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WO2012112842A3 - Compositions and methods for treating poliovirus - Google Patents

Compositions and methods for treating poliovirus Download PDF

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Publication number
WO2012112842A3
WO2012112842A3 PCT/US2012/025571 US2012025571W WO2012112842A3 WO 2012112842 A3 WO2012112842 A3 WO 2012112842A3 US 2012025571 W US2012025571 W US 2012025571W WO 2012112842 A3 WO2012112842 A3 WO 2012112842A3
Authority
WO
WIPO (PCT)
Prior art keywords
poliovirus
methods
compositions
treating
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/025571
Other languages
French (fr)
Other versions
WO2012112842A2 (en
Inventor
Zhaochun Chen
Robert H. Purcell
Konstantin Chumakov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of WO2012112842A2 publication Critical patent/WO2012112842A2/en
Publication of WO2012112842A3 publication Critical patent/WO2012112842A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1009—Picornaviridae, e.g. hepatitis A virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

Chimeric chimpanzee/human antibodies and antigen-binding fragments thereof that are capable of neutralizing poliovirus are provided. In addition, methods of using the antibodies and antigen-binding fragments thereof to prevent or treat poliovirus infection are also provided.
PCT/US2012/025571 2011-02-17 2012-02-17 Compositions and methods for treating poliovirus Ceased WO2012112842A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161443915P 2011-02-17 2011-02-17
US61/443,915 2011-02-17

Publications (2)

Publication Number Publication Date
WO2012112842A2 WO2012112842A2 (en) 2012-08-23
WO2012112842A3 true WO2012112842A3 (en) 2013-01-31

Family

ID=45953219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/025571 Ceased WO2012112842A2 (en) 2011-02-17 2012-02-17 Compositions and methods for treating poliovirus

Country Status (1)

Country Link
WO (1) WO2012112842A2 (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1975A (en) 1841-02-12 Manner of constructing corn-shellers
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEN ZHAOCHUN ET AL: "Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 103, no. 6, 7 February 2006 (2006-02-07), pages 1882 - 1887, XP002389476, ISSN: 0027-8424, DOI: 10.1073/PNAS.0510598103 *
CHEN ZHAOCHUN ET AL: "Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis.", JOURNAL OF VIROLOGY MAY 2011 LNKD- PUBMED:21345966, vol. 85, no. 9, May 2011 (2011-05-01), pages 4354 - 4362, XP002682219, ISSN: 1098-5514 *
CHU C-T ET AL: "A HUMAN-HUMAN HYBRIDOMA WHICH PRODUCES ANTIBODIES TO POLIOVIRUSES", PROCEEDINGS OF THE NATIONAL SCIENCE COUNCIL REPUBLIC OF CHINA PART B LIFE SCIENCES, vol. 13, no. 4, 1989, pages 284 - 288, XP009162216, ISSN: 0255-6596 *
SCHOFIELD D J ET AL: "Four chimpanzee monoclonal antibodies isolated by phage display neutralize hepatitis a virus.", VIROLOGY 5 JAN 2002 LNKD- PUBMED:11878915, vol. 292, no. 1, 5 January 2002 (2002-01-05), pages 127 - 136, XP002965366, ISSN: 0042-6822 *
UHLIG H ET AL: "Intertypic cross-neutralization of polioviruses by human monoclonal antibodies", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 163, no. 1, 1 March 1988 (1988-03-01), pages 214 - 217, XP023047507, ISSN: 0042-6822, [retrieved on 19880301], DOI: 10.1016/0042-6822(88)90251-6 *

Also Published As

Publication number Publication date
WO2012112842A2 (en) 2012-08-23

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