted up and the moving part 12 is moved, but since the load member 11 is connected to the non-movable or adjustable external fixing device 15, the load member 11 will thus bear the external fixing device 15
  • Another external force hereinafter referred to as a fixed external force F x
  • the force reaction component 131 is partially deformed, and the force sensing module 13 senses the shape variable as a basis for calculating the T displacement amount of the tissue.
  • the force reaction component 131 may specifically be a resistive, capacitive or strain force sensor, and depending on the type, the corresponding housing or other component structure is selected.
  • the force-reaction component 131 is a capacitive force sensor, it may be two thin conductive plates with an insulating buffer material interposed therebetween, and the upper and lower outer sides are provided with a protective member, when subjected to a displacement external force F D With fixed external force? At this time, the two thin conductive plates are each deformed and the pitch is shortened to form a sensible capacitance change. Referring to FIG.
  • the force-responsive component 131 is the strain-type force sensor of the embodiment, it may be a strain gauge disposed in the housing 132, and the strain gauge may also be deformed under the action of two external forces. , causing a change in the resistance value, which becomes an object for sensing and judging the magnitude of the force value.
  • the force sensing module 13 includes, for example, a sensing circuit, an amplifier, a processing component, or a memory component in addition to the partial structure shown in FIG. 1 or FIG.
  • FIG. 3 it is a system block diagram of the power sensing module according to the first embodiment of the present invention, and the force-responsive component 131 is a strain-type force sensor as an example.
  • the force sensing module 13 is electrically connected to the force response component 131 by the sensing circuit 133, and senses the voltage difference generated by the force response component 131 due to the resistance change after the force is applied.
  • the sensing circuit 133 can be a Wheatstone bridge circuit to improve sensing sensitivity and stability.
  • the sensing circuit 133 can be reconnected to the amplifier 134 to amplify the sensed voltage difference signal.
  • the signal output by the amplifier 134 is sent to the processing component 135, and combined with the data of a series of tissues T stored in the storage component 136, the amount of displacement of the tissue T can be calculated.
  • the data related to the organization T may be, for example but not limited to, power-displacement parameter data, which is jointly established by the force magnitude data and the fluorescence photography photo data acquired at the same time. Of course, the data established by other methods and data may also be used. The invention is not limited in use.
  • the displacement measuring device 1 can cooperate with the learning before the operation.
  • the mode or correction mode is used as an aid to obtain a set of learning data or correction data in advance.
  • the housing 132 is covered with the force-reactive component 131, and the sensing circuit 133 is further disposed to form a whole body.
  • the unit can be a load cell, and the application can be operated only by connecting the exposed circuit of the sensing circuit 133.
  • the processing component 135 and the storage group The device 136 can additionally be part of a stand-alone computer to provide functionality over a line connection, as can the amplifier 134.
  • the power sensing module 13 in the present invention may be a combination of a plurality of units or components connected through a line without being limited to be all disposed in the same housing.
  • the user can selectively configure the components shown in FIG. 3 as needed, for example, in other aspects, only the force-reactive component 131 can be disposed between the load member 11 and the pressing member 12.
  • the external sensing circuit 133 and the like are not particularly limited in the present invention.
  • the displacement measuring device 1 further includes a display module 14 electrically connected to the power sensing module 13, preferably electrically connected to the amplifier 134 of the power sensing module 13 for the user. Directly observe the sensing results or data.
  • the force sensing module 43 of the displacement measuring device 4 includes a strain member 437 and a joint supporting member 438.
  • the load member 41 has a load platform 411 and a lower extension portion 412.
  • the load platform 411 is coupled to the fixture 45, and the lower extension portion 412 is coupled to one end of the strain member 437.
  • the joint support member 438 connects the other end of the strain member 437 and the pressing member 42.
  • the force reaction assembly 431 is disposed between the load member 41 and the position where the connection support member 438 is coupled to the strain member 437.
  • the displacement measuring device of the present invention can be used in a variety of applications, including medical testing and therapeutic assistance, but preferably as a radiation therapy assisting system. Therefore, please refer to FIG. 6, which is a schematic diagram of a system of a radiation therapy assisting system according to an embodiment of the present invention.
  • the radiation therapy assisting system AS includes a displacement measuring device 6 having the foregoing features.
  • a supporting device 7 and a driving device 8 are connected to each other by wire or wirelessly, but the contents of the drawings are clear, and the devices are not drawn to scale.
  • the support device 7 supports a body BD, usually a cancer patient, and the displacement measuring device 6 is adapted to measure the displacement of the tumor tissue T' or cancer tissue in the individual BD.
  • the displacement measuring device 6 is adapted to measure the displacement of the tumor tissue T, or the cancer tissue located in the thoracic cavity or the abdominal cavity, or adjacent to the diaphragm, and is disposed on the chest or abdominal cavity of the individual BD.
  • the resulting chest undulation or diaphragmatic levitation may cause the tumor tissue T' or cancer tissue to be displaced, but if combined with the radiation therapy assisting system AS of the present invention,
  • the displacement amount of the tumor tissue is measured according to the displacement measuring device 6 and outputs a signal, and the driving device 8 drives the support device 7 to move the individual BD-relative amount in the reverse direction according to the signal, thereby using the tumor tissue T 'Displacement offsets each other, maintains the position of tumor tissue T', reduces the safety margin and the probability of side effects in normal tissues, and can also increase the dose of radiation, thereby improving the therapeutic effect of the tumor.
  • the displacement is not limited to the axial direction Y', but may also be in the axial direction X, or Z, so that the supporting device 7 can be correspondingly simultaneously or sequentially in three Individual BDs are moved in any combination of axes.
  • the displacement measuring device can also be applied to, for example, computed tomography.
  • computed tomography computed tomography, CT for short
  • MRI magnetic resonance imaging
  • PET positron emission tomography
  • proton therapy or phototherapy tomotherapy
  • the ground assists, for example, the displacement of the target object when the individual breathes, to eliminate image artifacts and improve resolution.
  • Figure ⁇ is a flow chart showing the steps of a displacement measurement method according to an embodiment of the present invention.
  • the displacement measurement method is applied to a tissue and cooperates with a displacement measuring device.
  • the displacement measuring device comprises a load component, a pressing component and a force sensing module.
  • the force sensing module has at least one force reaction component, and the force reaction component is sandwiched between the load component and the pressing component.
  • the detailed technical features of the displacement measuring device are substantially the same as those described in the first embodiment. For reference, the foregoing description is omitted.
  • the displacement measuring method comprises the steps of: directly or indirectly pressing the tissue against the pressing member (S71); when the tissue is displaced, receiving an external force with the load member (S73); and transmitting the force through the force sensing module
  • the reaction component calculates the amount of displacement of the tissue (S75).
  • the displacement measurement method may further include a step of displaying the data obtained by the force sensing module sensing the force response component in the display module after the step S75.
  • the force sensing module and its force reaction component can be set to sense the change of the force generated by the displacement corresponding to the target tissue, thereby calculating the The amount of displacement of the tissue is a real-time measurement technique.
  • the pressing member is directly or indirectly pressed against the target tissue, and the load member can be simply fixed, the measurement can be performed, so that even if the target tissue is located in the body cavity of the individual, no additional surgery is required, and it can also be called a A simple and non-invasive measurement technique.
  • the displacement measuring device and method of the present invention provides an alternative to optical monitoring means as compared to known techniques, and this technique does not require indirect access to complex camera systems and tags.
  • the screen does not need to perform a large number of subsequent image analysis through software programs, but instead directly feels the change of power to avoid possible errors, and at the same time, the device can be simplistic and easy to integrate with existing medical instruments.
  • the control drive can drive the individual to move in the opposite direction, offsetting the displacement of the tumor tissue caused by the individual during breathing, and achieving the goal that the tumor is stationary or almost stationary relative to the radiation therapy device. Therefore, the treatment of high irradiation dose can be concentrated, and the tumor control rate is high, and a better therapeutic effect is obtained.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un appareil de détection de déplacement applicable à un tissu qui comprend un composant de charge, un composant de pression et un module de détection de force. Le composant de pression presse directement ou indirectement contre le tissu. Le module de détection de force comprend au moins un composant de réponse à un stress qui est disposé entre le composant de charge et le composant de pression. Lorsque le déplacement du tissu survient, le composant de charge accepte une force externe, et le module de détection de force calcule la quantité de déplacement du tissu par détection du composant de réponse à un stress. De plus, l'invention concerne un procédé pour détecter un déplacement et un système d'assistance radiothérapeutique. Grâce à la détection des variations de la force à la place de la surveillance optique connue, l'appareil et le procédé selon l'invention constituent une technique pour détecter précisément le déplacement d'une manière non invasive.
PCT/CN2011/072333 2011-03-31 2011-03-31 Appareil et procédé pour détecter un déplacement, et système d'assistance radiothérapeutique Ceased WO2012129804A1 (fr)

Priority Applications (1)

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PCT/CN2011/072333 WO2012129804A1 (fr) 2011-03-31 2011-03-31 Appareil et procédé pour détecter un déplacement, et système d'assistance radiothérapeutique

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PCT/CN2011/072333 WO2012129804A1 (fr) 2011-03-31 2011-03-31 Appareil et procédé pour détecter un déplacement, et système d'assistance radiothérapeutique

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109965884A (zh) * 2019-04-19 2019-07-05 哈尔滨理工大学 一种基于加速度传感器的体表呼吸运动测量系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2865564Y (zh) * 2006-01-18 2007-02-07 胡晓兵 呼吸检测探头和呼吸检测装置
WO2009012240A1 (fr) * 2007-07-13 2009-01-22 Calypso Medical Technologies, Inc. Systèmes et procédés de positionnement de patients pendant le suivi de cibles en radiothérapie et autres applications médicales
US20100274151A1 (en) * 2009-04-27 2010-10-28 Chi Kwan-Hwa Assisting method and apparatus for radiotherapy
WO2011001300A1 (fr) * 2009-06-29 2011-01-06 Koninklijke Philips Electronics, N.V. Procédé et système de détermination de position
CN101972515A (zh) * 2010-11-02 2011-02-16 华中科技大学 图像和呼吸引导的辅助放疗床垫系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2865564Y (zh) * 2006-01-18 2007-02-07 胡晓兵 呼吸检测探头和呼吸检测装置
WO2009012240A1 (fr) * 2007-07-13 2009-01-22 Calypso Medical Technologies, Inc. Systèmes et procédés de positionnement de patients pendant le suivi de cibles en radiothérapie et autres applications médicales
US20100274151A1 (en) * 2009-04-27 2010-10-28 Chi Kwan-Hwa Assisting method and apparatus for radiotherapy
WO2011001300A1 (fr) * 2009-06-29 2011-01-06 Koninklijke Philips Electronics, N.V. Procédé et système de détermination de position
CN101972515A (zh) * 2010-11-02 2011-02-16 华中科技大学 图像和呼吸引导的辅助放疗床垫系统

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109965884A (zh) * 2019-04-19 2019-07-05 哈尔滨理工大学 一种基于加速度传感器的体表呼吸运动测量系统

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