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WO2012108744A2 - Composition et alimentation fonctionnelle pour traiter le cancer du cerveau comprenant un extrait de la fleur inula - Google Patents

Composition et alimentation fonctionnelle pour traiter le cancer du cerveau comprenant un extrait de la fleur inula Download PDF

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Publication number
WO2012108744A2
WO2012108744A2 PCT/KR2012/001078 KR2012001078W WO2012108744A2 WO 2012108744 A2 WO2012108744 A2 WO 2012108744A2 KR 2012001078 W KR2012001078 W KR 2012001078W WO 2012108744 A2 WO2012108744 A2 WO 2012108744A2
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Prior art keywords
brain cancer
composition
extract
brain
cancer
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English (en)
Korean (ko)
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WO2012108744A3 (fr
Inventor
황성연
정경채
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KOREA BIO MEDICAL SCIENCE INSTITUTE
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KOREA BIO MEDICAL SCIENCE INSTITUTE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • the present invention relates to a novel use of the mussel extract. Specifically, the present invention relates to a therapeutic composition and a functional food containing a capillary extract as an active ingredient exhibiting excellent prophylactic or therapeutic efficacy against brain cancer.
  • Brain cancer refers to abnormally increased proliferation of any type of neuron, also referred to as primary brain cancer, or any other cancer that metastasizes to the central nervous system (CNS), also referred to as brain metastasis.
  • CNS central nervous system
  • Primary brain cancer can only occur in those cases where the nerve cells lose their protective ability to undergo apoptosis.
  • Examples of primary brain cancers include, but are not limited to, neuroma, astrocytoma, neuroblastoma, glioma, meningioma, oligodendrocyte, stromal blastoma, spinal cord tumor and neuromyoma.
  • Gliomas comprise about 60% of all primary CNS tumors and typically occur in the cerebral hemispheres of the brain, but can be found in other areas such as the visual nerve, brain stem or cerebellum. Gliomas can be classified into groups according to the type of glial cell from which they originated (Kornblith et al, (1986), Cancer: Principles and Practice of Oncology, 2nd Ed., DeVita, V., Hellman, S., Rosenberg , S, eds., JB Lippincott Company, Philadelphia, Chapter 41: Neoplasms of the Central Nervous System). The most common type of glioma is astrocytoma. These tumors develop from star-shaped glial cells called astroglia.
  • Astrocytes are assigned a rating according to their malignancy.
  • Low-grade astrocytomas also known as grade I and II astrocytomas
  • Mid-grade astrocytoma also known as grade III astrocytoma
  • Grade III astrocytoma is treated with radiation and some chemotherapy following surgery.
  • High-grade astrocytoma also known as grade IV astrocytoma
  • Grade IV astrocytomas are usually treated with a combination of radiation and chemotherapy following surgery.
  • Glioblastoma multiforme is a grade IV astrocytoma, which is the most malignant and lethal primary brain tumor (Id).
  • Id primary brain tumor
  • the benefit of treatment is minimal, and treatment can significantly reduce the quality of the patient's short-lived life.
  • CNS tumors represent the most common group of solid tumors in young patients, there is a clear need in the art for primary brain cancer prevention and treatment methods that overcome the disadvantages of the above-mentioned conventional approaches.
  • Brain tumors are a secondary-induced cause of cancer-related death in infants, with approximately 25% of all such deaths, with current therapies in which most of these infants die within the first year of diagnosis.
  • Brain metastasis results from primary tumors elsewhere in the body, including, but not limited to, lung cancer (both small and non-small cell), breast cancer, colorectal cancer, prostate cancer, melanoma and pancreatic cancer. Particularly in patients with metastatic breast cancer, the incidence of brain metastasis is diagnosed at a rate of 10-20% (Tyson, R.M. et al, Therapy 3 (1), 97-112 (2006)).
  • Breast cancer is the second leading cause of cancer-related death in women, and nearly all deaths from breast cancer are due to metastatic disease with brain metastases found in 30% of patients at autopsy.
  • Standard modes of treatment include surgical resection, chemotherapy and radiation therapy, in particular whole-brain radiation therapy (WBRT) and stereotactic radiosurgery or combinations thereof.
  • Surgery for brain metastases can improve survival, especially in patients with a single lesion. Surgery, however, may not be possible in terms of multiple lesions, lesions that are difficult to surgically approach, or inability to withstand surgery. In breast cancer, 50% of patients with brain cancer metastases have multiple metastases, making them less suitable as surgical candidates.
  • WBRT can improve intermediate survival over untreated and as an adjuvant for surgery, which reduces the chance of relapse and dying nerve death, but does not change survival or level of action.
  • SRS provides a method for treating brain metastases that cannot be surgically resected by location or patient symptoms.
  • SRS provides an improvement in quality of life but does not provide survival benefits, except for patients with a single metastasis.
  • the use of chemotherapy in the treatment of brain metastases is hampered by the impossibility of high molecular weight compounds, limiting most chemotherapeutic agents across the blood brain barrier. This is reflected in the fact that chemosensitive tumors, such as most metastatic breast carcinomas, often exhibit a complete systemic response to chemotherapy simultaneously with tumor progression in the brain.
  • this initial resistance to the use of chemotherapy in the treatment of brain metastases has recently changed based on observations in animal models and human brain tumor autopsies, and metastatic lesions cause blood brain barrier insufficiency, whereby chemotherapy Drugs can always enter the tumor.
  • Radiation therapy combined with chemotherapy has evolved from a first-line approach in the treatment of brain metastases.
  • Some problems associated with the above approaches include (i) deleterious side effects, including alteration of intelligence, learning ability, memory, motor skills, consciousness and emotions; (ii) recurrence of tumors within 3 to 5 years of treatment because of the development of resistance to these therapies; (iii) death due to ineffectiveness of this treatment. From the foregoing, it will be apparent that there is an urgent need to develop a chemotherapeutic agent that can cross the blood brain barrier in an effective amount to reduce neoplastic expansion and / or growth of cancer in the central nervous system, which is not yet satisfied.
  • Brain cancer is a generic term for primary brain cancer that develops in the brain tissue and the envelope that surrounds the brain, and secondary brain cancer that has metastasized from cancer that occurs in the skull or other parts of the body.
  • Such brain cancers are often distinguished from cancers occurring in other organs.
  • lung, stomach, and breast cancers occur in one or two types of organs, and their properties are the same and similar.
  • the brain develops a wide variety of cancers. For example, glioblastoma multiforme, malignant gliomas, lymphomas, germ cell tumors, metastatic tumors, and the like.
  • glioma especially glioblastoma multiforme (GBM)
  • GBM glioblastoma multiforme
  • Inulae Flos is a flower of the perennial Inula Japonica Thunb.
  • the diameter is 10-15 mm and has a spherical shape. It is composed of several guns and arranged in a tile shape. It has an unusual smell, tastes sweet and bitter behind.
  • Antidiabetic effects have been reported in scientific studies on capillary extracts (Shan JJ, et al., Anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica in alloxan-induced diabetic mice, Biol. Pharm , Bull., 29, pp 455-459, 2006),
  • the present inventors completed the present invention by confirming that the extracts can effectively kill brain cancer cells during the study of the herbal medicines for the recovery.
  • the present invention provides a composition for the prevention and treatment of brain cancer comprising an active ingredient extracted from the organic solvent.
  • the organic solvent is preferably ethanol.
  • the present invention provides a functional food for preventing brain cancer containing a ethanol extract of the above-mentioned containing a food supplement acceptable food supplement as an active ingredient.
  • the present invention provides a composition for the prevention and treatment of brain cancer containing Inulae Flos ethanol extract as an active ingredient.
  • the composition of the present invention comprises a capsular extract as an active ingredient, and may further include a pharmaceutically acceptable carrier or diluent.
  • the ethanol extract is preferably extracted for 24 hours at 50 °C, wherein the ethanol extract is more preferably dried and concentrated at 45 °C reduced pressure conditions, the ethanol is Most preferred is 95%.
  • the composition for the prevention and treatment of brain cancer of the present invention is selected from the primary brain cancer crowd consisting of neuroma, astrocytoma, neuroblastoma, glioma, meningioma, rare oligodendrocyte, stromal blastoma, spinal cord tumor and neuromyoma It is preferably applied to brain cancer.
  • the composition for preventing and treating brain cancer of the present invention, preferably comprises a pharmaceutically acceptable carrier or diluent.
  • the "pharmaceutically acceptable carrier” is a pharmaceutically acceptable substance such as a liquid or solid filler, diluent, excipient or solvent which serves to transport the active ingredient from one organ or part of the body to another organ or part of the body. , Composition or vehicle.
  • composition for treating brain cancer of the present invention may be prepared as a medicament by adding one or more pharmaceutically acceptable carriers together with the active ingredient.
  • the carrier may include, but is not limited to, saline, buffered saline, water, glycerol and ethanol, and any suitable agent known in the art (Remingtons's Pharmaceutical Science (Recent Edition), Mack Publishing Company, Easton PA) may be used. .
  • Formulations for pharmacizing the extract of the present invention can be administered orally during clinical administration and can be used in the form of general pharmaceutical formulations, when formulated, commonly used fillers, extenders, binders, wetting agents, disintegrants And diluents such as surfactants or excipients.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc.
  • liquid preparations for oral use include suspensions, solvents, emulsions, and syrups.
  • various excipients may be included, such as wetting sweeteners, fragrances, preservatives and the like.
  • composition of the present invention may be administered in various parenteral formulations during actual clinical administration, and solid preparations include tablets, pills, powders, granules, capsules, and the like.
  • solid preparations include tablets, pills, powders, granules, capsules, and the like.
  • excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included.
  • preparations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • non-aqueous solvent and the suspension solvent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.
  • calcium or vitamin D 3 may be added to enhance the efficacy of the treatment.
  • Such compositions may be presented in unit-dose (single) or multi-dose (several) containers, such as sealed ampoules and vials, and immediately before use, sterile liquid carriers such as injectable water. Can be stored under freeze-drying conditions requiring only the addition of. Immediate injection solutions and suspensions can be prepared from sterile powders, granules and tablets.
  • the formulations of the present invention can be applied differently depending on the age, sex, condition of the subject, the absorption of the active ingredient in the body, the inactivation rate and excretion rate, the drug used in combination.
  • the invention also includes formulations of dosage units.
  • the formulations are present in individual dosage forms, such as tablets, coated tablets, capsules, pills, suppositories, and ampoules, wherein the amount of active compound in the drug corresponds to the fraction or multiple of the individual dosage.
  • Dosage units may contain, for example, one, two, three or four times the individual dosage, or 1/2, 1/3 or 1/4 times.
  • the individual dosages preferably contain an amount in which the active compound is administered at one time, which usually corresponds to all, 1/2, 1/3 or 1/4 times the daily dosage.
  • extract refers to an active ingredient isolated from natural products.
  • the extract may be obtained by an extraction process using water, an organic solvent, or a mixed solvent thereof, and includes an extract, a dry powder thereof, or any form formulated using the same.
  • the ethanol extract of the ablation killed 73.4% of U-87 MG brain cancer cells at 100 ⁇ g / ml and the EC 50 (half maximal effective concentration) was 25.132 ⁇ g / ml.
  • the above results demonstrate that the mussel extract of the present invention has excellent killing activity of U-87 MG cells and further has brain cancer treatment and prophylactic activity.
  • prevention means any action that inhibits or delays the onset of brain cancer by administration of the composition.
  • treatment means any action that improves or advantageously alters the symptoms of brain cancer by administration of the composition.
  • the sundae extract in the present invention can be extracted and used using water, an organic solvent, or a mixed solvent thereof. Preferably it is extracted using an organic solvent, in particular ethanol.
  • the extracted solution can be used directly or can be concentrated and / or dried.
  • methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof may be used and extracted by room temperature or warming under conditions where the active ingredient of the herbal medicine is not destroyed or minimized.
  • the degree of extraction and loss of the active ingredient of the drug may vary, so select an appropriate organic solvent.
  • the extraction method is not particularly limited, and examples thereof include cold needle extraction, ultrasonic extraction, reflux cooling extraction, and the like.
  • Filtration is a process of removing the suspended solid particles from the extract, it may be used to filter the particles using cotton, nylon or the like, or may be used, such as ultrafiltration, cryofiltration, centrifugal separation, but is not limited thereto.
  • Concentration of the extract may be used, such as concentrated under reduced pressure, reverse osmosis concentration.
  • the drying step after concentration includes freeze drying, vacuum drying, hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, infrared drying, and the like. If desired, a process of grinding the final dried extract may be added.
  • the extract can perform an additional fractionation process.
  • the extract is suspended in distilled water to obtain a nonpolar solvent soluble layer by extraction and separation with a nonpolar organic solvent such as hexane, ether, dichloromethane, chloroform, ethyl acetate, or a mixed solvent thereof. It can be used by concentrating and / or drying it.
  • a nonpolar organic solvent such as hexane, ether, dichloromethane, chloroform, ethyl acetate, or a mixed solvent thereof. It can be used by concentrating and / or drying it.
  • the term "pharmaceutically acceptable salts” means salts derived from pharmacologically or physiologically acceptable inorganic acids, organic acids and bases.
  • suitable acid include hydrochloric acid, bromic acid, sulfuric acid, nitric acid, perchloric acid, fumaric acid, maleic acid, phosphoric acid, glycolic acid, lactic acid, salicylic acid, succinic acid, toluene-p-sulfonic acid, tartaric acid, acetic acid, citric acid, methanesulfonic acid, Formic acid, benzoic acid, malonic acid, naphthalene-2-sulfonic acid, benzenesulfonic acid, and the like.
  • Salts derived from suitable bases may include alkali metals such as sodium, alkaline earth metals such as magnesium, ammonium and the like.
  • the pharmaceutical composition for preventing and treating brain cancer diseases of the present invention comprises 0.1 to 50% by weight of the extract or compound based on the total weight of the composition.
  • the composition does not increase the efficacy, but may include additional ingredients that are commonly used in the pharmaceutical composition to improve the smell, taste, time and the like.
  • the composition adds inorganic and organic additives such as vitamins B1, B2, B6, C, E, niacin, carnitine, betaine, folate pantothenic acid, biotin, zinc, iron, calcium, chromium, magnesium, and mixtures thereof. It can be included as.
  • the composition may include a substance having a therapeutic activity against brain cancer used alone or used in the past.
  • the term "patient” refers to humans and horses, sheep, pigs, goats, camels, who have a disease caused by brain cancer and its direct and indirect causes, and whose symptoms can be improved by administering the composition of the present invention. Means antelope, dog and other animals.
  • a composition comprising the extract of the present invention, the above-mentioned brain cancer can be effectively prevented and treated.
  • the composition of the present invention can be administered in parallel with existing brain cancer therapeutics.
  • the term "administration” means introducing a predetermined substance into a patient by any suitable method, and the route of administration of the composition of the present invention is oral or parenteral via any general route as long as the target tissue can be reached. May be administered.
  • the composition may be administered by any device in which the active agent may migrate to the target cell.
  • composition of the present invention is administered in a pharmaceutically effective amount.
  • pharmaceutically effective amount means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and an effective dose level refers to the sexually transmitted disease, age, severity, and drug activity of the patient.
  • the compositions of the present invention may be administered as individual therapeutic agents or in combination with other therapeutic agents and may be administered sequentially or simultaneously with conventional therapeutic agents. It may be single or multiple doses.
  • the method of administering the composition comprising the extract or compound prepared according to the preparation method of the present invention is preferably oral administration or intravenous administration.
  • the effective dose is oral administration, it is usually 1 to 1 time per adult. 500 mg / kg is preferred, and in the case of intravenous administration, 1 to 100 mg / kg is preferred, and may be administered 2-3 times a day.
  • Dosage levels for a particular patient may vary depending on sex, age, health condition, diet, time of administration, method of administration, drug mixture, the condition of the patient, and the extent of the onset of neurological disease.
  • the present invention provides a functional food for preventing brain cancer containing an Inulae Flos ethanol extract containing a food supplement acceptable additive as an active ingredient.
  • Functional food of the present invention preferably contains 0.1 to 5% by weight, more preferably 1% by weight of the ethanol extract relative to the total weight.
  • the present invention As a result of introducing the capillary extract of the present invention into U-87 MG brain cancer cells, it was confirmed that U-87 MG brain cancer cells are killed (see FIG. 1 ). Therefore, it can be seen newly that the extract of the sun has a brain cancer treatment effect.
  • the present invention was completed by preparing a functional food for preventing brain cancer containing the abalone extract as an active ingredient (see Preparation Example 2 ).
  • the mucus extract of the present invention inhibits the growth of brain cancer cells and induces apoptosis. Therefore, the composition for treating brain cancer according to the present invention will be very effective in the treatment of brain cancer patients.
  • FIG. 1 is a result of the Alamar Blue analysis to determine the effect of the introduction of acupuncture on the growth of brain cancer cells in human brain cancer U-87 MG cells.
  • the horizontal axis of the figure shows the concentration of the extract, the vertical axis shows the survival rate of brain cancer cells.
  • FIG. 2 is a result of Alamar Blue analysis to determine the effect of the introduction of turmeric extract on the growth of brain cancer cells in human brain cancer U-87 MG cells.
  • the horizontal axis of the figure shows the concentration of the extract, the vertical axis shows the survival rate of brain cancer cells.
  • Alamar Blue analysis was performed on U-87 MG, a human brain cancer cell.
  • the Alamar Blue assay is a modified form of the MTT assay, in which a specific enzyme degrades a living cell and then measures the fluorescence intensity of the product as the compound breaks down to determine the relative number of living cells after treatment. I am an experimental method. It is described in more detail below.
  • U-87 MG cells a brain cancer cell line used in the present invention, were distributed from the Korean Cell Line Bank (KCLB) and used for experiments.
  • MEM Minimum Essential Medium
  • FBS fetal bovine serum, fetal bovine serum
  • HEPES 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid
  • the vitrified extract extracted in Example 1 confirmed the cell growth inhibitory effect on U-87 MG, a brain cancer cell. Specifically, 8.0 x 10 per each well in a 96 well plate 3 Said mucination in which U-87 MG cells were seeded and dissolved in dimethyl sulfoxide (DMSO) When the ethanol extract was treated at concentrations of 0 to 100 ⁇ g / ml (specifically, concentrations of 0, 3.125, 6.25, 12.5, 25, 50 and 100 ⁇ g / ml, respectively) for 48 hours, the degree of inhibition of cell growth was confirmed. (Table 1).
  • the mucination used in the present invention was widely used as a medicinal herb, so it was judged that there would be no problem in stability.
  • Acute toxicity test was performed using 6-week-old SPF SD rats. Two animals per group were suspended orally administered at a dose of 5 g / kg in suspension of the capillary extract of Example 1 of the present invention in 0.5% methylcellulose solution, respectively. After administration of the test substance, mortality, clinical symptoms, and changes in body weight were observed. Hematological and hematological examinations were performed. Necropsy was performed to observe abdominal and thoracic organ abnormalities.
  • Turmeric is a substance that shows anticancer activity against various kinds of cancers such as lung cancer, uterine cancer and breast cancer.
  • the present inventors confirmed the effectiveness of the capillary extract of the present invention by confirming the extent to which the turmeric affects the growth of brain cancer cells.
  • the turmeric extract was confirmed the growth inhibition of the U-87 MG cells in the same manner as in Example 2, and the results are shown in Table 2 and FIG.
  • turmeric hardly reduced the growth of brain cancer cells even when the treatment concentration was high.
  • turmeric which is widely known as an anticancer substance, has almost no brain cancer treatment efficacy, whereas the mucosa extract of the present invention has excellent U-87 MG cell killing activity, and further shows that it has brain cancer treatment and prophylactic activity.
  • the inventors of the present invention confirmed that the superior effect of the anticancer extract for the brain cancer treatment, and prepared a brain cancer treatment containing the extract as an active ingredient as follows.
  • the preparation of the following therapeutic agent can be used for the application of the health food as well as the therapeutic agent.
  • the present inventors have confirmed that the sensitized extract is excellent in the brain cancer treatment activity through the above embodiment to prepare a functional food containing it as an active ingredient as follows.
  • Chewing gum was prepared using a conventional method using the composition and the content of 20% of gum base, 76.36 to 76.76% of sugar, 0.24 to 0.64% of pear extract, 1% of fruit flavor, and 2% of water.
  • Candy was prepared by the conventional method using the composition and content of 50-60% of sugar, 39.26-49.66% of starch syrup, 0.24-0.64% of bokbok extract, and 0.1% of orange flavor.

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Abstract

L'invention concerne une nouvelle utilisation d'extrait de la fleur Inula, et concerne notamment une composition pour prévenir et guérir le cancer du cerveau, la composition comprenant un extrait éthanolique de la fleur Inula en tant qu'ingrédient actif, et une alimentation fonctionnelle pour prévenir le cancer du cerveau, l'alimentation fonctionnelle comprenant l'extrait éthanolique de la fleur Inula, qui comprend un additif alimentaire cytologiquement acceptable en tant qu'ingrédient actif. La composition et l'alimentation fonctionnelle pour traiter le cancer du cerveau selon la présente invention sont efficaces pour inhiber la croissance et provoquer la mort des cellules cancéreuses; cela permet de les utiliser efficacement pour prévenir et guérir le cancer du cerveau.
PCT/KR2012/001078 2011-02-11 2012-02-13 Composition et alimentation fonctionnelle pour traiter le cancer du cerveau comprenant un extrait de la fleur inula Ceased WO2012108744A2 (fr)

Applications Claiming Priority (2)

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KR1020110012210A KR20120092271A (ko) 2011-02-11 2011-02-11 선복화 추출물을 포함하는 뇌암 치료용 조성물 및 건강 기능성 식품
KR10-2011-0012210 2011-02-11

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WO2014069692A1 (fr) * 2012-10-31 2014-05-08 주식회사 한국전통의학연구소 Composition pour traiter le cancer rénal et aliment santé fonctionnel contenant un extrait d'inula britannica var. chinensis
KR20220061689A (ko) 2020-11-06 2022-05-13 재단법인 자생의료재단 선복화(Inula britannica var. chinensis Regel) 추출물을 유효성분으로 포함하는 신경계 질환의 예방 또는 치료용 조성물

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KR100500298B1 (ko) * 2000-12-12 2005-07-11 주식회사 안지오랩 멜리사엽 엑스를 유효성분으로 하는 혈관신생 억제용 조성물
US7455862B2 (en) * 2005-03-23 2008-11-25 Lee's Pharmaceutical (Hong Kong) Limited Herbal compositions useful in cancer treatment
JP2009046391A (ja) * 2005-07-06 2009-03-05 Takehito Kono 悪液質改善治療製剤および悪液質改善作用を有する食品製剤

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