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WO2012119767A1 - Endoprothèses résonantes à haute fréquence pour la surveillance non invasive d'une resténose - Google Patents

Endoprothèses résonantes à haute fréquence pour la surveillance non invasive d'une resténose Download PDF

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Publication number
WO2012119767A1
WO2012119767A1 PCT/EP2012/001012 EP2012001012W WO2012119767A1 WO 2012119767 A1 WO2012119767 A1 WO 2012119767A1 EP 2012001012 W EP2012001012 W EP 2012001012W WO 2012119767 A1 WO2012119767 A1 WO 2012119767A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
frequency
magnetic field
resonant frequency
resonant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/001012
Other languages
German (de)
English (en)
Inventor
Frank Daschner
Carsten RICKERS
Reinhard Knöchel
Michael Jerosch-Herold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Christian Albrechts Universitaet Kiel
Universitatsklinikum Schleswig Holstein UKSH
Original Assignee
Christian Albrechts Universitaet Kiel
Universitatsklinikum Schleswig Holstein UKSH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christian Albrechts Universitaet Kiel, Universitatsklinikum Schleswig Holstein UKSH filed Critical Christian Albrechts Universitaet Kiel
Publication of WO2012119767A1 publication Critical patent/WO2012119767A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03C—MODULATION
    • H03C3/00—Angle modulation
    • H03C3/10—Angle modulation by means of variable impedance
    • H03C3/12—Angle modulation by means of variable impedance by means of a variable reactive element
    • H03C3/18—Angle modulation by means of variable impedance by means of a variable reactive element the element being a current-dependent inductor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0091—Three-dimensional shapes helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants

Definitions

  • Steps or a closure are introduced by means of a catheter in the vessels.
  • the non-contact measurement of the resonant frequencies of RF resonators by detecting the electromagnetic scattering signature is state of the art in itself and seems adequate to detect any RF resonant implants in the living body without burdening the patient and with comparatively inexpensive measuring devices.
  • the resonant frequency carries state information indicating the presence of restenosis.
  • their precise detection is severely hampered by the background signal inevitably caused by HF scattering in the living organism.
  • the object of the invention is to propose an RF-resonant stent, which provides a well-identifiable scatter signal in the implanted state, which is easy to distinguish from the background signal.
  • the method comprises a step of extrapolating a value for a channel volume and / or a channel diameter of the stent and / or a value for a layer thickness of a plaque layer formed on the stent for a selected future time at least partly from the difference of the determined resonance frequency.
  • a concentrated HF energy store is additionally arranged on the stent, whose capacitance or inductance-and thus the energy storage capacity-can be changed by the application of a magnetic field.
  • the concentrated energy storage is right in the
  • the RF resonant stent may be assigned an equivalent circuit diagram, which is shown in Fig. 1 below. Shown are only inductors and capacitors. Ohmic losses are of course present, but are ignored here. The largest contributions to the capacitance of the stent oscillator circuit are to be seen where the opposite boundaries of the marked area come closest. As can be seen, the dumbbell configuration results in that preferably electric fields are formed along the stent axis, which is favorable for the sensitivity of the plaque detection.
  • FIG. 4 Another embodiment of the stent according to the invention uses at least one varactor diode (also: capacitance diode) and can be seen in FIG.
  • the varactor diode is reverse biased and the thickness of the barrier depends on the applied reverse voltage.
  • the varactor diode is thus used here as a tunable capacitance.
  • two varactor diodes are arranged in the stent such that they form the largest part of the capacitance of the slot resonator. Any change in tunable capacitance alters the resonant frequency of the stent. To periodically change the capacitance requires a periodic voltage signal which must be produced by the modulation magnetic field.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Power Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne une endoprothèse résonante à haute fréquence comprenant au moins un élément de modulation intégré dans la structure métallique de l'endoprothèse, entrant en contact avec le résonateur HF et réalisé comme un accumulateur d'énergie HF. Ledit élément de modulation modifie sa capacité d'accumulation d'énergie lorsqu'il est soumis à l'effet d'un champ magnétique. L'invention concerne également un procédé d'évaluation d'une sténose dans une endoprothèse réalisée de la sorte.
PCT/EP2012/001012 2011-03-07 2012-03-07 Endoprothèses résonantes à haute fréquence pour la surveillance non invasive d'une resténose Ceased WO2012119767A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201110013308 DE102011013308B4 (de) 2011-03-07 2011-03-07 Hochfrequenz-resonante Stents für das nicht-invasive Restenose-Monitoring
DE102011013308.9 2011-03-07

Publications (1)

Publication Number Publication Date
WO2012119767A1 true WO2012119767A1 (fr) 2012-09-13

Family

ID=45833296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/001012 Ceased WO2012119767A1 (fr) 2011-03-07 2012-03-07 Endoprothèses résonantes à haute fréquence pour la surveillance non invasive d'une resténose

Country Status (2)

Country Link
DE (1) DE102011013308B4 (fr)
WO (1) WO2012119767A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6689699B2 (ja) * 2016-07-22 2020-04-28 シスメックス株式会社 血液回収具、及び血液回収セット

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100815A1 (en) 2001-11-27 2003-05-29 Pearl Technology Holdings, Llc In-stent restenosis detection device
WO2005110526A2 (fr) * 2004-04-30 2005-11-24 Biophan Technologies, Inc. Dispositif pour la détection de resténose
US20050267569A1 (en) 2004-03-27 2005-12-01 Gary Barrett Non-invasive detection of in-stent stenosis and drug elution
WO2010019773A2 (fr) 2008-08-13 2010-02-18 Proteus Biomedical, Inc. Endoprothèse vasculaire intelligente
WO2011121581A1 (fr) * 2010-04-02 2011-10-06 Universita' Degli Studi Di Roma "Tor Vergata" Dispositif implantable dans des conduits biologiques

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100815A1 (en) 2001-11-27 2003-05-29 Pearl Technology Holdings, Llc In-stent restenosis detection device
WO2003045236A2 (fr) 2001-11-27 2003-06-05 Pearl Technology Holdings, Llc Dispositif de detection de restenose intrastent
US20050267569A1 (en) 2004-03-27 2005-12-01 Gary Barrett Non-invasive detection of in-stent stenosis and drug elution
WO2005110526A2 (fr) * 2004-04-30 2005-11-24 Biophan Technologies, Inc. Dispositif pour la détection de resténose
WO2010019773A2 (fr) 2008-08-13 2010-02-18 Proteus Biomedical, Inc. Endoprothèse vasculaire intelligente
WO2011121581A1 (fr) * 2010-04-02 2011-10-06 Universita' Degli Studi Di Roma "Tor Vergata" Dispositif implantable dans des conduits biologiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOFFMANN, ENTWICKLUNG EINES RESONANTEN STENTS ZUR DRAHTLOSEN, NICHT-INVASIVEN MESSUNG VON STENOSEN, 2009, pages 105 - 106
MELZER, A. ET AL.: "Signal Enhancement of Stents in Magnetic Resonance Imaging", PROC. INTL. SOC. MAG. RESON. MED., vol. 8, 2000, pages 1317, XP002402021
RAMAN VK; KARMARKAR PV; GUTTMAN MA; DICK AJ; PETERS DC; OZTURK C; PESSANHA BS; THOMPSON RB; RAVAL AN; DESILVA R: "Real-time magnetic resonance-guided endovascular repair of experimental abdominal aortic aneurysm in swine", J AM COLL CARDIOL., vol. 45, no. 12, 21 June 2005 (2005-06-21), pages 2069 - 77, XP027720245
VON KIVELITZ D; WAGNER S; HANSEL J; SCHNORR J; WETZLER R; BUSCH M; MELZER A; TAUPITZ M; HAMM B: "The active magnetic resonance imaging stent (AMRIS): initial experimental in vivo results with locally amplified MR angiography and flow measurements", INVEST RADIOL, vol. 36, 2001, pages 625 - 631

Also Published As

Publication number Publication date
DE102011013308A1 (de) 2012-09-13
DE102011013308B4 (de) 2013-09-19

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