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WO2012119780A3 - Novel lipids and novel phospholipids structures - Google Patents

Novel lipids and novel phospholipids structures Download PDF

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Publication number
WO2012119780A3
WO2012119780A3 PCT/EP2012/001052 EP2012001052W WO2012119780A3 WO 2012119780 A3 WO2012119780 A3 WO 2012119780A3 EP 2012001052 W EP2012001052 W EP 2012001052W WO 2012119780 A3 WO2012119780 A3 WO 2012119780A3
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WO
WIPO (PCT)
Prior art keywords
novel
lipids
structures
phospholipids
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/001052
Other languages
French (fr)
Other versions
WO2012119780A2 (en
Inventor
Andreas Zumbuehl
Pierre-Léonard ZAFFALON
Illya FEDOTENKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Geneve
Original Assignee
Universite de Geneve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Geneve filed Critical Universite de Geneve
Publication of WO2012119780A2 publication Critical patent/WO2012119780A2/en
Publication of WO2012119780A3 publication Critical patent/WO2012119780A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a lipids comprising or consisting of 1,3-diamidolipids or/and 1,2-diamidolipids or/and 2,3-diamidolipids or/and 1,3-diurealipids or/and 1,2-diurealipids or/and 2,3-diurealipids or/and 1,3 -dithiourealipids or/and 1,2-dithiourealipids or/and 2,3-dithiourealipids or/and 1,3-diacylurealipids or/and 1,2-diacylurealipids or/and 2,3-diacylurealipids or/and 1 -amidolipids or/and 1-urealipids or/and 1-thiourealipids or/and 1-acylurealipids or/and cyclic-amidolipids or/and cyclic urealipids or/and cyclic thiourealipids or/and cyclic acylurealipids, and their medical and non-medical use.
PCT/EP2012/001052 2011-03-10 2012-03-09 Novel lipids and novel phospholipids structures Ceased WO2012119780A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161451153P 2011-03-10 2011-03-10
US61/451,153 2011-03-10

Publications (2)

Publication Number Publication Date
WO2012119780A2 WO2012119780A2 (en) 2012-09-13
WO2012119780A3 true WO2012119780A3 (en) 2012-12-20

Family

ID=45922636

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2012/001053 Ceased WO2012119781A2 (en) 2011-03-10 2012-03-09 Novel lipids, phospholipids, phospholipid and lipid compositions and their use
PCT/EP2012/001052 Ceased WO2012119780A2 (en) 2011-03-10 2012-03-09 Novel lipids and novel phospholipids structures

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/001053 Ceased WO2012119781A2 (en) 2011-03-10 2012-03-09 Novel lipids, phospholipids, phospholipid and lipid compositions and their use

Country Status (1)

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WO (2) WO2012119781A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10940201B2 (en) * 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
DE102015014912B4 (en) * 2015-11-18 2017-09-28 Urotech Gmbh Coating for a medical instrument, method for its coating and medical instrument coated with this method
CN106750450B (en) * 2016-11-07 2020-10-27 西安科技大学 Preparation method of cross-linked adhesive biomimetic coating containing epoxy phosphorylcholine polymer and dopamine
JP6242532B1 (en) * 2017-07-13 2017-12-06 佐々木食品工業株式会社 Novel compound, agent for preventing or treating fatty liver, blood cholesterol lowering agent, and food composition for lowering blood cholesterol
EP3520819A1 (en) * 2018-01-31 2019-08-07 Universität Basel Shear stress sensitive liposomes
CN112236437A (en) * 2018-04-13 2021-01-15 得克萨斯州大学系统董事会 Noble metal coated mechanically responsive vesicles
KR102312654B1 (en) * 2020-12-28 2021-10-15 (주)네오팜 Anti-inflammaging composition
KR102323657B1 (en) * 2021-10-06 2021-11-09 (주)네오팜 Composition for anti-inflammatory
KR20250037122A (en) * 2023-09-08 2025-03-17 경희대학교 산학협력단 Composition for preventing or treating atopic dermatitis or psoriasis comprising candesartan

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GB0910723D0 (en) * 2009-06-22 2009-08-05 Sylentis Sau Novel drugs for inhibition of gene expression

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US6168778B1 (en) * 1990-06-11 2001-01-02 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
WO1997038966A2 (en) * 1996-04-15 1997-10-23 Virginia Commonwealth University Cytoprotective compounds
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US20050095280A1 (en) * 2003-10-15 2005-05-05 Michalakis Savva Single-component pH-sensitive liposomes of reduced solid-to-liquid phase transition temperatures
WO2006006161A2 (en) * 2004-07-09 2006-01-19 Vascular Biogenics Ltd. Improved process for the preparation of oxidized phospholipids
WO2006009464A2 (en) * 2004-07-19 2006-01-26 Thia Medica As Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities
US20060155146A1 (en) * 2005-01-13 2006-07-13 Lenges Christian P Rheology control agents
WO2009056955A1 (en) * 2007-10-30 2009-05-07 University Of Basel Amine-bearing phospholipids (abps), their synthesis and use
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SUNAMOTO J ET AL: "SYNTHESIS AND CHARACTERIZATION OF 1 2 DIMYRISTOYLAMIDO-1 2-DEOXYPHOSPHATIDYLCHOLINE AS AN ARTIFICIAL BOUNDARY LIPID", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1024, no. 2, 1990, pages 209 - 219, XP002680062, ISSN: 0006-3002 *
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Publication number Publication date
WO2012119781A3 (en) 2013-01-03
WO2012119780A2 (en) 2012-09-13
WO2012119781A2 (en) 2012-09-13

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