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WO2012128129A1 - Aiguille de perforation, appareil d'administration de médicament et pompe à seringue - Google Patents

Aiguille de perforation, appareil d'administration de médicament et pompe à seringue Download PDF

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Publication number
WO2012128129A1
WO2012128129A1 PCT/JP2012/056456 JP2012056456W WO2012128129A1 WO 2012128129 A1 WO2012128129 A1 WO 2012128129A1 JP 2012056456 W JP2012056456 W JP 2012056456W WO 2012128129 A1 WO2012128129 A1 WO 2012128129A1
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WO
WIPO (PCT)
Prior art keywords
needle
lumen
outer needle
inner needle
puncture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/056456
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English (en)
Japanese (ja)
Inventor
剛 外川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Publication of WO2012128129A1 publication Critical patent/WO2012128129A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1583—Needle extractors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient

Definitions

  • the present invention relates to a puncture needle that is punctured into a living tissue, a drug administration device that administers a drug to the living tissue, and a syringe pump.
  • EUS-FNI Edoscopic Ultrasonography guided Needle Injection: ultrasound endoscopic drug solution injection
  • EUS-FNI ultrasound endoscopic drug solution injection
  • the present invention has been made in view of the above, and an object thereof is to provide a puncture needle, a drug administration device, and a syringe pump that can realize easy multipoint administration of a predetermined amount of drug.
  • a puncture needle is a puncture needle that is punctured into a living tissue, has a first lumen inside, and is provided on the side surface on the distal end side.
  • An outer needle provided with an opening communicating with the first lumen; an inner needle having a second lumen inside; and at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward.
  • the inner needle has a first state in which the tip portion is accommodated in the first lumen of the outer needle by the forward and backward movement, and at least one of the tip portions from the opening of the outer needle. A transition is made between the second state in which the portion protrudes.
  • the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the tip of the inner needle forms an acute angle when it protrudes from the opening of the outer needle.
  • the puncture needle in the above invention, when the inner needle moves forward with respect to the first lumen of the outer needle, a part of the tip portion of the inner needle protrudes,
  • the outer needle has a guide surface on the first lumen for guiding the tip of the inner needle from the first lumen to the opening.
  • the puncture needle according to the present invention is characterized in that, in the above invention, a plurality of the openings are provided on a side surface of the outer needle.
  • the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the plurality of openings have different positions in the longitudinal direction of the outer needle.
  • the puncture needle according to the present invention is characterized in that, in the above invention, the inner needle has a tip branched corresponding to the plurality of openings.
  • the outer needle has a guide surface for guiding the tip of the inner needle from the first lumen to the opening, and the first lumen has the opening.
  • Each guide surface has an inclination of a different angle.
  • the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, a marker is attached on an extension line extending in the axial direction of the opening of the outer needle toward the proximal end.
  • the puncture needle in the above invention, when the inner needle is in the first state, the movement of the inner needle and the rotational movement about the longitudinal axis of the outer needle are linked. It is characterized by further comprising a cooperation mechanism to be made.
  • the cooperation mechanism causes the outer needle to rotate by the advance and retreat of the inner needle when the inner needle is in the first state.
  • An engagement mechanism is included.
  • the puncture needle according to the present invention is characterized in that, in the above invention, the engagement mechanism includes an engagement pin and a cam groove, and the engagement pin engages with the cam groove. .
  • the cam groove includes a plurality of linear grooves extending in an axial direction, a base end of each linear groove, and one linear groove adjacent to each linear groove. It is characterized by being formed by a plurality of inclined grooves that respectively connect the front ends of the plurality of slanted grooves and that obliquely connect the plurality of linear grooves.
  • the engagement pin is provided on a connection member that is connected to the outer needle and that moves forward according to the forward movement of the inner needle.
  • the outer needle is rotated by advancing the inclined groove of the cam groove by advancing.
  • the puncture needle according to the present invention is characterized in that, in the above-described invention, the puncture needle further includes a biasing mechanism that biases the outer needle to rotate in a certain direction.
  • the cooperation mechanism causes the outer needle to rotate by the rotation of the inner needle when the inner needle is in the first state. It has an engagement mechanism.
  • the engagement mechanism may include an engagement pin provided on one of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle. And an engaged member provided on the other of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle, and the engaging pin and the engaged member are configured such that the inner needle is the first member.
  • the outer needle has a positional relationship to be engaged when it is in the section 1, and the rotational movement of the inner needle is transmitted to the outer needle by the engagement of the engagement pin and the engaged member. Rotational motion occurs in
  • the puncture needle according to the present invention is the puncture needle according to the above invention, wherein the outer needle is positioned around the axis of the outer needle with respect to the proximal end portion while the proximal end portion, the opening and the cooperation mechanism are located.
  • a distal end portion that is movable, and the distal end portion of the outer needle is configured to rotate with respect to the proximal end portion by the cooperation mechanism.
  • the inner needle is connected to a syringe pump at a proximal end, and the syringe pump includes a plunger having an external thread formed on an outer surface and a female on an inner surface. And a syringe having a screw formed thereon.
  • the drug administration device is a drug administration device having a puncture needle that is punctured into a living tissue and a drug delivery unit that delivers the drug to the puncture needle, and the puncture needle has a first inside.
  • An outer needle having an opening communicating with the first lumen on the side surface on the distal end side, a second lumen inside, and at least a distal end portion of the first lumen of the outer needle.
  • the second lumen of the inner needle And a pressure for delivering a drug to the delivery pump when at least the inner needle is in the second state and the inner needle is retracted relative to the outer needle.
  • a control unit for controlling the operation.
  • the syringe pump according to the present invention is characterized by comprising a plunger having a male screw formed on the outer surface and a syringe having a female screw formed on the inner surface.
  • the fitting between the male screw formed on the plunger and the female screw formed on the inner surface of the syringe is configured to be releasable. It is characterized by that.
  • the puncture needle has a first lumen inside, an outer needle provided with an opening communicating with the first lumen on the side surface on the distal end side, And an inner needle having at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward.
  • the inner needle is moved forward and backward to move the first lumen of the outer needle.
  • the inner needle protrudes from the opening of the outer needle because the transition between the first state in which the distal end is accommodated in the second state and the second state in which at least a part of the distal end protrudes from the opening of the outer needle can be made.
  • the syringe pump according to the present invention since it includes the plunger with the external thread formed on the outer surface and the syringe with the internal thread formed on the inner surface, by controlling the rotation speed of the plunger, Even medicines can be discharged accurately.
  • FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
  • FIG. 2 is a perspective view of the distal end portion of the puncture needle shown in FIG.
  • FIG. 3 is a perspective view of the distal end portion of the puncture needle shown in FIG.
  • FIG. 4 is a cross-sectional view of the distal end portion of the puncture needle shown in FIG. 2 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 5 is a cross-sectional view of the distal end portion of the puncture needle shown in FIG. 3 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 6 is a cross-sectional view of a portion of the puncture needle shown in FIG.
  • FIG. 7 is a perspective view showing a main part and a plunger of the syringe shown in FIG.
  • FIG. 8 is a flowchart showing a procedure of a drug administration process using the drug administration device shown in FIG.
  • FIG. 9 is a perspective view of the puncture needle and gripping portion shown in FIG.
  • FIG. 10 is a view for explaining a drug administration locus of the drug administration device shown in FIG.
  • FIG. 11 is an exploded perspective view of the syringe and the plunger in the first modification of the first embodiment.
  • FIG. 12 is an exploded perspective view of the syringe and the plunger in the first modification of the first embodiment.
  • FIG. 13 is a schematic diagram illustrating the configuration of the drug administration device according to the second modification of the first embodiment.
  • FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 15 is a cross-sectional view of the distal end portion of another puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 16 is an exploded perspective view of the drug administration device according to the second embodiment.
  • FIG. 17 is a cross-sectional view of the main part on the proximal end side of the drug administration device shown in FIG. 16 cut along the central axis in the longitudinal direction.
  • FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 15
  • FIG. 18 is a cross-sectional view of the main part on the proximal end side of the drug administration device shown in FIG. 16 cut along the central axis in the longitudinal direction.
  • FIG. 19 is a cross-sectional view taken along line AA in FIG.
  • FIG. 20 is a diagram showing cam grooves formed on the inner surface of the base cavity shown in FIG.
  • FIG. 21 is a cross-sectional view of the base-end-side main part of the drug administration device according to the third embodiment, cut along the central axis in the longitudinal direction.
  • FIG. 22 is a perspective view of the distal end portion of the puncture needle in the fourth embodiment.
  • FIG. 23 is a perspective view of the distal end portion of the puncture needle in the fourth embodiment.
  • FIG. 24 is a cross-sectional view of the tip portion of the puncture needle shown in FIG. 22 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 25 is a cross-sectional view of the tip portion of the puncture needle shown in FIG. 23 cut along the central axis in the longitudinal direction of the puncture needle.
  • FIG. 26 is a schematic diagram for explaining the shape of the engaged member shown in FIGS. 24 and 25.
  • FIG. 27 is a schematic diagram for explaining the shape of another engaged member shown in FIGS. 24 and 25.
  • FIG. 28 is a schematic diagram for explaining the shape of the engaged member shown in FIGS. 24 and 25.
  • FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
  • a drug administration device 1 includes a puncture needle 2 provided at a distal end and punctured into a living tissue, a gripping portion 3 provided on a proximal end side of the puncture needle 2, and a puncture needle 2. And a syringe 5 for delivering the drug held inside to the tube 4.
  • the puncture needle 2 is made of, for example, stainless steel or titanium.
  • the tube 4 is made of, for example, silicon, polyethylene, polyurethane, or the like.
  • the puncture needle 2 is punctured into an organ 7 located at the back of the body surface 6.
  • the operator can administer the medicine stored in the syringe 5 into the organ through the tube 4 and the puncture needle 2 by moving the plunger 8 forward with respect to the syringe 5.
  • FIGS. 2 and 3 are perspective views of the distal end portion of the puncture needle 2 shown in FIG.
  • FIG. 4 is a cross-sectional view of the distal end portion of the puncture needle 2 shown in FIG. 2 cut along the central axis in the longitudinal direction of the puncture needle 2.
  • FIG. 5 is a cross-sectional view of the tip portion of the puncture needle 2 shown in FIG. 3 cut along the central axis in the longitudinal direction of the puncture needle 2.
  • the puncture needle 2 includes an outer needle 10 and an inner needle 11.
  • the outer needle 10 has a first lumen 12 inside, an opening 13 communicating with the first lumen 12 is provided on the side surface on the tip side, and has an elongated shape with a pointed tip.
  • the outer needle 10 is cut by facing a circle with the central axis in the longitudinal direction, the outer surface forms a circle.
  • the inner needle 11 is inserted through the first lumen 12 of the outer needle 10 at least at the tip so as to be able to advance and retreat.
  • the inner needle 11 can move forward and backward with respect to the first lumen 12.
  • the inner needle 11 has a second lumen 14 with an open end.
  • the inner needle 11 is connected to the tube 4, and the second lumen 14 communicates with the inner lumen of the tube 4.
  • the internal lumen of the tube 4 communicates with the internal space of the syringe 5.
  • the second lumen 14 functions as a passage through which the medicine, physiological saline and the like held in the syringe 5 are conveyed, and the medicine, physiological saline and the like are discharged from the opening 11a at the tip of the inner needle 11.
  • the outer needle 10 and the gripping part 3 are formed integrally, for example, and the operator grips the gripping part 3 and operates the gripping part 3 to move the outer needle 10 to the living body. It is possible to puncture the tissue and rotate the outer needle 10 around the axis.
  • the inner needle 11 is in a first state in which the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10 by the forward and backward movement of the inner needle 11 (see FIGS. 2 and 4), A transition is made between the second state (see FIGS. 3 and 5) in which at least a part of the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10.
  • the inner needle 11 advances from the first lumen 12 to move the inner needle 11 from the opening 13 of the outer needle 10 from the first state where the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10. It changes to the 2nd state from which a part of tip part of needle 11 protrudes.
  • the outer needle 10 has a guide surface 10 a for guiding the tip of the inner needle 11 from the first lumen 12 to the opening 13 in the first lumen 12.
  • the guide surface 10 a is an inclined surface that is inclined from the distal end side end portion of the opening 13 toward the proximal end side. Based on the protruding length of the inner needle 11 and the position where the drug is to be administered so that the tip position of the protruding inner needle 11 reaches the position where the drug is to be administered when the distal end of the inner needle 11 is projected the longest.
  • the inclination angle of the guide surface 10a is set.
  • the outer angle forms an acute angle.
  • the tip of the inner needle 11 protruding from the opening 13 can easily enter the living tissue while opening the living tissue around the outer needle 10, so that the inner needle 11 extends from the opening toward the outside of the outer needle 10. Can protrude.
  • a stopper 15 is provided on the first lumen 12 of the outer needle 10 so as to be separated by a predetermined distance (between the position P and the position Q).
  • a protrusion 16 is provided on the outer side surface of the inner needle 11 and is positioned between the front and rear stoppers 15. The range in which the inner needle 11 can move in the first lumen 12 by the contact of the protrusion 16 of the inner needle 11 with the stopper 15 is limited. Therefore, in the puncture needle 2, the inner needle 11 does not protrude excessively from the outer needle 10 and the inner needle 11 is not pulled out by mistake.
  • FIG. 7 is a perspective view showing the main part of the syringe 5 and the plunger 8 shown in FIG.
  • a male screw 8 a is formed in a region inserted into the syringe 5 on the outer surface of the plunger 8.
  • a female screw 5 a that fits into the male screw 8 a of the plunger 8 is formed.
  • the plunger 8 is rotated with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5, thereby discharging the medicine or the like from the distal end of the syringe 5.
  • 12.5 microliters of medicine or the like can be discharged from the tip of the syringe 5. Therefore, according to the syringe 5 and the plunger 8, by controlling the number of rotations of the plunger 8, it is possible to accurately discharge a small amount of medicine or the like.
  • Markers 5b and 8b are provided at the proximal end of the syringe 5 and the proximal end of the plunger 8 so that the amount of rotation of the plunger 8 relative to the syringe 5 can be determined.
  • the plunger 8 and the syringe 5 are fitted with each other with the male screw 8a and the female screw 5a, the plunger 8 maintains the position as it is with respect to the syringe 5 even when the force for pushing the plunger 8 is lost. , never pushed out. Therefore, the operator can release his / her hand from the plunger 8 even while the medicine is being discharged.
  • FIG. 8 is a flowchart showing a procedure of a drug administration process using the drug administration device 1 shown in FIG.
  • step S1 after the distal end portion of the inner needle 11 is housed in the first lumen 12 inside the outer needle 10 (step S1), the outer needle 10 is moved to the first state (see FIGS. 2 and 4). The living tissue is punctured and the tip of the outer needle 10 is introduced into the organ 7 to be administered with the drug (step S2).
  • step S3 In a state where the outer needle 10 is introduced into the living tissue, the operator pushes the tube 4 toward the distal end side to advance the inner needle 11 relative to the outer needle 10, thereby moving the distal end of the inner needle 11. Let it protrude from the opening 13 of the outer needle 10 (step S3), and assume a second state (see FIGS. 3 and 5). By the protruding operation of the tip of the inner needle 11, the living tissue located in the direction in which the tip of the inner needle 11 spreads is cut open by the tip of the inner needle 11, and can be cut.
  • the operator rotates the plunger 8 with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5 by a rotation amount corresponding to the discharge amount of the medicine, etc.
  • the medicine and the like are discharged from the opening 11a at the tip of the inner needle 11 (step S4).
  • the discharged medicine infiltrates into the incision opened by the tip of the inner needle 11.
  • step S5 the inner needle 11 is set to the first state.
  • step S6 determines whether or not the scheduled number of times of ejection of the medicine has been reached.
  • step S6 determines that the scheduled number of ejections of the medicine or the like has not been reached.
  • step S7 the operator holds the grip portion 3 and rotates the outer needle 10 by a predetermined angle around the longitudinal axis.
  • the operator rotates the outer needle 10 by about 60 ° in one rotation.
  • a marker 3a is attached on the extension line in the axial direction.
  • the present invention is not limited to the marker 3 a shown in FIG. 9, and a part of the side surface of the grip portion 3 located on the extension line in the axial direction of the opening 13 of the outer needle 10 is cut out and flattened. It may be possible to determine which direction of the direction is currently facing.
  • step S3 the process returns to step S3, and the distal end of the inner needle 11 is protruded from the opening 13 of the outer needle 10 in a state where the outer needle 10 is punctured into the living tissue (step S3), and the second state is set. Due to the protruding operation of the tip of the inner needle 11, a cut with an angle different from the previous time is formed in the living tissue.
  • step S6 when it is determined that the number of times that the medicine or the like has been ejected has been reached (step S6: Yes), the operator determines whether to extract the outer needle 10 or leave the outer needle 10 in place. (Step S8).
  • step S8: extraction When the operator determines that the outer needle 10 is to be extracted (step S8: extraction), the outer needle 10 is extracted from the organ 7 with the inner needle 11 stored in the first lumen 12 inside the outer needle 10 ( Step S9).
  • step S8 placement
  • the outer needle 10 is placed in the organ 7 as it is (step S10).
  • the medicine is ejected from the inner needle 11 with the inner needle 11 protruding from the opening 13, and the outer needle 10 is stored in the opening 13 while the inner needle 11 is housed in the opening 13.
  • Multi-point administration can be easily performed by repeating the operation of rotating around a predetermined number of times.
  • the plunger 8 and the syringe 5 are fitted with the male screw 8a and the female screw 5a.
  • the medicine is ejected on the locus of the inner needle 11 in the organ 7. That is, by repeating the discharge of the medicine or the like from the inner needle by changing the angle as described above, when the inner needle 11 protrudes from the outer needle 10, as shown schematically in FIG. Since the upper portion is located on the circumference L1 of the bottom surface, by repeating the steps shown in FIG. 8 as described above, the medicine is discharged to a plurality of locations on the circumference L1, and a sufficient amount of medicine is held in the medicine administration target region. Can do.
  • the outer needle 10 having an outer diameter larger than that of the inner needle 11 is attached to the living tissue only when the puncture needle 2 is introduced into the living tissue and when the puncture needle 2 is extracted from the living tissue. Move forward and backward. Therefore, according to the first embodiment, multipoint administration to a plurality of locations in the organ 7 can be realized while reducing the invasion of the organ 7 by the outer needle 10 having a large outer diameter.
  • step S4 and step S5 in FIG. 8 described above may be performed in parallel. That is, when the inner needle 11 is moved backward with respect to the outer needle 10, the plunger 8 is rotated with respect to the syringe 5, and the inner needle 11 is moved backward while maintaining the pressure of the medicine. You may make it discharge a chemical
  • FIG. By operating in this way, as schematically shown in FIG. 10, in addition to the space formed in the locus of the retreating inner needle 11, that is, the substantially conical bottom circumference L1 in FIG. Since the medicine corresponding to the side surface L2 of the shape can be filled with the medicine, the filling efficiency of the medicine into the living tissue can be increased.
  • a contact portion 105a is formed on the grip at the base end so that the inside contacts the male screw 8a of the plunger 8.
  • a protrusion 105b into which one end of the spring 107 is fitted is formed on the outside of the contact portion 105a.
  • the grip of the syringe 105 is formed with a knob portion 105c in which a part of the grip is extended and bent.
  • the engaging member 106 is formed with a female screw portion 106a that can be fitted to the male screw 8a on a part of the opening side surface through which the plunger 8 can be inserted.
  • a protruding portion 106 b is formed so as to face the female screw portion 106 a and into which the other end of the spring 107 is fitted.
  • the engaging member 106 is formed with a knob portion 106c that is partially extended and bent. The knob portion 105c and the knob portion 106c face each other as shown in FIG.
  • the knob portion 105c of the syringe 105 and the knob portion 106c of the engaging member 106 are pinched so as to be pressed inward, whereby the knob portion 106c moves inward, and accordingly, The female screw portion 106a also moves outward.
  • the fitting of the female screw portion 106a to the male screw 8a is released, and the plunger 8 becomes free and can move up and down as indicated by the arrow Y2.
  • the spring 107 that has been contracted is extended, and the female screw 106a is engaged with the male screw 8a of the plunger 8.
  • the drug or the like can be discharged from the syringe 105 by rotating the plunger 8 so as to move forward with respect to the syringe 105 as in the first embodiment.
  • the plunger 8 can be detached from the syringe 105 by simply pinching the knob portion 105c and the knob portion 106c, processing such as drug replenishment processing into the syringe 105 is also easily performed. be able to.
  • the drug administration device 1a includes a pump 17 and a reservoir 18 that stores a drug instead of the syringe 5 and the plunger 8 illustrated in FIG. 1. It has a drug delivery unit.
  • the pump 17 has a function of sending the medicine stored in the reservoir 18 to the inner needle 11.
  • This pump 17 is controlled by the control unit 19 for delivery processing.
  • a sensor 20 that detects the relative positional relationship between the outer needle 10 and the inner needle 11 is connected to the control unit 19.
  • the control unit 19 Based on the detection result of the sensor 20, the control unit 19 detects that the inner needle 11 is in the second state in which the tip portion protrudes from the opening of the outer needle 10, and the inner needle 11 moves forward most. At the position where the inner needle 11 has reached the most advanced position once, or when it is detected that the inner needle 11 is retracted toward the opening 13 of the outer needle 10, The pump 17 is controlled to deliver.
  • the relative position between the outer needle 10 and the inner needle 11 is detected by the sensor 20, and the medicine is automatically ejected according to the detected position. Since the medicine can be automatically administered at the advanced position and the medicine can be filled into the space formed in the backward locus of the inner needle 11, the filling efficiency of the medicine into the living tissue can be increased.
  • FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
  • the outer needle 10A As shown in FIG. 14, the outer needle 10A according to the third modification of the first embodiment has first lumens 12a and 12b inside, and openings 13a and 13b communicating with the first lumens 12a and 12b, respectively.
  • the inner needles 11A and 11B are inserted through the first lumens 12a and 12b, respectively.
  • the two inner needles 11A and 11B can be moved forward and backward independently, and at the proximal end (not shown), a tube and a syringe are connected to each other, and drug administration is performed independently.
  • the plurality of first lumens 12a and 12b and the openings 13a and 13b are provided, and the advancing / retreating movements and the drug administration process in the inner needles 11A and 11B are independently controlled, so that the plurality of locations in the organ 7 Can be easily realized.
  • the inner first lumen 12c may be branched at the tip.
  • the first lumen 12c is branched asymmetrically to communicate with the branched first lumens 12c, and the openings 13c and 13d having different positions in the longitudinal direction of the outer needle 10C are provided on the side surfaces of the outer needle 10C. It may be provided.
  • an inner needle 11C having a second lumen 14c and having a distal end branched corresponding to the plurality of openings 13c and 13d is used.
  • a guide surface 10c for guiding one tip 11c of the inner needle 11C from the first lumen 12c to the opening 13c, and a guide surface 10d for guiding the other tip 11d of the inner needle 11C from the first lumen 12c to the opening 13d. May be formed so as to be inclined at different angles, thereby changing the protrusion angle of the tips 11c and 11d of the inner needle 11C from the openings 13c and 13d.
  • Embodiment 2 Next, a second embodiment will be described.
  • the movement of the inner needle and the center of the longitudinal axis of the outer needle are only when the inner needle is in the first state in which the tip of the inner needle is accommodated in the first lumen of the outer needle.
  • the case where the cooperation mechanism which cooperates rotational movement is provided is demonstrated.
  • FIG. 16 is an exploded perspective view of the drug administration device according to the second embodiment.
  • 17 and 18 are cross-sectional views of the main part on the proximal end side of the drug administration device 201 shown in FIG. 16 cut along the central axis in the longitudinal direction.
  • FIG. 17 shows a state in which the main part on the proximal end side of the drug administration device 201 is disassembled.
  • FIG. 18 shows a state in which the main part of the proximal end of the drug administration device 201 is assembled, and shows a state in which a pusher described later is pushed most into a plunger described later.
  • the drug administration device 201 includes an outer needle 10 that can accommodate the inner needle 11 therein, an outer cylinder 202 that accommodates the outer needle 10 in the inner lumen, and a substantially cylindrical base member 222. And a substantially cylindrical charge grip 223.
  • the charge grip 223 has a non-slip groove formed on the outer periphery. Further, the charge grip 223 has a structure that can rotate with respect to the base member 222.
  • the inner cavity of the base member 222 has different inner diameters on the distal end side and the proximal end side, and the proximal end side cavity 222a has a larger diameter.
  • a cam groove 228 that goes around the inner surface is formed on the inner surface of the cavity 222a.
  • the cam groove 228 is a groove that connects a plurality of linear grooves extending in the axial direction, a base end of each linear groove, and a tip of one linear groove adjacent to each linear groove. Are formed by a plurality of inclined grooves that are diagonally connected to each other.
  • the tip of the base member 222 is connected to the outer cylinder 202.
  • the outer cylinder 202 accommodates the outer needle 10 in a lumen so as to be rotatable.
  • the outer cylinder 202 is, for example, a PEEK resin tube.
  • the syringe 224 has a hollow inside, and has a small-diameter portion 224a in which at least a tip portion is rotatably accommodated in the cavity 222a of the base member 222, and a large-diameter portion 224b having a large diameter connected to the small-diameter portion 224a.
  • the proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a.
  • a linear guide groove 226 extending in the longitudinal axis direction is formed on the inner surface of the cavity 224c inside the large diameter portion 224b.
  • An engaging pin 229 that can engage with the cam groove 228 is provided on the outer surface of the small diameter portion 224a. As shown by the arrow in FIG. 17, the engaging pin 229 is urged so as to protrude to the outside, and is configured to be accommodated in the outer wall of the small-diameter portion 224a when pushed from above. Is done.
  • the distal end portion of the syringe 224 is a cavity of the base member 222 until the received engaging pin 229 reaches the cam groove 228 of the base member 222 in a state where the engaging pin 229 is received in the outer wall of the small diameter portion 224a. 222a is inserted.
  • the engaging pin 229 biased in the outward direction protrudes when it reaches the cam groove 228 and engages with the cam groove 228.
  • the engaging pin 229 can move in the groove of the cam groove 228 to make a round of the inner surface of the base member 222.
  • the syringe 224 main body can also rotate along the contour of the cam groove 228. Since the proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a, the outer needle 10 also rotates integrally with the syringe 224.
  • the plunger 225 has a substantially cylindrical shape, and at least a tip portion is rotatably accommodated in the cavity 224c of the syringe 224.
  • An engagement pin 227 that engages with the guide groove 226 of the syringe 224 is provided on the outer surface of the plunger 225.
  • the proximal end of the inner needle 11 is connected to the distal end of the plunger 225, and the plunger 225 and the inner needle 11 move integrally.
  • the pusher 225a is inserted into the cavity 224c of the plunger 225 from the proximal end side of the plunger 225, and is pushed toward the distal end side by the operator when the medicine is discharged.
  • a tube 204 connected to the reservoir 18 is connected to the side surface on the proximal end side of the pusher 225a.
  • the one-way valve 234 allows a drug or the like in the tube 204 to pass into the plunger 225 when pressure in the direction from the tube 204 into the plunger 225 is applied.
  • the one-way valve 234 allows the medicine or the like to pass into the cavity of the plunger 225 when the pusher 225 a is pulled out from the plunger 225.
  • a one-way valve 235 is provided at the distal end of the cavity of the plunger 225 so that when a force in the direction from the plunger 225 toward the distal direction is applied, the medicine in the plunger 225 passes in the direction toward the outside. It is done. That is, the one-way valve 235 discharges the medicine or the like in the plunger 225 from the tip of the plunger 225 when the pusher 225a is pushed into the plunger 225.
  • a first spring 230 is disposed on the outer surface of the syringe 224.
  • the front end side edge part 230a is being fixed to the base end side bottom face of the charge grip 223, and the base end side end part 230b is being fixed to the large diameter part 224b of the syringe 224.
  • FIG. 19 is a sectional view taken along line AA of FIG.
  • a hole 222 d is formed on the outer surface of the base member 222 on the tip side of the cam groove 228.
  • a hole 223 b is formed on the inner side surface of the charge grip 223 on the tip side of the cam groove 228.
  • the holes 222d and 223b are engaged by an engaging member 232 interposed therebetween, and the charge grip 223 rotates in one direction with respect to the base member 222, but rotates in the opposite direction. It is configured not to.
  • the engaging member 232 is formed as a set of one spring and one ball.
  • the engaging member 232 engages the base member 222 and the charge grip 223, when the charge grip 223 and the syringe 224 are rotated in a rotatable direction, the energy of rotation is applied to the first spring 230. Charged. Since the outer needle 10 is connected to the syringe 224, the engaging member 232 shown in FIG. 19 functions as an urging mechanism that urges the outer needle 10 to rotate in a certain direction.
  • a second spring 231 is disposed on the outer surface of the plunger 225.
  • the base end side edge part is being fixed to the base end of the plunger 225, and the front end side edge part is not being fixed so that a movement becomes free.
  • a third spring 233 is disposed on the pusher 225a. When the pusher 225a is pushed into the plunger 225, the third spring 233 contracts to charge energy in the proximal direction, and the pusher 225a is urged in the pushing back direction.
  • the second spring 231 is a spring having stronger elasticity than the first spring 230.
  • the third spring 233 is a spring having even stronger elasticity than the second spring 231.
  • FIG. 20 is a diagram illustrating the cam groove 228 formed on the inner surface of the cavity 222 a of the base member 222.
  • the engagement pin 229 is located at the position A (see FIG. 20).
  • the force pushing the pusher 225a is transmitted to the syringe 224 via the third spring 233 and the second spring 231 and becomes the force pushing the syringe 224.
  • the engaging pin 229 is also pushed to the tip side, and the engaging pin 229 moves along the inclined groove portion of the cam groove 228 to the position B of the cam groove 228. To do.
  • the syringe 224 also rotates within the cavity 222a of the base member 222.
  • the angle at which the syringe 224 rotates when viewed from a plane orthogonal to the paper surface of FIG. 18 is preferably, for example, 30 ° to 180 °. Then, as the syringe 224 is pushed, the first spring 230 contracts.
  • the force pushing the pusher 225a is transmitted to the plunger 225 via the third spring 233 and pushes the plunger 225, and the plunger 225 moves forward in the syringe 224 toward the distal end.
  • the second spring 231 provided on the outer surface of the plunger 225 starts to contract.
  • the engaging pin 227 advances to the tip of the guide groove 226, and accordingly, the inner needle 11 connected to the tip of the plunger 225 also advances, and the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10.
  • the protrusion of the tip of the inner needle 11 stops when the advance of the engagement pin 227 stops at the tip of the guide groove 226.
  • the member that is urged by the second spring 231 and the third spring 233 is provided with a stopper in advance to limit the stroke, that is, a state in which a slight pressing force is applied to the distal end side even before the operation is started. May be.
  • the movement of each member related to the contraction of the second spring 231 and the third spring 233 starts after the movement related to one spring is completed, and thus the movement related to the next spring is started.
  • the member operates more regularly. That is, the second spring 231 starts to contract after the movement of the member related to the contraction of the first spring 230 (the rotation operation of the syringe 224) is completed.
  • the third spring 233 starts to contract after the movement of the member related to the contraction of the second spring 231 (the protruding operation of the inner needle 11) is completed.
  • the third spring 233 contracts and the pusher 225a is pushed into the plunger 225.
  • a force in the direction from the plunger 225 toward the distal end is applied to the plunger 225, and the medicine or the like in the plunger 225 is discharged from the plunger 225 distal end via the one-way valve 235.
  • the medicine or the like discharged from the distal end of the plunger 225 flows through the inner lumen of the inner needle 11 and is discharged toward the living tissue from the distal end of the inner needle 11.
  • the force pushing the pusher 225a is released, so that the pusher 225a is first retracted in the proximal direction by the elastic energy stored in the third spring 233. Since the pressure in the direction from the tube 204 into the plunger 225 is applied by the retraction of the pusher 225a, the medicine is supplied from the tube 204 into the plunger 225 via the one-way valve 234.
  • the plunger 225 moves backward in the proximal direction by the elastic energy stored in the second spring 231.
  • the inner needle 11 connected to the distal end of the plunger 225 is also retracted.
  • the tip of the inner needle 11 is accommodated again in the outer needle 10 via the opening 13 of the outer needle 10.
  • the elastic energy stored in the first spring 230 causes the syringe 224 to retreat in the proximal direction and return to the initial state.
  • the engagement pin 229 moves backward from the position B to the position C in the cam groove 228.
  • the outer needle 10 rotates around the axis, the inner needle 11 protrudes from the opening 13 of the outer needle 10, and the inner needle. 11 It is possible to repeat a discharge cycle of the medicine from the tip, supply of the medicine from the tube 204 into the plunger 225, and storage of the inner needle 11 into the opening 13 of the outer needle 10, so Multipoint administration to a plurality of locations can be realized more easily.
  • FIG. 21 is a cross-sectional view of the base-end-side main part of the drug administration device according to the third embodiment, cut along the central axis in the longitudinal direction.
  • the drug administration device according to the third embodiment has a configuration in which the third spring 233 shown in FIGS. 16 to 18 is omitted as compared with the drug administration device 201 according to the second embodiment.
  • the drug administration device 301 has a plunger 8 shown in FIG. 7 as a pusher in place of the pusher 225a shown in FIGS.
  • the drug administration device 301 includes a plunger 325 in which a female screw 325 a into which the male screw 8 a of the plunger 8 is fitted is formed in the proximal end side.
  • a small amount of medicine can be delivered by rotating the plunger 8 that functions as a pusher with respect to the plunger 325.
  • the relative positional relationship between the base member 222, the syringe 224, and the plunger 325 may be locked by a lock mechanism.
  • the operator can release his / her hand from the plunger 325.
  • medical agent is implement
  • the lock mechanism When the operator pushes the plunger 325, the lock mechanism is released. Thereafter, when the operator removes his / her finger from the plunger 325, the force pushing the plunger 325 is released, so that the plunger 325 is retracted in the proximal direction by the elastic energy stored in the second spring 231. Subsequently, due to the elastic energy stored in the first spring 230, the plunger 325 is further retracted in the proximal direction together with the syringe 224, and returns to the initial state. By this movement, the engagement pin 229 moves backward from the position B (see FIG. 20) to the position C (see FIG. 20) in the cam groove 228.
  • the plunger 325 whose tip is accommodated in the syringe 224 is also retracted, so that the inner needle 11 connected to the distal end of the plunger 325 is also retracted, and the distal end of the inner needle 11 is the outer needle 10. Housed again inside.
  • FIG. 22 and 23 are perspective views of the distal end portion of the puncture needle according to the fourth embodiment.
  • FIG. 24 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 22 cut along the central axis in the longitudinal direction of the puncture needle 402.
  • FIG. 25 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 23 taken along the central axis in the longitudinal direction of the puncture needle 402.
  • the puncture needle 402 has a distal end portion 441 in which an opening 13 is provided on a side surface and a cooperation mechanism is provided inside, and a rotation about an axis relative to the distal end portion 441.
  • An outer needle 410 having a movable proximal end 442 is provided.
  • the cooperation mechanism rotates only the distal end portion 441 of the outer needle 410, and does not rotate the proximal end portion 442.
  • the inner needle 411 is inserted into the first lumen 412 of the outer needle 410 so as to be able to advance and retract.
  • the inner needle 411 moves at least from the first state (see FIGS. 22 and 24) in which the distal end portion of the inner needle 411 is accommodated in the outer needle 410 by the forward and backward movement of the inner needle 411 and from the opening 13 of the outer needle 410.
  • a transition is made between the second state (see FIGS. 23 and 25) in which a part of the tip of the inner needle 411 protrudes.
  • the proximal end of the inner needle 411 extends the first lumen 412 of the proximal end portion 442 of the outer needle 410.
  • the proximal end of the inner needle 411 is connected to the tube 4 communicating with the internal space of the syringe 5 as in the first embodiment.
  • An engagement mechanism is provided on the outer surface of the inner needle 411 and the inner surface of the first lumen 412 of the outer needle 410 so that they can be engaged with each other.
  • the engagement pin 443 is provided on the outer surface of the inner needle 411, and the engagement pin 443 can be engaged with the inner surface of the first lumen 412.
  • a member 444 is provided. As shown in FIGS. 24 and 25, the engagement pin 443 and the engaged member 444 are when the inner needle 11 is in the first state in which the distal end portion of the inner needle 11 is accommodated in the outer needle 410. It is in a positional relationship that only engages.
  • a stopper 445 that can prevent the engagement pin 443 from moving forward is provided on the inner surface of the outer needle 410 and on the distal end side of the engaged member 444, and the distal end of the inner needle 411 protrudes excessively. Is preventing.
  • FIG. 26 is a schematic diagram for explaining the shape of the engaged member 444 shown in FIGS. 24 and 25.
  • FIG. 26 shows a state where the engaged member 444 is rotated 90 ° counterclockwise from the state shown in FIGS. 24 and 25 for the sake of explanation.
  • the engaged member 444 has a shape in which the side surface of the cylinder is notched into a mountain shape.
  • the notch shape includes a surface parallel to the axial direction of the outer needle 410, a base end of a surface parallel to the axial direction of the outer needle 410, and a surface parallel to the axial direction of another outer needle 410 adjacent to this surface. It is formed by the inclined surface which connects a front-end
  • Embodiment 4 the operator advances the inner needle 411 relative to the outer needle 410.
  • the engagement pin 443 of the inner needle 411 is also advanced, so that the engagement between the engagement pin 443 of the inner needle 411 and the engaged member 444 of the outer needle 410 is released.
  • the operator further advances the inner needle 411 until the engagement pin 443 stops at the stopper 445, so that the tip of the inner needle 411 protrudes from the opening 13 of the outer needle 410 (FIGS. 23 and 25).
  • the medicine is supplied to the second lumen 14 of the inner needle 411 for dosing. Even if the operator rotates the inner needle 411 in this state, the outer needle 410 does not rotate because the engaged member 444 is not engaged with the engaging pin 443 of the inner needle 411.
  • the operator retracts the inner needle 411 with respect to the outer needle 410, and stores the tip of the inner needle 411 in the first lumen 412 of the outer needle 410 (see FIGS. 22 and 24). ). After the operator retracts the inner needle 411 until the engaging pin 443 of the inner needle 411 contacts the engaged member 444, the operator rotates the inner needle 411 in a predetermined direction.
  • the rotational movement is engaged by the engagement pin 443 that hits the surface parallel to the axial direction of the engaged member 444.
  • the outer needle 410 is also rotated in the direction of the arrow Y42, and the direction in which the opening 13 is directed changes.
  • the rotation movement of the inner needle 411 causes the engagement pin 443 to move in the axial direction of the engaged member 444.
  • the outer pin 410 is not transmitted from the engaging pin 443 to the engaged member 444, and the outer needle 410 does not rotate. Therefore, the engagement pin 443 and the engaged member 444 function as an engagement mechanism that causes the outer needle 410 to rotate by the rotation of the inner needle 411 when the inner needle 411 is in the first state. .
  • the inner needle 11 protrudes from the opening 13 of the outer needle 410, and the inner needle. Since the discharge of the medicine from the tip of 411, the storage of the inner needle 411 into the opening 13 of the outer needle 410, and the rotation cycle around the axis of the outer needle 410 can be repeated, a plurality of the internal needles 411 Multipoint administration to a location can be easily realized.
  • the angled surface of the outer needle 410 that is parallel to the axial direction of the engaged member 444 shown in FIG.
  • An engaged member 444a (see FIG. 27) having a further acute apex angle may be used.
  • the engagement pin 443 may be elastic so that it can get over the angled apex portion of the engaged member 444a when the inner needle 411 moves forward.
  • the engaged member of the outer needle 410 is engaged with the retracted inner needle 411 so that when the inner needle 411 is rotated in one direction, the rotation movement is transmitted by the engagement pin 443. Since it is sufficient that the angle at which the coupling pin 443 is caught is on the proximal end side, it is not always necessary to form the mountain shape like the engaged member 444b shown in FIG.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un appareil d'administration de médicament (1) doté des éléments suivants : une aiguille externe (10) ayant une première lumière interne (12) et une ouverture (13) sur une surface latérale de la pointe, l'ouverture (13) communiquant avec la première lumière (12) ; et une aiguille interne (11) qui a une seconde lumière interne (14) et qui est introduite de telle sorte que la pointe de l'aiguille interne est apte à se déplacer vers l'avant et vers l'arrière dans la première lumière (12) de l'aiguille externe (10). Par le déplacement vers l'avant et vers l'arrière, l'aiguille interne (11) peut passer d'une première position, où la pointe de celle-ci est logée dans la première lumière (12) de l'aiguille externe (10) à une seconde position, où au moins une partie de la pointe de l'aiguille interne fait saillie à partir de l'ouverture (13) de l'aiguille externe (10).
PCT/JP2012/056456 2011-03-22 2012-03-13 Aiguille de perforation, appareil d'administration de médicament et pompe à seringue Ceased WO2012128129A1 (fr)

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JP2011-063373 2011-03-22
JP2011063373A JP2012196346A (ja) 2011-03-22 2011-03-22 穿刺針、薬剤投与装置およびシリンジポンプ

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023048230A1 (fr) * 2021-09-27 2023-03-30 テルモ株式会社 Kit dispositif thérapeutique

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015080692A (ja) * 2013-10-24 2015-04-27 オリンパス株式会社 医療用針および医療用器具
JPWO2022071080A1 (fr) * 2020-09-30 2022-04-07

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Publication number Priority date Publication date Assignee Title
US6159196A (en) * 1998-03-09 2000-12-12 Ruiz; Carlos Methods and apparatus for transvascular muscular revascularization and drug delivery
JP2001009033A (ja) * 1997-06-17 2001-01-16 Novo Nordisk As 傾動可能なナット部材を有する注入器
JP2002507458A (ja) * 1998-03-25 2002-03-12 トランスバスキュラー インコーポレイテッド 体内の選択された位置に薬を搬送するシステム及び方法
JP2004329485A (ja) * 2003-05-06 2004-11-25 Asahi Intecc Co Ltd 薬液注入装置
JP2005506101A (ja) * 2001-02-28 2005-03-03 レックス メディカル リミテッド パートナーシップ 新生物を治療するアブレーション液を供給するための装置
WO2009128393A1 (fr) * 2008-04-16 2009-10-22 株式会社バイオマスター Seringue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001009033A (ja) * 1997-06-17 2001-01-16 Novo Nordisk As 傾動可能なナット部材を有する注入器
US6159196A (en) * 1998-03-09 2000-12-12 Ruiz; Carlos Methods and apparatus for transvascular muscular revascularization and drug delivery
JP2002507458A (ja) * 1998-03-25 2002-03-12 トランスバスキュラー インコーポレイテッド 体内の選択された位置に薬を搬送するシステム及び方法
JP2005506101A (ja) * 2001-02-28 2005-03-03 レックス メディカル リミテッド パートナーシップ 新生物を治療するアブレーション液を供給するための装置
JP2004329485A (ja) * 2003-05-06 2004-11-25 Asahi Intecc Co Ltd 薬液注入装置
WO2009128393A1 (fr) * 2008-04-16 2009-10-22 株式会社バイオマスター Seringue

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023048230A1 (fr) * 2021-09-27 2023-03-30 テルモ株式会社 Kit dispositif thérapeutique

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