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WO2012108780A1 - Procédé et système de dépistage pour analyse biomédicale et procédure pour sa construction - Google Patents

Procédé et système de dépistage pour analyse biomédicale et procédure pour sa construction Download PDF

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Publication number
WO2012108780A1
WO2012108780A1 PCT/RO2011/000008 RO2011000008W WO2012108780A1 WO 2012108780 A1 WO2012108780 A1 WO 2012108780A1 RO 2011000008 W RO2011000008 W RO 2011000008W WO 2012108780 A1 WO2012108780 A1 WO 2012108780A1
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WO
WIPO (PCT)
Prior art keywords
biomedical
substances
analysis
interest
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RO2011/000008
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English (en)
Inventor
Raluca-loana VAN STADEN
Staden Jacobus Frederick Van
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2012108780A1 publication Critical patent/WO2012108780A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Definitions

  • the invention relates the method of screening and fast screening systems minimally invasive and noninvasive to identify and quantify substances of biomedical interest, with immediate results for patients, easy to scan the mass of the population to improve health.
  • the technical problem which aims to solve the present invention is to achieve a mass screening system that allows people to identify and quantify substances of biomedical interest in biological fluids and tissues, using methods of screening and screening systems for minimally invasive or non-invasive, with results obtained in real-time.
  • the system includes sensors with characteristics superior to those presented in the previous patents, BI123101 - the proposed stochastic sensor for ascorbic acid determination based on porphyrins, having macro size, and an electrolyte (KCI) in the plastic body, and Bl 125050 - proposed a stochastic microsensor for diagnosing of cancer at the molecular level, a few drops of blood can be used before and/or after cancer has been installed in the body, and the patent application A01 120/2010 where the DOT sensor formed from a working electrode, a reference electrode and an auxiliary electrode (amperometric electrodes only and stochastic electrodes) that can make analysis of two or more analytes simultaneously, using different techniques such as potentiometric, amperometric, stochastic, optical, the method being correlated with the nature of the substance to be determined, the working electrode consisting of a simple or modified diamond paste with different chiral selectors such as inulin, phthalocyanine.
  • the working electrode consisting of a simple or modified
  • A608/2010 patent application have been proposed a method and system for detection, identification and rapid quantitative evaluation of specific biomarkers in biological fluids that can perform medical tests by automatic detection of the biomarkers known by the system, automatic identification of particular elements of the electrical signal generated by the biomarker, indicating precisely the type of biomarker and performing a quantitative evaluation of biomarkers in the sample of fluid, resulting in relative concentration.
  • Screening system comprising: system for generation of the analytical information composed of analytical sensor systems consisting of electrochemical and/or optical sensors which are in direct contact with biological fluids or tissue for analysis, measurement system with electrochemical and/or optical detection features with ability to transform . the analytical information into experimental data, system for acquisition, processing and storing data that will allow their visualization at any time, and remote transmission of data processed, which will be selected depending on the possibilities of the area where the analysis is performed.
  • the system used for the generation of the analytical information consists of electrochemical and optical sensors with different sizes and shapes, and it can be used for measurements of biological fluids and/or tissues according to the analysis required by the physician or the patient, with the ability to make one measurement or multiple measurements.
  • Electrochemical and optical sensors are composed of a matrix that can be paste, sol-gel, plastic, metal (eg gold, platinum, silver), and an electroactive or/and optical compound which is of biological or synthetic nature, depending on the particular nature and composition of biological substance - reviewed biomedical interest.
  • Fig. 1 - Represents a perspective view of the screening system for biomedical analysis, accordingly with the method, the object of the invention.
  • Fig. 2 - Represents the block diagram of the screening system for biomedical analysis, according to the invention.
  • Fig. 3 - Represents the perspective view of the system that generates analytical information.
  • FIG. 1 Screening system for biomedical analysis consists (Fig. 1), according to the invention, of a system for generating analytical information 1 that comes into direct contact with biological fluid or tissue and the system for processing system 7 up to experimental data - proper analysis results.
  • the results can be viewed on a screen 6, can be printed with a simple push of the button 3 or/and transmitted to a medical center or medical doctor by pressing 4. Pressing button 5 will allow the interruption of the power supply unit.
  • Electrochemical/optical working sensors consist of a matrix of any of the following types: sol-gel, plastic, metal (eg gold, platinum, silver) or solid which incorporate the electroactive or optical compound which can be of biological or synthetic nature.
  • Medical examination is done by putting in contact biological sample (fluid or tissue) with the system for the generation of the analytic information 1 , processing is done in real time by the system of processing of the analytical information 7, resulting in experimental data reflecting the quality and quantity of the biological compounds of biomedical interest in biological fluid or tissue, which represents the result of analysis.
  • the analytical result can be printed by selecting 3 and transmitted by means at the disposal site analysis or a doctor specialized databases by pressing 4.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un procédé et un système de dépistage pour analyse biomédicale utilisés dans la détermination qualitative et quantitative de substances d'intérêt biomédical en temps réel, facilitant l'examen en masse de la population pour améliorer son état de santé. Le procédé d'identification et de quantification de substances d'intérêt biologique dans des fluides et des tissus biologiques vise à déterminer l'existence de substances d'intérêt biomédical de maladies spécifiques ou à effectuer des tests de routine pour déterminer l'état de santé du patient, leur nombre est illimité, à identifier la substance d'intérêt biomédical et à la quantifier, les deux mesures étant nécessaires à la détermination de l'état de santé, de l'évolution de la maladie ou à l'établissement de l'efficience du traitement médical ou d'un quelconque autre type de traitement administré au patient. Un système de dépistage pour analyse biomédicale selon l'invention est constitué d'un système destiné à générer une information analytique 1, qui entre en contact direct avec un système de traitement de fluides ou de tissus biologiques et un système 7 de traitement de données, qui transmet les résultats d'analyse à une imprimante 3 et à un médecin ou à une base de données en pressant 4.
PCT/RO2011/000008 2011-02-08 2011-02-17 Procédé et système de dépistage pour analyse biomédicale et procédure pour sa construction Ceased WO2012108780A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ROA201100111A RO126898B1 (ro) 2011-02-08 2011-02-08 Sistem de scanare pentru analize biomedicale
ROA201100111 2011-02-08

Publications (1)

Publication Number Publication Date
WO2012108780A1 true WO2012108780A1 (fr) 2012-08-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RO2011/000008 Ceased WO2012108780A1 (fr) 2011-02-08 2011-02-17 Procédé et système de dépistage pour analyse biomédicale et procédure pour sa construction

Country Status (2)

Country Link
RO (1) RO126898B1 (fr)
WO (1) WO2012108780A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278270A (en) 1964-03-13 1966-10-11 Unimed Inc Pregnancy test
US6043492A (en) 1997-10-27 2000-03-28 Industrial Technology Research Institute Non-invasive blood glucose meter
US6205354B1 (en) 1999-06-18 2001-03-20 University Of Utah Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
WO2010081219A1 (fr) * 2009-01-13 2010-07-22 Fio Corporation Dispositif portatif de test de diagnostic et procédé pour son utilisation avec un dispositif électronique et une cartouche de test dans un test de diagnostic rapide
RO123101B1 (ro) 2008-11-17 2010-10-29 Institutul Naţional De Cercetare-Dezvoltare Pentru Electrochimie Şi Materie Condensată Senzori stocastici, pentru determinarea acidului ascorbic, şi procedeu de realizare a acestora
US20100279418A1 (en) * 2009-05-04 2010-11-04 Loren Robert Larson Glucose meter adaptable for use with handheld devices, and associated communication network
RO125050B1 (ro) 2009-07-01 2010-12-30 Institutul Naţional De Cercetare-Dezvoltare Pentru Electrochimie Şi Materie Condensată Microsenzor stocastic, pentru diagnosticarea cancerului la nivel molecular, şi procedeu de realizare a acestuia

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278270A (en) 1964-03-13 1966-10-11 Unimed Inc Pregnancy test
US6043492A (en) 1997-10-27 2000-03-28 Industrial Technology Research Institute Non-invasive blood glucose meter
US6205354B1 (en) 1999-06-18 2001-03-20 University Of Utah Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
RO123101B1 (ro) 2008-11-17 2010-10-29 Institutul Naţional De Cercetare-Dezvoltare Pentru Electrochimie Şi Materie Condensată Senzori stocastici, pentru determinarea acidului ascorbic, şi procedeu de realizare a acestora
WO2010081219A1 (fr) * 2009-01-13 2010-07-22 Fio Corporation Dispositif portatif de test de diagnostic et procédé pour son utilisation avec un dispositif électronique et une cartouche de test dans un test de diagnostic rapide
US20100279418A1 (en) * 2009-05-04 2010-11-04 Loren Robert Larson Glucose meter adaptable for use with handheld devices, and associated communication network
RO125050B1 (ro) 2009-07-01 2010-12-30 Institutul Naţional De Cercetare-Dezvoltare Pentru Electrochimie Şi Materie Condensată Microsenzor stocastic, pentru diagnosticarea cancerului la nivel molecular, şi procedeu de realizare a acestuia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 201102, Derwent World Patents Index; Class B04, AN 2010-P04050, XP002678448 *
R-I S VAN STADEN ET AL: "Micro- and nanosensors, recent developments and features: a minireview", ANALYTICAL LETTERS, vol. 43, 1 January 2010 (2010-01-01), pages 1111 - 1118, XP009160317, ISSN: 0003-2719 *

Also Published As

Publication number Publication date
RO126898B1 (ro) 2016-05-30
RO126898A0 (ro) 2011-12-30

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