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WO2012115493A3 - 암에 대한 바이오마커 및 이를 이용한 암 진단 - Google Patents

암에 대한 바이오마커 및 이를 이용한 암 진단 Download PDF

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Publication number
WO2012115493A3
WO2012115493A3 PCT/KR2012/001471 KR2012001471W WO2012115493A3 WO 2012115493 A3 WO2012115493 A3 WO 2012115493A3 KR 2012001471 W KR2012001471 W KR 2012001471W WO 2012115493 A3 WO2012115493 A3 WO 2012115493A3
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WIPO (PCT)
Prior art keywords
cancer
present
marker
mest
reliability
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Ceased
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PCT/KR2012/001471
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English (en)
French (fr)
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WO2012115493A2 (ko
WO2012115493A9 (ko
Inventor
강성균
이현숙
이정현
김상진
권개경
임형순
김윤재
황영옥
진욱
조용균
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Korea Ocean Research and Development Institute (KORDI)
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Korea Ocean Research and Development Institute (KORDI)
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Priority to US14/001,655 priority Critical patent/US20170240971A1/en
Publication of WO2012115493A2 publication Critical patent/WO2012115493A2/ko
Publication of WO2012115493A3 publication Critical patent/WO2012115493A3/ko
Publication of WO2012115493A9 publication Critical patent/WO2012115493A9/ko
Anticipated expiration legal-status Critical
Priority to US16/558,455 priority patent/US20190382853A1/en
Priority to US18/078,391 priority patent/US20230111706A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 암 진단 또는 예후 분석용 키트에 관한 것이다. 본 발명에서의 MEST는 암에 대한 마커로서의 정확성 및 신뢰도가 크게 개선된 마커이다. 특히, 본 마커는 유방암과 간암에 대한 마커로서의 정확성 및 신뢰도가 우수하다. 본 발명에서의 MEST는 전이암에 대한 마커에 있어서 매우 우수한 정확성과 신뢰도를 나타낸다. 또한, 본 발명은 암 환자의 세포 및 조직에서만 특이적으로 발현이 증가되는 MEST을 이용하여 생물학적 시료(예컨대, 혈액이나 혈청)로부터 매우 특이적으로 암의 조기 진단 및 예후를 판정할 수 있다.
PCT/KR2012/001471 2011-02-25 2012-02-27 암에 대한 바이오마커 및 이를 이용한 암 진단 Ceased WO2012115493A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/001,655 US20170240971A1 (en) 2011-02-25 2012-02-27 Biomarkers for cancer diagnosis and prognosis and method for using thereof
US16/558,455 US20190382853A1 (en) 2011-02-25 2019-09-03 Mest as biomarker for cancer diagnosis and prognosis and method for using thereof
US18/078,391 US20230111706A1 (en) 2011-02-25 2022-12-09 Mest as biomarker for cancer diagnosis and prognosis and method for using thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110016983A KR101270944B1 (ko) 2011-02-25 2011-02-25 암에 대한 바이오마커 및 이를 이용한 암 진단
KR10-2011-0016983 2011-02-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/001,655 A-371-Of-International US20170240971A1 (en) 2011-02-25 2012-02-27 Biomarkers for cancer diagnosis and prognosis and method for using thereof
US16/558,455 Continuation-In-Part US20190382853A1 (en) 2011-02-25 2019-09-03 Mest as biomarker for cancer diagnosis and prognosis and method for using thereof

Publications (3)

Publication Number Publication Date
WO2012115493A2 WO2012115493A2 (ko) 2012-08-30
WO2012115493A3 true WO2012115493A3 (ko) 2012-12-20
WO2012115493A9 WO2012115493A9 (ko) 2013-02-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001471 Ceased WO2012115493A2 (ko) 2011-02-25 2012-02-27 암에 대한 바이오마커 및 이를 이용한 암 진단

Country Status (3)

Country Link
US (1) US20170240971A1 (ko)
KR (1) KR101270944B1 (ko)
WO (1) WO2012115493A2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101588018B1 (ko) * 2012-12-04 2016-01-25 연세대학교 산학협력단 암에 대한 바이오마커 및 이를 이용한 암 진단 방법
US20200232044A1 (en) * 2017-10-02 2020-07-23 Universität Zu Köln Tumor and metastasizing marker
CN108152496B (zh) * 2017-11-24 2020-10-27 暨南大学 Mest蛋白在制备肺癌辅助诊断和/或预后判断的试剂盒中的应用
CN107807243B (zh) * 2017-11-24 2020-08-07 暨南大学 一种食管癌的生物标志物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007306801A (ja) * 2004-07-08 2007-11-29 Japan Health Science Foundation 肥満関連疾患診断方法、Ｍｅｓｔ発現調節因子検査方法及びＭｅｓｔ発現調節因子のスクリーニング方法
US20100124747A1 (en) * 2008-11-03 2010-05-20 University Of Southern California Compositions and methods for diagnosis or prognosis of testicular cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007306801A (ja) * 2004-07-08 2007-11-29 Japan Health Science Foundation 肥満関連疾患診断方法、Ｍｅｓｔ発現調節因子検査方法及びＭｅｓｔ発現調節因子のスクリーニング方法
US20100124747A1 (en) * 2008-11-03 2010-05-20 University Of Southern California Compositions and methods for diagnosis or prognosis of testicular cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AIK CHOON TAN ET AL.: "Characterizing DNA methylation patterns in pancreatic cancer genome.", MOL. ONCOL., vol. 3, no. 5-6, 2009, pages 425 - 438 *
ALESSANDRO D. SANTIN ET AL.: "Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy.", VIROLOGY, vol. 331, no. 2, 2005, pages 269 - 291 *

Also Published As

Publication number Publication date
KR101270944B1 (ko) 2013-06-11
KR20120097647A (ko) 2012-09-05
US20170240971A1 (en) 2017-08-24
WO2012115493A2 (ko) 2012-08-30
WO2012115493A9 (ko) 2013-02-14

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