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WO2012112119A8 - Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman - Google Patents

Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman Download PDF

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Publication number
WO2012112119A8
WO2012112119A8 PCT/SG2011/000065 SG2011000065W WO2012112119A8 WO 2012112119 A8 WO2012112119 A8 WO 2012112119A8 SG 2011000065 W SG2011000065 W SG 2011000065W WO 2012112119 A8 WO2012112119 A8 WO 2012112119A8
Authority
WO
WIPO (PCT)
Prior art keywords
analytes
sers
liquid sample
different locations
inhomogenous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SG2011/000065
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English (en)
Other versions
WO2012112119A1 (fr
Inventor
Md. Khalid NIZAMUDIN
Shaik SALIM
Effendi Widjaja
Geok Hong LIM
Marc Garland
Ajay Agarwal
Cheng Fang
Kavitha Devi BUDDHARAJU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science Technology and Research Singapore
Original Assignee
Agency for Science Technology and Research Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Science Technology and Research Singapore filed Critical Agency for Science Technology and Research Singapore
Priority to PCT/SG2011/000065 priority Critical patent/WO2012112119A1/fr
Priority to SG2013061445A priority patent/SG192753A1/en
Publication of WO2012112119A1 publication Critical patent/WO2012112119A1/fr
Anticipated expiration legal-status Critical
Publication of WO2012112119A8 publication Critical patent/WO2012112119A8/fr
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Selon la présente invention, un échantillon liquide contenant des analytes multiples est utilisé pour produire une couche sur une surface SERS d'un substrat SERS. Des spectres Raman sont recueillis à partir des différents emplacements. Les spectres Raman pour des emplacements différents ont des rapports différents des composantes de signal des analytes respectifs multiples, par exemple car les analytes sont présents dans des proportions différentes aux différents emplacements, ou car les analytes interagissent avec la surface SERS de manières différentes aux différents emplacements. Une technique de résolution de courbe auto-modelante telle que BTEM est utilisée pour extraire à partir des spectres Raman recueillis de multiples spectres de composants purs, correspondant aux composants d'analytes respectifs. Les spectres de composants purs peuvent être utilisés pour identifier les analytes. Une façon de produire la couche inhomogène est d'évaporer l'échantillon liquide. Une autre est de disposer la surface du substrat SERS de sorte qu'elle soit inhomogène, de sorte qu'une couche inhomogène d'analytes adsorbés soit formée et/ou de telle sorte que l'effet SERS lui-même soit inhomogène.
PCT/SG2011/000065 2011-02-16 2011-02-16 Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman Ceased WO2012112119A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/SG2011/000065 WO2012112119A1 (fr) 2011-02-16 2011-02-16 Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman
SG2013061445A SG192753A1 (en) 2011-02-16 2011-02-16 Method and apparatus for analyzing a liquid sample by raman spectroscopy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2011/000065 WO2012112119A1 (fr) 2011-02-16 2011-02-16 Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman

Publications (2)

Publication Number Publication Date
WO2012112119A1 WO2012112119A1 (fr) 2012-08-23
WO2012112119A8 true WO2012112119A8 (fr) 2013-09-12

Family

ID=46672841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2011/000065 Ceased WO2012112119A1 (fr) 2011-02-16 2011-02-16 Procédé et appareil pour l'analyse d'un échantillon liquide par spectroscopie raman

Country Status (2)

Country Link
SG (1) SG192753A1 (fr)
WO (1) WO2012112119A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105606584A (zh) * 2015-12-15 2016-05-25 厦门出入境检验检疫局检验检疫技术中心 一种使用拉曼光谱鉴别物品一致性的方法和系统

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103940934B (zh) * 2014-03-25 2016-04-27 张华俊 一种分析混合物成分的方法
WO2016041842A1 (fr) 2014-09-17 2016-03-24 Danmarks Tekniske Universitet Procédé et système de détection d'un analyte cible
CN104267108A (zh) * 2014-09-23 2015-01-07 广西壮族自治区药用植物园 一种基于mrem化学计量法与色谱联用的中药成分分析方法
WO2023205279A1 (fr) * 2022-04-19 2023-10-26 The Johns Hopkins University Spectroscopie raman améliorée avec addition de composés aromatiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7515269B1 (en) * 2004-02-03 2009-04-07 The United States Of America As Represented By The Secretary Of The Army Surface-enhanced-spectroscopic detection of optically trapped particulate
US20070082409A1 (en) * 2005-09-15 2007-04-12 The Regents Of The University Of Michigan Method and apparatus for measuring cartilage condition biomarkers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105606584A (zh) * 2015-12-15 2016-05-25 厦门出入境检验检疫局检验检疫技术中心 一种使用拉曼光谱鉴别物品一致性的方法和系统

Also Published As

Publication number Publication date
WO2012112119A1 (fr) 2012-08-23
SG192753A1 (en) 2013-09-30

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