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WO2012176218A8 - Process for preparing rosuvastatin calcium through novel amine salt - Google Patents

Process for preparing rosuvastatin calcium through novel amine salt Download PDF

Info

Publication number
WO2012176218A8
WO2012176218A8 PCT/IN2012/000442 IN2012000442W WO2012176218A8 WO 2012176218 A8 WO2012176218 A8 WO 2012176218A8 IN 2012000442 W IN2012000442 W IN 2012000442W WO 2012176218 A8 WO2012176218 A8 WO 2012176218A8
Authority
WO
WIPO (PCT)
Prior art keywords
amine salt
rosuvastatin calcium
novel amine
preparing rosuvastatin
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2012/000442
Other languages
French (fr)
Other versions
WO2012176218A1 (en
Inventor
Shekhar Bhaskar Bhirud
Anshul Kumar Jain
Vinay Kumar SAINI
Alok Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Original Assignee
IND-SWIFT LABORATORIES Ltd
Ind Swift Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND-SWIFT LABORATORIES Ltd, Ind Swift Laboratories Ltd filed Critical IND-SWIFT LABORATORIES Ltd
Publication of WO2012176218A1 publication Critical patent/WO2012176218A1/en
Publication of WO2012176218A8 publication Critical patent/WO2012176218A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention provides a process for preparing pure rosuvastatin of formula (I), or pharmaceutically acceptable salts thereof through rosuvastatin l-(l-naphthyl)ethyl salt of formula (II) wherein wavy line (〰) represent (R), (S) stereochemistry or racemate thereof.
PCT/IN2012/000442 2011-06-24 2012-06-21 Process for preparing rosuvastatin calcium through novel amine salt Ceased WO2012176218A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1812DE2011 2011-06-24
IN1812/DEL/2011 2011-06-24

Publications (2)

Publication Number Publication Date
WO2012176218A1 WO2012176218A1 (en) 2012-12-27
WO2012176218A8 true WO2012176218A8 (en) 2013-07-25

Family

ID=47422112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000442 Ceased WO2012176218A1 (en) 2011-06-24 2012-06-21 Process for preparing rosuvastatin calcium through novel amine salt

Country Status (1)

Country Link
WO (1) WO2012176218A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9630906B2 (en) 2013-03-29 2017-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Amine salts of pitavastatin and rosuvastatin
CN104370827B (en) * 2013-08-13 2016-09-07 天津汉瑞药业有限公司 Rosuvastatin calcium compound
US9695130B2 (en) 2014-02-06 2017-07-04 Api Corporation Rosuvastatin calcium and process for producing intermediate thereof
WO2019008593A1 (en) * 2017-07-05 2019-01-10 Melody Healthcare Pvt. Ltd Process for manufacture of rosuvastatin calcium amorphous
JP7113397B2 (en) * 2018-06-15 2022-08-05 金剛化学株式会社 Process for producing intermediate of rosuvastatin calcium
CN108586358A (en) * 2018-07-06 2018-09-28 苏州中联化学制药有限公司 The preparation process of Rosuvastatin calcium preparation
CN108948078A (en) * 2018-09-11 2018-12-07 浙江乐普药业股份有限公司 A kind of synthetic method of rosuvastatin intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
CN1906175A (en) * 2003-11-24 2007-01-31 特瓦制药工业有限公司 Crystalline ammonium salts of rosuvastatin
EP1709008A1 (en) * 2004-01-19 2006-10-11 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
EP2508514B1 (en) * 2005-06-24 2017-10-18 LEK Pharmaceuticals d.d. Process for preparing amorphous rosuvastatin calcium free of impurities

Also Published As

Publication number Publication date
WO2012176218A1 (en) 2012-12-27

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